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Pesquisa : B01.650.940.800.575.912.250.618.875.750 [Categoria DeCS]
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  1 / 14 MEDLINE  
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[PMID]:28624472
[Au] Autor:Gao Y; Li C; Wang Y; Liu Y; Li G; Fan X; Li Y; Tian J; Lee AW
[Ad] Endereço:School of Life Sciences, Yantai University, Yantai, 264005, PR China.
[Ti] Título:Nonclinical safety of astilbin: A 4-week oral toxicity study in rats with genotoxicity, chromosomal aberration, and mammalian micronucleus tests.
[So] Source:Food Chem Toxicol;107(Pt A):1-9, 2017 Sep.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Astilbin is an active flavonoid compound isolated from Rhizoma Smilacis Glabrae. It has been widely used as an anti-hepatic, anti-arthritic, and anti-renal injury agent. However, its safety has not yet been established. The objective of this study was to evaluate 4-week repeated oral toxicity and genotoxicity of astilbin. We examined oral toxicity in Sprague-Dawley rats after daily oral administration of astilbin at 50, 150, and 500 mg/kg for 4 weeks. Negative control animals received the same volume of the solvent. Astilbin administration did not lead to death, body weight gain, food consumption, or adverse events. There were no significant differences in toxicity between the astilbin and control group; we observed no toxic effects on hematological or urinalysis parameters, biochemical values, organ weight, or histopathological findings. We assessed the genotoxicity of astilbin with the Ames test (TA97a, TA98, TA100, TA102, and TA1535), chromosomal aberration assay (using Chinese hamster ovary cells), and mammalian micronucleus test (in mice). We found no genotoxicity in any tested strains. The no-observed-adverse-effect level (NOAEL) for astilbin in the 4-week repeated oral toxicity study in rats was greater than 500 mg/kg body weight/day, regardless of gender. Results also suggested that astilbin does not have genotoxicity potential.
[Mh] Termos MeSH primário: Aberrações Cromossômicas/efeitos dos fármacos
Medicamentos de Ervas Chinesas/efeitos adversos
Flavonóis/efeitos adversos
Smilacaceae/química
[Mh] Termos MeSH secundário: Animais
Células CHO
Cricetinae
Cricetulus
Dano ao DNA/efeitos dos fármacos
Feminino
Flavonóis/administração & dosagem
Masculino
Camundongos
Testes para Micronúcleos
Testes de Mutagenicidade
Nível de Efeito Adverso não Observado
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
Salmonella typhimurium/efeitos dos fármacos
Salmonella typhimurium/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Flavonols); 0 (Plant Extracts); 29838-67-3 (astilbin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE


  2 / 14 MEDLINE  
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[PMID]:27323613
[Au] Autor:Zhang Q; Li T; Xu YG; Yang XH
[Ti] Título:[Effect of Chinese Herbs Used in Treating Multiple Sclerosis on T Subsets Using Association Rules].
[So] Source:Zhongguo Zhong Xi Yi Jie He Za Zhi;36(4):425-9, 2016 Apr.
[Is] ISSN:1003-5370
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To analyze the effect of Chinese herbs used by Prof. LI Tao on peripheral blood T subsets in treating multiple sclerosis (MS) by using association rules and statistical methods, thereby providing evidence for optimizing prescriptions. METHODS: Data of MS inpatients and outpatients recorded by data collecting system, Xiyuan Hospital, China Academy of Chinese Medical Sciences were resorted. The relationship between Chinese herbs and T cell subsets were analyzed using SPSS17.0 and Aprior module in SPSS Clementine 12.0. RESULTS: Radix bupleuri, Radix Paeoniae alba, Fructus Aurantii, Atractylodes, and Radix Glycyrrhizae were most commonly used herbal combinations.Radix Aconiti lateralis preparata and Rhizoma Smilacis glabrae were often added. Radix Aconiti lateralis preparata was associated with decreased Th1 cells (confidence level 83.78%, supportive level 36.26%). Decreased Th1 cell was associated with Radix Aconiti lateralis preparata (confidence level 71.26%, supportive level 36.26%).Radix Aconiti lateralis preparata was obviously associated with decreased Th1 cells. Radix Bupleuri, Radix Paeoniae alba, bitter orange, Atractylodes , Radix glycyrrhizae, and Radix Aconiti lateralis preparata could reduce peripheral blood Th1 subsets of MS patients and elevate Th2 subsets (all P < 0.01). CONCLUSIONS: The herbal combination of Radix Bupleuri, Radix Paeoniae alba, Fructus Aurantii, Atractylodes, Radix Glycyrrhizae, Rhizoma Smilacis glabrae, and Radix Aconiti lateralis preparata could lower peripheral blood Th1 cells and elevate Th2 cells, and prevent the relapse of MS possibly by reducing Th1 cells and elevating Th2 cells. Especially Radix Aconiti lateralis preparata played important roles in aforesaid changes of Th1 and Th2.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/uso terapêutico
Esclerose Múltipla/terapia
Subpopulações de Linfócitos T/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aconitum/química
Atractylodes/química
Bupleurum/química
China
Frutas/química
Glycyrrhiza/química
Seres Humanos
Paeonia/química
Raízes de Plantas/química
Rizoma/química
Smilacaceae/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160622
[St] Status:MEDLINE


