Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.100.060 [Categoria DeCS]
Referências encontradas : 77 [refinar]
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[PMID]:28727758
[Au] Autor:Pannakal ST; Jäger S; Duranton A; Tewari A; Saha S; Radhakrishnan A; Roy N; Kuntz JF; Fermas S; James D; Mellor J; Misra N; Breton L
[Ad] Endereço:L'Oreal Research & Innovation, Bangalore, India.
[Ti] Título:Longevity effect of a polysaccharide from Chlorophytum borivilianum on Caenorhabditis elegans and Saccharomyces cerevisiae.
[So] Source:PLoS One;12(7):e0179813, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The traditional Indian medicine, Ayurveda, provides insights and practical solutions towards a healthy life style. Rasayana is a branch of Ayurveda known for preserving and promoting health, enhancing the quality of life and delaying the aging process. In the traditional knowledge, the Rasayana herb, Chlorophytum borivilianum (C. borivilanum) is regarded as a general health promoting tonic that delays aging and increases lifespan, cognitive function and physical strength. Aging is a complex and multifactorial physiological phenomenon that manifests itself over a wide range of biological systems, tissues, and functions. Longevity is an obvious marker of physiological aging. Simple model systems such as the single-cell budding yeast Saccharomyces cerevisiae (S. cerevisiae) and the nematode, Caenorhabditis elegans (C. elegans) are widely used to study the aging process and longevity. Here, we show that a polysaccharide fraction obtained from C. borivilianum increases the lifespan of S. cerevisiae and C. elegans, using an automated screening platform (ChronoscreenTM). Chemical analysis of this extract revealed a low molecular weight polysaccharide of 1000 Da, predominantly comprising Glu1→6Glu linkage. This polysaccharide showed significant dose-dependent extension of the median lifespan of S. cerevisiae by up to 41% and of the median lifespan of C. elegans by up to 10%. Taking cue from these results and the traditionally described benefits of Rasayanas on skin rejuvenation, we tested in vitro the polysaccharide for potential skin benefits. In a keratinocyte culture, we observed that this polysaccharide increased cell proliferation significantly, and induced synthesis of hyaluronic acid (HA), a well-known extracellular matrix component. Furthermore, when added to culture medium of human reconstructed epidermis, we observed an enhanced production of epidermal markers, e.g. CD44 and HA that are otherwise diminished in aged skin. Together, these results suggest that in addition to life-span extension of S. cerevisiae and C. elegans, a polysaccharide from the Rasayana herb, C. borivilianum may have beneficial effects on skin aging parameters.
[Mh] Termos MeSH primário: Asparagaceae
Longevidade/efeitos dos fármacos
Medicina Ayurvédica
Extratos Vegetais/farmacologia
Polissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Envelhecimento
Animais
Caenorhabditis elegans/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Queratinócitos/efeitos dos fármacos
Saccharomyces cerevisiae/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Polysaccharides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179813


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[PMID]:28497409
[Au] Autor:Lledías F; Hernández F; Rivas V; García-Mendoza A; Cassab GI; Nieto-Sotelo J
[Ad] Endereço:Departamento de Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001, Col. Chamilpa C.P., 62210, Cuernavaca, Morelos, Mexico.
[Ti] Título:A Rapid and Reliable Method for Total Protein Extraction from Succulent Plants for Proteomic Analysis.
[So] Source:Protein J;36(4):308-321, 2017 Aug.
[Is] ISSN:1875-8355
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Crassulacean acid metabolism plants have some morphological features, such as succulent and reduced leaves, thick cuticles, and sunken stomata that help them prevent excessive water loss and irradiation. As molecular constituents of these morphological adaptations to xeric environments, succulent plants produce a set of specific compounds such as complex polysaccharides, pigments, waxes, and terpenoids, to name a few, in addition to uncharacterized proteases. Since all these compounds interfere with the analysis of proteins by electrophoretic techniques, preparation of high quality samples from these sources represents a real challenge. The absence of adequate protocols for protein extraction has restrained the study of this class of plants at the molecular level. Here, we present a rapid and reliable protocol that could be accomplished in 1 h and applied to a broad range of plants with reproducible results. We were able to obtain well-resolved SDS/PAGE protein patterns in extracts from different members of the subfamilies Agavoideae (Agave, Yucca, Manfreda, and Furcraea), Nolinoideae (Dasylirion and Beucarnea), and the Cactaceae family. This method is based on the differential solubility of contaminants and proteins in the presence of acetone and pH-altered solutions. We speculate about the role of saponins and high molecular weight carbohydrates to produce electrophoretic-compatible samples. A modification of the basic protocol allowed the analysis of samples by bidimensional electrophoresis (2DE) for proteomic analysis. Furostanol glycoside 26-O-ß-glucosidase (an enzyme involved in steroid saponin synthesis) was successfully identified by mass spectrometry analysis and de novo sequencing of a 2DE spot from an Agave attenuata sample.
[Mh] Termos MeSH primário: Extração Líquido-Líquido/métodos
Folhas de Planta/química
Proteínas de Plantas/isolamento & purificação
Proteômica/métodos
beta-Glucosidase/isolamento & purificação
[Mh] Termos MeSH secundário: Acetona/química
Agave/química
Asparagaceae/química
Cactaceae/química
Eletroforese em Gel Bidimensional
Espectrometria de Massas
Solventes/química
Yucca/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Solvents); 1364PS73AF (Acetone); EC 3.2.1.- (furostanol glycoside 26-O-beta-glucosidase); EC 3.2.1.21 (beta-Glucosidase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.1007/s10930-017-9720-3


