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Pesquisa : B01.650.940.800.575.912.250.618.100.230.190 [Categoria DeCS]
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[PMID]:28916257
[Au] Autor:Chen X; Zuo A; Deng Z; Huang X; Zhang X; Geng C; Li T; Chen J
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
[Ti] Título:New phenolic glycosides from Curculigo orchioides and their xanthine oxidase inhibitory activities.
[So] Source:Fitoterapia;122:144-149, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Seven new phenolic glycosides including two heterocyclic phenolic derivatives orcinosides I-J (1-2) and five chlorophenolic glycosides curculigines J-N (3-7), together with nineteen known compounds were isolated from the rhizome of Curculigo orchioides. Based on extensive spectroscopic analyses (UV, IR, HRESIMS, 1D and 2D NMR), the structures of the new compounds were identified. Orcinoside I (1) and J (2) displayed xanthine oxidase inhibitory activities with IC values 0.25 and 0.62mM respectively.
[Mh] Termos MeSH primário: Curculigo/química
Inibidores Enzimáticos/química
Glicosídeos/química
Fenóis/química
Xantina Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Inibidores Enzimáticos/isolamento & purificação
Glicosídeos/isolamento & purificação
Estrutura Molecular
Fenóis/isolamento & purificação
Rizoma/química
Uricosúricos/química
Uricosúricos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Glycosides); 0 (Phenols); 0 (Uricosuric Agents); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE


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[PMID]:28126417
[Au] Autor:Wang L; He YJ; Han T; Zhao L; Lv L; He YQ; Zhang QY; Xin HL
[Ad] Endereço:School of Pharmacy, Second Military Medical University, Shanghai, PR China.
[Ti] Título:Metabolites of curculigoside in rats and their antiosteoporotic activities in osteoblastic MC3T3-E1 cells.
[So] Source:Fitoterapia;117:109-117, 2017 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Curculigoside isolated from Curculiginis Rhizoma exhibits a wide spectrum of bioactivities. In this study, a high performance liquid chromatography/quadrupole time-of- flight tandem mass spectrometry (UHPLC/Q-TOF MS) method was employed to investigate the metabolism of curculigoside in rats. Plasma, bile, urine, feces and 17 tissues were collected from rats after a single PO dose of curculigoside at 100mg/kg and prepared through methanol precipitation. Parent compound and a total of 7 metabolites were detected and identified based on their retention time and fragment ions. Metabolic pathways of curculigoside in rats include hydrolysis, demethylation and glucuronidation. Exposure of major metabolite M2 in plasma and it's antiosteoporotic activity in osteoblastic MC3T3-E1 cells were studied to help understand that curculigoside assimilates less but works more.
[Mh] Termos MeSH primário: Benzoatos/farmacocinética
Conservadores da Densidade Óssea/farmacocinética
Glucosídeos/farmacocinética
Osteoblastos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Cromatografia Líquida de Alta Pressão
Curculigo/química
Medicamentos de Ervas Chinesas/farmacocinética
Feminino
Masculino
Redes e Vias Metabólicas
Ratos
Ratos Wistar
Rizoma/química
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoates); 0 (Bone Density Conservation Agents); 0 (Drugs, Chinese Herbal); 0 (Glucosides); 85643-19-2 (curculigoside)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE


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[PMID]:27228189
[Au] Autor:Murali VP; Kuttan G
[Ad] Endereço:a Department of Immunology , Amala Cancer Research Centre, Affiliated to the University of Calicut , Thrissur , Kerala State , India.
[Ti] Título:Curculigoside augments cell-mediated immune responses in metastatic tumor-bearing animals.
[So] Source:Immunopharmacol Immunotoxicol;38(4):264-9, 2016 Aug.
