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[PMID]:29232127
[Au] Autor:Wu J; Sabag-Daigle A; Metz TO; Deatherage Kaiser BL; Gopalan V; Behrman EJ; Wysocki VH; Ahmer BMM
[Ad] Endereço:Department of Chemistry and Biochemistry, The Ohio State University , Columbus, Ohio 43210, United States.
[Ti] Título:Measurement of Fructose-Asparagine Concentrations in Human and Animal Foods.
[So] Source:J Agric Food Chem;66(1):212-217, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The food-borne bacterial pathogen, Salmonella enterica, can utilize fructose-asparagine (F-Asn) as its sole carbon and nitrogen source. F-Asn is the product of an Amadori rearrangement following the nonenzymatic condensation of glucose and asparagine. Heating converts F-Asn via complex Maillard reactions to a variety of molecules that contribute to the color, taste, and aroma of heated foods. Among these end derivatives is acrylamide, which is present in some foods, especially in fried potatoes. The F-Asn utilization pathway in Salmonella, specifically FraB, is a potential drug target because inhibition of this enzyme would lead to intoxication of Salmonella in the presence of F-Asn. However, F-Asn would need to be packaged with the FraB inhibitor or available in human foods. To determine if there are foods that have sufficient F-Asn, we measured F-Asn concentrations in a variety of human and animal foods. The 400 pmol/mg F-Asn found in mouse chow is sufficient to intoxicate a Salmonella fraB mutant in mouse models of salmonellosis, and several human foods were found to have F-Asn at this level or higher (fresh apricots, lettuce, asparagus, and canned peaches). Much higher concentrations (11 000-35 000 pmol/mg dry weight) were found in heat-dried apricots, apples, and asparagus. This report reveals possible origins of F-Asn as a nutrient source for Salmonella and identifies foods that could be used together with a FraB inhibitor as a therapeutic agent for Salmonella.
[Mh] Termos MeSH primário: Ração Animal/análise
Asparagina/análise
Asparagus (Planta)/química
Frutose/análise
Malus/química
Prunus armeniaca/química
Solanum tuberosum/química
[Mh] Termos MeSH secundário: Animais
Asparagus (Planta)/microbiologia
Temperatura Alta
Seres Humanos
Reação de Maillard
Malus/microbiologia
Prunus armeniaca/microbiologia
Salmonella enterica/genética
Salmonella enterica/metabolismo
Solanum tuberosum/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
30237-26-4 (Fructose); 7006-34-0 (Asparagine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04237


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[PMID]:28946917
[Au] Autor:Lei L; Chen Y; Ou L; Xu Y; Yu X
[Ad] Endereço:College of Ecology, Lishui University, Lishui, Zhejiang, 323000, China.
[Ti] Título:Aqueous root extract of Asparagus cochinchinensis (Lour.) Merr. Has antioxidant activity in D-galactose-induced aging mice.
[So] Source:BMC Complement Altern Med;17(1):469, 2017 Sep 25.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Extracts of plants have been considered as sources of natural antioxidant agents. In this study, we aimed to explore the antioxidant capacity of the aqueous root extract of Asparagus cochinchinensis (Lour.) Merr. METHODS: Using vitamin C (Vc) as a positive control, we analyzed the aqueous root extract of A. cochinchinensis free radical scavenging ability in vitro. We also established a mouse aging model using D-galactose and then treated it with aqueous root extract or Vc. The blood cell count and superoxide dismutase (SOD), catalase (CAT), and nitric oxide synthase (NOS) activities as well as malondialdehyde (MDA) and nitric oxide (NO) contents were measured; pathological examination of tissues was performed; and SOD, glutathione peroxidase (GPX), and NOS expression levels in the serum, liver, and brain tissues were investigated. RESULTS: In vitro, compared with the antioxidant Vc, the aqueous root extract showed similar 1,1-Diphenyl-2-picrylhydrazyl radical and 3-ethylbenzothiazoline-6-sulfonic·scavenging activities and even significantly increased superoxide anion (p < 0.05) and hydroxyl radical (OH) (p < 0.01) scavenging activities. The aqueous extract significantly increased the white blood cell count as well as enhanced SOD, CAT, and NOS activities (p < 0.01) in aging mice. In addition, the aqueous extract increased the NO content (p < 0.05) and reduced the MDA content (p < 0.05). CONCLUSIONS: The aqueous root extract of A. cochinchinensis showed as strong antioxidant ability as Vc and might prevent aging by reducing radicals.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Antioxidantes/farmacologia
Asparagus (Planta)/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Compostos de Bifenilo/análise
Compostos de Bifenilo/química
Compostos de Bifenilo/metabolismo
Química Encefálica/efeitos dos fármacos
Catalase/análise
Galactose
Fígado/química
Fígado/efeitos dos fármacos
Masculino
Malondialdeído/análise
Camundongos
Óxido Nítrico/análise
Picratos/análise
Picratos/química
Picratos/metabolismo
Extratos Vegetais/química
Raízes de Plantas/química
Superóxido Dismutase/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Picrates); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); 4Y8F71G49Q (Malondialdehyde); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1975-x


