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  1 / 109 MEDLINE  
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[PMID]:29402248
[Au] Autor:Al-Afifi NA; Alabsi AM; Bakri MM; Ramanathan A
[Ad] Endereço:Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats.
[So] Source:BMC Complement Altern Med;18(1):50, 2018 Feb 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon's blood, the Twobrother's Blood or Damm Alakhwain. The current study performed to evaluate the safety of the DC resin methanol extract after a single or 28 consecutive daily oral administrations. METHODS: In assessing the safety of DC resin methanol extract, acute and sub-acute oral toxicity tests performed following OECD guidelines 423 and 407, respectively, with slight modifications. In acute oral toxicity test, DC resin methanol extract administered to female Sprague Dawley rats by oral gavage at a single dose of 300 and 2000 mg/kg body weight. Rats observed for toxic signs for 14 days. In sub-acute oral toxicity test, DC resin methanol extract administered to the rats by oral gavage at 500, 1000, and 1500 mg/kg body weight daily up to 28 days to male and female Spradgue Dawley rats. The control and high dose in satellite groups were also maintained and handled as the previous groups to determine the late onset toxicity of DC resin methanol extract. At the end of each test, hematological and biochemical analysis of the collected blood were performed as well as gross and microscopic pathology. RESULTS: In acute oral toxicity, no treatment-related death or toxic signs were observed. It revealed that the DC resin methanol extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5. The sub-acute test observations indicated that there are no treatment-related changes up to the high dose level compared to the control. Food consumption, body weight, organ weight, hematological parameters, biochemical parameters and histopathological examination (liver, kidney, heart, spleen and lung) revealed no abnormalities. Water intake was significantly higher in the DC resin methanol extract treated groups compared to the control. CONCLUSION: This study demonstrates tolerability of DC resin methanol extract administered daily for 28 days up to 1500 mg/kg dose.
[Mh] Termos MeSH primário: Dracaena/química
Resinas Vegetais/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Peso Corporal/efeitos dos fármacos
Ingestão de Líquidos/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Feminino
Coração/efeitos dos fármacos
Rim/efeitos dos fármacos
Masculino
Metanol
Tamanho do Órgão/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Resinas Vegetais/administração & dosagem
Testes de Toxicidade Aguda
Testes de Toxicidade Subcrônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resins, Plant); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2110-3


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[PMID]:28648631
[Au] Autor:Wang H; Jiang HM; Li FX; Chen HQ; Liu WC; Ren SZ; Mei WL; Dai HF
[Ad] Endereço:Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
[Ti] Título:Flavonoids from artificially induced dragon's blood of Dracaena cambodiana.
[So] Source:Fitoterapia;121:1-5, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dragon's blood is a rare traditional medicine used in many countries. Because of its various therapeutic uses, its requirement is increasing dramatically, while formation of dragon's blood need at least several years, so many researchers tried to induce the formation of dragon's blood artificially, but the chemical constituents of artificially induced dragon's blood were rarely studied. In our research, twenty constituents, including three new ones, were isolated from artificially induced dragon's blood of Dracaena cambodiana, five of which are the same with those from natural dragon's blood. In addition, six compounds exhibited cytotoxic activities, and eleven compounds demonstrated antibacterial activities. Artificially induced dragon's blood is expected to be the substituent of natural dragon's blood.
[Mh] Termos MeSH primário: Dracaena/química
Flavonoides/química
Extratos Vegetais/química
Resinas Vegetais/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Flavonoides/isolamento & purificação
Seres Humanos
Estrutura Molecular
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids); 0 (Plant Extracts); 0 (Resins, Plant); M3YJ2C28IC (dragon's blood)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  3 / 109 MEDLINE  
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[PMID]:27585974
[Au] Autor:Jura-Morawiec J
[Ad] Endereço:Polish Academy of Sciences Botanical Garden, Centre for Biological Diversity Conservation in Powsin, Prawdziwka 2, 02-973, Warsaw, Poland. j.jura@gazeta.pl.
[Ti] Título:Atypical origin, structure and arrangement of secondary tracheary elements in the stem of the monocotyledonous dragon tree, Dracaena draco.
[So] Source:Planta;245(1):93-99, 2017 Jan.
