Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.100.230.395 [Categoria DeCS]
Referências encontradas : 51 [refinar]
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[PMID]:27401301
[Au] Autor:Jegede AI; Offor U; Onanuga IO; Naidu EC; Azu OO
[Ad] Endereço:Discipline of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa.
[Ti] Título:Effect of co-administration of Hypoxis hemerocallidea extract and antiretroviral therapy (HAART) on the histomorphology and seminal parameters in Sprague Dawley rats.
[So] Source:Andrologia;49(2), 2017 Mar.
[Is] ISSN:1439-0272
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Although the successful introduction and rollout of antiretroviral therapy has impacted positively on morbidity and mortality of HIV-positive patients, its interaction with plant-based adjuvants remain sparsely investigated. We report the interaction and effects of adjuvant treatment with highly active antiretroviral therapy (HAART) and Hypoxis hemeocallidea (HH) extracts on testicular structure of rats. A total of 63 pathogen-free adult male Sprague Dawley rats were divided into nine groups and treated according to protocols. HAART cocktail predisposed to significant negative testicular parameters of sperm count, motility and seminiferous tubular epithelial height (quantitatively) (p < .03) and also altered the histomorphology of tubules with diffuse hypoplasia in seminiferous tubules. The higher dose of HH showed a better ability to mitigate the altered parameters and compares favourably with vitamin C in this protocol. While HH did not show any deleterious impact on morphometric data, its role as adjuvant did not significantly reduce the negative impact of HAART on morphometric indices especially with the lower dosage. Further investigations are warranted on the interactions between HAART and Hypoxis.
[Mh] Termos MeSH primário: Fármacos Anti-HIV/farmacologia
Terapia Antirretroviral de Alta Atividade
Infecções por HIV/tratamento farmacológico
Interações Ervas-Drogas
Hypoxis/química
Extratos Vegetais/farmacologia
Espermatozoides/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Fármacos Anti-HIV/uso terapêutico
Ácido Ascórbico/farmacologia
Quimioterapia Adjuvante/métodos
Lamivudina/farmacologia
Lamivudina/uso terapêutico
Masculino
Nevirapina/farmacologia
Nevirapina/uso terapêutico
Extratos Vegetais/administração & dosagem
Ratos
Ratos Sprague-Dawley
Túbulos Seminíferos/efeitos dos fármacos
Túbulos Seminíferos/patologia
Contagem de Espermatozoides
Motilidade Espermática/efeitos dos fármacos
Estavudina/farmacologia
Estavudina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Plant Extracts); 2T8Q726O95 (Lamivudine); 99DK7FVK1H (Nevirapine); BO9LE4QFZF (Stavudine); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE
[do] DOI:10.1111/and.12640


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[PMID]:27437404
[Au] Autor:Balogun FO; Tshabalala NT; Ashafa AO
[Ad] Endereço:Phytomedicine and Phytopharmacology Research Group, Department of Plant Sciences, University of the Free State, Qwaqwa Campus, Private Bag X 13, Phuthaditjhaba 9866, South Africa.
[Ti] Título:Antidiabetic Medicinal Plants Used by the Basotho Tribe of Eastern Free State: A Review.
[So] Source:J Diabetes Res;2016:4602820, 2016.
[Is] ISSN:2314-6753
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Diabetes mellitus (DM) belongs to the group of five leading important diseases causing death globally and remains a major health problem in Africa. A number of factors such as poverty, poor eating habit, and hormonal imbalance are responsible for the occurrence of the disease. It poses a major health challenge in Africa continent today and the prevalence continues to increase at an alarming rate. Various treatment options particularly the usage of herbs have been effective against diabetes because they have no adverse effects. Interestingly, South Africa, especially the Basotho tribe, is blessed with numerous medicinal plants whose usage in the treatment of DM has been effective since the conventional drugs are expensive and often unaffordable. The present study attempted to update the various scientific evidence on the twenty-three (23) plants originating from different parts of the world but widely used by the Sotho people in the management of DM. Asteraceae topped the list of sixteen (16) plant families and remained the most investigated according to this review. Although limited information was obtained on the antidiabetic activities of these plants, it is however anticipated that government parastatals and scientific communities will pay more attention to these plants in future research.
