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[PMID]:29300751
[Au] Autor:Ohshima K; Mitoma S; Gibbs AJ
[Ad] Endereço:Laboratory of Plant Virology, Department of Applied Biological Sciences, Faculty of Agriculture, Saga University, Saga, Japan.
[Ti] Título:The genetic diversity of narcissus viruses related to turnip mosaic virus blur arbitrary boundaries used to discriminate potyvirus species.
[So] Source:PLoS One;13(1):e0190511, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Narcissus plants (Narcissus tazetta var. chinensis) showing mosaic or striping leaves were collected from around Japan, and tested for virus infections using potyvirus-specific primers. Many were found to be infected with a macluravirus and mixtures of different potyviruses, one third of them narcissus yellow stripe virus (NYSV)-like viruses. Genomes of nine of the NYSV-like viruses were sequenced and, together with four already published, provided data for phylogenetic and pairwise identity analyses of their place in the turnip mosaic virus (TuMV) phylogenetic group. Using existing ICTV criteria for defining potyvirus species, the narcissus viruses in TuMV group were found to be from five species; the previously described NLSYV, and four new species we call narcissus virus 1 (NV-1) and narcissus yellow stripe-1 to -3 (NYSV-1, NYSV-2 and NYSV-3). However, as all are from a single host species, and natural recombinants with NV-1 and NYSV-3 'parents have been found in China and India, we also conclude that they could be considered to be members of a single mega-species, narcissus virus; the criteria for defining such a potyvirus species would then be that their polyprotein sequences have greater than 69% identical nucleotides and greater than 75% identical amino acids.
[Mh] Termos MeSH primário: Variação Genética
Narcissus/virologia
Potyvirus/genética
[Mh] Termos MeSH secundário: Proteínas do Capsídeo/genética
Genes Virais
Filogenia
Potyvirus/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190511


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[PMID]:28208239
[Au] Autor:Jin J; Shen JG; Cai W; Xie GH; Liao FR; Gao FL; Ma JF; Chen XH; Wu ZJ
[Ad] Endereço:State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, China.
[Ti] Título:Narcissus yellow stripe virus and Narcissus mosaic virus detection in Narcissus via multiplex TaqMan-based reverse transcription-PCR assay.
[So] Source:J Appl Microbiol;122(5):1299-1309, 2017 May.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Development of a multiplex TaqMan RT-qPCR assay to simultaneously detect Narcissus yellow stripe virus (NYSV) and Narcissus mosaic virus (NMV), frequently causing mixed narcissus infection. Feasibility verification was confirmed in natural samples. METHODS AND RESULTS: Primers and probes were designed based on the conserved CP gene regions of NYSV or NMV and their suitability for singleplex and multiplex TaqMan RT-qPCR assays as well as for conventional RT-PCR. Conventional RT-PCR, singleplex and multiplex TaqMan RT-qPCR assays proved to be NYSV and NMV specific. P-values and coefficients of variation of TaqMan RT-qPCR assays indicated high reproducibility. Significantly increased sensitivity was achieved compared to conventional RT-PCR. The detection limit of both viruses was 10 copies with superior correlation coefficients and linear standard curve responses between plasmid concentrations and Ct values. NYSV and NMV infection of narcissus leaves, petals and bulbs could successfully be detected via our multiplex RT-qPCR method at 1·25 mg. CONCLUSION: Our multiplex TaqMan RT-qPCR assay provides rapid, specific, sensitive and reliable testing to simultaneously detect NYSV and NMV, supplying useful routine monitoring for different narcissus samples. SIGNIFICANCE AND IMPACT OF THE STUDY: Efficient identification and discrimination of the narcissus viruses provides reliable information for scientists and conventional growers. Furthermore, it enriches the information of NYSV, NMV and other narcissus viruses.
[Mh] Termos MeSH primário: Narcissus/virologia
Potyvirus/isolamento & purificação
Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos
[Mh] Termos MeSH secundário: Primers do DNA/genética
Reação em Cadeia da Polimerase Multiplex/métodos
Potyvirus/classificação
Potyvirus/genética
Potyvirus/fisiologia
Reprodutibilidade dos Testes
Transcrição Reversa
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1111/jam.13422


