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Pesquisa : B01.650.940.800.575.912.250.618.875.500 [Categoria DeCS]
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[PMID]:29300767
[Au] Autor:Chung MY; Vu SH; López-Pujol J; Herrando-Moraira S; Son S; Suh GU; Le HTQ; Chung MG
[Ad] Endereço:Department of Biology and the Research Institute of Natural Science, Gyeongsang National University, Jinju, Republic of Korea.
[Ti] Título:Comparison of genetic variation between northern and southern populations of Lilium cernuum (Liliaceae): Implications for Pleistocene refugia.
[So] Source:PLoS One;13(1):e0190520, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The so-called "Baekdudaegan" (BDDG), a mountain range that stretches along the Korean Peninsula, has been recently proposed as a major "southern" glacial refugium for boreal or temperate plant species based on palaeoecological and, especially, genetic data. Genetic studies comparing genetic variation between population occurring on the BDDG and more northern ones (i.e. in NE China and/or in Russian Far East) are, however, still too few to draw firm conclusions on the role of the BDDG as a refugium and a source for possible northward post-glacial recolonizations. In order to fill this gap, we selected a boreal/temperate herb, Lilium cernuum, and compared levels of allozyme-based genetic diversity of five populations from NE China with five populations from South Korea (home of its hypothesized refuge areas). As a complementary tool, we used the maximum entropy algorithm implemented in MaxEnt to infer the species' potential distribution for the present time, which was projected to different past climate scenarios for the Last Glacial Maximum (LGM). Permutation tests revealed that Korean populations harbored significantly higher levels of within-population genetic variation than those from NE China (expected heterozygosity = 0.173 vs. 0.095, respectively). Our results suggest that the lowered levels of genetic diversity in NE Chinese populations might be due to founder effects associated with post-glacial migration from southern regions. Congruent with genetic data, past distribution models showed higher probability of occurrence in southern ranges than in northern ones during the LGM. In addition, a positive correlation was detected between the expected heterozygosity and environmental LGM suitability. From a conservation perspective, our results further suggest that the southern populations in South Korea may be particularly worthy of protection.
[Mh] Termos MeSH primário: Variação Genética
Liliaceae/genética
[Mh] Termos MeSH secundário: Algoritmos
Ásia
Fósseis
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190520


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[PMID]:27770616
[Au] Autor:Xiang L; Wang Y; Yi X; He X
[Ad] Endereço:School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
[Ti] Título:Antiproliferative and anti-inflammatory furostanol saponins from the rhizomes of Tupistra chinensis.
[So] Source:Steroids;116:28-37, 2016 12.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigations of the rhizome of Tupistra chinensis led to the isolation of ten new furostanol saponins along with fourteen known spirostanols. Their chemical structures were elucidated on the basis of spectroscopic and chemical methods, including IR, NMR, MS, and GC analyses. The antiproliferative effects against FaDu and Detroit 562 cell lines and inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in a macrophage cell line RAW 264.7 were assayed for all the isolated compounds. Compound 14 exhibited significant antiproliferative effects against FaDu and Detroit 562 cells with IC values of 1.1±0.1 and 1.2±0.1µM, respectively. Compounds 1, 2, 6, 13, 16, 19 and 24 exhibited inhibitory effects on NO production with IC values ranging from 15.7 to 46.2µM.
[Mh] Termos MeSH primário: Liliaceae/química
Rizoma/química
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios
Linhagem Celular
Seres Humanos
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Óxido Nítrico/metabolismo
Células RAW 264.7
Saponinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (Saponins); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:25839116
[Au] Autor:Karadeniz A; Alexie G; Greten HJ; Andersch K; Efferth T
[Ad] Endereço:Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany; Mehmet Akif Ersoy University, Biology Department, Burdur, Turkey.
[Ti] Título:Cytotoxicity of medicinal plants of the West-Canadian Gwich׳in Native Americans towards sensitive and multidrug-resistant cancer cells.