[Is] ISSN:1432-2048
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:MAIN CONCLUSION: Tracheary elements within the secondary body of a dragon tree shared features characteristic of fibres. Their considerable intrusive growth resulted in a rigid network with a braid-like arrangement which contributes towards the tree-like form of the plant. Monocot cambium gives rise to xylem and phloem which become organized into vascular bundles. The xylem consists entirely of tracheids, and these undergo considerable intrusive elongation during their development, unlike the tracheids of conifers and those of vesselless dicotyledons. Monocot tracheids have not been fully investigated, and our understanding of their structure is incomplete. Therefore, in this study the degree of variation in the structure and arrangement of secondary tracheary elements of monocots were determined, based on the Dracaena draco stem. In addition, its mechanical and physiological implications were discussed. Analysis of series of thin serial sections and macerations of the immature and fully developed tracheids showed that the course of intrusive elongation of tracheids was determined by the spatial relationship that exists between the growing tracheid and surrounding cells, and was not usually parallel to the stem axis. It influenced the shape of tracheids, as well the cross-sectional shape of vascular bundles. Tracheids become twisted or even interwoven and so, their ends do not join with the ends of other tracheids. The complexity of the tracheid network, that functions both in transport and mechanical support, seems to have a major impact on the tree-like growth habit of D. draco.
[Mh] Termos MeSH primário: Dracaena/anatomia & histologia
Caules de Planta/anatomia & histologia
Árvores/anatomia & histologia
Xilema/anatomia & histologia
[Mh] Termos MeSH secundário: Dracaena/citologia
Caules de Planta/citologia
Xilema/citologia
Xilema/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE
[do] DOI:10.1007/s00425-016-2593-4


  4 / 109 MEDLINE  
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[PMID]:27769819
[Au] Autor:Pang DR; Su XQ; Zhu ZX; Sun J; Li YT; Song YL; Zhao YF; Tu PF; Zheng J; Li J
[Ad] Endereço:Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
[Ti] Título:Flavonoid dimers from the total phenolic extract of Chinese dragon's blood, the red resin of Dracaena cochinchinensis.
[So] Source:Fitoterapia;115:135-141, 2016 Dec.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Eight new flavonoid dimers, named cochinchinenins I-M (1-5), including three pairs of enantiomers (1a/1b-3a/3b) and two optically pure flavonoid dimers (4-5), along with a known analogue (6), were isolated from total phenolic extract of the red resin of Dracaena cochinchinensis (Chinese dragon's blood). The planar structures of 1-5 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. Their absolute configurations were determined on the basis of experimental and calculated electronic circular dichroism (ECD) data. Compounds 4 and 5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC value of 4.9±0.4 and 5.4±0.6µM, respectively.
[Mh] Termos MeSH primário: Dracaena/química
Flavonoides/química
Extratos Vegetais/química
Resinas Vegetais/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Coix/química
Flavonoides/isolamento & purificação
Camundongos
Microglia/efeitos dos fármacos
Estrutura Molecular
Óxido Nítrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (Resins, Plant); 31C4KY9ESH (Nitric Oxide); M3YJ2C28IC (dragon's blood)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:27683055
[Au] Autor:Wen F; Zhao X; Zhao Y; Lu Z; Guo Q
[Ad] Endereço:Department of Radiology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, Liaoning Province, 110004, China.
[Ti] Título:The anticancer effects of Resina Draconis extract on cholangiocarcinoma.
