Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.100.400.500 [Categoria DeCS]
Referências encontradas : 486 [refinar]
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[PMID]:28460761
[Au] Autor:Samarghandian S; Azimi-Nezhad M; Farkhondeh T
[Ad] Endereço:Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: samarghandians@mums.ac.ir.
[Ti] Título:Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats.
[So] Source:Indian Heart J;69(2):151-159, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Crocus sativus L. (saffron) has many biological effects such as antioxidant property. The present study investigated the immunomodulatory effects of the aqueous saffron extract on streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: In this study, the rats were divided into the following groups of 9 animals each: control, untreated diabetic, three saffron extract-treated diabetic groups. Diabetes was induced by STZ in rats. Saffron was administered 3 days after STZ administration; these injections were continued to the end of the study (4 weeks). At the end of the 4-week period, blood was drawn for biochemical assays and the abdominal aorta was removed for detecting the inflammatory cytokines expression. RESULTS: We found that saffron decreased blood glucose, malondialdehyde, nitric oxide, total lipids, triglycerides, cholesterol levels significantly (p<0.01) and increased glutathione level, catalase, and superoxide dismutase activities in the saffron-treated diabetic groups compared with the untreated groups, in a dose dependent manner (p<0.05, p<0.01, p<0.001). On the other hand, saffron-treated diabetic rats inhibited the expression of inflammatory cytokines in the abdominal aorta versus the untreated diabetic rats. CONCLUSION: Our results validate the use of saffron as a treatment against diabetes mellitus and its vascular complications.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Crocus
Diabetes Mellitus Experimental/tratamento farmacológico
Imunomodulação
Lipídeos/sangue
Oxidantes/sangue
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Espécies Reativas de Oxigênio/sangue
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/imunologia
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Blood Glucose); 0 (Lipids); 0 (Oxidants); 0 (Plant Extracts); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28471166
[Au] Autor:Batarseh YS; Bharate SS; Kumar V; Kumar A; Vishwakarma RA; Bharate SB; Kaddoumi A
[Ad] Endereço:Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe , Monroe, Louisiana 71201, United States.
[Ti] Título:Crocus sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid ß Load and Related Toxicity in 5XFAD Mice.
[So] Source:ACS Chem Neurosci;8(8):1756-1766, 2017 08 16.
[Is] ISSN:1948-7193
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crocus sativus, commonly known as saffron or Kesar, is used in Ayurveda and other folk medicines for various purposes as an aphrodisiac, antispasmodic, and expectorant. Previous evidence suggested that Crocus sativus is linked to improving cognitive function in Alzheimer's disease (AD) patients. The aim of this study was to in vitro and in vivo investigate the mechanism(s) by which Crocus sativus exerts its positive effect against AD. The effect of Crocus sativus extract on Aß load and related toxicity was evaluated. In vitro results showed that Crocus sativus extract increases the tightness of a cell-based blood-brain barrier (BBB) model and enhances transport of Aß. Further in vivo studies confirmed the effect of Crocus sativus extract (50 mg/kg/day, added to mice diet) on the BBB tightness and function that was associated with reduced Aß load and related pathological changes in 5XFAD mice used as an AD model. Reduced Aß load could be explained, at least in part, by Crocus sativus extract effect to enhance Aß clearance pathways including BBB clearance, enzymatic degradation and ApoE clearance pathway. Furthermore, Crocus sativus extract upregulated synaptic proteins and reduced neuroinflammation associated with Aß pathology in the brains of 5XFAD mice. Crocin, a major active constituent of Crocus sativus and known for its antioxidant and anti-inflammatory effect, was also tested separately in vivo in 5XFAD mice. Crocin (10 mg/kg/day) was able to reduce Aß load but to a lesser extent when compared to Crocus sativus extract. Collectively, findings from this study support the positive effect of Crocus sativus against AD by reducing Aß pathological manifestations.
