Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.100.230 [Categoria DeCS]
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[PMID]:27437404
[Au] Autor:Balogun FO; Tshabalala NT; Ashafa AO
[Ad] Endereço:Phytomedicine and Phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, Qwaqwa Campus, Private Bag X 13, Phuthaditjhaba 9866, South Africa.
[Ti] Título:Antidiabetic Medicinal Plants Used by the Basotho Tribe of Eastern Free State: A Review.
[So] Source:J Diabetes Res;2016:4602820, 2016.
[Is] ISSN:2314-6753
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Diabetes mellitus (DM) belongs to the group of five leading important diseases causing death globally and remains a major health problem in Africa. A number of factors such as poverty, poor eating habit, and hormonal imbalance are responsible for the occurrence of the disease. It poses a major health challenge in Africa continent today and the prevalence continues to increase at an alarming rate. Various treatment options particularly the usage of herbs have been effective against diabetes because they have no adverse effects. Interestingly, South Africa, especially the Basotho tribe, is blessed with numerous medicinal plants whose usage in the treatment of DM has been effective since the conventional drugs are expensive and often unaffordable. The present study attempted to update the various scientific evidence on the twenty-three (23) plants originating from different parts of the world but widely used by the Sotho people in the management of DM. Asteraceae topped the list of sixteen (16) plant families and remained the most investigated according to this review. Although limited information was obtained on the antidiabetic activities of these plants, it is however anticipated that government parastatals and scientific communities will pay more attention to these plants in future research.
[Mh] Termos MeSH primário: Diabetes Mellitus/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Preparações de Plantas/uso terapêutico
Plantas Medicinais
[Mh] Termos MeSH secundário: Aloe
Apocynaceae
Asparagus (Planta)
Asteraceae
Cannabis
Commelina
Fabaceae
Seres Humanos
Hypoxidaceae
Hypoxis
Malvaceae
Mimulus
Myricaceae
Rubiaceae
Rumex
África do Sul
Xanthorrhoeaceae
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Preparations)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE
[do] DOI:10.1155/2016/4602820


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[PMID]:27322226
[Au] Autor:Ooi DJ; Chan KW; Sarega N; Alitheen NB; Ithnin H; Ismail M
[Ad] Endereço:Nutri-Cosmeceuticals, Nutrigenomics & Nanodelivery Programme, Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Malaysia. ooiderjiun@gmail.com.
[Ti] Título:Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent.
[So] Source:Molecules;21(6), 2016 Jun 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Increasing evidence from both experimental and clinical studies depicts the involvement of oxidative stress in the pathogenesis of various diseases. Specifically, disruption of homeostatic redox balance in accumulated body fat mass leads to obesity-associated metabolic syndrome. Strategies for the restoration of redox balance, potentially by exploring potent plant bioactives, have thus become the focus of therapeutic intervention. The present study aimed to bioprospect the potential use of the curculigoside-cinnamic acid-rich fraction from Molineria latifolia rhizome as an antioxidant therapeutic agent. The ethyl acetate fraction (EAF) isolated from M. latifolia rhizome methanolic extract (RME) contained the highest amount of phenolic compounds, particularly curculigoside and cinnamic acid. EAF demonstrated glycation inhibitory activities in both glucose- and fructose-mediated glycation models. In addition, in vitro chemical-based and cellular-based antioxidant assays showed that EAF exhibited high antioxidant activities and a protective effect against oxidative damage in 3T3-L1 preadipocytes. Although the efficacies of individual phenolics differed depending on the structure and concentration, a correlational study revealed strong correlations between total phenolic contents and antioxidant capacities. The results concluded that enriched phenolic contents in EAF (curculigoside-cinnamic acid-rich fraction) contributed to the overall better reactivity. Our data suggest that this bioactive-rich fraction warrants therapeutic potential against oxidative stress-related disorders.
[Mh] Termos MeSH primário: Antioxidantes/química
Hypoxidaceae/química
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Células 3T3-L1
Animais
Antioxidantes/administração & dosagem
Benzoatos/administração & dosagem
Benzoatos/química
Cinamatos/administração & dosagem
Cinamatos/química
Flavonoides/química
Glucosídeos/administração & dosagem
Glucosídeos/química
Camundongos
Oxirredução
Fenóis/química
Picratos/química
Extratos Vegetais/administração & dosagem
Rizoma/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzoates); 0 (Cinnamates); 0 (Flavonoids); 0 (Glucosides); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 85643-19-2 (curculigoside); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE



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