[Is] ISSN:1532-2513
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A positive modulation of immune system is necessary for preparing the body to fight against malignant tumor cells. In the present study, the stimulatory effect of Curculigoside on cell-mediated immune response against the metastasis of B16F10 melanoma cells was analyzed in C57BL/6 mice. Curculigoside is a phenolic glucoside present in the plant Curculigo orchioides Gaertn. (Family - Amaryllidaceae). Administration of Curculigoside enhanced the natural killer (NK) cell activity, antibody-dependent cell-mediated cytotoxicity and complement-mediated cytotoxicity in metastatic tumor-bearing animals, when compared to the untreated control animals. The compound was also found to be effective in reducing the levels of proinflammatory cytokines such as TNF-α, IL-1ß, IL-6 and GM-CSF during metastasis. Besides these, levels of TH1 cytokines, such as IL-2 and IFN-γ, were significantly enhanced (p < 0.001) by Curculigoside administration and thereby reduces the metastatic lung colony formation along with an increased lifespan of the experimental animals. These studies provide an evidence for the stimulation of cell-mediated immune responses by Curculigoside against B16F10-induced metastatic tumor progression in experimental animals.
[Mh] Termos MeSH primário: Benzoatos/farmacologia
Curculigo/química
Glucosídeos/farmacologia
Imunidade Celular/efeitos dos fármacos
Neoplasias Experimentais/imunologia
[Mh] Termos MeSH secundário: Animais
Benzoatos/química
Citocinas/imunologia
Glucosídeos/química
Xenoenxertos
Seres Humanos
Células K562
Masculino
Camundongos
Metástase Neoplásica
Neoplasias Experimentais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoates); 0 (Cytokines); 0 (Glucosides); 85643-19-2 (curculigoside)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160527
[St] Status:MEDLINE
[do] DOI:10.1080/08923973.2016.1188401


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[PMID]:26637957
[Au] Autor:Ding H; Gao G; Zhang L; Shen G; Sun W; Gu Z; Fan W
[Ad] Endereço:Department of Orthopedics, BenQ Medical Center of Nanjing Medical University, Nanjing 210000, China.
[Ti] Título:The protective effects of curculigoside A on adjuvant-induced arthritis by inhibiting NF-кB/NLRP3 activation in rats.
[So] Source:Int Immunopharmacol;30:43-49, 2016 Jan.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the protective effects of curculigoside A (CA) on adjuvant arthritis (AA) rats and explore its possible mechanisms. AA was induced by intradermal injection of Freund's complete adjuvant (FCA). Male SD rats were treated with CA(10 and 20mg/kg) from days 18 to 24 after immunization. The levels of interleukin (IL)-6, IL-1ß, tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) in serum were determined by ELISA. Moreover, the levels of super oxide dismutase (SOD) and malondialdehyde (MDA) were determined using commercial kits. In particular, NLRP3 inflammasome and NF-кB pathway were detected by Western blot. As expected, CA at 10 and 20mg/kg significantly relieved the hind paw swelling and arthritis index, reduced the levels of IL-6 IL-1ß, PGE2, TNF-α, MDA and increased SOD activity in serum. In addition, CA effectively down-regulated the expression of NF-кB/NLRP3 pathway. These findings showed that CA exerted beneficial effects on rheumatoid arthritis in rats.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Artrite Experimental/prevenção & controle
Benzoatos/administração & dosagem
Proteínas de Transporte/metabolismo
Glucosídeos/administração & dosagem
NF-kappa B/metabolismo
[Mh] Termos MeSH secundário: Animais
Artrite Experimental/imunologia
Proteínas de Transporte/genética
Curculigo/imunologia
Citocinas/metabolismo
Dinoprostona/metabolismo
Regulação para Baixo/efeitos dos fármacos
Adjuvante de Freund/imunologia
Seres Humanos
Masculino
Medicina Tradicional Chinesa
NF-kappa B/genética
Proteína 3 que Contém Domínio de Pirina da Família NLR
Ratos
Ratos Sprague-Dawley
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzoates); 0 (Carrier Proteins); 0 (Cytokines); 0 (Glucosides); 0 (NF-kappa B); 0 (NLR Family, Pyrin Domain-Containing 3 Protein); 0 (Nlrp3 protein, rat); 85643-19-2 (curculigoside); 9007-81-2 (Freund's Adjuvant); EC 1.15.1.1 (Superoxide Dismutase); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170729
[Lr] Data última revisão:
170729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151207
[St] Status:MEDLINE


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[PMID]:26424815
[Au] Autor:Murali VP; Kuttan G
[Ad] Endereço:Amala Cancer Research Centre, Affiliated to the University of Calicut, Thrissur, Kerala, India.