[So] Source:J Ethnopharmacol;168:191-200, 2015 Jun 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Traditional medicine of the Native Americans has a long tradition of medicinal plants, which also influenced modern oncology. For instance, podophyllotoxin the active ingredient of Podophyllum peltatum L. (Berberidaceae) used by Native Americans to treat warts led to the development of etoposide and teniposide. In the present investigation, we studied 10 medicinal plants used by the Gwich׳in First Nation of West-Canada, which have been used against diverse diseases including cancer. MATERIAL AND METHODS: Sensitive and multidrug-resistant (MDR) tumor cell lines expressing various ATP-binding cassette (ABC) transporters (P-glycoprotein/ABCB1/MDR1, MRP1/ABCC1, or BCRP/ABCG2) have been used. Cytotoxicity was determined by the resazurin assay. RESULTS: Arctium minus Bernh. (Asteraceae). Lysichiton americanus Hultén & St. John (Araceae), and Maianthemum dilatatum (Alph.Wood) A.Nelson & J.F.Macbr.(Asparagaceae) were cytotoxic with IC50 values ranging from 2.40 to 86.35 µg/mL. The MDR cell lines did not exert cross-resistance to these extracts. CONCLUSION: As these medicinal plants of the West-Canadian Gwich׳in First Nation were not involved in classical drug resistance mechanisms and might therefore be valuable to bypass anticancer drug resistance in refractory tumors.
[Mh] Termos MeSH primário: Transportadores de Cassetes de Ligação de ATP/genética
Antineoplásicos/farmacologia
Araceae
Arctium
Liliaceae
Extratos Vegetais/farmacologia
Plantas Medicinais
[Mh] Termos MeSH secundário: Canadá
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Resistência a Múltiplos Medicamentos/efeitos dos fármacos
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Seres Humanos
Índios Norte-Americanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP-Binding Cassette Transporters); 0 (Antineoplastic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150404
[St] Status:MEDLINE


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[PMID]:28898076
[Au] Autor:Zhan G; Zhou J; Liu J; Huang J; Zhang H; Liu R; Yao G
[Ad] Endereço:Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.
[Ti] Título:Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata.
[So] Source:J Nat Prod;80(9):2462-2471, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eleven new alkaloids (1-11), classified as the 12-acetylplicamine (1), N-deformyl-seco-plicamine (2), plicamine (3-6), 4a-epi-plicamine (7), seco-plicamine (8), and lycorine (9-11) framework types, along with 15 known alkaloids (12-26) were isolated from the whole plants of Zephyranthes carinata. The structures of the new alkaloids 1-11 were established by extensive spectroscopic data interpretation. The absolute configurations of 9 and 10 were defined by single-crystal X-ray diffraction analysis. Zephycarinatines A (1), B (2), and G (7) represent the first examples of 12-acetylplicamine, N-deformyl-seco-plicamine, and 4a-epi-plicamine alkaloids, respectively. Alkaloids 6, 11, 17, and 20-23 exhibited AChE inhibitory activities with IC values ranging from 1.21 to 184.05 µM, and a preliminary structure-activity relationship is discussed.
[Mh] Termos MeSH primário: Acetilcolinesterase/isolamento & purificação
Acetilcolinesterase/metabolismo
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Alcaloides de Amaryllidaceae/isolamento & purificação
Alcaloides de Amaryllidaceae/farmacologia
Amaryllidaceae/química
Inibidores da Colinesterase/isolamento & purificação
Inibidores da Colinesterase/farmacologia
Compostos Heterocíclicos de 4 ou mais Anéis/isolamento & purificação
Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia
Liliaceae/química
Fenantridinas/isolamento & purificação
Fenantridinas/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/química
Alcaloides/química
Alcaloides de Amaryllidaceae/química
Inibidores da Colinesterase/química
Compostos Heterocíclicos de 4 ou mais Anéis/química
Concentração Inibidora 50
Estrutura Molecular
Fenantridinas/química
Relação Estrutura-Atividade
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Amaryllidaceae Alkaloids); 0 (Cholinesterase Inhibitors); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Phenanthridines); 0 (Zephycarinatine G); 0 (plicamine); 0 (zephycarinatine A); 0 (zephycarinatine B); EC 3.1.1.7 (Acetylcholinesterase); I9Q105R5BU (lycorine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00301


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[PMID]:28675019
[Au] Autor:Qiumin H; Biao X; Weihong W; Chongyun B; Shaowei H
[Ad] Endereço:Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Kunming Medical University, Kunming 650106, China.