[Mh] Termos MeSH primário: Diabetes Mellitus/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Preparações de Plantas/uso terapêutico
Plantas Medicinais
[Mh] Termos MeSH secundário: Aloe
Apocynaceae
Asparagus (Planta)
Asteraceae
Cannabis
Commelina
Fabaceae
Seres Humanos
Hypoxidaceae
Hypoxis
Malvaceae
Mimulus
Myricaceae
Rubiaceae
Rumex
África do Sul
Xanthorrhoeaceae
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Preparations)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE
[do] DOI:10.1155/2016/4602820


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[PMID]:27307203
[Au] Autor:Okem A; Moyo M; Stirk WA; Finnie JF; Van Staden J
[Ad] Endereço:Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg, Scottsville, South Africa.
[Ti] Título:Investigating the effect of cadmium and aluminium on growth and stress-induced responses in the micropropagated medicinal plant Hypoxis hemerocallidea.
[So] Source:Plant Biol (Stuttg);18(5):805-15, 2016 Sep.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hypoxis hemerocallidea is a highly utilized medicinal plant in South Africa. Its cultivation has received considerable attention in order to meet the high demand. High levels of cadmium (Cd) and aluminum (Al) in H. hemerocallidea plants sold in traditional medicinal markets was previously reported. The present study used an in vitro propagation model to investigate the uptake of Cd and Al by H. hemerocallidea and their effect on plant growth, elemental uptake and some stress-induced responses such as pigment, malondialdehyde (MDA), proline content and ultrastructural changes. Shoot and root growth of plantlets exposed to Cd, Cd:Al and high concentrations of Al was significantly reduced. Highest concentrations of Cd accumulated in the corms of Cd-treated plantlets while highest Al concentrations occurred in the leaves and roots. There was higher accumulation of Cd and Al when applied singularly compared to the Cd:Al combination treatments. Cd and Al also reduced accumulation of trace elements in micropropagted H. hemerocallidea with lowest concentrations in the Cd:Al combination treatments. Exposure to Cd, Al and Cd:Al significantly reduced the level of chlorophyll but increased the levels of carotenoids, MDA and proline. Ultrastructural changes were also observed in H. hemerocallidea exposed to Cd and Al. All these factors contributed to the inhibition of plant growth and could potentially affect the ability of this important medicinal plant to synthesize bioactive compounds. It is thus necessary to understand heavy metal stress-induced responses in this highly valued medicinal plant to ensure a high quality product for the consumer.
[Mh] Termos MeSH primário: Alumínio/farmacologia
Cádmio/farmacologia
Hypoxis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alumínio/metabolismo
Cádmio/metabolismo
Clorofila/metabolismo
Hypoxis/crescimento & desenvolvimento
Hypoxis/fisiologia
Hypoxis/ultraestrutura
Malondialdeído/metabolismo
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/crescimento & desenvolvimento
Folhas de Planta/fisiologia
Folhas de Planta/ultraestrutura
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/fisiologia
Raízes de Plantas/ultraestrutura
Plantas Medicinais
Prolina/metabolismo
África do Sul
Oligoelementos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trace Elements); 00BH33GNGH (Cadmium); 1406-65-1 (Chlorophyll); 4Y8F71G49Q (Malondialdehyde); 9DLQ4CIU6V (Proline); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12480


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[PMID]:26473664
[Au] Autor:Okem A; Stirk WA; Street RA; Southway C; Finnie JF; Van Staden J
[Ad] Endereço:Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville, 3209, South Africa.
[Ti] Título:Effects of Cd and Al stress on secondary metabolites, antioxidant and antibacterial activity of Hypoxis hemerocallidea Fisch. & C.A. Mey.
