Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.875.500.313 [Categoria DeCS]
Referências encontradas : 173 [refinar]
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  1 / 173 MEDLINE  
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[PMID]:28605675
[Au] Autor:Liu YM; Feng YD; Lu X; Nie JB; Li W; Wang LN; Tian LJ; Liu QH
[Ad] Endereço:Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address: coumarin1968@hotmail.com.
[Ti] Título:Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.
[So] Source:Eur J Med Chem;137:280-291, 2017 Sep 08.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Five new isosteroidal alkaloids, walujewine A (1), walujewine B (4), walujewine C (5), walujewine D (6), walujewine E (10) were isolated from the bulbs of Fritillaria walujewii together with seven known isosteroidal alkaloids (2, 3, 7-9, 11, 12). Their structures were elucidated on the basis of IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR spectroscopic data analyses and single-crystal X-ray diffraction. All the isolates were tested for ChE inhibiting activity by the Ellman's method. Compounds 3-5 and 8-10 were potent dual AChE-BChE inhibitors, and compound 1 showed highly selective AChE inhibition. The structure-activity relationship of compounds 1-12 was discussed in details. And kinetic analysis showed that compounds 1, 3-5, and 8-10 were mixed-type reversible inhibitors of AChE, simultaneously binding to the catalytic and peripheral anionic sites, which was verified by in silico docking studies. The docking simulation also showed that active compound 3 and 8 created many interactions with the CAS and PAS gorges of BChE, revealing their mixed-type inhibition. ADMET analysis further confirmed the therapeutic potential of some isosteroidal alkaloids based on their high BBB-penetration.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Alcaloides/farmacologia
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/farmacologia
Fritillaria/química
Esteroides/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Animais
Inibidores da Colinesterase/química
Inibidores da Colinesterase/isolamento & purificação
Relação Dose-Resposta a Droga
Electrophorus
Cavalos
Simulação de Acoplamento Molecular
Estrutura Molecular
Raízes de Plantas/química
Esteroides/química
Esteroides/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Cholinesterase Inhibitors); 0 (Steroids); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  2 / 173 MEDLINE  
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[PMID]:28073664
[Au] Autor:Guo X; Ni J; Xue J; Wang X
[Ad] Endereço:School of Life Sciences, The Engineering Research Center of Sustainable Development and Utilization of Biomass Energy, Yunnan Normal University, Kunming, Yunnan, China; School of Life Sciences, Yunnan University, Kunming, Yunnan, China.
[Ti] Título:Extract of bulbus Fritillaria cirrhosa perturbs spindle assembly checkpoint, induces mitotic aberrations and genomic instability in human colon epithelial cell line.
[So] Source:Exp Toxicol Pathol;69(3):163-171, 2017 Mar 02.
[Is] ISSN:1618-1433
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bulbus Fritillaria cirrhosa D. Don (BFC) has been used in China as a folk medicine for the treatment of cough and asthma for more than 2000 years. The antitussive and antiasthmatic effects of BFC have been reported before, nevertheless its toxicity and safety have not been documented. This study investigated the possible effects of BFC on spindle assembly checkpoint (SAC), mitotic fidelity and genomic stability in human NCM460 colon epithelial cells. METHODS: Cells were treated with BFC (0, 20, 40, 80 and 160µg/ml) for 24, 48 and 72h and harvested differently according to the biomarkers observed. Mitotic aberrations were assessed by the biomarkers of chromosome misalignment (CMA), chromosome lagging (CL) and chromatin bridge (CB). Frequencies of micronuclei (MN), nucleoplasmic bridge and nuclear bud (NB) in cytokinesis-block micronucleus assay were used as indicators of genomic instability (GIN). SAC activity was determined by anaphase to metaphase ratio (AMR) and the expression of several SAC genes, including CENP-E, Mps1, Bub1, Mad-1, BubR1 and Mad-2. RESULTS: Compared with the control, cells in BFC treated groups (80 and 160µg/ml) showed: 1) increased AMR (p<0.05), up-regulated expression of Mps1, Bub1 and Mad-1 (p<0.05) and down-regulated expression of CENP-E, BubR1 and Mad-2 (p<0.05); 2) increased frequencies of CMA, CL and CB (p<0.01); 3) increased incidences of MN and NB (p<0.01). CONCLUSIONS: This study revealed for the first time that BFC causes mitotic aberrations and GIN in human colon epithelial cells and these effects maybe the result of SAC dysfunction.
[Mh] Termos MeSH primário: Colo/efeitos dos fármacos
Medicamentos de Ervas Chinesas/toxicidade
Células Epiteliais/efeitos dos fármacos
Fritillaria/química
Instabilidade Genômica/efeitos dos fármacos
Pontos de Checagem da Fase M do Ciclo Celular/efeitos dos fármacos
Mitose/efeitos dos fármacos
[Mh] Termos MeSH secundário: Linhagem Celular
Colo/citologia
Células Epiteliais/citologia
Fritillaria/toxicidade
Seres Humanos
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Raízes de Plantas/toxicidade
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE


  3 / 173 MEDLINE  
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[PMID]:28012380
[Au] Autor:Zhou M; Ma X; Ding G; Wang Z; Liu D; Tong Y; Zhou H; Gao J; Hou Y; Jiang M; Bai G
[Ad] Endereço:State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
[Ti] Título:Comparison and evaluation of antimuscarinic and anti-inflammatory effects of five Bulbus fritillariae species based on UPLC-Q/TOF integrated dual-luciferase reporter assay, PCA and ANN analysis.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1041-1042:60-69, 2017 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Many species of Bulbus fritillariae are used as traditional medicines for thousands of years; however, their application is not standardized. To clarify the differences and homologies, the antimuscarinic and anti-inflammatory effects of five BM species were firstly tested and compared at cellular level. With an integrated strategy combining UPLC-Q/TOF MS, PCA and ANN analysis, the active ingredients among 28 different chemical markers were predicted and identified. SB and QB extracts showed the best antimuscarinic effects and several steroidal alkaloids, such as solanidine, contributed to this effects. However, ZB was superior to reduce the inflammatory response. Another five components were responsible by decreasing the expression of NF-κB, including puqiedine, zhepeiresinol, 2-monopalmitin, N-demethylpuqietinone, and isoverticine. More novelty, a new cluster of five BM species based on active ingredients as potential quality markers was depicted to illustrate their functions. These results of the study could make a reference for the medicinal application of BM species in clinic; and the integrated strategy provided an effective method to obtain the quality markers from medical herbs, which was helpful for the quality control of traditional medicinal products.
[Mh] Termos MeSH primário: Anti-Inflamatórios
Fritillaria/química
Antagonistas Muscarínicos
NF-kappa B/antagonistas & inibidores
Extratos Vegetais
Receptor Muscarínico M2/antagonistas & inibidores
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Anti-Inflamatórios/metabolismo
Anti-Inflamatórios/farmacologia
Biomarcadores/análise
Biomarcadores/metabolismo
Cromatografia Líquida de Alta Pressão/métodos
Diosgenina
Células HEK293
Seres Humanos
Luciferases/metabolismo
Espectrometria de Massas
Simulação de Acoplamento Molecular
Antagonistas Muscarínicos/química
Antagonistas Muscarínicos/metabolismo
Antagonistas Muscarínicos/farmacologia
NF-kappa B/análise
NF-kappa B/metabolismo
Extratos Vegetais/química
Extratos Vegetais/metabolismo
Extratos Vegetais/farmacologia
Análise de Componente Principal
Receptor Muscarínico M2/química
Receptor Muscarínico M2/metabolismo
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Muscarinic Antagonists); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Receptor, Muscarinic M2); EC 1.13.12.- (Luciferases); K49P2K8WLX (Diosgenin); W7801OHM8B (solanidine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE


  4 / 173 MEDLINE  
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[PMID]:28480363
[Au] Autor:Zhang D; Mo X; Xiang J; Zhou N
[Ad] Endereço:College of pharmacy and chemistry, Dali University, Dali, Yunnan 671000, PR China.
[Ti] Título:MOLECULAR IDENTIFICATION OF ORIGINAL PLANTS OF FRITILLARIAE CIRRHOSAE BULBUS, A TRADTIONAL CHINESE MEDICINE (TCM) USING PLANT DNA BARCODING.
[So] Source:Afr J Tradit Complement Altern Med;13(6):74-82, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: DNA barcoding is a widely used tool that enables rapid and accurate identification of species based on standardized DNA regions. MATERIALS AND METHODS: In this study, potential DNA barcodes, namely three plastid regions ( L, H- A and K) and one nuclear ribosomal internal transcribed spacer (ITS) were adopted for species identification of original plants of Fritillariae Cirrhosae Bulbus. RESULTS: The L and H- A regions showed better success rate of PCR amplification and DNA sequencing, as well as superior discriminatory ability. On the contrary, ITS region did not possess effective genetic variation and K was faced with low success rate of sequencing. Combination of multi-loci sequences could improve identification ability of DNA barcoding. The H- A + rbcL could discriminate 25% - 100% species based on the Blast, Tree-Building and Distance methods. CONCLUSION: The potential DNA barcodes could not completely solving species identification of botanic origins of Fritillariae Cirrhosae Bulbus. In future, we should pay more attention to super-barcoding or specific barcode that enhance ability to discriminate the closely related plants.
[Mh] Termos MeSH primário: Código de Barras de DNA Taxonômico/métodos
DNA de Plantas/análise
Medicamentos de Ervas Chinesas/análise
Fritillaria/genética
[Mh] Termos MeSH secundário: DNA Espaçador Ribossômico/genética
Plastídeos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (DNA, Ribosomal Spacer); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.12


  5 / 173 MEDLINE  
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[PMID]:27524867
[Au] Autor:Wang D; Du Q; Li H; Wang S
[Ad] Endereço:Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu 610041, China; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
[Ti] Título:The Isosteroid Alkaloid Imperialine from Bulbs of Fritillaria cirrhosa Mitigates Pulmonary Functional and Structural Impairment and Suppresses Inflammatory Response in a COPD-Like Rat Model.
[So] Source:Mediators Inflamm;2016:4192483, 2016.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the world. Present therapies for COPD have limited effect on reducing the progression of COPD and suppressing the inflammatory response in the lung. Bulbs of Fritillaria cirrhosa D. Don (BFC) have been used in many Asian countries for a long time to treat pulmonary diseases, such as cough, expectoration, and asthma. Steroidal alkaloids are the major biological active constituents in BFC, whereby imperialine is one of the important steroidal alkaloids. So far, there are no studies reporting the effect of imperialine on COPD. In this study, we investigated the effect of imperialine on pulmonary function and structure and inflammation in a COPD-like rat model which was induced by the combination of exposure to CS and intratracheal administration of LPS. Our data show that imperialine mitigates pulmonary functional and structural impairment and suppressed inflammatory response in a COPD-like rat model by mediating expression of related cytokines in lung tissues of the COPD-like rats, such as IL-1ß, IL-6, IL-8, TNF-α, NF-κB, TGF-ß1, MMP-9, and TIMP-1.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Fritillaria/química
Inflamação/tratamento farmacológico
Pulmão/efeitos dos fármacos
Extratos Vegetais/farmacologia
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Peso Corporal
Cevanas/metabolismo
Citocinas/metabolismo
Modelos Animais de Doenças
Imuno-Histoquímica
Pulmão/metabolismo
Masculino
Raízes de Plantas/química
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
Ratos
Ratos Wistar
Testes de Função Respiratória
Esteroides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Inflammatory Agents); 0 (Cevanes); 0 (Cytokines); 0 (Plant Extracts); 0 (Steroids); JKN43410XZ (peiminine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE
[do] DOI:10.1155/2016/4192483


  6 / 173 MEDLINE  
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[PMID]:27497638
[Au] Autor:Wang D; Yang J; Du Q; Li H; Wang S
[Ad] Endereço:Department of Pharmacognosy, West China College of Pharmacy, Sichuan University, No. 17, RenMin NanLu 3 Duan, Chengdu 610041, PR China; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, Vienna A-1090, Austria. Electronic address: wddong1988@hotmail.com.
[Ti] Título:The total alkaloid fraction of bulbs of Fritillaria cirrhosa displays anti-inflammatory activity and attenuates acute lung injury.
[So] Source:J Ethnopharmacol;193:150-158, 2016 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Bulb of Fritillaria cirrhosa D.Don (BFC) has been wildly used in China for a long time for folk medicine since its significant therapeutic effects on respiratory diseases, such as cough, expectoration, pneumonia and bronchial inflammation, which are related to respiratory inflammatory response. However, there is a lack of investigation on the in vivo anti-inflammatory properties of BFC. AIM OF THE STUDY: The aim of this study was to evaluate the in vivo anti-inflammatory activity of the purified total alkaloid fraction of BFC (TAF) by using different animal models of inflammation to provide scientific evidence for its traditional use. MATERIALS AND METHODS: The total alkaloid fraction from BFC was prepared by using H-103 resin column. Anti-inflammatory effect of TAF was evaluated by models of acetic acid-induced capillary permeability accentuation, carrageenan-induced rat paw edema, cotton pellet-induced granuloma formation and LPS-induced acute lung injury (ALI). The level of cytokines (TNF, IL-6, IL-4 and IL-10) was measured by ELISA. Histopathological analyses were performed by using hematoxylin and eosin staining. RESULTS: TAF can inhibit acetic acid-induced capillary permeability accentuation, carrageenan-induced paw edema, cotton pellet-induced granuloma formation, suppress inflammatory cells recruitment and cytokine production in the bronchoalveolar lavage fluid from LPS-induced ALI mice, and attenuate pathological changes in the lung tissues of ALI mice. CONCLUSION: This study provides scientific evidence for bulb of F. cirrhosa to treat respiratory inflammation.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/prevenção & controle
Alcaloides/farmacologia
Anti-Inflamatórios/farmacologia
Fritillaria/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar
Citocinas/metabolismo
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160808
[St] Status:MEDLINE


