Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.100.400 [Categoria DeCS]
Referências encontradas : 177 [refinar]
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  1 / 177 MEDLINE  
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[PMID]:28360398
[Au] Autor:Singh N; Meena B; Pal AK; Roy RK; Tewari SK; Tamta S; Rana TS
[Ad] Endereço:CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India. ranatikam@gmail.com.
[Ti] Título:Nucleotide diversity and phylogenetic relationships among Gladiolus cultivars and related taxa of family Iridaceae.
[So] Source:J Genet;96(1):135-145, 2017 Mar.
[Is] ISSN:0973-7731
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The plastid genome regions of two intergenic spacers, psbA-trnH and trnL-trnF, were sequenced to study the nucleotide diversity and phylogenetic relationships among Gladiolus cultivars. Nucleotide diversity of psbA-trnH region was higher than trnL-trnF region of chloroplast. We employed Bayesian, maximum parsimony (MP) and neighbour-joining (NJ) approaches for phylogenetic analysis of Gladiolus and related taxa using combined datasets from chloroplast genome. The psbA-trnH and trnL-trnF intergenic spacers of Gladiolus and related taxa-like Babiana, Chasmanthe, Crocus, Iris, Moraea, Sisyrinchium, Sparaxis and two out group species (Hymenocallis littoralis and Asphodeline lutea) were used in the present investigation. Results showed that subfamily Iridoideae have sister lineage with subfamily Ixioideae and Crocoideae. H. littoralis and A. lutea were separately attached at the base of tree as the diverging Iridaceae relative's lineage. Present study revealed that psbA-trnH region are useful in addressing questions of phylogenetic relationships among the Gladiolus cultivars, as these intergenic spacers are more variable and have more phylogenetically informative sites than the trnL-trnF spacer, and therefore, are suitable for phylogenetic comparison on a lower taxonomic level. Gladiolus cultivars are extensively used as an ornamental crop and showed high potential in floriculture trade. Gladiolus cultivation still needs to generate new cultivars with stable phenotypes. Moreover, one of the most popular methods for generating new cultivars is hybridization. Hence, information on phylogenetic relationships among cultivars could be useful for hybridization programmes for further improvement of the crop.
[Mh] Termos MeSH primário: DNA de Plantas
Variação Genética
Iridaceae/classificação
Iridaceae/genética
Nucleotídeos
Filogenia
[Mh] Termos MeSH secundário: Cloroplastos/genética
DNA Espaçador Ribossômico
Evolução Molecular
Genomas de Plastídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (DNA, Ribosomal Spacer); 0 (Nucleotides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


  2 / 177 MEDLINE  
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[PMID]:28094438
[Au] Autor:Skeels A; Cardillo M
[Ad] Endereço:Macroevolution and Macroecology Group, Research School of Biology, Australian National University, Canberra, 0200, Australia.
[Ti] Título:Environmental niche conservatism explains the accumulation of species richness in Mediterranean-hotspot plant genera.
[So] Source:Evolution;71(3):582-594, 2017 Mar.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The causes of exceptionally high plant diversity in Mediterranean-climate biodiversity hotspots are not fully understood. We asked whether a mechanism similar to the tropical niche conservatism hypothesis could explain the diversity of four large genera (Protea, Moraea, Banksia, and Hakea) with distributions within and adjacent to the Greater Cape Floristic Region (South Africa) or the Southwest Floristic Region (Australia). Using phylogenetic and spatial data we estimated the environmental niche of each species, and reconstructed the mode and dynamics of niche evolution, and the geographic history, of each genus. For three genera, there were strong positive relationships between the diversity of clades within a region and their inferred length of occupation of that region. Within genera, there was evidence for strong evolutionary constraint on niche axes associated with climatic seasonality and aridity, with different niche optima for hotspot and nonhotspot clades. Evolutionary transitions away from hotspots were associated with increases in niche breadth and elevated rates of niche evolution. Our results point to a process of "hotspot niche conservatism" whereby the accumulation of plant diversity in Mediterranean-type ecosystems results from longer time for speciation, with dispersal away from hotspots limited by narrow and phylogenetically conserved environmental niches.
[Mh] Termos MeSH primário: Biodiversidade
Evolução Biológica
Ecossistema
Iridaceae/fisiologia
Proteaceae/fisiologia
[Mh] Termos MeSH secundário: Austrália
Clima
Filogenia
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13179


