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Pesquisa : B01.650.940.800.575.912.250.618.100.060.313 [Categoria DeCS]
Referências encontradas : 19 [refinar]
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  1 / 19 MEDLINE  
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[PMID]:28603122
[Au] Autor:Belhaddad OE; Charef N; Amamra S; Zerargui F; Baghiani A; Khennouf S; Arrar L
[Ad] Endereço:Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University Setif, Setif 1, Algeria.
[Ti] Título:Chromatographic fractionation, antioxidant and antibacterial activities of Urginea maritima methanolic extract.
[So] Source:Pak J Pharm Sci;30(1):127-134, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present work concerns a phytochemical study of Urginea maritima L. from Algeria, and an evaluation of antioxidant activity of the methanolic extract (UMME) and its chromatographic fractions. UMME was fractionated using open glass chromatography on silica gel and antioxidant effects were evaluated using DPPH and ß-carotene/linoleate assays. The phytochemical screening revealed that the bulb of plant contains flavonoids, glycosides, tannins, reducing compounds, anthraquinones combined, anthocyanins, mucilage, triterpenes and steroids. DPPH method showed that the UMME has a scavenger effect on radical DPPH with an IC =57.83±1.59µg/ml. The fractions isolated from U. maritima (L.) presented an IC50 ranging between 499.23 and 39.68µg/ml. In ß-carotene/linoleate test, UMME and fractions give an I% =69.56±0.08% and between 31.29±0.49% and 90.79±0.29%, respectively. UMME showed a high inhibitory effect on the xanthine oxidase (IC50=0.67±0.01 mg/ml) and on the cytochrome c reduction (IC =0.68 mg/ml). Wide range of phytochemical constituents in Urginea maritima were detected in methanolic extract which exhibited antioxidant and antibacterial activity. This plant could serve as pilot for the development of novel agents for pathological disorders.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada/métodos
Drimia/química
Metanol/química
Extratos Vegetais/farmacologia
Solventes/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Bactérias/efeitos dos fármacos
Bactérias/crescimento & desenvolvimento
Compostos de Bifenilo/química
Citocromos c/metabolismo
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/farmacologia
Ácido Linoleico/química
Oxirredução
Fitoterapia
Picratos/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Sílica Gel/química
Xantina Oxidase/antagonistas & inibidores
Xantina Oxidase/metabolismo
beta Caroteno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Enzyme Inhibitors); 0 (Picrates); 0 (Plant Extracts); 0 (Solvents); 01YAE03M7J (beta Carotene); 60650-90-0 (Silica Gel); 9007-43-6 (Cytochromes c); 9KJL21T0QJ (Linoleic Acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.17.3.2 (Xanthine Oxidase); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  2 / 19 MEDLINE  
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[PMID]:28044935
[Au] Autor:Bevara GB; Kumar ADN; Koteswramma K L; Badana AK; Kumari S; Yarla NS; Malla RR
[Ad] Endereço:Cancer Biology Lab, Department of Biochemistry, GIS, GITAM University, Visakhapatnam, Andhra Pradesh. India.
[Ti] Título:C-glycosyl Flavone from Urginea indica Inhibits Growth and Dissemination of Ehrlich Ascites Carcinoma Cells in Mice.
[So] Source:Anticancer Agents Med Chem;17(9):1256-1266, 2017.
[Is] ISSN:1875-5992
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: C-glycosyl flavone, a phytochemical constituent in U.indica bulb, has been reported to possess cytotoxic activity. OBJECTIVE: The present study aims to investigate the toxicity and anticancer potentials of C-glycosyl flavone against Ehrlich ascites carcinoma mice model. METHOD: In present study, acute and chronic toxicity along with antitumor activity of C-glycosyl flavone isolated from U.indica bulb were Performed using in vitro and in vivo methods. Acute and chronic toxicity of C-glycosyl flavone was evaluated using Swiss albino mice. The effect of C-glycosyl flavone on proliferation of Ehrlich ascites carcinoma (EAC) cells was determined. Further, growth inhibition and dissemination were studied using EAC induced mice model. RESULTS: C-glycosyl flavone showed significant therapeutic potency against EAC cells in terms of reduced viability, cell cycle arrest, induction of apoptosis, inhibition of capillary formation, reduced VEGF levels. Moreover, there was reduction in body weight, tumor volume, viable tumor cells, increased survival of EAC induced mice upon C-glycosyl flavone treatment. Treatment also reduced dissemination of EAC cells into heart, kidney, liver and brain and diminished the pathological alterations induced by EAC cells in mice. In addition, there was an improvement in hemoglobin levels and counts of RBC, neutrophils, lymphocytes and monocytes in C-glycosyl flavone-treated mice with tumor. An enhancement of antioxidant status in C-glycosyl flavone treated EAC-bearing mice which appeared in terms of decreased serum thiobarbituric acid reactive substance and lipid peroxidation, increased GSH, SOD, Catalase and GPX. These results were comparable to a standard 5- fluorouracil treatment. C-glycosyl flavone exhibited safety profile in toxicity studies. CONCLUSION: Our study confirms the therapeutic potency of C-glycosyl flavone against EAC in inhibition of dissemination and growth of EAC in mice.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Carcinoma de Ehrlich/tratamento farmacológico
Carcinoma de Ehrlich/patologia
Drimia/química
Flavonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Flavonas/química
Flavonas/isolamento & purificação
Masculino
Camundongos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Flavones)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.2174/1871520617666170103101844