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[PMID]:27336590
[Au] Autor:Turlure C; Schtickzelle N; Van Dyck H; Seymoure B; Rutowski R
[Ad] Endereço:Université catholique de Louvain, Biodiversity Research Centre, Earth and Life Institute, Louvain-la-Neuve, Belgium.
[Ti] Título:Flight Morphology, Compound Eye Structure and Dispersal in the Bog and the Cranberry Fritillary Butterflies: An Inter- and Intraspecific Comparison.
[So] Source:PLoS One;11(6):e0158073, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding dispersal is of prime importance in conservation and population biology. Individual traits related to motion and navigation during dispersal may differ: (1) among species differing in habitat distribution, which in turn, may lead to interspecific differences in the potential for and costs of dispersal, (2) among populations of a species that experiences different levels of habitat fragmentation; (3) among individuals differing in their dispersal strategy and (4) between the sexes due to sexual differences in behaviour and dispersal tendencies. In butterflies, the visual system plays a central role in dispersal, but exactly how the visual system is related to dispersal has received far less attention than flight morphology. We studied two butterfly species to explore the relationships between flight and eye morphology, and dispersal. We predicted interspecific, intraspecific and intersexual differences for both flight and eye morphology relative to i) species-specific habitat distribution, ii) variation in dispersal strategy within each species and iii) behavioural differences between sexes. However, we did not investigate for potential population differences. We found: (1) sexual differences that presumably reflect different demands on both male and female visual and flight systems, (2) a higher wing loading (i.e. a proxy for flight performance), larger eyes and larger facet sizes in the frontal and lateral region of the eye (i.e. better navigation capacities) in the species inhabiting naturally fragmented habitat compared to the species inhabiting rather continuous habitat, and (3) larger facets in the frontal region in dispersers compared to residents within a species. Hence, dispersers may have similar locomotory capacity but potentially better navigation capacity. Dispersal ecology and evolution have attracted much attention, but there are still significant gaps in our understanding of the mechanisms of dispersal. Unfortunately, for many species we lack detailed information on the role of behavioural, morphological and physiological traits for dispersal. Our novel study supports the existence of inter- and intra-specific evolutionary responses in both motion and navigation capacities (i.e. flight and eye morphology) linked to dispersal.
[Mh] Termos MeSH primário: Borboletas/anatomia & histologia
Borboletas/fisiologia
Olho/anatomia & histologia
Voo Animal
Fritillaria
[Mh] Termos MeSH secundário: Animais
Bélgica
Ecossistema
Olho/citologia
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0158073