[Ti] Título:[Inhibitory effect and underlying mechanism of total saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic carcinoma ACC-83 cells].
[So] Source:Hua Xi Kou Qiang Yi Xue Za Zhi;35(3):317-321, 2017 Jun 01.
[Is] ISSN:1000-1182
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the inhibitory effect and underlying mechanism of total saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic carcinoma ACC-83 cells. METHODS: In vitro cell culture was performed. The proliferation of ACC-83 cells treated with different concentrations (5, 10, 20, 40, 60, 80, 100 µg·mL⁻¹) of total saponins from Paris polyphylla var. yunnanensis was observed using CCK-8 assay. Meanwhile, the apoptosis of ACC-83 cells treated with different concentrations (25, 50, 100 µg·mL⁻¹) of the total saponins was observed using flow cytometry. The expression levels of macrophage migration inhibitory factor (MIF) and CD74 were measured using Western blot and reverse transcription-polymerase chain reaction. RESULTS: The total saponins from Paris polyphylla var. yunnanensis induced apoptosis and expressed dose-effect relationship. ACC-83 cells expressed MIF and CD74, and the total saponins suppressed MIF and CD74 expression in ACC-83 cells. CONCLUSIONS: The total saponins from Paris polyphylla var. yunnanensis can significantly inhibit the proliferation, suppress MIF and CD74 expression, and promote apoptosis in ACC-83 cells. This study provides a theoretical basis for the treatment of salivary adenoid cystic carcinoma using Paris polyphylla var. yunnanensis.
.
[Mh] Termos MeSH primário: Carcinoma Adenoide Cístico/tratamento farmacológico
Neoplasias das Glândulas Salivares/tratamento farmacológico
Saponinas/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Oxirredutases Intramoleculares
Liliaceae
Fatores Inibidores da Migração de Macrófagos
Rizoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Macrophage Migration-Inhibitory Factors); 0 (Saponins); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.2.1 (MIF protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.7518/hxkq.2017.03.016


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[PMID]:28590122
[Au] Autor:Wood JM; Furkert DP; Brimble MA
[Ad] Endereço:School of Chemical Sciences, The University of Auckland , 23 Symonds Street, Auckland 1142, New Zealand.
[Ti] Título:Total Synthesis and Stereochemical Revision of the 2-Formylpyrrole Alkaloid Hemerocallisamine I.
[So] Source:J Nat Prod;80(6):1926-1929, 2017 Jun 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first total synthesis of the 2-formylpyrrole alkaloid hemerocallisamine I is reported. The convergent synthesis features a key Maillard-type condensation of a complex amine derived from cis-4-hydroxy-l-proline with a dihydropyranone, to directly furnish the 2-formylpyrrole ring system. The absolute configuration of hemerocallisamine I has been revised on the basis of optical rotation data obtained for the synthesized compound.
[Mh] Termos MeSH primário: Alcaloides/química
Alcaloides/síntese química
Pirróis/química
Pirróis/síntese química
[Mh] Termos MeSH secundário: Liliaceae/química
Estrutura Molecular
Prolina/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Pyrroles); 0 (hemerocallisamine I); 9DLQ4CIU6V (Proline)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00314


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[PMID]:28535126
[Au] Autor:Zawahir S; Gawarammana I; Dargan PI; Abdulghni M; Dawson AH
[Ad] Endereço:a Faculty of Medicine , University of Ruhuna , Galle , Sri Lanka.
[Ti] Título:Activated charcoal significantly reduces the amount of colchicine released from Gloriosa superba in simulated gastric and intestinal media.