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[PMID]:28764033
[Au] Autor:Zannella C; Carucci F; Aversano R; Prohaska T; Vingiani S; Carputo D; Adamo P
[Ad] Endereço:Department of Agricultural Sciences, University of Naples Federico II, 80055, Via Università 100, Portici, Italy.
[Ti] Título:Genetic and geochemical signatures to prevent frauds and counterfeit of high-quality asparagus and pistachio.
[So] Source:Food Chem;237:545-552, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A fingerprinting strategy based on genetic (simple sequence repeat) and geochemical (multielement and Sr/ Sr ratio) analysis was tested to prove the geographical origin of high-quality Italian products "White Asparagus from Bassano del Grappa" and "Green Pistachio from Bronte". Genetic analysis generated many polymorphic alleles and different specific amplified fragments in both agriproducts. In addition, a core set of markers was defined. According to variability within production soils and products, potential candidate elements linking asparagus (Zn, P, Cr, Mg, B, K) and pistachio (Mn, P, Cr, Mg, Ti, B, K, Sc, S) to the production areas were identified. The Sr isotopic signature was an excellent marker when Italian asparagus was compared with literature data for Hungarian and Peruvian asparagus. This work reinforces the use of Sr isotope composition in the soil bioavailable fraction, as assessed by 1mol/L NH NO , to distinguish white asparagus and pistachio originating from different geographical areas.
[Mh] Termos MeSH primário: Asparagus (Planta)/genética
Pistacia/genética
[Mh] Termos MeSH secundário: Fraude
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28623245
[Au] Autor:Rishniw M
[Ad] Endereço:Cornell University Hospital for Animals, Ithaca, NY 14853, USA.
[Ti] Título:"Perception v production" of asparagus odour in urine needs to be determined in a controlled study.
[So] Source:BMJ;357:j2882, 2017 06 16.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Asparagus (Planta)
Odorantes
[Mh] Termos MeSH secundário: Seres Humanos
Percepção
Olfato
Verduras
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170618
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j2882


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[PMID]:28388915
[Au] Autor:Anane RF; Sun H; Zhao L; Wang L; Lin C; Mao Z
[Ad] Endereço:College of Agronomy and Biotechnology, Yunnan Agricultural University, Kunming, 650201, China.
[Ti] Título:Improved curdlan production with discarded bottom parts of Asparagus spear.
[So] Source:Microb Cell Fact;16(1):59, 2017 Apr 07.
[Is] ISSN:1475-2859
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This work evaluated the improvement of curdlan production of Agrobacterium sp. ATCC 31749 by using culture medium containing juice of discarded bottom part of green Asparagus spear (MJDA). Curdlan production was carried out using Agrobacterium sp. ATCC 31749 in flasks with different volumes of MJDA and its non-juice-adding control (CK) incubated in shaker at 30 °C, 200 rpm rotation for 168 h. RESULTS: All MJDA media increased Agrobacterium sp. ATCC 31749 cell mass and enhanced the cells' ability to utilise sucrose, the carbon source for curdlan biosynthesis, and thereby produced higher concentration of curdlan than CK which is used for commercial production of curdlan. After 168 h of fermentation, 10% MJDA produced 40.2 g/l of curdlan whiles CK produced 21.1 g/l. Curdlan production was increased by 90.4% higher in 10% MJDA than CK. Curdlan produced by 10% MJDA contains 1.2 and 1.5 µg/ml of Asparagus flavonoids and saponins respectively as additives which have wide range of health benefits. The mass of sucrose needed to produce 1.0 g curdlan by Agrobacterium sp. ATCC 31749 in CK is 1.7-fold more than in 10% MJDA. CONCLUSION: The results strongly revealed that 5-10% MJDA is a good curdlan fermentation media which increase curdlan production yield with cheaper cost of production and simultaneously reduce environmental waste resulting from the large scaled discarded bottom parts of green Asparagus spear during Asparagus production.
[Mh] Termos MeSH primário: Agrobacterium/metabolismo
Asparagus (Planta)/metabolismo
beta-Glucanas/metabolismo
[Mh] Termos MeSH secundário: Agrobacterium/citologia
Asparagus (Planta)/química
Biomassa
beta-Glucanas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (beta-Glucans); 6930DL209R (curdlan)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE
[do] DOI:10.1186/s12934-017-0671-3