  3 / 177 MEDLINE  
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[PMID]:27723785
[Au] Autor:Takahashi Y; Takakura KI; Kawata M
[Ad] Endereço:Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba, Sendai, Miyagi, 980-8578, Japan.
[Ti] Título:Spatial Distribution of Flower Color Induced by Interspecific Sexual Interaction.
[So] Source:PLoS One;11(10):e0164381, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the mechanisms shaping the spatiotemporal distribution of species has long been a central concern of ecology and evolutionary biology. Contemporary patterns of plant assemblies suggest that sexual interactions among species, i.e., reproductive interference, lead to the exclusive distributions of closely related species that share pollinators. However, the fitness consequences and the initial ecological/evolutionary responses to reproductive interference remain unclear in nature, since reproductive isolation or allopatric distribution has already been achieved in the natural community. In Japan, three species of blue-eyed grasses (Sisyrinchium) with incomplete reproductive isolation have recently colonized and occur sympatrically. Two of them are monomorphic with white flowers, whereas the other exhibits heritable color polymorphism (white and purple morphs). Here we investigated the effects of the presence of two monomorphic species on the distribution and reproductive success of color morphs. The frequency and reproductive success of white morphs decreased in area where monomorphic species were abundant, while those of purple morphs did not. The rate of hybridization between species was higher in white morphs than in the purple ones. Resource competition and habitat preference seemed not to contribute to the spatial distribution and reproductive success of two morphs. Our results supported that color-dependent reproductive interference determines the distribution of flower color polymorphism in a habitat, implying ecological sorting promoted by pollinator-mediated reproductive interference. Our study helps us to understand the evolution and spatial structure of flower color in a community.
[Mh] Termos MeSH primário: Quimera/fisiologia
Flores/fisiologia
Iridaceae/fisiologia
Pigmentação/fisiologia
Polimorfismo Genético
[Mh] Termos MeSH secundário: Japão
Reprodução/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0164381


  4 / 177 MEDLINE  
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[PMID]:27706726
[Au] Autor:Miz RB; Tacuatiá LO; Cidade FW; de Souza AP; Bered F; Eggers L; de Souza-Chies TT
[Ad] Endereço:Programa de Pós-Graduação em Genética e Biologia Molecular, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
[Ti] Título:Isolation and characterization of microsatellite loci in Sisyrinchium (Iridaceae) and cross amplification in other genera.
[So] Source:Genet Mol Res;15(3), 2016 Sep 16.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Recent phylogenetic studies on Sisyrinchium strongly suggest that species classified in section Hydastylus and section Viperella belong to a single group of plants in recent adaptive radiation (Clade IV). These species neither present clear morphological differentiation among them nor show clear identification using DNA barcode markers. Thus, the main goal of this study was to develop a set of polymorphic microsatellite markers compatible for representative species of both sections to ensure variability that could be revealed by SSR markers. Therefore, microsatellite primers were isolated and characterized for Sisyrinchium palmifolium and S. marchioides. In addition, transferability of the developed primers was tested in Iridoideae, primarily in closely related species of Sisyrinchium. Sixteen microsatellite loci were developed from enriched genomic libraries, of which ten were polymorphic. G values indicated higher differentiation among subpopulations of S. palmifolium than those from S. marchioides. Major transferability was obtained using primers isolated from S. marchioides. All primers exhibited higher rates of cross-amplification for species belonging to Clade IV of Sisyrinchium, as well as to the genera Calydorea and Herbertia. These developed microsatellite markers can be used as an efficient tool for characterization of genetic variability in species belonging to Iridoideae, as well as for studies on population dynamics, genetic structure, and mating system in other Sisyrinchium species.
[Mh] Termos MeSH primário: Iridaceae/genética
Repetições de Microssatélites/genética
Filogenia
[Mh] Termos MeSH secundário: Polimorfismo Genético
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15038474