  3 / 19 MEDLINE  
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[PMID]:27998692
[Au] Autor:Nejatbakhsh F; Karegar-Borzi H; Amin G; Eslaminejad A; Hosseini M; Bozorgi M; Gharabaghi MA
[Ad] Endereço:Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial.
[So] Source:J Ethnopharmacol;196:186-192, 2017 Jan 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: In Traditional Iranian Medicine (TIM), Squill (Drimia maritima (L.) Stearn) Oxymel was utilized in the treatment of asthma. Squill has been reported to exert anti-inflammatory, anti-oxidant, anti-cholinergic, and mucus secretion modulating effects. OBJECTIVE: This study aimed to make a preliminary evaluation of the efficacy and safety of an add-on Squill Oxymel treatment in patients with moderate to severe persistent asthma. METHODS: In a 6-week, triple-blind, randomized, placebo-controlled trial, 60 patients with stable moderate to severe persistent asthma were randomly allocated to receive either 10ml syrup of Squill Oxymel, simple oxymel, or a placebo 2 times a day, as an add-on to their routine treatment (inhaled corticosteroids and ß2 agonists). Spirometry and plethysmography were performed on patients to evaluate the effect of the treatment at baseline and end of intervention. Forced Expiratory Volume in first second (FEV1) was considered the primary outcome. St. George's respiratory questionnaire (SGRQ) was also used for the subjective evaluation of patients' responses. RESULTS: Fifty-four patients completed the study. The results showed significant improvement in spirometry parameters, especially FEV1 (1.54±.38 vs. 2.11±.49l), in the Squill Oxymel group compared with the other groups. The increases in FEV1 liter, FEV1%, FEV1/FVC%, and MEF 25-75% during the intervention were significantly higher in the Squill Oxymel group than in the other groups (p<.001). However, the improvement of plethysmographic parameters showed no significant difference between the study groups (p>.05). The SGRQ scores (symptoms, activity, and total score) were significantly improved after intervention in both the Squill Oxymel and the simple honey oxymel groups (p<.001), but not in the placebo group. Nausea and vomiting was reported in 5 patients in Squill oxymel and simple oxymel groups. No other serious adverse event was observed. CONCLUSIONS: The results of the current study show preliminary evidence for the efficacy and safety of the add-on treatment of Squill Oxymel in patients with moderate to severe persistent asthma.
[Mh] Termos MeSH primário: Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Drimia
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Antiasmáticos/efeitos adversos
Asma/fisiopatologia
Feminino
Volume Expiratório Forçado/efeitos dos fármacos
Seres Humanos
Masculino
Meia-Idade
Fitoterapia
Projetos Piloto
Preparações de Plantas/efeitos adversos
Raízes de Plantas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Plant Preparations)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE


  4 / 19 MEDLINE  
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[PMID]:25542685
[Au] Autor:Mikail HG; Karvouni H; Kotsiou A; Tesseromatis C; Magiatis P
[Ad] Endereço:Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece; Department of Pharmacology, Medical School, University Athens, M. Asias 75, Athens 11527, Greece.
[Ti] Título:New alkylresorcinols from a lipophilic extract of Urginea indica L. bulbs showing experimental trauma healing activity.
[So] Source:Fitoterapia;101:41-5, 2015 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Several alkylresorcinols presenting the substitution pattern of structures I (3-methyl ether of 5-alkyl-2-methylresorcinol) and II (1,3-dimethyl ether of 5-alkylresorcinol), were isolated from the dichloromethane extract of the air-dried bulbs of Urginea indica L. Compounds of structure I with 15, 17 and 20 carbon atoms in the alkyl chain as well as compounds of structure II with 20, 22, 24 carbon atoms in the alkyl chain are new. The structures of the new compounds were elucidated on the basis of their NMR and MS data. The exact number of homologues in each series I and II and the exact length of the side chain were found using GC-MS analysis. The dichloromethane extract of the bulbs was evaluated for its trauma healing properties after local application and a statistically significant tendency to trauma remodeling was observed in comparison to control groups.
[Mh] Termos MeSH primário: Drimia/química
Raízes de Plantas/química
Resorcinóis/farmacologia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Masculino
Estrutura Molecular
Ratos Wistar
Resorcinóis/isolamento & purificação
Pele/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resorcinols)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141228
[St] Status:MEDLINE