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[PMID]:28445423
[Au] Autor:Lou Q; Wang L; Liu H; Liu Y
[Ad] Endereço:College of Horticulture, Northwest A & F University, Yangling 712100, Shaanxi, China. louqian@nwsuaf.edu.cn.
[Ti] Título:Anthocyanin Profiles in Flowers of Grape Hyacinth.
[So] Source:Molecules;22(5), 2017 Apr 26.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Grape hyacinth ( spp.) is a popular ornamental bulbous perennial famous for its blue flowers. To understand the chemical basis of the rich blue colors in this plant, anthocyanin profiles of six blue flowering grape hyacinths as well as one pink and one white cultivar were determined using high-performance liquid chromatography and mass spectrometry. Along with two known compounds, eight putative anthocyanins were identified in the tepals of grape hyacinth for the first time. The accumulation and distribution of anthocyanins in the plant showed significant cultivar and flower development specificity. Violet-blue flowers mainly contained simple delphinidin-type anthocyanins bearing one or two methyl-groups but no acyl groups, whereas white and pink flowers synthesised more complex pelargonidin/cyanidin-derivatives with acyl-moieties but no methyl-groups. The results partially reveal why solid blue, orange or red flowers are rare in this plant in nature. In addition, pelargonidin-type anthocyanins were found for the first time in the genus, bringing more opportunities in terms of breeding of flower color in grape hyacinth.
[Mh] Termos MeSH primário: Antocianinas/isolamento & purificação
Asparagaceae/química
Flores/química
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: Acilação
Antocianinas/química
Metilação
Extratos Vegetais/química
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


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[PMID]:28051316
[Au] Autor:Schwikkard S; Alqahtani A; Knirsch W; Wetschnig W; Jaksevicius A; Opara EI; Langat MK; Andriantiana JL; Mulholland DA
[Ad] Endereço:Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey , Guildford, GU2 7XH, United Kingdom.
[Ti] Título:Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species.
[So] Source:J Nat Prod;80(1):30-37, 2017 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar, and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated, and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3 and 6-8), have been isolated and identified. Compounds 1-3 and 6-8 have not been described previously. The COX-2 inhibitory activity of compound 6 and compound 7 acetate (compound 7A) was investigated on isolated colorectal cancer cells. Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 µM compared to 12% for 1 mM aspirin (the positive control).
[Mh] Termos MeSH primário: Asparagaceae/química
Bufanolídeos/isolamento & purificação
Bufanolídeos/farmacologia
Inibidores de Ciclo-Oxigenase 2/farmacologia
Isoflavonas/isolamento & purificação
Isoflavonas/farmacologia
Lactonas/isolamento & purificação
Lactonas/farmacologia
Lignanas/isolamento & purificação
Lignanas/farmacologia
Liliaceae/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Bufanolídeos/química
Inibidores de Ciclo-Oxigenase 2/química
Inibidores de Ciclo-Oxigenase 2/isolamento & purificação
Seres Humanos
Isoflavonas/química
Lactonas/química
Lignanas/química
Madagáscar
Estrutura Molecular
Compostos Fitoquímicos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3,3'-dimethoxy-4,4'-diacetoxy-7'-ketolignano-9,9'-lactone); 0 (3beta-(O-beta-D-glucopyranosyl)-14beta-hydroxy-5alpha,19-oxobufa-20,22-dienolid); 0 (5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)chroman-4-one); 0 (Bufanolides); 0 (Cyclooxygenase 2 Inhibitors); 0 (Isoflavones); 0 (Lactones); 0 (Lignans); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00240