  5 / 177 MEDLINE  
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[PMID]:27219484
[Au] Autor:Geerts S
[Ad] Endereço:Department of Conservation and Marine Sciences, Cape Peninsula University of Technology, Cape Town, South Africa. Geertss@cput.ac.za.
[Ti] Título:Can short-billed nectar thieving sunbirds replace long-billed sunbird pollinators in transformed landscapes?
[So] Source:Plant Biol (Stuttg);18(6):1048-1052, 2016 Nov.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pollinator specialisation through exploitation barriers (such as long floral tubes) does not necessarily mean a lack of pollination when the favoured pollinator is rare or absent. Theory predicts that suboptimal visitors will contribute to plant reproduction in the absence of the most effective pollinator. Here I address these questions with Chasmanthe floribunda a long-tubed plant species in the Cape Floristic Region, which is reliant on one species of pollinator, the long-billed Malachite Sunbird. In contrast to short-billed sunbirds, the Malachite Sunbird occurs in lower abundance or is absent in transformed landscapes. Short-billed sunbirds rob and thieve nectar from long-tubed flowers, but their potential contribution towards pollination is unknown. Experiments assessing seed set after single flower visits were performed to determine whether thieving short-billed sunbirds can act as substitute pollinators. To determine whether short-billed sunbirds reduce pollen limitation in transformed areas, pollen supplementation was done by hand and compared to natural fruit set. Short billed sunbirds are unable to act as substitute pollinators, and seed set is significantly lower in the flowers that they visited, compared to flowers visited by long-billed sunbirds. This is substantiated on a landscape scale, where fruit production in Chasmanthe floribunda could artificially be increased by 35% in transformed landscapes, but not so in natural areas. These findings have important consequences for the management and conservation of long-tubed bird-pollinated plant species that exist in recently transformed landscapes. The potential vulnerability of specialised plant species in transformed landscapes is highlighted.
[Mh] Termos MeSH primário: Iridaceae/fisiologia
Passeriformes/fisiologia
Polinização
[Mh] Termos MeSH secundário: Animais
Flores/anatomia & histologia
Flores/fisiologia
Iridaceae/anatomia & histologia
Néctar de Plantas/fisiologia
Pólen/anatomia & histologia
Pólen/fisiologia
Reprodução
Sementes/anatomia & histologia
Sementes/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Nectar)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170222
[Lr] Data última revisão:
170222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12474


  6 / 177 MEDLINE  
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[PMID]:27107698
[Au] Autor:Seng S; Wu J; Sui J; Wu C; Zhong X; Liu C; Liu C; Gong B; Zhang F; He J; Yi M
[Ad] Endereço:Beijing Key Laboratory of Development and Quality Control of Ornamental Crops, Department of Ornamental Horticulture and Landscape Architecture, China Agricultural University, Yuan Mingyuan Western Road 2#, Beijing 100193, China. Electronic address: seshsh108@126.com.
[Ti] Título:ADP-glucose pyrophosphorylase gene plays a key role in the quality of corm and yield of cormels in gladiolus.
[So] Source:Biochem Biophys Res Commun;474(1):206-212, 2016 05 20.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Starch is the main storage compound in underground organs like corms. ADP-glucose pyrophosphorylase (AGPase) plays a key role in regulating starch biosynthesis in storage organs and is likely one of the most important determinant of sink strength. Here, we identify an AGPase gene (GhAGPS1) from gladiolus. The highest transcriptional levels of GhAGPS1 were observed in cormels and corms. Transformation of GhAGPS1 into Arabidopsis rescued the phenotype of aps1 mutant. Silencing GhAGPS1 in gladiolus corms by virus-induced gene silencing (VIGS) decreased the transcriptional levels of two genes and starch content. Transmission electron microscopy analyses of leaf and corm sections confirmed that starch biosynthesis was inhibited. Corm weight and cormel number reduced significantly in the silenced plants. Taken together, these results indicate that inhibiting the expression of AGPase gene could impair starch synthesis, which results in the lowered corm quality and cormel yield in gladiolus.
[Mh] Termos MeSH primário: Glucose-1-Fosfato Adenililtransferase/metabolismo
Iridaceae/enzimologia
Iridaceae/crescimento & desenvolvimento
Folhas de Planta/fisiologia
Tubérculos/fisiologia
Amido/biossíntese
[Mh] Termos MeSH secundário: Especificidade de Órgãos
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9005-25-8 (Starch); EC 2.7.7.27 (Glucose-1-Phosphate Adenylyltransferase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160425
[St] Status:MEDLINE