[Mh] Termos MeSH primário: Doença de Alzheimer/tratamento farmacológico
Peptídeos beta-Amiloides/efeitos dos fármacos
Barreira Hematoencefálica/efeitos dos fármacos
Crocus
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Doença de Alzheimer/metabolismo
Doença de Alzheimer/patologia
Peptídeos beta-Amiloides/metabolismo
Peptídeos beta-Amiloides/toxicidade
Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/farmacologia
Barreira Hematoencefálica/metabolismo
Barreira Hematoencefálica/patologia
Linhagem Celular
Crocus/química
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Células Endoteliais/efeitos dos fármacos
Células Endoteliais/metabolismo
Células Endoteliais/patologia
Inflamação/tratamento farmacológico
Inflamação/metabolismo
Inflamação/patologia
Masculino
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Microvasos/efeitos dos fármacos
Microvasos/metabolismo
Microvasos/patologia
Fármacos Neuroprotetores/química
Fitoterapia
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Neuroprotective Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1021/acschemneuro.7b00101


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[PMID]:29217355
[Au] Autor:Wang X; Zhang G; Qiao Y; Feng C; Zhao X
[Ad] Endereço:Department of Anesthesiology, The Second Hospital of Shandong University, 247 Bei Yuan Street, Jinan 250033, China.
[Ti] Título:Crocetin attenuates spared nerve injury-induced neuropathic pain in mice.
[So] Source:J Pharmacol Sci;135(4):141-147, 2017 Dec.
[Is] ISSN:1347-8648
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Crocetin is the main component of saffron and exhibits anti-oxidative and anti-inflammatory effects. Neuroinflammation and oxidative stress have been recognized to play a crucial role in the pathogenesis of neuropathic pain. We investigated the effect of crocetin in a mouse model with neuropathic pain induced by spared nerve injury (SNI). Crocetin was intrathecally perfused at various doses for up to 12 days starting 3 days before the surgery. Behavioral tests were performed to determine pain sensitivity. The concentrations of proinflammatory cytokines tumor necrosis factor (TNF-α) and interleukin-1ß (IL-1ß) were measured to assess neuroinflammation. In addition, the enzymatic activity of superoxide dismutase (SOD) was measured to reveal the oxidative stress level. We found that repeated treatment with crocetin dose-dependently attenuated mechanical and thermal allodynia in SNI mice. In addition, treatment with high dose of crocetin reduced SNI-induced increase of TNF-α and IL-1ß. Crocetin also restored the activity of mitochondrial MnSOD which was reduced in the sciatic nerve and the spinal cord of SNI mice. Collectively, our data demonstrate that crocetin effectively attenuates the neuropathic pain and significantly suppresses oxidative stress and neuroinflammation in the SNI mouse model, supporting the potential of crocetin in the treatment against neuropathic pain.
[Mh] Termos MeSH primário: Carotenoides/administração & dosagem
Carotenoides/farmacologia
Neuralgia/tratamento farmacológico
Neuralgia/etiologia
Traumatismos dos Nervos Periféricos/complicações
Fitoterapia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios
Antioxidantes
Biomarcadores
Carotenoides/isolamento & purificação
Crocus/química
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Mediadores da Inflamação/metabolismo
Interleucina-1beta/metabolismo
Masculino
Camundongos Endogâmicos
Neuralgia/diagnóstico
Neuralgia/metabolismo
Estresse Oxidativo
Nervo Isquiático/metabolismo
Medula Espinal
Superóxido Dismutase
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biomarkers); 0 (Inflammation Mediators); 0 (Interleukin-1beta); 0 (Tumor Necrosis Factor-alpha); 20TC155L9C (crocetin); 36-88-4 (Carotenoids); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:28873641
[Au] Autor:Sereshti H; Poursorkh Z; Aliakbarzadeh G; Zarre S; Ataolahi S
[Ad] Endereço:School of Chemistry, College of Science, University of Tehran, Tehran, Iran. Electronic address: sereshti@ut.ac.ir.
[Ti] Título:An image analysis of TLC patterns for quality control of saffron based on soil salinity effect: A strategy for data (pre)-processing.
[So] Source:Food Chem;239:831-839, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Quality of saffron, a valuable food additive, could considerably affect the consumers' health. In this work, a novel preprocessing strategy for image analysis of saffron thin layer chromatographic (TLC) patterns was introduced. This includes performing a series of image pre-processing techniques on TLC images such as compression, inversion, elimination of general baseline (using asymmetric least squares (AsLS)), removing spots shift and concavity (by correlation optimization warping (COW)), and finally conversion to RGB chromatograms. Subsequently, an unsupervised multivariate data analysis including principal component analysis (PCA) and k-means clustering was utilized to investigate the soil salinity effect, as a cultivation parameter, on saffron TLC patterns. This method was used as a rapid and simple technique to obtain the chemical fingerprints of saffron TLC images. Finally, the separated TLC spots were chemically identified using high-performance liquid chromatography-diode array detection (HPLC-DAD). Accordingly, the saffron quality from different areas of Iran was evaluated and classified.