  5 / 19 MEDLINE  
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[PMID]:23659371
[Au] Autor:Dai Y; Harinantenaina L; Brodie PJ; Goetz M; Shen Y; TenDyke K; Kingston DG
[Ad] Endereço:Department of Chemistry and the Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States.
[Ti] Título:Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa.
[So] Source:J Nat Prod;76(5):865-72, 2013 May 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Investigation of the South African plant Urginea depressa Baker (Asparagaceae Juss.) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the six new homoisoflavonoids urgineanins A-F (1-6), the two known bufatrienolides 7 and 9, and the new bufatrienolides urginins B and C (8 and 10). Structures were elucidated based on analysis of their 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometric data. Five of the six new homoisoflavonoids had good antiproliferative activity against the A2780 ovarian cancer, A2058 melanoma, and H522-T1 human non-small-cell lung cancer cells, and urgineanin A (1) had submicromolar activity against all three cell lines. The four bufatrienolides 7-10 had strong antiproliferative activity against the same cell line, with IC50 values of 24.1, 11.2, 111, and 40.6 nM, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Drimia/química
Isoflavonas/isolamento & purificação
Isoflavonas/farmacologia
Esteroides/isolamento & purificação
Esteroides/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Feminino
Seres Humanos
Concentração Inibidora 50
Isoflavonas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Esteroides/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Isoflavones); 0 (Steroids); 0 (urgineanin A)
[Em] Mês de entrada:1308
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130511
[St] Status:MEDLINE
[do] DOI:10.1021/np300900a


  6 / 19 MEDLINE  
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[PMID]:23228916
[Au] Autor:El-Seedi HR; Burman R; Mansour A; Turki Z; Boulos L; Gullbo J; Göransson U
[Ad] Endereço:Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, 751 23 Uppsala, Sweden. hesham.el-seedi@fkog.uu.se
[Ti] Título:The traditional medical uses and cytotoxic activities of sixty-one Egyptian plants: discovery of an active cardiac glycoside from Urginea maritima.
[So] Source:J Ethnopharmacol;145(3):746-57, 2013 Feb 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants from the Sinai desert are widely used in traditional Bedouin medicine to treat a range of conditions including, cancers, and may thus be useful sources of novel anti-tumor compounds. Information on plants used in this way was obtained through collaboration with Bedouin herbalists. AIM OF THE STUDY: To document the traditional uses of 61 species from 29 families of Egyptian medicinal plants and to investigate their biological activity using a cytotoxicity assay. MATERIAL AND METHODS: MeOH extracts of the 61 plant species investigated were dissolved in 10% DMSO and their cytotoxic activity was evaluated. The extracts were tested in duplicate on three separate occasions at three different concentrations (1, 10 and 100µg/ml) against human lymphoma U-937 GTB. The most active extract was subjected to bioassay-guided fractionation using HPLC and LC/ESI-MS to isolate and identify its active components. RESULTS AND DISCUSSION: The most potent extracts were those from Asclepias sinaica, Urginea maritima, Nerium oleander and Catharanthus roseus, followed by those from Cichorium endivia, Pulicaria undulate and Melia azedarach. Literature reports indicate that several of these plants produce cardiac glycosides. Bioassay-guided fractionation of alcoholic U. maritima extracts led to the isolation of a bioactive bufadienolide that was subsequently shown to be proscillaridin A, as determined by 1D and 2D NMR spectroscopy. This result demonstrates the value of plants used in traditional medicine as sources of medicinally interesting cytotoxic compounds.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Drimia
Extratos Vegetais/farmacologia
Plantas Medicinais
Proscilaridina/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/isolamento & purificação
Sobrevivência Celular/efeitos dos fármacos
Egito
Seres Humanos
Medicina Tradicional
Proscilaridina/isolamento & purificação
Células U937
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); KC6BL281EN (Proscillaridin)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121212
[St] Status:MEDLINE