[Ti] Título:Curculigo orchioides Gaertn Effectively Ameliorates the Uro- and Nephrotoxicities Induced by Cyclophosphamide Administration in Experimental Animals.
[So] Source:Integr Cancer Ther;15(2):205-15, 2016 06.
[Is] ISSN:1552-695X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background Curculigo orchioides Gaertn is an ancient medicinal plant (Family: Amaryllidaceae), well known for its immunomodulatory and rejuvenating effects. Cyclophosphamide (CPA) is an alkylating agent widely used for treating a variety of human malignancies, but associated with different toxicities too. Our previous reports regarding the hemoprotective and hepatoprotective effects of the plant against CPA toxicities provide the background for the present study, which is designed to analyze the ameliorative effect of the methanolic extract of C orchioides on the urotoxicity and nephrotoxicity induced by CPA. Methods CPA was administered to male Swiss albino mice at a single dose of 1.5 mmol/kg body weight to induce urotoxicity after 5 days of prophylactic treatment with C orchioides extract (20 mg/kg body weight). Mesna (2-mercaptoethanesulfonate) was used as a control drug. Serum, tissue, and urine levels of kidney function markers and antioxidant levels were checked along with the serum cytokine levels. Results The plant extract was found to be effective in ameliorating the urotoxic and nephrotoxic side effects of CPA. Upregulation of serum interferon-γ and interleukin-2 levels were observed with C orchioides treatment, which was decreased by CPA administration. Besides these, serum tumor necrosis factor-α level was also downregulated by C orchioides treatment. Conclusion Curculigo orchioides was found to be effective against the CPA-induced bladder and renal toxicities by its antioxidant capability and also by regulating the pro-inflammatory cytokine levels.
[Mh] Termos MeSH primário: Curculigo/química
Ciclofosfamida/administração & dosagem
Ciclofosfamida/efeitos adversos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia
Interferon gama/metabolismo
Interleucina-2/metabolismo
Masculino
Camundongos
Modelos Animais
Neoplasias/tratamento farmacológico
Plantas Medicinais/química
Fator de Necrose Tumoral alfa/metabolismo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Interleukin-2); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 82115-62-6 (Interferon-gamma); 8N3DW7272P (Cyclophosphamide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151002
[St] Status:MEDLINE
[do] DOI:10.1177/1534735415607319


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[PMID]:25612143
[Au] Autor:Tacchini M; Spagnoletti A; Marieschi M; Caligiani A; Bruni R; Efferth T; Sacchetti G; Guerrini A
[Ad] Endereço:a Department of Life Sciences and Biotechnology (SVeB) , University of Ferrara , C.so Ercole I d'Este 32, 44121 Ferrara , Italy.
[Ti] Título:Phytochemical profile and bioactivity of traditional ayurvedic decoctions and hydro-alcoholic macerations of Boerhaavia diffusa L. and Curculigo orchioides Gaertn.