[So] Source:Tumour Biol;37(11):15203-15210, 2016 Nov.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cholangiocarcinoma (CCA) is a relatively rare, heterogeneous malignant tumor with poor clinical outcomes. Because of high insensitivity to chemotherapy and radiotherapy, there are no effective treatment options. Efforts to identify and develop new agents for prevention and treatment of this deadly disease are urgent. Here, we assessed the apoptotic cytotoxicity of Resina Draconis extract (RDE) using in vitro and in vivo assays and identified the mechanisms underlying antitumor effects of RDE. RDE was obtained via vacuum distillation of Resina Draconis with 75 % ethanol. The ethanol extract could inhibit CCA cell proliferation and trigger apoptotic cell death in both QBC939 and HCCC9810 cell lines in a time- and concentration-dependent manner. RDE treatment resulted in intracellular caspase-8 and poly (ADP-ribose) polymerase protease activation. RDE significantly downregulated antiapoptotic protein survivin expression and upregulated proapoptotic protein Bak expression. RDE also inhibited CCA tumor growth in vivo. We observed that human CCA tissues had much higher survivin expression than did paired adjacent normal tissue. Taken together, the current data suggested that RDE has anticancer effects on CCA, and that RDE could function as a novel anticancer agent to benefit patients with CCA.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Neoplasias dos Ductos Biliares/patologia
Ductos Biliares Intra-Hepáticos/patologia
Colangiocarcinoma/patologia
Dracaena/química
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Neoplasias dos Ductos Biliares/tratamento farmacológico
Ductos Biliares Intra-Hepáticos/efeitos dos fármacos
Western Blotting
Proliferação Celular/efeitos dos fármacos
Colangiocarcinoma/tratamento farmacológico
Feminino
Seres Humanos
Técnicas Imunoenzimáticas
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Células Tumorais Cultivadas
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE


  6 / 109 MEDLINE  
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[PMID]:27497307
[Au] Autor:Xu X; Cheng K; Cheng W; Zhou T; Jiang M; Xu J
[Ad] Endereço:Chemical Biology Center, Lishui Institute of Agricultural Sciences, 827 Liyang Stress, Lishui, Zhejiang 323000, China; Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine,
[Ti] Título:Isolation and chatacterization of homoisoflavonoids from Dracaena cochinchinensis and their osteogenic activities in mouse mesenchymal stem cells.
[So] Source:J Pharm Biomed Anal;129:466-472, 2016 Sep 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new homoisoflavonoids, dracaeconolide A (1) and dracaeconolide B (2), together with ten known compounds, namely (3R)-7,4'-dihydroxy-8-methoxyhomoisoflavane (3), (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane (4), (3R)-7,4'-dihydroxy-5-methoxy-homoisoflavane (5), (3R)-6,4'-dihydroxy-8-methoxyhomoisoflavan (6), 7,4'-dihydroxy-8-methylflavan (7), (2R)-7,4'-dihydroxy-5-methoxy-8-methylflavan (8), 5,4'-dihydroxy-7-methoxy-6-methylflavane (9), 7,4'-dihydroxy-3'-methoxyflavan (10), 7,4'-dihydroxyflavan (11), 4,4'-dihydroxy-2,6-dimethoxydihydrochlcone (12), were isolated from the red resin of Dracaena cochinchinensis (dragon's blood, DB). All the compounds were then evaluated for their effects on mouse bone marrow-derived mesenchymal stem cells (MSCs) proliferation using CCK8 assay and their abilities in promoting MSCs differentiating into osteoblast through the assay of alkaline phosphatase (ALP) activity in vitro. Compounds 2, 3, 4, 7, 9, and 11, at a concentration of 10µM with no cytotoxicity, significantly promoted MSC osteogenic differentiation by increasing the levels of ALP activity to percents of 159.6±5.9, 167.6±10.9, 162.0±1.4, 151.3±4.0, 171.0±8.2, and 169.9±7.3 in relative to the control, respectively. The results of ALP staining were in accordance to that of ALP activity.
[Mh] Termos MeSH primário: Dracaena/química
Flavonoides/química
Flavonoides/farmacologia
Células Mesenquimais Estromais/efeitos dos fármacos
Osteogênese/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Osteoblastos/efeitos dos fármacos
Resinas Vegetais/química
Resinas Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (Resins, Plant); M3YJ2C28IC (dragon's blood)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE


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[PMID]:27455904
[Au] Autor:Nya PC; Moretti R; Nicoletti M; Calvitti M; Tomassini L
[Ti] Título:Larvicidal Activity of Steroidal Saponins from Dracaena arborea on Aedes albopictus.
[So] Source:Curr Pharm Biotechnol;17(12):1036-1042, 2016.