  7 / 177 MEDLINE  
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[PMID]:27032710
[Au] Autor:Zhang L; Wei K; Xu J; Yang D; Zhang C; Wang Z; Li M
[Ad] Endereço:Baotou Medical College, Inner Mongolia, Baotou 014060, China; Guangxi key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
[Ti] Título:Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review.
[So] Source:J Ethnopharmacol;186:1-13, 2016 Jun 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Belamcanda chinensis (L.) DC is the sole species in the genus Belamcanda Adans. (Iridaceae), found mainly in Northeast Asia. Bombus chinensis has long been used in traditional Chinese medicine for its multiple therapeutic uses in the form of antipyretic agents, antidote, expectorant, antiphlogistic and analgesic. AIM OF THE REVIEW: This manuscript comprehensively summarizes the various studies published in recent years on the botany, ethnopharmacology, phytochemistry, biological activity and toxicology of B. chinensis. We hope to provide a foundation for future studies on the mechanism of action and development of better therapeutic agents based on B. chinensis. MATERIAL AND METHODS: All information available on B. chinensis was collected using electronic search engines, such as PubMed, SciFinder Scholar, CNKI, TPL (www.theplantlist.org), Google Scholar and Web of Science. RESULTS: The analysis shown that ethno-medical uses of B. chinensis have been recorded in China, Japan and Korea since a long time. Based on a phytochemical investigation, this plant contains flavonoids, terpenoids, quinones, phenolic compounds, ketones, organic acids, etc. Crude extracts and pure compounds isolated from B. chinensis exhibited various biological effects. CONCLUSIONS: In light of its long traditional use and the modern phytochemical and pharmacological studies summarized here, B. chinensis is known to be a promising medicinal plant with the isolated extracts and chemical components showing a wide range of biological activities. Thus, it is imperative that the necessary programs and value assessment of B. chinensis be established for further studies. It is also important that the synergistic or antagonistic effects of this traditional herbal medicine are investigated in depth to identify more bioactive components by bioactivity-guided isolation strategies, and to illustrate the mechanisms of action targeting on ethnomedical uses. Future clinical studies can also focus on the main therapeutic aspects, toxicity and adverse effects of B. chinensis.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Antipiréticos/farmacologia
Iridaceae/química
Medicina Tradicional
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/química
Antipiréticos/química
Seres Humanos
Fitoterapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics); 0 (Antipyretics); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


  8 / 177 MEDLINE  
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[PMID]:26826388
[Au] Autor:Wu J; Seng S; Carianopol C; Sui J; Yang Q; Zhang F; Jiang H; He J; Yi M
[Ad] Endereço:Beijing Key Laboratory of Development and Quality Control of Ornamental Crops, Department of Ornamental Horticulture and Landscape Architecture, China Agricultural University, Beijing 100193, China.
[Ti] Título:Cloning and characterization of a novel Gladiolus hybridus AFP family gene (GhAFP-like) related to corm dormancy.
[So] Source:Biochem Biophys Res Commun;471(1):198-204, 2016 Feb 26.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Abscisic acid (ABA) is an important phytohormone controlling seed dormancy. AFPs (ABA INSENSITIVE FIVE BINDING PROTEINS) are reported to be negative regulators of the ABA signaling pathway. The involvement of AFPs in dormant vegetative organs remains poorly understood. Here, we isolated and characterized a novel AFP family member from Gladiolus dormant cormels, GhAFP-like, containing three conserved domains of the AFP family. Quantitative PCR analysis revealed that GhAFP-like was expressed in dormant organs and its expression was down-regulated along with corm storage. GhAFP-like was verified to be a nuclear-localized protein. Overexpressing GhAFP-like in Arabidopsis thaliana not only showed weaker seed dormancy with insensitivity to ABA, but also changed the expression of some ABA related genes. In addition, a primary root elongation assay showed GhAFP-like may involve in auxin signaling response. The results in this study indicate that GhAFP-like acts as a negative regulator in ABA signaling and is related to dormancy.
[Mh] Termos MeSH primário: Ácido Abscísico/metabolismo
Proteínas de Arabidopsis/metabolismo
Arabidopsis/fisiologia
Fatores de Transcrição de Zíper de Leucina Básica/metabolismo
Iridaceae/fisiologia
Fosfoproteínas Fosfatases/metabolismo
Dormência de Plantas/fisiologia
[Mh] Termos MeSH secundário: Clonagem Molecular
Germinação/fisiologia
Tubérculos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ABI5 protein, Arabidopsis); 0 (Arabidopsis Proteins); 0 (Basic-Leucine Zipper Transcription Factors); 72S9A8J5GW (Abscisic Acid); EC 3.1.3.- (ABI2 protein, Arabidopsis); EC 3.1.3.16 (Phosphoprotein Phosphatases)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160226
[Lr] Data última revisão:
160226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160131
[St] Status:MEDLINE