  7 / 19 MEDLINE  
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[PMID]:22006863
[Au] Autor:Abbas S; Bashir S; Khan A; Mehmood MH; Gilani AH
[Ad] Endereço:Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
[Ti] Título:Gastrointestinal stimulant effect of Urginea indica Kunth. and involvement of muscarinic receptors.
[So] Source:Phytother Res;26(5):704-8, 2012 May.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Urginea indica Kunth. (Family; Liliaceae) was studied for its gastrointestinal stimulant effect to rationalize the traditional medicinal uses as a digestive aid, stomachic and laxative. The crude aqueous-methanol extract of Urginea indica bulb (Ui.Cr) was tested on mice and isolated gut preparations. Ui.Cr, which was tested positive for alkaloids, tannins and coumarins, increased faecal output and accelerated charcoal meal transit in mice (6-12 mg/kg, p.o.), similar to that caused by carbachol (10 mg/kg). Ui.Cr (0.01-1 mg/mL) caused a spasmogenic effect in guinea-pig ileum that was reproduced in rabbit jejunum (0.01-0.3 mg/mL) followed by relaxation at a higher concentration. Like carbachol, the stimulant effect of Ui.Cr was blocked by atropine, suggesting the activation of muscarinic receptors mediating the prokinetic effect. Ui.Cr (0.01-5.0 mg/mL) also inhibited K(+) (80 mm)-induced contraction in rabbit jejunum and shifted the Ca(2+) concentration-response curves to the right, similar to verapamil, a standard calcium channel blocker. These data, indicating the presence of a gastrointestinal stimulant effect in Urginea indica possibly mediated through a cholinergic mechanism, provide a rationale for the use of Urginea indica in indigestion and constipation. The presence of a calcium antagonist effect in the plant may help to alleviate untoward effects of the plant that may result from an excessive increase in gut motility.
[Mh] Termos MeSH primário: Bloqueadores dos Canais de Cálcio/farmacologia
Colinérgicos/uso terapêutico
Drimia/química
Laxantes/uso terapêutico
Fitoterapia
Receptores Muscarínicos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/farmacologia
Alcaloides/uso terapêutico
Animais
Atropina/farmacologia
Bloqueadores dos Canais de Cálcio/química
Bloqueadores dos Canais de Cálcio/uso terapêutico
Colinérgicos/química
Colinérgicos/farmacologia
Constipação Intestinal/tratamento farmacológico
Cumarínicos/química
Cumarínicos/farmacologia
Cumarínicos/uso terapêutico
Relação Dose-Resposta a Droga
Feminino
Motilidade Gastrointestinal/efeitos dos fármacos
Cobaias
Íleo/efeitos dos fármacos
Jejuno/efeitos dos fármacos
Laxantes/química
Laxantes/farmacologia
Masculino
Camundongos
Contração Muscular/efeitos dos fármacos
Extratos Vegetais/antagonistas & inibidores
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Raízes de Plantas/química
Plantas Medicinais/química
Coelhos
Taninos/química
Taninos/farmacologia
Taninos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Calcium Channel Blockers); 0 (Cholinergic Agents); 0 (Coumarins); 0 (Laxatives); 0 (Plant Extracts); 0 (Receptors, Muscarinic); 0 (Tannins); 7C0697DR9I (Atropine)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111019
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.3634


  8 / 19 MEDLINE  
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[PMID]:20552524
[Au] Autor:Sultana N; Akter K; Nahar N; Khan MS; Mosihuzzaman M; Sohrab MH; Krohn K
[Ad] Endereço:Analytical Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories Dhaka, Dr Qudrat-i-Khuda Road, Dhanmondi, Dhaka, Bangladesh.
[Ti] Título:Novel flavonoid glycosides from the bulbs of Urginea indica Kunth.
[So] Source:Nat Prod Res;24(11):1018-26, 2010 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three novel flavonoid glycosides, 5,6-dimethyoxy-3',4''-dioxymethylene-7-O-(6''-beta-D-glucopyranosyl-beta-D-glucopyranosyl) flavanone (1), 5,4'-dihydroxy-3-O-alpha-L-rhamnopyranosyl-6-C-glucopyranosyl-7-O-(6''-para-coumaroyl-beta-D-glucopyranosyl) flavone (2) and 5,4'-dihydroxy-3-O-(2'''''-beta-glucopyranosyl-alpha-L-rhamnopyranosyl)-6-C-glucopyranosyl-7-O-(6''-para-coumaroyl-beta-D-glucopyranosyl) flavone (3) were isolated from the 1-butanol soluble fraction of the bulbs of the plant Urginea indica (Indian squill). The structures of the compounds were elucidated on the basis of spectral analysis, including homo- and heteronuclear correlation NMR experiments (COSY, NOESY, HSQC and HMBC) and mass spectra.
[Mh] Termos MeSH primário: Drimia/química
Flavonoides/química
Glicosídeos/química
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Glycosides)
[Em] Mês de entrada:1009
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100617
[St] Status:MEDLINE
[do] DOI:10.1080/14786410902899022