[Mh] Termos MeSH primário: Crocus
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Irã (Geográfico)
Controle de Qualidade
Salinidade
Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28964663
[Au] Autor:Efentakis P; Rizakou A; Christodoulou E; Chatzianastasiou A; López MG; León R; Balafas E; Kadoglou NPE; Tseti I; Skaltsa H; Kostomitsopoulos N; Iliodromitis EK; Valsami G; Andreadou I
[Ad] Endereço:National and Kapodistrian University of Athens, Laboratory of Pharmacology, Faculty of Pharmacy, Athens, Greece.
[Ti] Título:Saffron (Crocus sativus) intake provides nutritional preconditioning against myocardial ischemia-reperfusion injury in Wild Type and ApoE mice: Involvement of Nrf2 activation.
[So] Source:Nutr Metab Cardiovasc Dis;27(10):919-929, 2017 Oct.
[Is] ISSN:1590-3729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Saffron is an antioxidant herbal derivative; however, its efficacy as a nutritional cardioprotective agent has not been fully elucidated. We investigated the cardioprotective properties of a standardized saffron aqueous extract (SFE) against ischemia/reperfusion (I/R) injury in Wild-Type (WT) and ApoE mice and the underlying molecular mechanisms. METHODS AND RESULTS: WT and ApoE mice were subjected to 30 min I and 2 h R, with the following per os interventions for 4 weeks: 1) WT Control Group, receiving Water for Injection (WFI); 2) WT Crocus Group, receiving SFE at a dose of 60 mg/kg/day; 3) WT Crocus + Wort group, receiving SFE as described above and wortmannin at a dose of 60 µg/kg bolus 15 min before R; 4) ApoE Control Group, receiving WFI; 5) ApoE Crocus Group, receiving SFE at a dose of 60 mg/kg/day and 6) ApoE Crocus + Wort: receiving SFE as described above and wortmannin at a dose of 60 µg/kg bolus, 15 min before R. Ischemic area/area at risk (I/R%) ratio was measured. Blood samples and ischemic myocardial tissue were collected at the 10th min of reperfusion for assessment of troponin I, malondialdehyde (MDA), nitrotyrosine (NT), p-eNOS, eNOS, p-Akt, Akt, p-p42/p-p44, p-GSK3ß, GSK3ß, IL-6, Nrf2, HO-1 and MnSOD expression. The effect of SFE on Nrf2 expression was also evaluated in vitro. SFE reduced infarct size in WT (16.15 ± 3.7% vs 41.57 ± 2.48%, ***p < 0.001) and in ApoE mice (16.14 ± 1.47% vs 45.57 ± 1.73%, ***p < 0.001). The administration of wortmannin resulted in partial inhibition of the infarct size limitation efficacy of SFE (in both WT and Apo-E mice). Mice receiving SFE showed increased levels of eNOS, p-Akt, p-ERK1/2, p-44/p-42 and p-GSK3ß-Ser9 and reduced expression of IL-6 and iNOS; furthermore, SFE reduced the levels of MDA and NT. SFE induced Nrf2 expression and its downstream targets, HO-1 and MnSOD in the myocardium of the treated animals, and induced Nrf2 expression in vitro in a dose-dependent manner. CONCLUSIONS: SFE limits myocardial infarction in Wild-Type and ApoE mice in a multifaceted manner including activation of Akt/eNOS/ERK1/2/GSK3-ß and through Nrf2 pathway, bestowing antioxidant protection against I/R.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Crocus
Infarto do Miocárdio/prevenção & controle
Traumatismo por Reperfusão Miocárdica/prevenção & controle
Miócitos Cardíacos/efeitos dos fármacos
Fator 2 Relacionado a NF-E2/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Apolipoproteínas E/deficiência
Apolipoproteínas E/genética
Biomarcadores/metabolismo
Linhagem Celular
Crocus/química
Citocinas/metabolismo
Citoproteção
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Flores
Predisposição Genética para Doença
Mediadores da Inflamação/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Infarto do Miocárdio/genética
Infarto do Miocárdio/metabolismo
Infarto do Miocárdio/patologia
Traumatismo por Reperfusão Miocárdica/genética
Traumatismo por Reperfusão Miocárdica/metabolismo
Traumatismo por Reperfusão Miocárdica/patologia
Miócitos Cardíacos/metabolismo
Miócitos Cardíacos/patologia
Estresse Oxidativo/efeitos dos fármacos
Fenótipo
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Apolipoproteins E); 0 (Biomarkers); 0 (Cytokines); 0 (Inflammation Mediators); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE


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[PMID]:28735826
[Au] Autor:Kell G; Rao A; Beccaria G; Clayton P; Inarejos-García AM; Prodanov M
[Ad] Endereço:University of Southern Queensland, School of Psychology and Counselling, Toowoomba, Australia.