[So] Source:Clin Toxicol (Phila);55(8):914-918, 2017 Sep.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Poisoning with Gloriosa superba, a plant containing colchicine, is common in Sri Lanka. OBJECTIVES: This study was to estimate release of colchicine from 5 g of different parts of Gloriosa superba in simulated gastric and intestinal media, and examine the binding efficacy of activated charcoal (AC) to colchicine within this model. METHODS: A USP dissolution apparatus-II was used to prepare samples for analysis of colchicine using HPLC. RESULTS: Cumulative colchicine release from tuber in gastric media at 120 minutes was significantly higher (2883 µg/g) than in intestinal media (1015 µg/g) (p < .001). Mean ± SD cumulative colchicine concentration over 2 hours from tuber, leaves and trunk in gastric medium was 2883.15 ± 1295.63, 578.25 ± 366.26 and 345.60 ± 200.08 µg/g respectively and the release in intestinal media was 1014.75 ± 268.16, 347.40 ± 262.61 and 251.55 ± 285.72 µg/g respectively. Introduction of 50 g of AC into both media made colchicine undetectable (<0.1 µg/ml). CONCLUSIONS: The tuber released the highest quantity of colchicine. The colchicine release and elapse time to achieve saturated, equilibrium dissolution mainly depends on physicochemical properties of plant part. Significant in vitro binding of colchicine to AC suggests that AC has a role in decontamination of patients presenting to hospital after ingestion of Gloriosa superba.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Carvão Vegetal/farmacologia
Colchicina/envenenamento
Suco Gástrico/química
Secreções Intestinais/química
Liliaceae/envenenamento
Intoxicação por Plantas/tratamento farmacológico
[Mh] Termos MeSH secundário: Colchicina/química
Liberação Controlada de Fármacos
Concentração de Íons de Hidrogênio
Cinética
Liliaceae/química
Folhas de Planta/química
Folhas de Planta/envenenamento
Intoxicação por Plantas/etiologia
Caules de Planta/química
Caules de Planta/envenenamento
Tubérculos/química
Tubérculos/envenenamento
Solubilidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 16291-96-6 (Charcoal); SML2Y3J35T (Colchicine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1325897


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[PMID]:28534056
[Au] Autor:Chen SM; Ren L; Zhang D; Zhang YF; Shen XH
[Ad] Endereço:Key Laboratory of Urban Agriculture (South) Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:Carbon nanomaterials enhance survival of Agapanthus praecox callus after cryopreservation by vitrification.
[So] Source:Cryo Letters;38(2):125-136, 2017 Mar/Apr.
[Is] ISSN:0143-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Adding exogenous compounds is an effective way to improve cell survival after cryopreservation. Carbon nanomaterials (CNMs) are novel exogenous substances with small particle size and good biocompatibility. OBJECTIVE: In this work, four types of CNMs were used for the cryopreservation of Agapanthus praecox callus and their possible effects and mechanism of action were analyzed. MATERIALS AND METHODS: The thermal properties of the vitrification solutions tested were detected by differential scanning calorimetry. Raman spectroscopy and transmission electron microscopy analyses were used to study the distribution of CNMs inside cells. The MDA/H2O2 contents were measured to evaluate the toxicity of CNMs to cells. RESULTS AND CONCLUSION: Supplementation of PVS2 with various CNMs at different concentrations could enhance survival. The most effective concentration was 0.3 g/L C60, which increased survival by 159% compared to untreated controls and decreased the MDA and H2O2 contents. Single-walled carbon nanotubes (SWCNTs) and C60 entered callus cells. C60 was found only in mitochondria, whereas SWCNTs were located only around the cell walls.