  3 / 120 MEDLINE  
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[PMID]:28130769
[Au] Autor:Li X; Zhang P; Zhang N; Liang X; Wang W; Yuan Q; Li Q
[Ad] Endereço:College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.
[Ti] Título:Secretory Expression and Characterization of Chinese Narcissus GNA-Like Lectin in Pichia pastoris.
[So] Source:Appl Biochem Biotechnol;182(4):1433-1443, 2017 Aug.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Narcissus tazetta lectin (NTL) is a GNA-like lectin, which has a wide potential application in medicine, agriculture, and glycobiology. In the present paper, the codon-optimized ntl gene was transformed into the yeast Pichia pastoris; SDS-PAGE gel and western blotting analysis revealed that the recombinant lectin was expressed successfully in Pichia yeast. The similarity between the recombinant NTL and the native NTL was confirmed by circular dichroism (CD) and hemagglutination assay further. In the 5-L scale fermentator, the protein yield was as high as 1.2 g/L after fermentation for 96 h. In addition, the effect of metal ions (K , Mg , Ca , and Cu ), acid, and alkaline on hemagglutinating activity of NTL was tested, which provided biochemical characterizations of the mannose-binding lectin from Chinese Narcissus.
[Mh] Termos MeSH primário: Narcissus/genética
Pichia/genética
Lectinas de Plantas/genética
Lectinas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Sequência de Bases
Expressão Gênica
Hemaglutinação/efeitos dos fármacos
Concentração de Íons de Hidrogênio
Metais/farmacologia
Lectinas de Plantas/farmacologia
Lectinas de Plantas/secreção
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Proteínas Recombinantes/farmacologia
Proteínas Recombinantes/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals); 0 (Plant Lectins); 0 (Recombinant Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-017-2408-5


  4 / 120 MEDLINE  
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[PMID]:27094365
[Au] Autor:Herranz JM; Copete E; Copete MA; Márquez J; Ferrandis P
[Ad] Endereço:Department of Crop Production and Agricultural Technology, Higher Technical School of Agronomy and Forestry Engineering, Botanical Institute of the University of Castilla-La Mancha, University of Castilla-La Mancha, Albacete, Spain.
[Ti] Título:Dormancy induction by summer temperatures and/or desiccation in imbibed seeds of trumpet daffodils Narcissus alcaracensis and N. longispathus (Amaryllidaceae).
[So] Source:Plant Biol (Stuttg);19(1):46-52, 2017 Jan.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We analysed the effects of summer temperatures (28/14 °C) and/or desiccation (from 48% to 8% humidity) on imbibed Narcissus alcaracensis and N. longispathus seeds with an elongating embryo. In the N. alcaracensis seeds that overcame dormancy (embryo elongation = 27.14%), exposure to high temperatures induced secondary dormancy and reduced subsequent embryo growth. A further 3-month cold stratification (5 °C) was required to break secondary dormancy. Desiccation in early embryo growth stages (elongation = 11.42%) also reduced germination. Desiccation in the seeds in a more advanced growth stage (i.e. embryo elongation = 27.14%) induced secondary dormancy, which the further 3-month cold stratification did not overcome. When desiccation was preceded by high temperatures, seeds better overcame secondary dormancy (i.e. longer embryo elongation and seed germination). Treatments did not affect seed viability. In the N. longispathus seeds that overcame dormancy (embryo elongation = 59.21%), exposure to high temperatures induced secondary dormancy and they needed a further 1-month stratification at 15/4 °C + 2 months at 5 °C to reactivate the germination process. When embryo elongation was 42.10%, seed desiccation totally impeded subsequent germination. When embryo elongation reached 59.21%, desiccation induced secondary dormancy, which was not overcome by the above-described stratification treatment. When desiccation was preceded by high temperatures, seeds better overcame dormancy. Stress treatments killed 5-10% of seeds. This study suggests that the seeds of species with complex morphophysiological dormancy (MPD) levels are sensitive to desiccation in early embryo development stages, as opposed to the seeds of species with deep simple epicotyl MPD, which better tolerate water stress.
[Mh] Termos MeSH primário: Narcissus/fisiologia
Dormência de Plantas
Sementes/fisiologia
[Mh] Termos MeSH secundário: Temperatura Baixa
Dessecação
Germinação
Temperatura Alta
Umidade
Estações do Ano
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12467