[So] Source:Plant Physiol Biochem;97:147-55, 2015 Dec.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:This study investigated the effects of cadmium (Cd) and aluminium (Al) on the accumulation of phenolics, flavonoids and the bioactive compound hypoxoside in Hypoxis hemerocallidea. In addition, antioxidant scavenging and antibacterial activity were assessed to evaluate if Cd and Al stress affect the accumulation of bioactive compounds in H. hemerocallidea. In vitro grown plantlets of H. hemerocallidea were acclimatized for seven months in a greenhouse. Thereafter plants were exposed to various concentrations of Cd and Al both singularly and in combination in the form of Cd(NO3)2 (2, 5, 10 mg Cd/L); Al3(NO3)3 (500, 1000, 1500 mg Al/L) and combinations of Cd and Al (Cd 2:Al 500, Cd 5:Al 1000 and Cd 10:Al 1500 mg/L) for a further six weeks. The highest amounts of Cd and Al translocated to the shoot were 34 and 1608 mg/L respectively. Phytochemical screening showed significantly high amounts of total phenolics and flavonoids at the moderate Cd treatment (5 mg/L) compared to the controls. Exposure to Cd and Al significantly decreased the accumulation of hypoxoside. There was a significant increase in diphenylpicrylhydrazyl (DPPH) antioxidant scavenging activity in most of the metal-treated plants compared to the positive control ascorbic acid. Extracts from Cd 2 mg/L treatment exhibited moderate antibacterial activity against Staphylococcus aureus compared to the control. The results of the present study revealed that cultivating H. hemerocallidea on metal contaminated soils affects the accumulation of the bioactive compound, hypoxoside.
[Mh] Termos MeSH primário: Alumínio/toxicidade
Antioxidantes/metabolismo
Cádmio/toxicidade
Hypoxis/efeitos dos fármacos
Metabolismo Secundário/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alquinos/metabolismo
Antibacterianos/metabolismo
Flavonoides/metabolismo
Glucosídeos/metabolismo
Hypoxis/metabolismo
Fenóis/metabolismo
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkynes); 0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Glucosides); 0 (Phenols); 00BH33GNGH (Cadmium); 83643-94-1 (hypoxoside); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151017
[St] Status:MEDLINE


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[PMID]:25435617
[Au] Autor:Shaik S; Govender K; Leanya M
[Ad] Endereço:School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa.
[Ti] Título:GA3-mediated dormancy alleviation in the reputed African potato, Hypoxis hemerocallidea.
[So] Source:Afr J Tradit Complement Altern Med;11(2):330-3, 2014.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hypoxis hemerocallidea, arguably the most well-known medicinal species in South Africa, has been the subject of intensive harvesting from the wild leading to recent conservation concerns. The seeds of this species do not propagate easily and can lie dormant for up to twelve months. MATERIALS AND METHODS: In the in vitro germination experiments water, acid and chemical pre-sowing treatments were performed to determine the germination response of this species in both light and dark conditions. In the ex vitro experiment, intact seeds were sown and left to germinate in a potting soil mix under greenhouse conditions. RESULTS: Highest levels of germination (36.7-60.0% in the light and 36.7-46.7% in the dark) were achieved by treating mechanically scarified seeds with GA3 at various concentrations for 24 h. This was followed by scarified seeds soaked in water (26.7% in the light and 23.3% in the dark). Similar results (23.3 and 26.7%) were obtained in the 1% and 4% KNO3 treatments, respectively, under light conditions only. The fastest time to germinate was two days and was obtained in the 1200 ppm GA3 treatment in both light and dark conditions. Ex vitro germination of H. hemerocallidea seeds under greenhouse conditions was unsuccessful. CONCLUSION: H. hemerocallidea displays physical and non-deep physiological dormancy where pre-sowing treatments are required before the seeds will germinate.
[Mh] Termos MeSH primário: Giberelinas/farmacologia
Hypoxis/efeitos dos fármacos
Hypoxis/crescimento & desenvolvimento
Dormência de Plantas/efeitos dos fármacos
Reguladores de Crescimento de Planta/farmacologia
[Mh] Termos MeSH secundário: Hypoxis/efeitos da radiação
Luz
Sementes/efeitos dos fármacos
Sementes/crescimento & desenvolvimento
Sementes/efeitos da radiação
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gibberellins); 0 (Plant Growth Regulators); BU0A7MWB6L (gibberellic acid)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141202
[St] Status:MEDLINE


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[PMID]:25392578
[Au] Autor:Afolayan AJ; Otunola GA
[Ad] Endereço:Centre for Phytomedicine Research, Department of Botany, University of Fort Hare, Alice 5700, South Africa.