[Mh] Termos MeSH primário: Carbono/química
Criopreservação
Liliaceae
Nanoestruturas/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria/métodos
Sobrevivência Celular/efeitos dos fármacos
Criopreservação/instrumentação
Criopreservação/métodos
Crioprotetores/química
Peróxido de Hidrogênio/toxicidade
Liliaceae/efeitos dos fármacos
Liliaceae/fisiologia
Teste de Materiais
Microscopia Eletrônica de Transmissão/métodos
Tamanho da Partícula
Vitrificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cryoprotective Agents); 7440-44-0 (Carbon); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28267659
[Au] Autor:Yang G; Zhao X; Wen J; Zhou T; Fan G
[Ad] Endereço:Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, PR China; Shanghai Key Laboratory for Pharmaceutical Metabolite Research, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, P
[Ti] Título:Simultaneous fingerprint, quantitative analysis and anti-oxidative based screening of components in Rhizoma Smilacis Glabrae using liquid chromatography coupled with Charged Aerosol and Coulometric array Detection.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1049-1050:41-50, 2017 Apr 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An analytical approach including fingerprint, quantitative analysis and rapid screening of anti-oxidative components was established and successfully applied for the comprehensive quality control of Rhizoma Smilacis Glabrae (RSG), a well-known Traditional Chinese Medicine with the homology of medicine and food. Thirteen components were tentatively identified based on their retention behavior, UV absorption and MS fragmentation patterns. Chemometric analysis based on coulmetric array data was performed to evaluate the similarity and variation between fifteen batches. Eight discriminating components were quantified using single-compound calibration. The unit responses of those components in coulmetric array detection were calculated and compared with those of several compounds reported to possess antioxidant activity, and four of them were tentatively identified as main contributors to the total anti-oxidative activity. The main advantage of the proposed approach was that it realized simultaneous fingerprint, quantitative analysis and screening of anti-oxidative components, providing comprehensive information for quality assessment of RSG.
[Mh] Termos MeSH primário: Antioxidantes
Colorimetria/métodos
Medicamentos de Ervas Chinesas
Liliaceae/química
[Mh] Termos MeSH secundário: Antioxidantes/análise
Antioxidantes/química
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/análise
Medicamentos de Ervas Chinesas/química
Limite de Detecção
Modelos Lineares
Análise de Componente Principal
Reprodutibilidade dos Testes
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28217929
[Au] Autor:Moyo M; Aremu AO; Chukwujekwu JC; Gruz J; Skorepa J; Dolezal K; Katsvanga CAT; Van Staden J
[Ad] Endereço:Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal, Pietermaritzburg, Private Bag X01, Scottsville, 3209, South Africa.
[Ti] Título:Phytochemical Characterization, Antibacterial, Acetylcholinesterase Inhibitory and Cytotoxic Properties of Cryptostephanus vansonii, an Endemic Amaryllid.
[So] Source:Phytother Res;31(5):713-720, 2017 May.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cryptostephanus vansonii I. Verd., an endemic Amaryllidaceae species from Zimbabwe, was evaluated for its acetylcholinesterase (AChE) inhibitory and cytotoxicity properties using Ellman's colorimetric method and the tetrazolium-based colorimetric assay against Vero monkey kidney cells, respectively. The plant extracts were also evaluated for their antibacterial activity against five bacteria. Furthermore, phytochemical profiles of the extracts were determined using ultra-high performance liquid chromatography coupled with tandem mass spectrometry analysis. A plant part-dependent AChE inhibitory activity was observed, in the order, root > rhizome > basal leaf > leaf. Overall, C. vansonii extracts exhibited better antibacterial activity against Gram-negative compared with Gram-positive bacteria. Cytotoxic effects were not detected in Vero monkey kidney cell lines suggesting the possible absence of toxophores in C. vansonii extracts. Similar to the trend in biological activity, a distinct plant part-dependent variation in hydroxybenzoates, hydroxycinnamates and flavonoids was observed in the plant extracts. In addition, 5-hydroxymetylfurfural and eucomic acid were detected in the different plant parts of C. vansonii. The results of the present study provide valuable AChE inhibition activity, toxicological and phytochemical profiles of C. vansonii. Further studies on isolation of bioactive compounds and their subsequent evaluation in other pharmacological and toxicological model systems are required. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Inibidores da Colinesterase/farmacologia
Liliaceae/química
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Inibidores da Colinesterase/química
Flavonoides/farmacologia
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cholinesterase Inhibitors); 0 (Flavonoids); 0 (Phytochemicals); 0 (Plant Extracts); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5788



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