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Pesquisa : B01.650.940.800.575.912.250.618.875.625.960 [Categoria DeCS]
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[PMID]:26771639
[Au] Autor:Welch KD; Green BT; Gardner DR; Stonecipher CA; Pfister JA; Cook D
[Ad] Endereço:United States Department of Agriculture-Agriculture Research Services-Poisonous Plant Research Laboratory, Logan, UT 84341, USA. kevin.welch@ars.usda.gov.
[Ti] Título:The Effect of Co-Administration of Death Camas (Zigadenus spp.) and Low Larkspur (Delphinium spp.) in Cattle.
[So] Source:Toxins (Basel);8(1), 2016 Jan 12.
[Is] ISSN:2072-6651
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In many rangeland settings, there is more than one potential poisonous plant. Two poisonous plants that are often found growing simultaneously in the same location in North American rangelands are death camas (Zigadenus spp.) and low larkspur (Delphinium spp.). The objective of this study was to determine if co-administration of death camas would exacerbate the toxicity of low larkspur in cattle. Cattle dosed with 2.0 g of death camas/kg BW showed slight frothing and lethargy, whereas cattle dosed with both death camas and low larkspur showed increased clinical signs of poisoning. Although qualitative differences in clinical signs of intoxication in cattle co-treated with death camas and low larkspur were observed, there were not any significant quantitative differences in heart rate or exercise-induced muscle fatigue. Co-treatment with death camas and low larkspur did not affect the serum zygacine kinetics, however, there was a difference in the larkspur alkaloid kinetics in the co-exposure group. Overall, the results from this study suggest that co-exposure to death camas and low larkspur is not significantly more toxic to cattle than exposure to the plants individually. The results from this study increase our knowledge and understanding regarding the acute toxicity of death camas and low larkspur in cattle.
[Mh] Termos MeSH primário: Delphinium/toxicidade
Plantas Tóxicas/toxicidade
Zigadenus/toxicidade
[Mh] Termos MeSH secundário: Alcaloides/análise
Alcaloides/sangue
Alcaloides/toxicidade
Animais
Bovinos
Delphinium/química
Frequência Cardíaca/efeitos dos fármacos
Masculino
Plantas Tóxicas/química
Zigadenus/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160116
[St] Status:MEDLINE


  2 / 4 MEDLINE  
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[PMID]:24055068
[Au] Autor:Welch KD; Green BT; Gardner DR; Stonecipher CA; Panter KE; Pfister JA; Cook D
[Ad] Endereço:USDA-ARS Poisonous Plant Research Laboratory, 1150 E. 1400 N., Logan, UT 84341, USA. Electronic address: Kevin.Welch@ars.usda.gov.
[Ti] Título:The effect of low larkspur (Delphinium spp.) co-administration on the acute toxicity of death camas (Zigadenus spp.) in sheep.
[So] Source:Toxicon;76:50-8, 2013 Dec 15.
[Is] ISSN:1879-3150
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In most cases where livestock are poisoned by plants in a range setting, there is more than one potential poisonous plant in the same area. Two poisonous plants that are often found growing simultaneously in the same location are death camas (Zigadenus spp.) and low larkspur (Delphinium spp.). Sheep are known to be susceptible to death camas poisoning while they are thought to be resistant to larkspur. The objective of this study was to determine if co-administration of low larkspur would exacerbate the toxicity of death camas in sheep. A dose finding study was performed to find a dose of death camas that caused minimal clinical signs of poisoning. Sheep were observed for clinical signs of poisoning as well as changes in heart rate and muscle fatigue. Sheep dosed with 1.14 g of death camas per kg BW showed slight frothing and lethargy, whereas sheep dosed with death camas and low larkspur showed slightly more noticeable clinical signs of poisoning. Sheep dosed with only low larkspur, at 7.8 g/kg BW, showed no signs of poisoning. Although we observed a qualitative difference in clinical signs of intoxication in sheep co-treated with death camas and low larkspur we did not detect any quantitative differences in heart rate, exercise-induced muscle fatigue, or differences in serum zygacine kinetics. Consequently, the results from this study suggest that low larkspur does not affect the toxicity of death camas in sheep. The results from this study increase knowledge and understanding regarding the acute toxicity of death camas and low larkspur in sheep. As combined intoxications are most likely common, this information will be useful in further developing management recommendations for ranchers and in designing additional experiments to study the toxicity of death camas to other livestock species.
[Mh] Termos MeSH primário: Alcaloides/toxicidade
Delphinium/toxicidade
Intoxicação por Plantas/veterinária
Plantas Tóxicas/toxicidade
Doenças dos Ovinos/induzido quimicamente
Zigadenus/toxicidade
[Mh] Termos MeSH secundário: Alcaloides/sangue
Alcaloides/química
Animais
Cromatografia Líquida de Alta Pressão
Frequência Cardíaca/efeitos dos fármacos
Fadiga Muscular/efeitos dos fármacos
Ovinos
Espectrometria de Massas em Tandem
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:131125
[Lr] Data última revisão:
131125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130924
[St] Status:MEDLINE