[Ti] Título:Ultrastructure and elemental analysis of Hypoxis hemerocallidea: a multipurpose medicinal plant.
[So] Source:Afr J Tradit Complement Altern Med;11(4):39-43, 2014.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Herbal medicine is a popular means of medical management in some parts of the world especially in Africa. Hypoxis hemerocallidea Fisch.C.A.Mey. & Avé-Lall, also known as African potato of the Hypoxidaecae family, is one of the medicinal plants that have enjoyed long usage as an herbal medicine in South Africa. In this study, the morphology and elemental constituents of H. hemerocallidea leaf was investigated to correlate the functional role of the ultrastructure in the production of therapeutic compounds. MATERIALS AND METHODS: Fresh leaves of H. hemerocallidea were prepared for analysis using standard methods. The ultrastructure and crystal deposits of the plant were assessed using scanning electron microscopy (SEM), and energy dispersive x-ray (EDX). RESULTS: It was observed that the leaves were characterised by multicelullar glandular and non glandular trichomes which are sparsely distributed over the entire surfaces. The glandular trichomes (GTs) in H. hemerocallidea leaf have boulbous heads which are probably filled with secretions, while the non glandular trichomes were long, fibrous and sparse. EDX-SEM of Hypoxis hemerocallidea leaf revealed that carbon, oxygen, nitrogen and silicon are the major components of the deposits, while other elements such as iron, sulphur, sodium, calcium, magnesium, potassium, manganese, iodine, chromium and iodine were present in small but variable amounts. CONCLUSION: The presence of these elements which are crucial to maintaining good health, in addition to other bioactive constituents might be accountable for the multipurpose therapeutic uses of Hypoxis hemerocallidea in the treatment of cancers, HIV/AIDS related diseases, urinary tract infections, cardiovascular disorders, diabetes and other chronic ailments of humans.
[Mh] Termos MeSH primário: Hypoxis/química
Minerais/uso terapêutico
Fitoterapia
Folhas de Planta/química
Plantas Medicinais/química
Oligoelementos/uso terapêutico
Tricomas
[Mh] Termos MeSH secundário: Hypoxis/ultraestrutura
Minerais/análise
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Folhas de Planta/ultraestrutura
Plantas Medicinais/ultraestrutura
África do Sul
Oligoelementos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Minerals); 0 (Plant Extracts); 0 (Trace Elements)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:170217
[Lr] Data última revisão:
170217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141114
[St] Status:MEDLINE


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[PMID]:25303104
[Au] Autor:Park KM; Blatchley MR; Gerecht S
[Ad] Endereço:Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences-Oncology Center and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.
[Ti] Título:The design of dextran-based hypoxia-inducible hydrogels via in situ oxygen-consuming reaction.
[So] Source:Macromol Rapid Commun;35(22):1968-75, 2014 Nov.
[Is] ISSN:1521-3927
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Hypoxia plays a critical role in the development and wound healing process, as well as a number of pathological conditions. Here, dextran-based hypoxia-inducible (Dex-HI) hydrogels formed with in situ oxygen consumption via a laccase-medicated reaction are reported. Oxygen levels and gradients were accurately predicted by mathematical simulation. It is demonstrated that Dex-HI hydrogels provide prolonged hypoxic conditions up to 12 h. The Dex-HI hydrogel offers an innovative approach to delineate not only the mechanism by which hypoxia regulates cellular responses, but may facilitate the discovery of new pathways involved in the generation of hypoxic and oxygen gradient environments.
[Mh] Termos MeSH primário: Dextranos/metabolismo
Hidrogéis/metabolismo
Hypoxis/metabolismo
Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/química
Materiais Biocompatíveis/metabolismo
Dextranos/química
Hidrogéis/química
Hypoxis/química
Lacase/química
Lacase/metabolismo
Estrutura Molecular
Oxigênio/química
Consumo de Oxigênio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Dextrans); 0 (Hydrogels); EC 1.10.3.2 (Laccase); S88TT14065 (Oxygen)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141011
[St] Status:MEDLINE
[do] DOI:10.1002/marc.201400369


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[PMID]:25219317
[Au] Autor:Moyo M; Amoo SO; Aremu AO; Gruz J; Subrtová M; Dolezal K; Van Staden J
[Ad] Endereço:Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa.