  9 / 19 MEDLINE  
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[PMID]:19415510
[Au] Autor:Okur N; Tuna AL; Okur B; Altunlu H; Kayikçioglu HH; Civelek HS
[Ad] Endereço:Faculty of Agriculture, Soil Science Department, Ege University, Bornova, Izmir, Turkey. nur.okur@ege.edu.tr
[Ti] Título:Non-target effect of organic insecticides: effect of two plant extracts on soil microbial biomass and enzymatic activities in soil.
[So] Source:Environ Monit Assess;165(1-4):389-97, 2010 Jun.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Efficacious botanical derivatives can provide an alternative to synthetic pesticides for organic farming systems. However, there is lack of information regarding the side effects of organic pesticides on key soil ecological processes. In this study, we investigated the effects of aqueous extracts from Urginea maritima and Euphorbia myrsinites exhibiting translaminar and systemic activity against pests on microbial biomass and enzymatic activities in soil. Two grams of plant material was extracted with 100 ml of water and then diluted 1:100, 2:100, and 4:100 with distilled water. Diluted plant extracts were applied around hypocotyl of tomato by soil drench. The effect of both plant extracts on microbial biomass C, amount of total N and organic C, and enzymatic activity in soil was significant. After the last application, the highest microbial biomass C was determined in the lowest U. maritima concentration (U 1:100). Soils treated with the highest concentration of U. maritima (U 4:100) had always lower SMBC content than control soil. All concentrations of E. myrsinites decreased microbial biomass C by 18% to 27% compared to the control. Total nitrogen and organic carbon decreased in soils without (control) and with treated U. maritima extract from first application to last application. Phosphatase, urease, and beta-glucosidase activities were monitored in plant extract-treated soils. Except U. maritima 1:100 treatments of second and fourth applications, the other treatments of plant extracts negatively affected enzymatic activity in soil. U. maritima and E. myrsinites plant extracts exhibited different effects on soil microbial biomass and activity, probably because of their different chemical contents.
[Mh] Termos MeSH primário: Biomassa
Drimia/química
Enzimas/análise
Euphorbia/química
Inseticidas
Extratos Vegetais/farmacologia
Microbiologia do Solo
Solo/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzymes); 0 (Insecticides); 0 (Plant Extracts); 0 (Soil)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090506
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-009-0954-1


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[PMID]:19527765
[Au] Autor:Rakotobe L; Berkal M; Huet H; Djediat C; Jeannoda V; Mambu L; Crespeau F; Edery M
[Ad] Endereço:FRE 3206, CNRS-USM 0505, Molécules de Communication et Adaptation des Micro-organismes, Muséum National d'Histoire Naturelle, Paris Cedex 05, France.
[Ti] Título:Effects of Rhodocodon madagascariensis extracts on embryo-larval development of medaka fish, Oryzias latipes.
[So] Source:Food Chem Toxicol;47(9):2289-93, 2009 Sep.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Rhodocodon madagascariensis, also named Urginea mascarenensis, is a malagasy plant belonging to the Hyacinthaceae family. As for the other members of the endemic malagasy genus Rhodocodon, the chemical and toxicological properties of this species have not yet been studied. The present study concerns the analysis of the toxicity of R. madagascariensis to medaka embryo-larval development. The incubation of medaka fish embryos or larvae in a medium containing R. madagascariensis extract resulted in a dose dependent reduction in development of embryos leading to lethality and a drastic reduction in survival rate of exposed larvae. Survival rates were reduced up to 100% with an extract concentration of 4 mg mL(-1). The LD(50) was estimated to be 1 mg mL(-1). Anatomopathological studies did show some neuro-embryonal modifications in the encephalic region. The data presented in this paper thus extends the use of medaka embryos as a valuable model to detect and analyse the effects of plant toxins.
[Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos
Drimia/química
Embrião não Mamífero/efeitos dos fármacos
Oryzias
Extratos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Cruzamento/métodos
Relação Dose-Resposta a Droga
Perda do Embrião/induzido quimicamente
Embrião não Mamífero/embriologia
Feminino
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Dose Letal Mediana
Masculino
Oryzias/embriologia
Oryzias/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:0910
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090617
[St] Status:MEDLINE
[do] DOI:10.1016/j.fct.2009.06.016



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