[Is] ISSN:1873-4316
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Development of new and improved mosquito control methods, that are economically sustainable and effective, is a critical requirement in the management of vector-borne epidemic diseases. Aedes albopictus is one of the main vectors of various important pathogens in the tropics, which now have the potential to also spread in temperate regions, owing to the environmental and climate changes in act. MATERIALS AND METHODS: We report about the isolation of steroidal saponins from Dracaena arborea by fractionation followed by column separation. The obtained fractions and/or pure compounds were tested by biological essays for their insecticidal activity against A. albopictus larvae. RESULTS: Various compounds were found to exert larvicidal effects. In specific, spiroconazole A demonstrated the best insecticidal activity, showing LT50 value of 57.23 hours at 25 ppm. DISCUSSION: We finally discuss about the value of this finding in the context of the present strategies of Integrated Mosquito Management.
[Mh] Termos MeSH primário: Aedes
Dracaena
Inseticidas/farmacologia
Controle de Mosquitos/métodos
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Larva/efeitos dos fármacos
Saponinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Saponins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE


  8 / 109 MEDLINE  
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[PMID]:27208821
[Au] Autor:Zhu JH; Li HL; Guo D; Wang Y; Dai HF; Mei WL; Peng SQ
[Ad] Endereço:Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.
[Ti] Título:Transcriptome-wide identification and expression analysis of glutathione S-transferase genes involved in flavonoids accumulation in Dracaena cambodiana.
[So] Source:Plant Physiol Biochem;104:304-11, 2016 Jul.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Dragon's blood is a traditional medicine widely used in the world, and the main components of which are flavonoids. However, little is known about its formation mechanism. Previous studies indicate that plant glutathione S-transferase (GST) genes are involved in transportation of flavonoids from cytosolic synthesis to vacuolar accumulation. In this study, 20 Dracaena cambodiana GST genes (DcGSTs) were identified based on transcriptome database. Phylogenetic analysis revealed that 20 DcGSTs belonged to seven different classes. Tissue-specific expression analysis suggested that DcGSTs displayed differential expressions either in their transcript abundance or expression patterns under normal growth conditions. The transcript profiles of three DcGSTs in response to the inducer of dragon's blood were strongly correlated with flavonoids biosynthetic genes, consistent with dragon's blood accumulation. Our survey provides useful information for future studies on GST genes involved in dragon's blood formation in D. cambodiana.
[Mh] Termos MeSH primário: Dracaena/enzimologia
Dracaena/genética
Flavonoides/metabolismo
Regulação Enzimológica da Expressão Gênica
Regulação da Expressão Gênica de Plantas
Genes de Plantas
Glutationa Transferase/genética
Transcriptoma/genética
[Mh] Termos MeSH secundário: Flavonoides/biossíntese
Perfilação da Expressão Gênica
Glutationa Transferase/metabolismo
Especificidade de Órgãos/genética
Filogenia
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Proteins); EC 2.5.1.18 (Glutathione Transferase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE


  9 / 109 MEDLINE  
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[PMID]:27123447
[Au] Autor:Alabsi AM; Lim KL; Paterson IC; Ali-Saeed R; Muharram BA
[Ad] Endereço:Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia; Oral Cancer Research and Coordinating Centre, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.
[Ti] Título:Cell Cycle Arrest and Apoptosis Induction via Modulation of Mitochondrial Integrity by Bcl-2 Family Members and Caspase Dependence in Dracaena cinnabari-Treated H400 Human Oral Squamous Cell Carcinoma.
