Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.875 [Categoria DeCS]
Referências encontradas : 4 [refinar]
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[Au] Autor:Thomas I; Gregg B
[Ad] Endereço:Division of Pediatric Endocrinology, Diabetes and Metabolism, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan.
[Ti] Título:Metformin; a review of its history and future: from lilac to longevity.
[So] Source:Pediatr Diabetes;18(1):10-16, 2017 Feb.
[Is] ISSN:1399-5448
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Metformin is a widely prescribed medication that has been used to treat children with type 2 diabetes in the United States for the past 15 years. Metformin now has a variety of clinical applications in pediatrics, and its potential clinical uses continue to expand. In addition to reviewing the current understanding of its mechanisms of action including the newly discovered effects on the gastrointestinal tract, we will also discuss current clinical uses in pediatrics, including in type 1 diabetes. Finally, we examine the existing state of monitoring for metformin efficacy and side effects and discuss prospective future clinical uses.
[Mh] Termos MeSH primário: Liliales/química
[Mh] Termos MeSH secundário: Criança
Diabetes Mellitus Tipo 1/tratamento farmacológico
Diabetes Mellitus Tipo 2/tratamento farmacológico
História do Século XVII
História do Século XVIII
História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
Hipoglicemiantes/uso terapêutico
Longevidade/efeitos dos fármacos
Metformina/isolamento & purificação
Metformina/uso terapêutico
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 9100L32L2N (Metformin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.1111/pedi.12473

  2 / 4 MEDLINE  
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[Au] Autor:Man S; Li J; Qiu P; Liu J; Liu Z; Ma L; Gao W
[Ad] Endereço:Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering, Lab of Metabolic Control Fermentation Technology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
[Ti] Título:Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins.
[So] Source:Mol Carcinog;56(5):1405-1413, 2017 May.
[Is] ISSN:1098-2744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lung cancer is the foremost cause of cancer mortality and a growing economic burden worldwide. Rhizoma paridis saponins (RPS) have been reported to exhibit potential anti-tumor effects on many kinds of tumor models. The present study was designed to investigate the mechanism-based chemopreventive nature of RPS against DEN-induced lung carcinogenesis in Kunming mice. As a result, the treatment with RPS reduced the severity of pulmonary histopathology. The mechanism of its antitumor effect involved in (a) reducing oxidative stress injury through up-regulating activities of CAT and SOD; (b) down-regulating the levels of inflammatory factors, like TNF-α, IL6, COX-2, and PGE2; (c) activation of caspase-3 and up-regulating the pro-apoptotic protein Bax; (d) decreasing the expression of PCNA; (e) depressing the expression of cancer stem cells marker CD133; (f) suppressing aberrant expression of cytokeratin 8 and 18; and (g) inhibiting EGFR/ PI3 K/Akt, EGFR/Ras/Erk and NF-κB pathways. Taken together, RPS would be a potent agent inhibiting lung tumor in the future.
[Mh] Termos MeSH primário: Liliales/química
Neoplasias Pulmonares/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Neoplasias Pulmonares/induzido quimicamente
Neoplasias Pulmonares/patologia
Neoplasias Experimentais/tratamento farmacológico
Células-Tronco Neoplásicas/efeitos dos fármacos
Células-Tronco Neoplásicas/patologia
Estresse Oxidativo/efeitos dos fármacos
Receptor do Fator de Crescimento Epidérmico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Saponins); 3IQ78TTX1A (Diethylnitrosamine); EC (EGFR protein, mouse); EC (Receptor, Epidermal Growth Factor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1002/mc.22601

  3 / 4 MEDLINE  
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[Au] Autor:Yang YG; Zhang J; Zhao YL; Zhang JY; Wang YZ
[Ad] Endereço:College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, China.
[Ti] Título:Quantitative determination and evaluation of Paris polyphylla var. yunnanensis with different harvesting times using UPLC-UV-MS and FT-IR spectroscopy in combination with partial least squares discriminant analysis.
[So] Source:Biomed Chromatogr;31(7), 2017 Jul.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A rapid method was developed and validated by ultra-performance liquid chromatography-triple quadrupole mass spectroscopy with ultraviolet detection (UPLC-UV-MS) for simultaneous determination of paris saponin I, paris saponin II, paris saponin VI and paris saponin VII. Partial least squares discriminant analysis (PLS-DA) based on UPLC and Fourier transform infrared (FT-IR) spectroscopy was employed to evaluate Paris polyphylla var. yunnanensis (PPY) at different harvesting times. Quantitative determination implied that the various contents of bioactive compounds with different harvesting times may lead to different pharmacological effects; the average content of total saponins for PPY harvested at 8 years was higher than that from other samples. The PLS-DA of FT-IR spectra had a better performance than that of UPLC for discrimination of PPY from different harvesting times.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Espectrometria de Massas/métodos
Espectrofotometria Ultravioleta/métodos
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
[Mh] Termos MeSH secundário: Análise dos Mínimos Quadrados
Padrões de Referência
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170704
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3913

  4 / 4 MEDLINE  
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[Au] Autor:Man S; Li J; Liu J; Chai H; Liu Z; Wang J; Gao W
[Ad] Endereço:Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
[Ti] Título:Curcumin alleviated the toxic reaction of Rhizoma Paridis saponins in a 45-day subchronic toxicological assessment of rats.
[So] Source:Environ Toxicol;31(12):1935-1943, 2016 Dec.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhizoma Paridis saponins (RPS), as steroid saponins, are the main components in Paris polyphylla. Curcumin (diferuloylmethane) is the most important component in the spice turmeric. In our previous research, RPS exhibited side effects such as nausea, vomiting, diarrhea, and so forth. Combination with curcumin not only alleviated the toxicity and gastric stimulus induced by RPS, but also improved the quality life of mice bearing tumor cells and enhanced their anticancer effect. This study evaluated subchronic toxicity of 45 dietary of RPS and curcumin on histopathology, biochemistry, and antioxidant index. As a result, RPS-treatment caused a slight liver injury (the elevation of serum AST, alkaline phosphatase (AKP), alanine transaminase (ALT), and gamma glutamyl transpeptidase (γ-GT), histopathological changes in liver section), oxidative stress (the enhancement of reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxy-2-deoxyguanosine (8-OHdG), separation of thioredoxin (Trx) and thioredoxin-interacting protein (TXNIP), but enhancement of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and nuclear factor-regulated factor 2 (Nrf2)), and inflammation (up-regulation of cyclooxygenase-2 (COX-2), interleukin-1ß (IL-1ß), and nuclear factor kappaB (NF-κB)). However, these changes were alleviated through co-treatment with curcumin. In conclusion, our work provided useful data for further research and new drug exploration of RPS and curcumin. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1935-1943, 2016.
[Mh] Termos MeSH primário: Curcumina/farmacologia
[Mh] Termos MeSH secundário: Alanina Transaminase/metabolismo
Ciclo-Oxigenase 2/metabolismo
Glutationa Transferase/metabolismo
Heme Oxigenase-1/metabolismo
Fígado/efeitos dos fármacos
NF-kappa B/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
Testes de Toxicidade Subcrônica
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (NF-kappa B); 0 (Reactive Oxygen Species); 0 (Saponins); 4Y8F71G49Q (Malondialdehyde); EC (Heme Oxygenase-1); EC (Cyclooxygenase 2); EC (Glutathione Transferase); EC (Alanine Transaminase); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150923
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22194

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