[So] Source:Nat Prod Res;29(22):2071-9, 2015.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Decoctions (DECs) and hydro-alcoholic extracts (HEs) prepared from roots of Boerhaavia diffusa L. (Nyctaginaceae) and Curculigo orchioides Gaertn. (Hypoxidaceae) were phytochemically characterised by HPLC-DAD and profiled for their antioxidant, antigenotoxic and cytotoxic activities. B. diffusa DEC was rich in ferulic acid and vanillin, while the HE also contained boeravinone B and eupalitin. Both C. orchioides HE and DEC displayed the main occurrence of orcinol-ß-d-glucoside and curculigoside A. Antioxidant activity was assayed through spectrophotometric DPPH, ABTS and ß-carotene bleaching test, and using (HP)TLC bioautographic strategies. For both crude drugs, HE was the best performing preparation. Properly modified SOS-Chromotest evidenced a 10% inhibition by phytocomplexes against 4-nitroquinoline-N-oxide, and a higher bioactivity for vanillin (36.60 ± 1.68%) and ferulic acid (35.09 ± 1.53%). C. orchioides HE was the preparation which showed higher cytotoxicity against drug-sensitive human T-lymphoblastoid cell line (CCRF-CEM) and multidrug-resistant leukaemia cell line (CEM/ADR5000), and eupalitin was the only pure compound to exhibit an IC50 value.
[Mh] Termos MeSH primário: Curculigo/química
Nyctaginaceae/química
Compostos Fitoquímicos/análise
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antioxidantes/química
Antioxidantes/isolamento & purificação
Linhagem Celular Tumoral
Seres Humanos
Medicina Ayurvédica
Fenóis/química
Fenóis/isolamento & purificação
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Phenols); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150923
[Lr] Data última revisão:
150923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150123
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2014.1003299


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[PMID]:25575532
[Au] Autor:Murali VP; Kuttan G
[Ad] Endereço:Amala Cancer Research Centre, Trissur, affiliated to The University of Calicut, Calicut, Kerala, India.
[Ti] Título:Enhancement of cancer chemotherapeutic efficacy of cyclophosphamide by Curculigo orchioides Gaertn and its ameliorative effects on cyclophosphamide-induced oxidative stress.
[So] Source:Integr Cancer Ther;14(2):172-83, 2015 Mar.
[Is] ISSN:1552-695X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cyclophosphamide (CTX) is a synthetic antineoplastic drug with severe and life-threatening side effects. Studies in search of protective agents, preferably natural products, that can alleviate these side effects are valuable because they can contribute to improve current chemotherapeutic treatment strategies. Curculigo orchioides Gaertn (family Hypoxidaceae) is well known for its medicinal use in the Indian Ayurvedic system of medicine, and various studies have been reported that proved its immunomodulatory and anti-inflammatory properties. In this study, the tumor reduction capacity of CTX in combination with C orchioides methanolic extract was studied using Dalton's lymphoma ascites-induced solid tumor models. Effect of C orchioides on the reversal of the damage induced by CTX administration (intraperitoneally) was also determined in this study. For this, solid tumor volume, serum cytokine levels, hematolological parameters, intestinal histopathology, and serum and tissue biochemical parameters (Glutathione [GSH], alkaline phosphatase [ALP], glutamate pyruvate transaminase [GPT], lipid peroxidation [LPO]) were analyzed. Immune suppression and increased serum proinflammatory cytokine levels caused by CTX administration (25 mg/kg body weight) were reversed by C orchioides (20 mg/kg body weight). The alcoholic extract enhanced the tumor reduction capacity of CTX and reduced GPT and ALP levels in liver and serum, which were elevated by CTX administration. The LPO level was also lower in the CTX-administered animals when treated with the C orchioides extract. In conclusion, the plant extract when administered in combination with CTX, can result in enhanced anticancer properties; it also ameliorates the toxic side effects of CTX.
[Mh] Termos MeSH primário: Curculigo/química
Ciclofosfamida/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alanina Transaminase/metabolismo
Fosfatase Alcalina/metabolismo
Animais
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia
Protocolos de Quimioterapia Combinada Antineoplásica/toxicidade
Ciclofosfamida/toxicidade
Citocinas/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Linfoma/tratamento farmacológico
Linfoma/patologia
Masculino
Medicina Ayurvédica
Camundongos
Camundongos Endogâmicos BALB C
Neoplasias Experimentais/tratamento farmacológico
Neoplasias Experimentais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Plant Extracts); 8N3DW7272P (Cyclophosphamide); EC 2.6.1.2 (Alanine Transaminase); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150214
[Lr] Data última revisão:
150214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150111
[St] Status:MEDLINE
[do] DOI:10.1177/1534735414564424


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[PMID]:25305598
[Au] Autor:He Y; Dong X; Jia X; Li M; Yuan T; Xu H; Qin L; Han T; Zhang Q
[Ad] Endereço:Department of Pharmacognosy, Second Military Medical University School of Pharmacy, Shanghai 200433, China.