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[PMID]:28275781
[Au] Autor:Sui Z; Qi C; Huang Y; Ma S; Wang X; Le G; Sun J
[Ad] Endereço:The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi214122, China.
[Ti] Título:Aqueous extracts from asparagus stems prevent memory impairments in scopolamine-treated mice.
[So] Source:Food Funct;8(4):1460-1467, 2017 Apr 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aqueous extracts from Asparagus officinalis L. stems (AEAS) are rich in polysaccharides, gamma-amino butyric acid (GABA), and steroidal saponin. This study was designed to investigate the effects of AEAS on learning, memory, and acetylcholinesterase-related activity in a scopolamine-induced model of amnesia. Sixty ICR mice were randomly divided into 6 groups (n = 10) including the control group (CT), scopolamine group (SC), donepezil group (DON), low, medium, and high dose groups of AEAS (LS, MS, HS; 1.6 mL kg , 8 mL kg , 16 mL kg ). The results showed that 8 mL kg of AEAS used in this study significantly reversed scopolamine-induced cognitive impairments in mice in the novel object recognition test (P < 0.05) and the Y-maze test (P < 0.05), and also improved the latency to escape in the Morris water maze test (P < 0.05). Moreover, it significantly increased acetylcholine and inhibited acetylcholinesterase activity in the hippocampus, which was directly related to the reduction in learning and memory impairments. It also reversed scopolamine-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) and the cAMP response element-binding protein (CREB) mRNA expression. AEAS protected against scopolamine-induced memory deficits. In conclusion, AEAS protected learning and memory function in mice by enhancing the activity of the cholinergic nervous system, and increasing BDNF and CREB expression. This suggests that AEAS has the potential to prevent cognitive impairments in age-related diseases, such as Alzheimer's disease.
[Mh] Termos MeSH primário: Amnésia/tratamento farmacológico
Asparagus (Planta)/química
Memória/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Hidrobrometo de Escopolamina/administração & dosagem
[Mh] Termos MeSH secundário: Amnésia/induzido quimicamente
Amnésia/metabolismo
Amnésia/psicologia
Animais
Fator Neurotrófico Derivado do Encéfalo/genética
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/genética
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos ICR
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Cyclic AMP Response Element-Binding Protein); 0 (Plant Extracts); 451IFR0GXB (Scopolamine Hydrobromide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00028f