[So] Source:Biomed Res Int;2016:4904016, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dracaena cinnabari Balf.f. is a red resin endemic to Socotra Island, Yemen. Although there have been several reports on its therapeutic properties, information on its cytotoxicity and anticancer effects is very limited. This study utilized a bioassay-guided fractionation approach to determine the cytotoxic and apoptosis-inducing effects of D. cinnabari on human oral squamous cell carcinoma (OSCC). The cytotoxic effects of D. cinnabari crude extract were observed in a panel of OSCC cell lines and were most pronounced in H400. Only fractions DCc and DCd were active on H400 cells; subfractions DCc15 and DCd16 exhibited the greatest cytotoxicity against H400 cells and D. cinnabari inhibited cells proliferation in a time-dependent manner. This was achieved primarily via apoptosis where externalization of phospholipid phosphatidylserine was observed using DAPI/Annexin V fluorescence double staining mechanism studied through mitochondrial membrane potential assay cytochrome c enzyme-linked immunosorbent and caspases activities revealed depolarization of mitochondrial membrane potential (MMP) and significant activation of caspases 9 and 3/7, concomitant with S phase arrest. Apoptotic proteins array suggested that MMP was regulated by Bcl-2 proteins family as results demonstrated an upregulation of Bax, Bad, and Bid as well as downregulation of Bcl-2. Hence, D. cinnabari has the potential to be developed as an anticancer agent.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Caspases/metabolismo
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Dracaena/química
Mitocôndrias/metabolismo
Neoplasias Bucais/patologia
Neoplasias de Células Escamosas/patologia
Extratos Vegetais/farmacologia
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
[Mh] Termos MeSH secundário: Bioensaio
Proliferação Celular/efeitos dos fármacos
Forma Celular/efeitos dos fármacos
Fracionamento Químico
Citocromos c/metabolismo
Fragmentação do DNA/efeitos dos fármacos
Fibroblastos/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Neoplasias Bucais/metabolismo
Neoplasias de Células Escamosas/metabolismo
Nucleossomos/efeitos dos fármacos
Nucleossomos/metabolismo
Fosfatidilserinas/metabolismo
Fase S/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nucleosomes); 0 (Phosphatidylserines); 0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-bcl-2); 9007-43-6 (Cytochromes c); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1155/2016/4904016


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[PMID]:26916920
[Au] Autor:Liu Z; Liu J; Zhao K; Shi Q; Zuo T; Wang G; Wang W
[Ad] Endereço:* Department of General Surgery, Wuhan University, Renmin Hospital, Wuhan 430060, China.
[Ti] Título:Role of Daphnetin in Rat Severe Acute Pancreatitis Through the Regulation of TLR4/NF-[Formula: see text]B Signaling Pathway Activation.
[So] Source:Am J Chin Med;44(1):149-63, 2016.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Severe acute pancreatitis (SAP) often results in multiple-organ dysfunction syndrome with high mortality. There is no effective clinical therapy for SAP, yet daphnetin, a coumarin extracted from Dracaena marginata, has analgesic and anti-inflammatory effects, and has been used clinically in several diseases. The objective of this study was to investigate the role and underlying mechanisms of daphnetin in a rat SAP model. Male Wistar rats were pretreated with daphnetin via intraperitoneal injection, 30[Formula: see text]min before retrograde infusion of 5% sodium taurocholate into the biliopancreatic duct. Twelve hours after sodium taurocholate administration, rats were sacrificed and tissues and blood were harvested. Then, histological, chemical, and molecular analyses were performed. Daphnetin treatment reduced the levels of serum alanine transaminase and creatinine (CR), increased superoxide dismutase(SOD) activity, and decreased neutrophil infiltration and cell apoptosis of the pancreatic tissues in rat SAP. Daphnetin treatment significantly decreased expression of pro-inflammatory cytokines and increased expression of anti-inflammatory cytokines in rat SAP. Molecular analyses revealed that daphnetin reduced TLR4 expression and inhibited NF-[Formula: see text]B signaling pathway activation. These findings demonstrate that daphnetin attenuates acute pancreatic injury by regulating the TLR4/NF-[Formula: see text]B signaling pathway and inflammation in rat SAP model. Daphnetin may be a potential therapeutic agent for SAP.
[Mh] Termos MeSH primário: Expressão Gênica/efeitos dos fármacos
NF-kappa B/genética
NF-kappa B/metabolismo
Pancreatite/tratamento farmacológico
Pancreatite/genética
Fitoterapia
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
Receptor 4 Toll-Like/genética
Receptor 4 Toll-Like/metabolismo
Umbeliferonas/farmacologia
Umbeliferonas/uso terapêutico
[Mh] Termos MeSH secundário: Doença Aguda
Analgésicos
Animais
Anti-Inflamatórios
Citocinas/genética
Citocinas/metabolismo
Modelos Animais de Doenças
Dracaena/química
Mediadores da Inflamação/metabolismo
Injeções Intraperitoneais
Masculino
Ratos Wistar
Índice de Gravidade de Doença
Umbeliferonas/administração & dosagem
Umbeliferonas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Inflammation Mediators); 0 (NF-kappa B); 0 (Tlr4 protein, rat); 0 (Toll-Like Receptor 4); 0 (Umbelliferones); XC84571RD2 (daphnetin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160227
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X16500105



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