[Ti] Título:Plant regeneration and biochemical accumulation of hydroxybenzoic and hydroxycinnamic acid derivatives in Hypoxis hemerocallidea organ and callus cultures.
[So] Source:Plant Sci;227:157-64, 2014 Oct.
[Is] ISSN:1873-2259
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Micropropagation of Hypoxis hemerocallidea Fisch. and C.A. Mey was used as a model system to study the influence of cytokinins (CKs) on plant regeneration and biochemical accumulation of hydroxybenzoic and hydroxycinnamic acid derivatives in organ and callus cultures and their antioxidant activity. Fourteen free phenolic acids were detected using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) while antioxidant activity was evaluated using oxygen radical absorbance capacity (ORAC) and 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging activity. Cytokinins had a significant effect on the biochemical accumulation of hydroxybenzoic and hydroxycinnamic acid derivatives in H. hemerocallidea organ cultures. In particular, meta-topolin-treated organ cultures produced high concentrations of gallic, protocatechuic, gentisic, p-hydroxybenzoic, m-hydroxybenzoic, salicylic, chlorogenic and trans-cinnamic acids. The isoprenoid CK, N(6)-(2-isopentenyl)-adenine significantly increased the accumulation of hydroxycinnamic acid derivatives, namely, caffeic, p-coumaric, sinapic and ferulic acids. Cytokinin-treated organ cultures exhibited a significant increase in antioxidant activity, particularly in the ORAC model. In callus cultures, CKs decreased the concentrations of hydroxycinnamic acid derivatives and antioxidant activity when compared to the control. Overall, both CK type and concentration had a significant effect on plant regeneration, callus proliferation, biochemical accumulation of free phenolic acids and antioxidant activity of the resultant extracts.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Ácidos Cumáricos/metabolismo
Citocininas/farmacologia
Hidroxibenzoatos/metabolismo
Hypoxis/metabolismo
Fenóis/metabolismo
Reguladores de Crescimento de Planta/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Compostos de Bifenilo/metabolismo
Ácidos Cumáricos/farmacologia
Hidroxibenzoatos/farmacologia
Hypoxis/crescimento & desenvolvimento
Isopenteniladenosina/farmacologia
Fenóis/farmacologia
Picratos/metabolismo
Técnicas de Embriogênese Somática de Plantas
Estruturas Vegetais/crescimento & desenvolvimento
Estruturas Vegetais/metabolismo
Regeneração
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Coumaric Acids); 0 (Cytokinins); 0 (Hydroxybenzoates); 0 (Phenols); 0 (Picrates); 0 (Plant Growth Regulators); 2365-40-4 (N(6)-(delta(2)-isopentenyl)adenine); 7724-76-7 (Isopentenyladenosine); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140916
[St] Status:MEDLINE


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[PMID]:24184189
[Au] Autor:Ncube B; Ndhlala AR; Okem A; Van Staden J
[Ad] Endereço:Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa.
[Ti] Título:Hypoxis (Hypoxidaceae) in African traditional medicine.
[So] Source:J Ethnopharmacol;150(3):818-27, 2013 Dec 12.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Hypoxis species (Hypoxidaceae) are popular medicinal plants used in the African traditional medicine to treat numerous ailments and are reported to have a wide spectrum of pharmacological properties. In this paper we reviewed and evaluated the traditional uses, pharmacological, phytochemistry and toxicity aspects of the genus Hypoxis. Potential medicinal prospects and possible knowledge gaps and pitfalls are discussed. MATERIALS AND METHODS: A comprehensive and systematic review of literature on Hypoxis species was done using numerous resources such as books and scientific databases that include Pubmed, Scopus, Scirus, Google scholar, Web of Science and others. Information on the various pharmacological and chemical properties of Hypoxis extracts was critically analysed and discussed under the various topics. RESULTS: The literature indicated a broad range of uses, pharmacological and toxicological properties of different Hypoxis species extracts and their relevance to African healthcare systems. Several compounds, mostly glucosides, sterols and sterolins, have been isolated, identified and tested in various in vitro and in vivo models as well as in a couple of clinical trials with a lot of promising prospects reported in some studies. CONCLUSION: A critical analysis of the available literature and studies identifies positive potential for the future use of Hypoxis species in both traditional and modern medicine and concurrently so with possible pitfalls and research gaps in current knowledge. An integrated and holistic approach to addressing research issues, particularly toxicology aspects could be more effectively applied and incorporate conservation strategies for the species.