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[PMID]:28260011
[Au] Autor:Lee HA; Koh EK; Sung JE; Kim JE; Song SH; Kim DS; Son HJ; Lee CY; Lee HS; Bae CJ; Hwang DY
[Ad] Endereço:College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, Gyeongsangnamdo 627­706, Republic of Korea.
[Ti] Título:Ethyl acetate extract from Asparagus cochinchinensis exerts anti­inflammatory effects in LPS­stimulated RAW264.7 macrophage cells by regulating COX­2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity.
[So] Source:Mol Med Rep;15(4):1613-1623, 2017 Apr.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Asparagus cochinchinesis (A. cochinchinesis) is a medicine traditionally used to treat fever, cough, kidney disease, breast cancer, inflammatory disease and brain disease in northeast Asian countries. Although numerous studies of the anti­inflammatory effects of A. cochinchinesis have been conducted, the underlying mechanisms of such effects in macrophages remain to be demonstrated. To investigate the mechanism of suppressive effects on the inflammatory response in macrophages, alterations of the nitric oxide (NO) level, the cell viability, inducible nitric oxide synthase (iNOS) and cyclooxygenase­2 (COX­2) expression levels, inflammatory cytokine expression, the mitogen-activated protein kinase (MAPK) signaling pathway, cell cycle arrest and reactive oxygen species (ROS) levels were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells following treatment with ethyl acetate extract from A. cochinchinesis root (EaEAC). RAW264.7 cells pretreated two different concentrations of EaEAC prior to LPS treatment exhibited no significant toxicity. The concentration of NO was significantly decreased in the EaEAC + LPS treated group compared with the vehicle + LPS treated group. A similar decrease in mRNA transcript level of COX­2, iNOS, pro-inflammatory cytokines [tumor necrosis factor­α and interleukin (IL)­1ß] and anti­inflammatory cytokines (IL­6 and IL­10) was detected in the EaEAC + LPS treated group compared with the vehicle + LPS treated group, although the decrease rate varied. Enhancement of the phosphorylation of MAPK family members following LPS treatment was partially rescued in the EaEAC pretreated group, and the cell cycle was arrested at the G2/M phase. Furthermore, the EaEAC pretreated group exhibited a reduced level of ROS generation compared with the vehicle + LPS treated group. Taken together, these results suggest that EaEAC suppresses inflammatory responses through inhibition of NO production, COX­2 expression and ROS production, as well as differential regulation of inflammatory cytokines and cell cycle in RAW264.7 cells. In addition, these results provide strong evidence to suggest that EaEAC may be considered as an important candidate for the treatment of particular inflammatory diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Asparagus (Planta)/química
Ciclo Celular/efeitos dos fármacos
Ciclo-Oxigenase 2/metabolismo
Citocinas/metabolismo
Macrófagos/metabolismo
Óxido Nítrico Sintase Tipo II/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetatos/química
Animais
Antioxidantes/metabolismo
Depuradores de Radicais Livres/farmacologia
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Macrófagos/efeitos dos fármacos
Camundongos
Óxido Nítrico/biossíntese
Células RAW 264.7
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cytokines); 0 (Free Radical Scavengers); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 31C4KY9ESH (Nitric Oxide); 76845O8NMZ (ethyl acetate); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2017.6166


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[PMID]:28189140
[Au] Autor:Kim M; Kim WB; Koo KY; Kim BR; Kim D; Lee S; Son HJ; Hwang DY; Kim DS; Lee CY; Lee H
[Ad] Endereço:Department of Food Science and Nutrition, College of Human Ecology, Pusan National University, Busan 46241, Republic of Korea.
[Ti] Título:Optimal Fermentation Conditions of Hyaluronidase Inhibition Activity on Merrill by .
[So] Source:J Microbiol Biotechnol;27(4):701-708, 2017 Apr 28.
[Is] ISSN:1738-8872
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:This study was conducted to evaluate the hyaluronidase (HAase) inhibition activity of (AC) extracts following fermentation by through response surface methodology. To optimize the HAase inhibition activity, a central composite design was introduced based on four variables: the concentration of AC extract ( : 1-5%), amount of starter culture ( : 1-5%), pH ( : 4-8), and fermentation time ( : 0-10 days). The experimental data were fitted to quadratic regression equations, the accuracy of the equations was analyzed by ANOVA, and the regression coefficients for the surface quadratic model of HAase inhibition activity in the fermented AC extract were estimated by the test and the corresponding values. The HAase inhibition activity indicated that fermentation time was most significant among the parameters within the conditions tested. To validate the model, two different conditions among those generated by the Design Expert program were selected. Under both conditions, predicted and experimental data agreed well. Moreover, the content of protodioscin (a well-known compound related to anti-inflammation activity) was elevated after fermentation of the AC extract at the optimized fermentation condition.
[Mh] Termos MeSH primário: Asparagus (Planta)/enzimologia
Fermentação
Hialuronoglucosaminidase/antagonistas & inibidores
Hialuronoglucosaminidase/metabolismo
Extratos Vegetais/farmacologia
Weissella/metabolismo
[Mh] Termos MeSH secundário: Análise de Variância
Anti-Inflamatórios/farmacologia
Asparagus (Planta)/química
Asparagus (Planta)/microbiologia
Cromatografia Líquida de Alta Pressão/métodos
Diosgenina/análogos & derivados
Diosgenina/farmacologia
Concentração de Íons de Hidrogênio
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Saponinas/farmacologia
Weissella/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 0 (Saponins); D0LC3PH24P (protodioscin); EC 3.2.1.35 (Hyaluronoglucosaminidase); K49P2K8WLX (Diosgenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE
[do] DOI:10.4014/jmb.1611.11051