  3 / 4 MEDLINE  
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[PMID]:21521823
[Au] Autor:Welch KD; Panter KE; Gardner DR; Stegelmeier BL; Green BT; Pfister JA; Cook D
[Ad] Endereço:USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84341, USA. Kevin.Welch@ars.usda.gov
[Ti] Título:The acute toxicity of the death camas (Zigadenus species) alkaloid zygacine in mice, including the effect of methyllycaconitine coadministration on zygacine toxicity.
[So] Source:J Anim Sci;89(5):1650-7, 2011 May.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Death camas (Zigadenus spp.) is a common poisonous plant on foothill rangelands in western North America. The steroidal alkaloid zygacine is believed to be the primary toxic component in death camas. Poisonings on rangelands generally occur in the spring when death camas is abundant, whereas other more desirable forage species are limited in availability. In most cases where livestock are poisoned by plants in a range setting, there is more than one potential poisonous plant in that area. One common poisonous plant that is often found growing simultaneously in the same area as death camas is low larkspur (Delphinium nuttallianum). Consequently, the objectives of this study were to conduct acute toxicity studies in mice and to determine if coadministration of low larkspur will exacerbate the toxicity of death camas. We first characterized the acute toxicity of zygacine in mice. The LD(50) of zygacine administered intravenously (i.v.) and orally was 2.0 ± 0.2 and 132 ± 21 mg/kg, respectively. The rate of elimination of zygacine from whole blood was determined to be 0.06 ± 0.01/min, which corresponds to an elimination half-life of 13.0 ± 2.7 min. The i.v. LD(50) of total alkaloid extracts from a Utah and a Nevada collection were 2.8 ± 0.8 and 2.2 ± 0.3 mg/kg, respectively. The i.v. LD(50) of methyllycaconitine (MLA), a major toxic alkaloid in low larkspur, was 4.6 ± 0.5 mg/kg, whereas the i.v. LD(50) of a 1:1 mixture of MLA and zygacine was 2.9 ± 0.7 mg/kg. The clinical signs in mice treated with this mixture were very similar to those of mice treated with zygacine alone, including the time of onset and death. These results suggest that there is an additive effect of coadministering these 2 alkaloids i.v. in mice. The results from this study increase knowledge and understanding regarding the acute toxicity of death camas. As combined intoxications are most likely common, this information will be useful in further developing management recommendations for ranchers and in designing additional experiments to study the toxicity of death camas to livestock.
[Mh] Termos MeSH primário: Aconitina/análogos & derivados
Alcaloides/toxicidade
Delphinium/química
Gado/metabolismo
Intoxicação por Plantas/veterinária
Zigadenus/química
[Mh] Termos MeSH secundário: Aconitina/metabolismo
Aconitina/farmacocinética
Aconitina/toxicidade
Alcaloides/metabolismo
Alcaloides/farmacocinética
Animais
Dose Letal Mediana
Masculino
Camundongos
Nevada
Farmacocinética
Intoxicação por Plantas/etiologia
Intoxicação por Plantas/metabolismo
Estações do Ano
Utah
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 21019-30-7 (methyllycaconitine); X8YN71D5WC (Aconitine)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110428
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2010-3444


  4 / 4 MEDLINE  
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[PMID]:19876855
[Au] Autor:West P; Horowitz BZ
[Ad] Endereço:Oregon Health and Science University, Oregon Poison Center, Portland, OR 97239, USA. westp@ohsu.edu
[Ti] Título:Zigadenus poisoning treated with atropine and dopamine.
[So] Source:J Med Toxicol;5(4):214-7, 2009 Dec.
[Is] ISSN:1556-9039
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Zigadenus (commonly known as "death camas" or "mountain camas") is a common plant in the lily family found throughout the United States. Its onion-like roots can be mistaken for an edible plant. Ingestion may cause hemodynamic instability which has successfully been treated with atropine. It has been suggested that vasopressors may be an effective therapy for this ingestion. We report the successful use of dopamine as therapy in Zigadenus ingestion. CASE REPORT: A 45 year-old, previously healthy male presented to the ED with complaints of severe nausea and vomiting after ingesting two "wild onion" bulbs. He was noted to have marked hypotension and bradycardia in the ED, which initially responded to treatment with IV fluids and atropine. The plant was identified as a species of Zigadenus. After a second drop in heart rate and blood pressure in the ICU, hypotension and bradycardia were treated successfully with a dopamine infusion. DISCUSSION: Zigadenus ingestion presents with vomiting, hypotension and bradycardia. The hemodynamic instability responded well to atropine for 1-2 hours. Dopamine infusion was used to stabilize both heart rate and blood pressure. With supportive care, poisoned individuals become relatively asymptomatic within 24 hours of their ingestion. Patients may be discharged once asymptomatic, typically the day after ingestion, and do not have any known long term sequelae. CONCLUSION: Zigadenus poisoning causes vomiting, hypotension and bradycardia. The hemodynamic instability may be treated with atropine administration and dopamine infusion.
[Mh] Termos MeSH primário: Atropina/uso terapêutico
Bradicardia/tratamento farmacológico
Dopamina/administração & dosagem
Hipotensão/tratamento farmacológico
Parassimpatolíticos/uso terapêutico
Simpatomiméticos/administração & dosagem
Zigadenus/envenenamento
[Mh] Termos MeSH secundário: Pressão Sanguínea/efeitos dos fármacos
Bradicardia/induzido quimicamente
Bradicardia/fisiopatologia
Quimioterapia Combinada
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Hipotensão/induzido quimicamente
Hipotensão/fisiopatologia
Infusões Intravenosas
Masculino
Meia-Idade
Náusea/induzido quimicamente
Náusea/tratamento farmacológico
Envenenamento/tratamento farmacológico
Resultado do Tratamento
Vômito/induzido quimicamente
Vômito/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parasympatholytics); 0 (Sympathomimetics); 7C0697DR9I (Atropine); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1001
[Cu] Atualização por classe:141204
[Lr] Data última revisão:
141204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091031
[St] Status:MEDLINE



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