[Ti] Título:Qualitative and quantitative analysis on chemical constituents from Curculigo orchioides using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
[So] Source:J Pharm Biomed Anal;102:236-45, 2015 Jan.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A rapid ultra-high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC-ESI-Q-TOF/MS) method was developed for qualitative and quantitative determination of constituents in the rhizome of Curculigo orchioides. Qualitative analysis was performed on a Waters ACQUITY UHPLC @ HSS T3 column (1.8 µm 100 × 2.1mm) using gradient elution with mobile phase of 0.1% formic acid and acetonitrile. Quantitative analysis was performed on an Agilent ZORBAX Eclipse plus C18 column (1.7 µm 100 × 2.1mm) using gradient elution with mobile phase of 0.1% acetic acid and acetonitrile for at least 20 min. Quadrupole TOF/MS in either full scan mode or extracted ion mode was used for qualitative and quantitative analysis of the constituents. According to the mass spectrometric fragmentation mechanism and UHPLC-ESI-Q-TOF-MS data, chemical structures of 45 constituents in the rhizome of Curculigo orchioides, including 19 phenols and phenolic glycosides, 16 lignans and lignan glycosides, 8 triterpenoid saponins, one flavone and one sesquiterpene, were identified tentatively on-line without the time-consuming process of isolation. In addition, 8 phenolic glycosides including 5-hydroxymethylfurfural (HMF), 2-hydroxy-5-(2-hydroxyethyl) phenyl-ß-D-glucopyranoside (HPG), anacardoside (ACD), orcinol glucoside (OGD), orcinol-1-O-ß-D-apiofuranosyl-(1 → 6)-ß-D-glucopyranoside (OAG), 2,6-dimethoxybenzoic acid (DBA), curculigoside (CUR) and curculigine A (CCL) were quantitated in 11 collected samples and 10 commercial samples from different providers. The results show that UHPLC-ESI-Q-TOF-MS is a viable method for analysis and quality evaluation of the constituents from the rhizome of Curculigo orchioides.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Curculigo/química
Espectrometria de Massas por Ionização por Electrospray/métodos
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1509
[Cu] Atualização por classe:141201
[Lr] Data última revisão:
141201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141012
[St] Status:MEDLINE


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[PMID]:24723799
[Au] Autor:Babaei N; Abdullah NA; Saleh G; Abdullah TL
[Ad] Endereço:Islamic Azad University, Bushehr Branch, 7519619555 Bushehr, Iran.
[Ti] Título:An efficient in vitro plantlet regeneration from shoot tip cultures of Curculigo latifolia, a medicinal plant.
[So] Source:ScientificWorldJournal;2014:275028, 2014.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A procedure was developed for in vitro propagation of Curculigo latifolia through shoot tip culture. Direct regeneration and indirect scalp induction of Curculigo latifolia were obtained from shoot tip grown on MS medium supplemented with different concentrations and combinations of thidiazuron and indole-3-butyric acid. Maximum response for direct regeneration in terms of percentage of explants producing shoot, shoot number, and shoot length was obtained on MS medium supplemented with combination of thidiazuron (0.5 mg L(-1)) and indole-3-butyric acid (0.25 mg L(-1)) after both 10 and 14 weeks of cultures. Indole-3-butyric acid in combination with thidiazuron exhibited a synergistic effect on shoot regeneration. The shoot tips were able to induce maximum scalp from basal end of explants on the medium with 2 mg L(-1) thidiazuron. Cultures showed that shoot number, shoot length, and scalp size increased significantly after 14 weeks of culture. Transferring of the shoots onto the MS medium devoid of growth regulators resulted in the highest percentage of root induction and longer roots, while medium supplemented with 0.25 mg L(-1) IBA produced more numbers of roots.