[Ti] Título:affron a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial.
[So] Source:Complement Ther Med;33:58-64, 2017 Aug.
[Is] ISSN:1873-6963
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In recent years phytotherapy has been explored as a source for alternative treatments for mood disorders. One potential candidate is saffron (Crocus sativus L.), whose main bioactive components are crocins and safranal. OBJECTIVES: The aim of this study was to investigate the efficacy of affron , a standardised stigmas extract from Crocus sativus L. for improving mood, stress, anxiety and sleep quality in healthy adults. METHODS: In this 3 arm study, 128 participants self-reporting low mood but not diagnosed with depression, were given affron at 28mg/day, 22mg/day, or a placebo treatment in a randomized, double-blind, placebo-controlled trial for 4 weeks. Mood was measured at baseline and at the end of the study, using the POMS (primary outcome measure) and PANAS questionnaires, and the DASS-21 scale. Sleep was monitored using Sleep Quality Index (PSQI). RESULTS: Analysis indicated a significant decrease in negative mood and symptoms related to stress and anxiety at a 28mg/day dose (with a significant difference between 28mg/day and placebo on the POMS Total Mood Disturbance scale, p<0.001, d=-1.10), but no treatment effect at the 22mg/day dose. LIMITATIONS: The main weaknesses of this investigation were found in the self-reporting nature of both the screening and the testing. CONCLUSIONS: affron increased mood, reduced anxiety and managed stress without side effects, offering a natural alternative to standard treatments.
[Mh] Termos MeSH primário: Afeto/efeitos dos fármacos
Ansiedade/tratamento farmacológico
Crocus/química
Depressão/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Estresse Psicológico/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Carotenoides/farmacologia
Carotenoides/uso terapêutico
Cicloexenos/farmacologia
Cicloexenos/uso terapêutico
Transtorno Depressivo/tratamento farmacológico
Método Duplo-Cego
Feminino
Flores/química
Seres Humanos
Masculino
Meia-Idade
Extratos Vegetais/farmacologia
Autorrelato
Terpenos/farmacologia
Terpenos/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Plant Extracts); 0 (Terpenes); 36-88-4 (Carotenoids); 4393FR07EA (safranal); 877GWI46C2 (crocin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE


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[PMID]:28643510
[Au] Autor:Granchi C; Fortunato S; Meini S; Rizzolio F; Caligiuri I; Tuccinardi T; Lee HY; Hergenrother PJ; Minutolo F
[Ad] Endereço:Dipartimento di Farmacia, Università di Pisa , Via Bonanno 6 and 33, 56126 Pisa, Italy.
[Ti] Título:Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer.
[So] Source:J Agric Food Chem;65(28):5639-5649, 2017 Jul 19.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC = 54.9 ± 4.7 µM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition properties manifested via its antiproliferative activity against two glycolytic cancer cell lines (A549 and HeLa, IC = 114.0 ± 8.0 and 113.0 ± 11.1 µM, respectively). The results described in this article suggest that saffron may be a helpful alimentary component in the prevention of cancer that potentially contributes to the efficacy of approved cancer therapies.
[Mh] Termos MeSH primário: Carotenoides/química
Crocus/química
Inibidores Enzimáticos/química
L-Lactato Desidrogenase/antagonistas & inibidores
Neoplasias/enzimologia
[Mh] Termos MeSH secundário: Carotenoides/farmacologia
Linhagem Celular
Inibidores Enzimáticos/farmacologia
Flores/química
Glicólise
Seres Humanos
Isoenzimas/antagonistas & inibidores
Isoenzimas/genética
Isoenzimas/metabolismo
L-Lactato Desidrogenase/genética
L-Lactato Desidrogenase/metabolismo
Ácido Láctico/metabolismo
Simulação de Acoplamento Molecular
Estrutura Molecular
Neoplasias/tratamento farmacológico
Neoplasias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Isoenzymes); 20TC155L9C (crocetin); 33X04XA5AT (Lactic Acid); 36-88-4 (Carotenoids); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 1.1.1.27.- (lactate dehydrogenase 5)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01668


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[PMID]:28554638
[Au] Autor:Amini M; Ghoranneviss M; Abdijadid S
[Ad] Endereço:Plasma Physics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: Maryam.amini63@yahoo.com.