  5 / 120 MEDLINE  
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[PMID]:27590715
[Au] Autor:Ohshima K; Nomiyama R; Mitoma S; Honda Y; Yasaka R; Tomimura K
[Ad] Endereço:Laboratory of Plant Virology, Department of Applied Biological Sciences, Faculty of Agriculture, Saga University, 1-banchi, Honjo-machi, Saga 840-8502, Japan; The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan. Electronic address: o
[Ti] Título:Evolutionary rates and genetic diversities of mixed potyviruses in Narcissus.
[So] Source:Infect Genet Evol;45:213-223, 2016 Nov.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:There is no attempt to evaluate evolutionary rates, timescales and diversities of viruses collected from mixedly infected hosts in nature. Plants of the genus Narcissus are a monocotyledon and are susceptible to several viruses. In this study, narcissus plants (Narcissus tazetta var. chinensis) showing mosaic or striping leaves were collected in Japan, and these were investigated for potyvirus infections using potyvirus-specific primers. Individual narcissus plants were found frequently to be mixedly infected with different potyviruses, different isolates and quasispecies of same virus. The viruses were potyviruses and a macluravirus in the family Potyviridae, namely Narcissus late season yellows virus (NLSYV), Narcissus yellow stripe virus (NYSV), Narcissus degeneration virus (NDV), Cyrtanthus elatus virus A (CyEVA) and Narcissus latent virus (NLV). Genetic diversities of coat protein coding region of different virus species were different; NYSV and CyEVA were most diverse whereas NDV was least. Evolutionary rates of all five narcissus viruses were 1.33-7.15×10 nt/site/year and were similar. The most recent common ancestors (TMRCAs) varied between virus species; NYSV and CyEVA were the oldest whereas NDV was the youngest. Thus, the oldness of TMRCAs of the viruses correlated well with the greatness of nucleotide diversities.
[Mh] Termos MeSH primário: Narcissus/virologia
Doenças das Plantas/virologia
Potyvirus/genética
[Mh] Termos MeSH secundário: Evolução Molecular
Variação Genética/genética
Filogenia
RNA Viral/análise
RNA Viral/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE


  6 / 120 MEDLINE  
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[PMID]:27542176
[Au] Autor:Fürst R
[Ad] Endereço:Institute of Pharmaceutical Biology, Biocenter, Goethe University, Frankfurt/Main, Germany.
[Ti] Título:Narciclasine - an Amaryllidaceae Alkaloid with Potent Antitumor and Anti-Inflammatory Properties.
[So] Source:Planta Med;82(16):1389-1394, 2016 Nov.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The isocarbostyril alkaloid narciclasine, also known as lycoricidinol, was discovered in species (Amaryllidaceae) in 1967. A few years later, the 60S subunit of ribosomes, and thus protein biosynthesis, were shown to be directly targeted by narciclasine. Due to its selective and highly potent cytotoxic action on cancer cells, narciclasine was intensively investigated as an antitumor compound both and . However, narciclasine did not show a strong pharmacological activity in animal tumor models. During the last decade, new fascinating actions, mechanisms, and targets of narciclasine have emerged. This review intends to present a brief but comprehensive overview of these novel insights. Beneficial therapeutical actions have been reported particularly in brain tumor models. The translation elongation factor eEF1A, which does not only participate in protein biosynthesis but also in the regulation of the actin cytoskeleton, was discovered as new direct target. Moreover, narciclasine was found to trigger actin stress fiber formation via the activation of the small GTPase RhoA. Progress has also been made regarding the pharmacokinetic characterization of the alkaloid. The synthesis of a great number of narciclasine derivatives led to a substantial understanding of its pharmacophore and of the structure-activity relationships. However, an optimized compound did not result from these efforts. Most importantly, a new field of indication has emerged: Narciclasine was proven to exert profound anti-inflammatory actions . Taken together, there has been a strong advance in the preclinical knowledge about the alkaloid. Nevertheless, narciclasine has not been tested in human clinical trials up to now.
[Mh] Termos MeSH primário: Alcaloides de Amaryllidaceae/farmacologia
Anti-Inflamatórios/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Narcissus/química
Fenantridinas/farmacologia
[Mh] Termos MeSH secundário: Alcaloides de Amaryllidaceae/química
Alcaloides de Amaryllidaceae/metabolismo
Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/metabolismo
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/metabolismo
Fenantridinas/química
Fenantridinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amaryllidaceae Alkaloids); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Phenanthridines); 29477-83-6 (narciclasine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE