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[PMID]:28152205
[Au] Autor:Jaramillo-Carmona S; Rodriguez-Arcos R; Jiménez-Araujo A; López S; Gil J; Moreno R; Guillén-Bejarano R
[Ad] Endereço:Phytochemicals and Food Quality Group, Inst. de la Grasa (CSIC), 41013, Seville, Spain.
[Ti] Título:Saponin Profile of Wild Asparagus Species.
[So] Source:J Food Sci;82(3):638-646, 2017 Mar.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to study the saponin profiles from spears of different wild asparagus species in the context of its genetic diversity aside from geographical seed origin. They included Asparagus pseudoscaber Grecescu, Asparagus maritimus (L.) Mill., Asparagus brachiphyllus Turcz., Asparagus prostrates Dumort., and Asparagus officinalis L. The saponin analysis by LC-MS has shown that saponin profile from wild asparagus is similar to that previously described for triguero asparagus from Huétor-Tájar landrace (triguero HT), which had not ever been reported in the edible part of asparagus. All the samples, except A. officinalis, were characterized for having saponins distinct to protodioscin and the total saponin contents were 10-fold higher than those described for commercial hybrids of green asparagus. In particular, A. maritimus from different origins were rich in saponins previously found in triguero HT. These findings supported previous suggestion, based on genetic analysis, about A. maritimus being the origin of triguero HT. Multivariate statistics including principal component analysis and hierarchical clustering analysis were used to define both similarities and differences among samples. The results showed that the greatest variance of the tested wild asparagus could be attributed to differences in the concentration of particular saponins and this knowledge could be a tool for identifying similar species.
[Mh] Termos MeSH primário: Asparagus (Planta)/química
Saponinas/análise
Verduras/química
[Mh] Termos MeSH secundário: Cromatografia Líquida
Diosgenina/análogos & derivados
Diosgenina/análise
Espectrometria de Massas
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saponins); D0LC3PH24P (protodioscin); K49P2K8WLX (Diosgenin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13628


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[PMID]:28024292
[Au] Autor:Tiwari N; Gupta VK; Pandey P; Patel DK; Banerjee S; Darokar MP; Pal A
[Ad] Endereço:CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
[Ti] Título:Adjuvant effect of Asparagus racemosus Willd. derived saponins in antibody production, allergic response and pro-inflammatory cytokine modulation.
[So] Source:Biomed Pharmacother;86:555-561, 2017 Feb.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The study manifests the immunoadjuvant potential of saponin rich fraction from Asparagus racemosus in terms of cellular and humoral immune response that can be exploited against microbial infections. Asparagus racemosus (AR) has been attributed as an adaptogen and rasayana in traditional medication systems for enhancing the host defence mechanism. Spectrophotometric and HPTLC analysis ensured the presence of saponins. The saponin rich fractions were tested for immunoadjuvant property in ovalbumin immunised mice for the humoral response, quantified in terms of prolonged antibody production upto a duration of 56days. Proinflammatory cytokines (IL-6 and TNF) were estimated for the cellular immune response in LPS stimulated primary murine macrophages. The safety evaluation in terms of cytotoxicity and allergic response has also been evaluated through in-vitro (MTT) and in-vivo (IgE) respectively. ARS significantly inhibited the pro-inflammatory cytokines, in LPS stimulated murine macrophages with no intrinsic cytotoxicity. The significant increase in IgG production infers the utility of ARS for prolonged humoral response. Further, the antigen specific response of IL-12 at early stage and IgE titres also suggests the generation of cellular immune response and low allergic reaction respectively, as compared to conventional adjuvants. IL-6 and TNF fluctuations in LPS stimulated and non-stimulated macrophages along with IgG and IL-12 also confirmed the Th1/Th2 modulating effect of ARS. The study indicates potential effect of ARS as an adjuvant for the stimulation of cellular immune response in addition to generating a sustained adaptive response without any adverse effects paving way for further validation with pathogenic organisms.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/farmacologia
Formação de Anticorpos/imunologia
Asparagus (Planta)/imunologia
Citocinas/imunologia
Hipersensibilidade/imunologia
Inflamação/imunologia
Saponinas/imunologia
[Mh] Termos MeSH secundário: Imunidade Adaptativa/imunologia
Animais
Feminino
Imunoglobulina G/imunologia
Interleucina-12/imunologia
Interleucina-6/imunologia
Macrófagos/imunologia
Masculino
Camundongos
Fatores de Necrose Tumoral/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Cytokines); 0 (Immunoglobulin G); 0 (Interleukin-6); 0 (Saponins); 0 (Tumor Necrosis Factors); 187348-17-0 (Interleukin-12)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE



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