[Ti] Título:Effect of cold plasma on crocin esters and volatile compounds of saffron.
[So] Source:Food Chem;235:290-293, 2017 Nov 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effect of cold plasma on crocin esters and volatile oils of saffron was studied for the first time. After the treatments, (Ar, Ar/5% O and Ar/10% O at 8 and 12kV of voltage), a decrease in crocin esters and saffranal and an increase in isophorone and 4-ketoisophorone was observed. After 4min, the saffron samples treated with Ar/20% O had blackened and the treatment was discontinued. The results show that increasing the input voltage and increasing the amount of added oxygen to Argon gas increased the changes in the safranal and crocin esters. There was no trans-2G, cis-4GG or cis-3Gg compounds observed after the Ar/10% O cold plasma treatment at 12kV.
[Mh] Termos MeSH primário: Crocus/química
Gases em Plasma/química
[Mh] Termos MeSH secundário: Carotenoides
Ésteres/química
Extratos Vegetais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Esters); 0 (Plant Extracts); 0 (Plasma Gases); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28372231
[Au] Autor:Villa C; Costa J; Oliveira MB; Mafra I
[Ad] Endereço:REQUIMTE-LAQV, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
[Ti] Título:Novel quantitative real-time PCR approach to determine safflower (Carthamus tinctorius) adulteration in saffron (Crocus sativus).
[So] Source:Food Chem;229:680-687, 2017 Aug 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work intended to develop DNA-based methods to detect and quantify safflower as an adulterant in saffron. Species-specific PCR and real-time PCR with EvaGreen dye targeting the ITS region of Carthamus tinctorius L. (safflower) were successfully proposed. The assays allowed absolute and relative sensitivities of 2pg of safflower DNA (∼1.4 DNA copies) and 0.1% of safflower in saffron (Crocus sativus L.), respectively. A normalised real-time PCR approach was also proposed in the range of 0.1-20% (w/w) of safflower in saffron, which was successfully validated and applied to commercial saffron samples (stigmas, powders and seasonings). From 19 samples, three were positive to safflower, though at levels below the limit of detection, suggesting cross-contamination rather than adulteration. In this work, specific, sensitive and accurate tools were proposed to authenticate saffron. To the best of our knowledge, this is the first successful attempt to quantify safflower by a DNA-based approach.
[Mh] Termos MeSH primário: Carthamus tinctorius/química
Crocus/química
Contaminação de Alimentos/análise
Reação em Cadeia da Polimerase em Tempo Real/métodos
[Mh] Termos MeSH secundário: Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:28317741
[Au] Autor:Guijarro-Díez M; Castro-Puyana M; Crego AL; Marina ML
[Ad] Endereço:Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Ctra. Madrid-Barcelona, Km. 33.600, 28871 Alcalá de Henares, Madrid, Spain.
[Ti] Título:A novel method for the quality control of saffron through the simultaneous analysis of authenticity and adulteration markers by liquid chromatography-(quadrupole-time of flight)-mass spectrometry.
[So] Source:Food Chem;228:403-410, 2017 Aug 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A liquid chromatography-(quadrupole-time of flight)-mass spectrometry methodology was developed to assess the authenticity of saffron through the analysis of a group of kaempferol derivatives recently proposed as novel authenticity markers as a result of a metabolomic study of saffron (kaempferol 3-O-glucoside, kaempferol 3-O-sophoroside, kaempferol 3,7-O-diglucoside, kaempferol 3,7,4'-O-triglucoside, kaempferol 3-O-sophoroside-7-O-glucoside). Geniposide was also studied as an adulteration marker of saffron with gardenia. The optimized chromatographic conditions enabling the simultaneous separation of glycosylated kaempferols and geniposide consisted of the use of a C18 column and an elution gradient with acetonitrile and water as mobile phases (both with formic acid at 0.1%). A strategy was proposed to evaluate the minimum quantifiable adulteration percentage which was established at a 0.2% regardless of the adulterant employed. The analysis of nineteen commercial samples showed the method to be specific and suitable for saffron quality control.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Crocus/química
Espectrometria de Massas/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/métodos
Controle de Qualidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE



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