[Mh] Termos MeSH primário: Curculigo/crescimento & desenvolvimento
Reguladores de Crescimento de Planta/farmacologia
Brotos de Planta/crescimento & desenvolvimento
Plantas Medicinais/crescimento & desenvolvimento
Regeneração/fisiologia
[Mh] Termos MeSH secundário: Curculigo/efeitos dos fármacos
Técnicas In Vitro
Brotos de Planta/efeitos dos fármacos
Plantas Medicinais/efeitos dos fármacos
Regeneração/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Growth Regulators)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140412
[St] Status:MEDLINE
[do] DOI:10.1155/2014/275028


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[PMID]:24007307
[Au] Autor:Liu M; Li Y; Yang ST
[Ad] Endereço:1 William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University , Columbus, Ohio.
[Ti] Título:Curculigoside improves osteogenesis of human amniotic fluid-derived stem cells.
[So] Source:Stem Cells Dev;23(2):146-54, 2014 Jan 15.
[Is] ISSN:1557-8534
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Curculigoside, a phenolic glycoside, is the main active compound of Curculigo orchioides (Amaryllidaceae, rhizome). C. orchioides is a traditional Chinese herbal medicine and has been commonly used to treat orthopedic disorders and bone healing in Asia. This study evaluated the effect of curculigoside on osteogenic differentiation of human amniotic fluid-derived stem cells (hAFSCs). The results showed that curculigoside stimulated alkaline phosphatase activity and calcium deposition of hAFSCs during osteogenic differentiation in a dose-dependent manner (1-100 µg/mL), while the effects were reduced at the higher concentration of 200 µg/mL. From reverse transcriptase-polymerase chain reaction analysis, the osteogenic genes osteopontin (OPN) and Collagen I were upregulated with curculigoside treatment (1-100 µg/mL). Concurrently, the ratio of osteoprotegerin (OPG) to receptor activator of nuclear factor kappa-B ligand (RANKL) was increased, indicating the inhibition of osteoclastogenesis by curculigoside. Moreover, the role of Wnt/ß-catenin signaling during curculigoside treatment was revealed by the upregulation of ß-catenin and Cyclin D1. In summary, curculigoside improved osteogenesis and inhibited osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders.
[Mh] Termos MeSH primário: Benzoatos/farmacologia
Diferenciação Celular/efeitos dos fármacos
Glucosídeos/farmacologia
Osteogênese/efeitos dos fármacos
Células-Tronco/metabolismo
[Mh] Termos MeSH secundário: Fosfatase Alcalina/biossíntese
Líquido Amniótico/citologia
Cálcio/metabolismo
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Colágeno/biossíntese
Colágeno/genética
Curculigo/metabolismo
Ciclina D1/biossíntese
Seres Humanos
Medicina Tradicional Chinesa
Osteoclastos/metabolismo
Osteopontina/biossíntese
Osteopontina/genética
Osteoporose/tratamento farmacológico
Osteoprotegerina/biossíntese
Ligante RANK/biossíntese
Células-Tronco/citologia
Regulação para Cima/efeitos dos fármacos
Via de Sinalização Wnt/efeitos dos fármacos
beta Catenina/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzoates); 0 (Glucosides); 0 (Osteoprotegerin); 0 (RANK Ligand); 0 (TNFSF11 protein, human); 0 (beta Catenin); 106441-73-0 (Osteopontin); 136601-57-5 (Cyclin D1); 85643-19-2 (curculigoside); 9007-34-5 (Collagen); EC 3.1.3.1 (Alkaline Phosphatase); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:140107
[Lr] Data última revisão:
140107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130907
[St] Status:MEDLINE
[do] DOI:10.1089/scd.2013.0261



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