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[PMID]:27033404
[Au] Autor:Xu J; Zhao W; Pan L; Zhang A; Chen Q; Xu K; Lu H; Chen Y
[Ad] Endereço:Chinese Herb Medicine Division, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China; The Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, 88 North Circle Road, Lin'an 311300, PR China.
[Ti] Título:Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level.
[So] Source:Fitoterapia;111:1-6, 2016 Jun.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fritillaria is one of the most important herbs in Chinese traditional medicine and represents an annual ï¿¥700 million industry. It is often used as an anti-inflammatory, pain relieving and antitussive medicine. However, the mechanisms of these effects are still unclear. Peimine is one of active ingredients of Fritillaria. Using the patch-clamp technique, we profiled the action of Peimine against selected ion channels stably expressed in HEK 293 cell lines. Our data indicated that Peimine was not only able to block the Nav1.7 ion channel but also preferably inhibited the Kv1.3 ion channel. Thus, the study suggested potential mechanisms of Fritillaria as a pain relieving and anti-inflammatory herb.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Cevanas/farmacologia
Fritillaria/química
Canal de Sódio Disparado por Voltagem NAV1.7/metabolismo
[Mh] Termos MeSH secundário: Analgésicos/química
Medicamentos de Ervas Chinesas/farmacologia
Células HEK293
Seres Humanos
Técnicas de Patch-Clamp
Plantas Medicinais/química
Bloqueadores do Canal de Sódio Disparado por Voltagem/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Cevanes); 0 (Drugs, Chinese Herbal); 0 (NAV1.7 Voltage-Gated Sodium Channel); 0 (SCN9A protein, human); 0 (Voltage-Gated Sodium Channel Blockers); 34QDF8UFSY (verticine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


  9 / 173 MEDLINE  
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[PMID]:27000942
[Au] Autor:Ruokolainen L; Ikonen S; Makkonen H; Hanski I
[Ad] Endereço:Department of Biosciences, University of Helsinki, Viikinkaari 1, P.O. Box 65, 00014, Helsinki, Finland. lasse.ruokolainen@helsinki.fi.
[Ti] Título:Larval growth rate is associated with the composition of the gut microbiota in the Glanville fritillary butterfly.
[So] Source:Oecologia;181(3):895-903, 2016 Jul.
[Is] ISSN:1432-1939
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The rapidly increasing body of literature on commensal microbiota has revealed a large phylotypic and functional diversity of microbes associated with vertebrates and invertebrates. In insects, the gut microbiota plays a role in digestion and metabolism of the host as well as protects the host against pathogens. In the study reported here, we sampled gut microbiota of the larvae of the Glanville fritillary butterfly (Melitaea cinxia). The larvae were collected from the field or reared in the laboratory. This butterfly has two host plant species, Plantago lanceolata and Veronica spicata, and the host plant species is known from previous studies to influence larval growth rate. However, our results demonstrate that about 50 % of the variation in larval growth rate can be attributed to the effect of the gut microbial composition plus the joint effect of microbiota and the host plant species, while host plant species alone makes no significant contribution. Our results support previous studies showing that diet influences the gut microbiota but, more unexpectedly, that the composition of the gut microbiota significantly influences larval growth rate. We suggest that host plant effects on larval growth and development observed in many previous studies may be mediated via the gut microbiota. While we measured the growth rate only in laboratory-reared larvae, the similarity of the gut microbial composition between samples from field-collected and laboratory-reared larvae suggests that the results can be generalized to natural conditions.
[Mh] Termos MeSH primário: Borboletas
Microbioma Gastrointestinal
Larva
[Mh] Termos MeSH secundário: Animais
Fritillaria
Plantago
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.1007/s00442-016-3603-8


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[PMID]:26965859
[Au] Autor:Li Y; Yili A; Li J; Muhamat A; Aisa HA
[Ad] Endereço:Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.
[Ti] Título:New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk.
[So] Source:Bioorg Med Chem Lett;26(8):1983-7, 2016 Apr 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four new isosteroidal alkaloids, yibeinones A-D (1-4), along with four known ones, imperialine-3ß-d-glucoside (5), imperialine (6), imperialine ß-N-oxide (7), and dongbeinine (8), were isolated from the bulbs of Fritillaria pallidiflora. Their structures were confirmed on the basis of extensive spectroscopic analysis or comparison with the data in the literatures (known compounds). Compounds 2, 3, 4, and 6 showed an apparent concentration-dependant relaxation of isolated tracheal preparation, amongst 3 and 6 exhibited significant effects with pA2 values of 6.19 ± 0.02 and 8.41 ± 0.10, and EC50 values of 0.65 ± 0.02 µmol L(-1) and 4.40 ± 0.90 nmol L(-1), respectively.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Fritillaria/química
Raízes de Plantas/química
Traqueia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Animais
Relação Dose-Resposta a Droga
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Conformação Molecular
Relaxamento Muscular/efeitos dos fármacos
Relaxamento Muscular/fisiologia
Cloreto de Potássio/farmacologia
Ratos
Relação Estrutura-Atividade
Traqueia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Drugs, Chinese Herbal); 660YQ98I10 (Potassium Chloride)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160312
[St] Status:MEDLINE



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