  9 / 177 MEDLINE  
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[PMID]:26615479
[Au] Autor:Mani D; Kumar C; Patel NK
[Ad] Endereço:Sheila Dhar Institute of Soil Science, Department of Chemistry, University of Allahabad, Allahabad 211002, India.
[Ti] Título:Integrated micro-biochemical approach for phytoremediation of cadmium and lead contaminated soils using Gladiolus grandiflorus L cut flower.
[So] Source:Ecotoxicol Environ Saf;124:435-446, 2016 Feb.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The potential of vermicompost, elemental sulphur, Thiobacillus thiooxidans and Pseudomonas putida for phytoremediation is well known individually but their integrated approach has not been discovered so far. The present work highlights the consideration of so far overlooked aspects of their integrated treatment by growing the ornamental plant, Gladiolus grandiflorus L in uncontaminated and sewage-contaminated soils (sulphur-deficient alluvial Entisols, pH 7.6-7.8) for phytoremediation of cadmium and lead under pot experiment. Between vermicompost and elemental sulphur, the response of vermicompost was higher towards improvement in the biometric parameters of plants, whereas the response of elemental sulphur was higher towards enhanced bioaccumulation of heavy metals under soils. The integrated treatment (T7: vermicompost 6g and elemental sulphur 0.5gkg(-1) soil and co-inoculation of the plant with T. thiooxidans and P. putida) was found superior in promoting root length, plant height and dry biomass of the plant. The treatment T7 caused enhanced accumulation of Cd up to 6.96 and 6.45mgkg(-1) and Pb up to 22.6 and 19.9mgkg(-1) in corm and shoot, respectively at the contaminated soil. T7 showed maximum remediation efficiency of 0.46% and 0.19% and bioaccumulation factor of 2.92 and 1.21 and uptake of 6.75 and 21.4mgkg(-1) dry biomass for Cd and Pb respectively in the contaminated soil. The integrated treatment T7 was found significant over the individual treatments to promote plant growth and enhance phytoremediation. Hence, authors conclude to integrate vermicompost, elemental sulphur and microbial co-inoculation for the enhanced clean-up of Cd and Pb-contaminated soils.
[Mh] Termos MeSH primário: Acidithiobacillus thiooxidans
Iridaceae/crescimento & desenvolvimento
Pseudomonas putida
Poluentes do Solo/metabolismo
Enxofre/farmacologia
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Biomassa
Cádmio/análise
Cádmio/metabolismo
Flores
Iridaceae/efeitos dos fármacos
Iridaceae/metabolismo
Chumbo/análise
Chumbo/metabolismo
Desenvolvimento Vegetal/efeitos dos fármacos
Solo/química
Poluentes do Solo/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); 2P299V784P (Lead); 70FD1KFU70 (Sulfur)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151130
[St] Status:MEDLINE


  10 / 177 MEDLINE  
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[PMID]:26468762
[Au] Autor:Campos A; Barbosa Vendramini-Costa D; Francisco Fiorito G; Lúcia Tasca Gois Ruiz A; Ernesto de Carvalho J; Maria Rodrigues de Souza G; Delle-Monache F; Cechinel Filho V
[Ad] Endereço:a Programa De Pós-Graduação Em Ciências Farmacêuticas and Núcleo De Investigações Químico-Farmacêuticas (NIQFAR), Universidade Do Vale Do Itajaí - UNIVALI , Itajaí , Santa Catarina , Brazil .
[Ti] Título:Antiproliferative effect of extracts and pyranonaphthoquinones obtained from Cipura paludosa bulbs.
[So] Source:Pharm Biol;54(6):1022-6, 2016.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Cipura paludosa Aubl. (Iridaceae) is widely used in folk medicine to treat several ailments. Experimental studies have confirmed its anti-inflammatory, antinociceptive, and neuroprotective effects. OBJECTIVE: This study evaluates the possible antiproliferative potential of the crude methanol extract and three isolated compounds from the bulbs of C. paludosa. MATERIALS AND METHODS: Phytochemical analysis was carried out by conventional chromatographic techniques, and the resulting compounds were identified by NMR (1)H and (13)C. The antiproliferative activity was analysed using the sulforhodamine B assay. RESULTS: Crude methanol extract of C. paludosa bulbs showed GI50 values of between 1.6 and 30.8 µg/mL. The naphthoquinone derivatives (eleutherine, isoeleutherine, and eleutherol) isolated from the bulbs of C. paludosa exhibited promising cytotoxicity against several human tumour cell lines, especially the two main compounds, eleutherine and isoeleutherine, against glioma and breast cancer cell lines, with TGI values of between 2.6 and 13.8 µg/mL. CONCLUSION: Cipura paludosa bulbs produce active principles with relevant antiproliferative potential, such as naphthoquinone derivatives, identified as eleutherine, isoeleutherine, and eleutherol. This is the first report indicating C. paludosa with antiproliferative potential.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Iridaceae/química
Naftoquinonas/farmacologia
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Furanos/isolamento & purificação
Furanos/farmacologia
Seres Humanos
Concentração Inibidora 50
Medicina Tradicional
Estrutura Molecular
Naftoquinonas/isolamento & purificação
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Furans); 0 (Naphthoquinones); 0 (Plant Extracts); 0 (eleutherin); 0 (isoeleutherin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151016
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1091847



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