  7 / 120 MEDLINE  
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[PMID]:27476617
[Au] Autor:Fu KL; Li X; Ye J; Lu L; Xu XK; Li HL; Zhang WD; Shen YH
[Ad] Endereço:Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
[Ti] Título:Chemical constituents of Narcissus tazetta var. chinensis and their antioxidant activities.
[So] Source:Fitoterapia;113:110-6, 2016 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Two new flavan derivatives tazettones C-D (1-2), one new ß-coumaranone (tazettone E, 3), one new flavan (tazettone F, 4), and one new phenylpropanoid (tazettone G, 5), together with six known flavonoids (6-11), were isolated from the bulbs of Narcissus tazetta var. chinensis Roem. Their structures were elucidated by spectroscopic analysis. In addition, the structures of 1-3 were confirmed by single crystal X-ray diffraction. All isolated compounds were tested for antioxidant activity by Cell Counting Kit-8 (CCK-8) assay. Compounds 6-8 and 10-11 exhibited potent antioxidant activity against H2O2-induced impairment in human SH-SY5Y neuroblastoma cells at tested concentrations.
[Mh] Termos MeSH primário: Antioxidantes/química
Flavanonas/química
Narcissus/química
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Linhagem Celular Tumoral
Flavanonas/isolamento & purificação
Seres Humanos
Peróxido de Hidrogênio
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavanones); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE


  8 / 120 MEDLINE  
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[PMID]:27252378
[Au] Autor:Kilgore MB; Holland CK; Jez JM; Kutchan TM
[Ad] Endereço:From the Donald Danforth Plant Science Center, St. Louis, Missouri 63132 and the Department of Biology, Washington University in St. Louis, St. Louis, Missouri 63130.
[Ti] Título:Identification of a Noroxomaritidine Reductase with Amaryllidaceae Alkaloid Biosynthesis Related Activities.
[So] Source:J Biol Chem;291(32):16740-52, 2016 08 05.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Amaryllidaceae alkaloids are a large group of plant natural products with over 300 documented structures and diverse biological activities. Several groups of Amaryllidaceae alkaloids including the hemanthamine- and crinine-type alkaloids show promise as anticancer agents. Two reduction reactions are required for the production of these compounds: the reduction of norcraugsodine to norbelladine and the reduction of noroxomaritidine to normaritidine, with the enantiomer of noroxomaritidine dictating whether the derivatives will be the crinine-type or hemanthamine-type. It is also possible for the carbon-carbon double bond of noroxomaritidine to be reduced, forming the precursor for maritinamine or elwesine depending on the enantiomer reduced to an oxomaritinamine product. In this study, a short chain alcohol dehydrogenase/reductase that co-expresses with the previously discovered norbelladine 4'-O-methyltransferase from Narcissus sp. and Galanthus spp. was cloned and expressed in Escherichia coli Biochemical analyses and x-ray crystallography indicates that this protein functions as a noroxomaritidine reductase that forms oxomaritinamine from noroxomaritidine through a carbon-carbon double bond reduction. The enzyme also reduces norcraugsodine to norbelladine with a 400-fold lower specific activity. These studies identify a missing step in the biosynthesis of this pharmacologically important class of plant natural products.
[Mh] Termos MeSH primário: Alcaloides de Amaryllidaceae/química
Galanthus/enzimologia
Narcissus/enzimologia
Oxirredutases/química
Proteínas de Plantas/química
[Mh] Termos MeSH secundário: Alcaloides de Amaryllidaceae/metabolismo
Galanthus/genética
Narcissus/genética
Oxirredução
Oxirredutases/genética
Oxirredutases/metabolismo
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Amaryllidaceae Alkaloids); 0 (Plant Proteins); 0 (Recombinant Proteins); EC 1.- (Oxidoreductases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.717827