[Mh] Termos MeSH primário: Hypoxis
Medicina Tradicional Africana
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Extratos Vegetais/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:131202
[Lr] Data última revisão:
131202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131105
[St] Status:MEDLINE


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[PMID]:24041457
[Au] Autor:Ndhlala AR; Stafford GI; Van Staden J
[Ad] Endereço:Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3201, South Africa.
[Ti] Título:Phytosynergy in some Hypoxis species and pharmacological properties of a Hypoxis-based phytopharmaceutical formula.
[So] Source:J Ethnopharmacol;150(2):492-500, 2013 Nov 25.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGY RELEVANCE: Hypoxis species are used extensively in traditional medicine in southern Africa for several ailments including tuberculosis, chest infections, and nervous and urinary disorders. Several other claims have been made for extracts emanating from Hypoxis species and have led to the production of several commercial products used as immunostimulants mostly for people living with HIV/AIDS and cancer. This study was aimed at investigating the biological activity of four Hypoxis species and a commercial herbal product, 'African potato extract' (APE). MATERIALS AND METHODS: Antibacterial, antifungal, cyclooxygenase (COX) and acetylcholineasterase (AChE) inhibitory activities of four Hypoxis species (H. acuminata, H. colchicifolia, H. hemerocallidea and H. rigidula) and a popular Hypoxis-based herbal preparation, APE were tested. The phytoconstituents of the mixture were also profiled using TLC methods. Several combinations of the Hypoxis species were prepared and their synergism, additive, autonomic and antagonism effects investigated. As a quality control measure, batch to batch comparison in the phytoconstituents and biological activity of APE was carried out. RESULTS: The results confirmed H. colchicifolia and H. hemerocallidea as the phytoconstituents of APE. The extracts showed a broad spectrum of activities against the bacterial and fungal strains used. Of particular interest were the activities exhibited by the APE and combinations of H. colchicifolia and H. hemerocallidea. The APE mixture exhibited good antibacterial activity (MIC values of 0.78mg/ml each) in all the tested batches against the bacterial strains used. The water extracts of all four Hypoxis species, three batches of APE and the combination (water extracts) of H. colchicifolia and H. hemerocallidea exhibited high COX-1 and moderate COX-2 inhibitory activity except for H. acuminata which showed low activity against COX-2. All the extract, batches of APE and combinations showed low to moderate AChE inhibitory activity. These results provided some evidence of phytosynergy in some extracts of H. hemerocallidea and H. colchicifolia except for a few extracts which act as additive, autonomous and antagonistic when used to inhibit some bacterial and fungal strains. However, this was not the case for COX and AChE inhibition, as only acetone extracts acted in a synergistic way to reduce the activity of the enzyme. CONCLUSION: Even though the results give an indication of a positive interaction between some extracts of H. hemerocallidea and H. colchicifolia, the study was carried out on 1:1 v/v combinations only. It is therefore important to carry out isobologram studies, which considers more than one ratio of the combinations.
[Mh] Termos MeSH primário: Hypoxis
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Antibacterianos/farmacologia
Antifúngicos/farmacologia
Bactérias/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Inibidores da Colinesterase/farmacologia
Ciclo-Oxigenase 1/metabolismo
Ciclo-Oxigenase 2/metabolismo
Inibidores de Ciclo-Oxigenase/farmacologia
Testes de Sensibilidade Microbiana
Raízes de Plantas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Cholinesterase Inhibitors); 0 (Cyclooxygenase Inhibitors); 0 (Plant Extracts); EC 1.14.99.1 (Cyclooxygenase 1); EC 1.14.99.1 (Cyclooxygenase 2); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:131111
[Lr] Data última revisão:
131111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130918
[St] Status:MEDLINE



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