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[PMID]:27388719
[Au] Autor:Fujino T; Yokosuka A; Higurashi H; Yokokawa R; Sakurai R; Harashima W; Miki Y; Fujiwara Y; Mimaki Y; Hayakawa M
[Ad] Endereço:Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo, 192-0392, Japan. tfujino@ps.toyaku.ac.jp.
[Ti] Título:AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner.
[So] Source:J Nat Med;71(1):36-43, 2017 Jan.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Here, we show that AU-1, spirostanol saponin isolated from Agavaceae plants, causes a transient increase in cyclin-dependent kinase inhibitor (CDKI) p21/Cip1 through the upregulation of miRNAs, miR-34 and miR-21. AU-1 stimulated p21/Cip1 expression without exerting cytotoxicity against different types of carcinoma cell lines. In renal adenocarcinoma ACHN cells, AU-1 transiently elevated the expression level of p21/Cip1 protein without marked increases in p21/Cip1 mRNA levels. Rapid and transient increases in miR-34 and miR-21, both of which are known to upregulate p21/Cip1, were observed in AU-1-treated cells. Inhibitor for miR-34 and for miR-21 significantly blocked the AU-1-caused increase in p21/Cip1, indicating that elevation of p21/Cip1 protein by AU-1 is dependent on these microRNAs. We further clarified that NAD-dependent deacetylase SIRT1, a direct target of miR-34, is decreased by the treatment with AU-1. Furthermore, we found that SIRT1-knockdown increases p21/Cip1 protein levels in an miR-21-dependent manner. On the other hand, ectopic expression of p21/Cip1 resulted in the lowered expression of miR-34 and miR-21, suggesting that reciprocal regulation exists between p21/Cip1 and these miRNAs. We propose that the following feedback network composed of miR-34/SIRT1/miR-21/p21 is triggered by the treatment with AU-1: in cells treated with AU-1, transient elevation of miR-34 leads to the downregulation of SIRT1, thereby miR-21 is freed from SIRT1-dependent suppression. Then, elevated miR-21 upregulates p21/Cip1 protein, followed by the suppression of miR-34 expression.
[Mh] Termos MeSH primário: Ampicilina/análogos & derivados
Asparagaceae/química
Inibidor de Quinase Dependente de Ciclina p21/metabolismo
[Mh] Termos MeSH secundário: Ampicilina/uso terapêutico
Carcinoma de Células Renais
Linhagem Celular Tumoral
Quinases Ciclina-Dependentes
Regulação para Baixo
Células Hep G2
Seres Humanos
RNA Mensageiro/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclin-Dependent Kinase Inhibitor p21); 0 (N-(6,7-difluoroquinolonyl)ampicillin); 0 (RNA, Messenger); 7C782967RD (Ampicillin); EC 2.7.11.22 (Cyclin-Dependent Kinases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-016-1024-y


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[PMID]:27879640
[Au] Autor:Dutra-Behrens M; Schmeda-Hirschmann G
[Ad] Endereço:Departamento de Produtos Naturais, Instituto de Tecnologia em Fármacos da Fundação Oswaldo Cruz-Farmanguinhos/Fiocruz, Rua Sizenando Nabuco 100, 21041-250 Rio de Janeiro, Brazil. behrens@fiocruz.br.
[Ti] Título:New Homoisoflavanes, a New Alkaloid and Spirostane Steroids from the Roots of Herreria montevidensis Klotzsch ex Griseb. (Herreriaceae).
[So] Source:Molecules;21(11), 2016 Nov 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The roots of the South American vine Klotzsch ex Griseb. (Herreriaceae) are used in traditional medicine by several Amerindian groups of the Paraguayan Chaco. Little is known on the chemistry of the plant, despite its widespread use across the South American Chaco. From the ethyl acetate/methanol 1:1 extract of the roots, four new and one known homoisoflavanoid, two flavan derivatives, a stilbene, a new alkaloid, and three new and four known spirostane steroids were isolated. The corresponding structures were elucidated by spectroscopic and spectrometric means. The homoisoflavonoids of the plant are related to compounds isolated from the Dracaenaceae (formerly Agavaceae) sources of the Chinese crude drug Dragon's Blood. The new alkaloid is a novel skeleton that can be used as a chemical marker of . The spirostane steroids suggest chemotaxonomic relations with the Liliales. This is the first comprehensive report on the chemistry of a South American species.
[Mh] Termos MeSH primário: Alcaloides/química
Asparagaceae/química
Raízes de Plantas/química
Esteroides/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Extracts); 0 (Steroids)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE


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[PMID]:27825178
[Au] Autor:Masullo M; Pizza C; Piacente S
[Ad] Endereço:Dipartimento di Farmacia, Università degli Studi di Salerno, Fisciano (SA), Italy.
[Ti] Título:Ruscus Genus: A Rich Source of Bioactive Steroidal Saponins.
[So] Source:Planta Med;82(18):1513-1524, 2016 Dec.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The genus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, L. (butcher's broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on spp. extracts. The underground parts of plants are a source of steroidal saponins that can be classified into two structural classes: the hexacyclic spirostanol saponins and the pentacyclic furostanol saponins. The main aglycones are ruscogenin and neoruscogenin. From the pharmacological point of view, the most studied species is undoubtedly , a very ancient phlebotherapeutic agent. Pharmacological investigations since the discovery of the vasoconstrictive and venotonic properties of ruscogenin and neoruscogenin in the underground parts of are discussed. Preparations based on species are currently used for the treatment of chronic venous insufficiency, varicose veins, haemorrhoids, and orthostatic hypotension. Finally, analytical techniques for the quality control of extracts are reported.
[Mh] Termos MeSH primário: Asparagaceae/química
Compostos Fitoquímicos/farmacologia
Plantas Medicinais/química
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Ressonância Magnética Nuclear Biomolecular
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Extratos Vegetais/química
Saponinas/química
Saponinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts); 0 (Saponins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


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[PMID]:27797203
[Au] Autor:Calle JM; Pérez AJ; Simonet AM; Guerra JO; Macías FA
[Ad] Endereço:Grupo de Alelopatía, Departamento de Química Orgánica, Instituto de Biomoléculas (INBIO), Facultad de Ciencias, Universidad de Cádiz , C/ República Saharaui, s/n, 11510-Puerto Real (Cádiz), Spain.
[Ti] Título:Steroidal Saponins from Furcraea hexapetala Leaves and Their Phytotoxic Activity.
[So] Source:J Nat Prod;79(11):2903-2911, 2016 Nov 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Four new steroidal saponins (1-4) along with 13 known saponins were isolated from the leaves of Furcraea hexapetala. The new compounds were identified as (20R,22R,25R)-3ß-hydroxy-5α-spirostan-12-one 3-O-{α-l-rhamnopyranosyl-(1→4)-O-ß-d-glucopyranosyl-(1→3)-O-[ß-d-glucopyranosyl-(1→3)-O-ß-d-glucopyranosyl-(1→2)]-O-ß-d-glucopyranosyl-(1→4)-O-ß-d-galactopyranoside} (1), (25R)-3ß-hydroxy-5α-spirost-20(21)-en-12-one 3-O-{α-l-rhamnopyranosyl-(1→4)-O-ß-d-glucopyranosyl-(1→3)-O-[ß-d-glucopyranosyl-(1→3)-O-ß-d-glucopyranosyl-(1→2)]-O-ß-d-glucopyranosyl-(1→4)-O-ß-d-galactopyranoside} (2), (25R)-5α-spirostan-3ß-ol 3-O-{ß-d-glucopyranosyl-(1→2)-O-ß-d-glucopyranosyl-(1→2)-O-ß-d-glucopyranosyl-(1→4)-O-ß-d-galactopyranoside} (3), and (25R)-5ß-spirostan-3ß-ol 3-O-{ß-d-glucopyranosyl-(1→6)-O-ß-d-galactopyranoside} (4) by spectroscopic analysis, including one- and two-dimensional NMR techniques, mass spectrometry, and chemical methods. The phytotoxicity of the isolated compounds against the standard target species Lactuca sativa was evaluated. Structure-activity relationships for these compounds with respect to phytotoxic effects are discussed.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Asparagaceae/química
Fitosteróis/isolamento & purificação
Fitosteróis/farmacologia
Folhas de Planta/química
Saponinas/isolamento & purificação
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Cuba
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Fitosteróis/química
Saponinas/química
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Phytosterols); 0 (Saponins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE


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[PMID]:27793858
[Au] Autor:McKain MR; McNeal JR; Kellar PR; Eguiarte LE; Pires JC; Leebens-Mack J
[Ad] Endereço:Donald Danforth Plant Science Center, 975 N. Warson Road, St. Louis, Missouri 63132 USA mrmckain@gmail.com.
[Ti] Título:Timing of rapid diversification and convergent origins of active pollination within Agavoideae (Asparagaceae).
[So] Source:Am J Bot;103(10):1717-1729, 2016 Oct.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Yucca species are ideal candidates for the study of coevolution due to the obligate mutualism they form with yucca moth pollinators (genera Tegeticula and Parategeticula). Yuccas are not the only species to exhibit a mutualism with yucca moths; the genus Hesperoyucca is pollinated by the California yucca moth (Tegeticula maculata). Relationships among yuccas, Hesperoyucca, and other members of subfamily Agavoideae are necessary to understand the evolution of this unique pollination syndrome. Here, we investigate evolutionary relationships of yuccas and closely related genera looking at the timing and origin of yucca moth pollination. METHODS: In this study, we sequenced the chloroplast genomes of 20 species in the subfamily Agavoideae (Asparagaceae) and three confamilial outgroup taxa to resolve intergeneric phylogenetic relationships of Agavoideae. We estimated divergence times using protein-coding genes from 67 chloroplast genomes sampled across monocots to determine the timing of the yucca moth pollination origin. KEY RESULTS: We confidently resolved intergeneric relationships in Agavoideae, demonstrating the origin of the yucca-yucca moth mutualism on two distinct lineages that diverged 27 million years ago. Comparisons of Yucca and Hesperoyucca divergence time to those of yucca moths (Tegeticula and Parategeticula, Prodoxidae) indicate overlapping ages for the origin of pollinating behavior in the moths and pollination by yucca moths in the two plant lineages. CONCLUSION: Whereas pollinating yucca moths have been shown to have a single origin within the Prodoxidae, there were independent acquisitions of active pollination on lineages leading to Yucca and Hesperoyucca within the Agavoideae.
[Mh] Termos MeSH primário: Asparagaceae/fisiologia
Biodiversidade
Evolução Biológica
Genoma de Cloroplastos/genética
Mariposas/fisiologia
Polinização
Simbiose
[Mh] Termos MeSH secundário: Animais
Asparagaceae/genética
Evolução Molecular
Sequenciamento de Nucleotídeos em Larga Escala
Filogenia
Análise de Sequência de DNA
Yucca/genética
Yucca/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


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[PMID]:27717698
[Au] Autor:Pahwa P; Goel RK
[Ad] Endereço:Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
[Ti] Título:Asparagus adscendens root extract enhances cognition and protects against scopolamine induced amnesia: An in-silico and in-vivo studies.
[So] Source:Chem Biol Interact;260:208-218, 2016 Dec 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Asparagus adscendens Roxb. commonly known as safed musli and belonging to the Liliaceae family is cultivated mainly in Asian countries. In traditional medicine, safed musli is recommended as nerve tonic and remedy for memory impairment. The present study was aimed to evaluate nootropic and antiamnesic activities of Asparagus adscendens extract (AAE) using in silico and in vivo approach. Phytoconstituents of A. adscendens root reported in literature were subjected to in silico prediction using PASS and Pharmaexpert. The radial arm maze and passive shock avoidance paradigm were employed to evaluate nootropic activity. Subsequently, the anti-amnesic activity was evaluated in scopolamine induced amnesia model. To elucidate the mechanism of nootropic activity, the effect of AAE on the activities of acetylcholinesterase and antioxidant enzymes in the cortex and hippocampus of mice were also evaluated. In silico activity spectrum for all of A. adscendens phytoconstituents exhibited excellent prediction score for nootropic activity. Pretreatment with AAE (50, 100 & 200 mg/kg, i.p.) for 15 days showed significant decrease in working memory error, reference memory error and retrieval latency in radial arm maze and decrease in step down latency in passive shock avoidance paradigm were observed. Further, AAE significantly reduced acetylcholinesterase and oxidative stress parameters in cortex and hippocampus of mice. Thus, in silico and in vivo results suggest that A. adscendens root may exert its nootropic activity through both anti-acetylcholinesterase and antioxidant activities.
[Mh] Termos MeSH primário: Amnésia/tratamento farmacológico
Amnésia/fisiopatologia
Asparagaceae/química
Simulação por Computador
Fármacos Neuroprotetores/uso terapêutico
Extratos Vegetais/uso terapêutico
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Aprendizagem da Esquiva/efeitos dos fármacos
Biomarcadores/metabolismo
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Camundongos
Atividade Motora/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Nitritos/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Compostos Fitoquímicos/farmacologia
Compostos Fitoquímicos/uso terapêutico
Extratos Vegetais/farmacologia
Hidrobrometo de Escopolamina
Análise e Desempenho de Tarefas
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Neuroprotective Agents); 0 (Nitrites); 0 (Phytochemicals); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE



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