  9 / 120 MEDLINE  
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[PMID]:26738752
[Au] Autor:Marques I; Jürgens A; Aguilar JF; Feliner GN
[Ad] Endereço:Department of Agricultural and Environmental Sciences, High Polytechnic School of Huesca, University of Zaragoza, C/Carretera de Cuarte Km 1, Huesca, E22071, Spain.
[Ti] Título:Convergent recruitment of new pollinators is triggered by independent hybridization events in Narcissus.
[So] Source:New Phytol;210(2):731-42, 2016 Apr.
[Is] ISSN:1469-8137
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hybridization can generate new species if some degree of isolation prevents gene flow between the hybrids and their progenitors. The recruitment of novel pollinators by hybrids has been hypothesized to be one way in which such reproductive isolation can be achieved. We tested whether pollinators contributed to isolation between two natural Narcissus hybrids and their progenitors using pollination experiments, observations, plus morphological and floral-volatile measurements. These hybrids share the same maternal but different paternal progenitors. We found that only the hybrids were visited by and pollinated by ants. The two hybrids exceeded their progenitors in floral-tube aperture size and nectar production. The emission of floral volatiles by hybrid plants was not only equal to or higher than the progenitor species, but also contained some new compounds not produced by the progenitors. The recruitment of ants as novel pollinators in the hybrids involved the combination of increased nectar secretion and the production of novel floral scent compounds. A breakdown of chemical defence against ants may also be involved. This study provides support for the hypothesis that the recruitment of novel pollinators can contribute to reproductive isolation between hybrids and their progenitors.
[Mh] Termos MeSH primário: Insetos/fisiologia
Narcissus/genética
Narcissus/fisiologia
Polinização/fisiologia
[Mh] Termos MeSH secundário: Animais
Flores/fisiologia
Frutas/fisiologia
Hibridização Genética
Odorantes
Filogenia
Característica Quantitativa Herdável
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Volatile Organic Compounds)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE
[do] DOI:10.1111/nph.13805


  10 / 120 MEDLINE  
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[PMID]:26475459
[Au] Autor:Morikawa T; Ninomiya K; Kuramoto H; Kamei I; Yoshikawa M; Muraoka O
[Ti] Título:Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis.
[So] Source:J Nat Med;70(1):89-101, 2016 Jan.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A methanol extract of the flowers of Narcissus tazetta var. chinensis Roem. (Amaryllidaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the extract, four new phenylethanoid glycosides, tazettosides A­D (1­4), and a new phenylpropanoid glycoside, tazettoside E (5), were isolated along with 23 known compounds (6­28). Of the isolates, 1 (IC50 = 22.0 µM) and 4 (82.5 µM), 3-methoxy-8,9-methylenedioxy-3,4-dihydrophenanthridine (13, IC50 = 28.5 µM), 5,6-dihydrobicolorine (14, 23.7 µM), tazettine (16, 60.8 µM), benzyl ß-D-glucopyranosyl-(1→6)-ß-D-glucopyranoside (18, 27.8 µM), 2-(3,4-dimethoxyphenyl)ethyl ß-D-glucopyranosyl-(1→6)-ß-D-glucopyranoside (21, 74.6 µM), 3-phenylpropyl ß-D-glucopyranoside (22, 59.0 µM), and cinnamyl ß-D-glucopyranosyl-(1→6)-ß-D-glucopyranoside (24, 88.0 µM) showed inhibitory effects without notable cytotoxicity at the effective concentrations.
[Mh] Termos MeSH primário: Glicosídeos/farmacologia
Melaninas/biossíntese
Melanoma Experimental/metabolismo
Narcissus/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Flores/química
Glicosídeos/química
Camundongos
Monofenol Mono-Oxigenase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycosides); 0 (Melanins); 0 (Plant Extracts); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151018
[St] Status:MEDLINE



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