  3 / 14 MEDLINE  
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[PMID]:25739202
[Au] Autor:Zhao FC; Wan KY; Liu XQ; Zhang QW; Gao HM; Wang ZM
[Ti] Título:[Rapid determination of the multi-marker ingredients in Heterosmilacis Japonicae Rhizoma and Sophorae Flavescentis Radix with near-infrared diffused reflection spectroscopy].
[So] Source:Guang Pu Xue Yu Guang Pu Fen Xi;34(10):2652-6, 2014 Oct.
[Is] ISSN:1000-0593
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A rapid NIRS method for determination of macrozamin in Heterosmilacis japonicae rhizoma (HJR), and the total content of oxymatrine and matrine (OMT + MT) as well as the total content of oxysophocarpine and sophocarpine (OSC + SC) in sophorae flavescens radix (SFR) was developed to explore the application feasibility of NIRS for the quality assurance system of Chinese patent drugs. The contents of macrozamin in HJR samples, and OMT + MT and OSC + SC in SFR samples were determined by HPLC as reference values. The NIR spectra of the samples were measured in a diffused reflection mode. The different characteristic wavebands and pretreatment methods were optimized. The quantitative calibration models between the NIR spectra and the content reference values of marker components in HJR and SFR samples, were established with partial least square method, and further optimized through the cross validation and external validation. The contents of macrozamin in 88 batches of HJR samples were over the range of 0.36-12.88 mg · g(-1). The total contents of OMT + MT and OSC + SC in 75 batches of SFR samples were over the range of 8.87-66.31 and 2.30-15.11 mg · g(-1), respectively. The performance of the final models for macrozamin, OMT + MT and OSC + SC was evaluated well according to correlation coefficients (r), root mean square error of cross-validation (RMSECV) and root mean square error of prediction (RMSEP). The R2 values of the cross-validation for macrozamin, OMT + MT and OSC + SC were 0.9025, 0.9491 and 0.9137, and those of RMSECV were 0.961, 2.45 and 0.724 mg · g(-1) respectively. The R2 values of external validation for the three models were 0.9817, 0.9826 and 0.9609, and those of RMSEP were 0.693, 2.27 and 0.658 mg · g(-1), respectively. This is the first report on rapid determination of macrozamin in Heterosmilacis japonicae rhizoma, and oxymatrine, matrine, oxysophocarpine and sophocarpine in sophorae flavescens radix by NIRS method. The presented method can fulfill the requirement of rapid acquirement of chemical information of raw medicinal materials prior the manufacturing of compound Kushen injection.
[Mh] Termos MeSH primário: Smilacaceae/química
Sophora/química
Espectroscopia de Luz Próxima ao Infravermelho
[Mh] Termos MeSH secundário: Alcaloides
Calibragem
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/análise
Análise dos Mínimos Quadrados
Raízes de Plantas/química
Quinolizinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Drugs, Chinese Herbal); 0 (Quinolizines); 0 (kushen); 58BVU7200M (oxysophocarpine); 6483-15-4 (sophocarpine); 85U4C366QS (oxymatrine); N390W430AC (matrine)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150306
[St] Status:MEDLINE


  4 / 14 MEDLINE  
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[PMID]:24227636
[Au] Autor:Tang Y; He X; Chen Q; Fan L; Zhang J; Zhao Z; Dong L; Liang Z; Yi T; Chen H
[Ad] Endereço:School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, People's Republic of China.
[Ti] Título:A mixed microscopic method for differentiating seven species of "Bixie"-related Chinese Materia Medica.
[So] Source:Microsc Res Tech;77(1):57-70, 2014 Jan.
[Is] ISSN:1097-0029
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Confusion in the species associated with the name of "Bixie" in Chinese Materia Medica began centuries ago. In recent decades, diverse medicinal plants from the genera Dioscorea and Smilax, and even minor species from the genus Heterosmilax, have been documented under the name Bixie or a very similar name as folk medicines in different areas of China. However, the traditional efficacies and chemical profiles of these herbs are not exactly the same and even vary wildly. Comprehensive authentication of multiple Bixie herbs has not yet been attempted. To differentiate and ensure the correct use of these Bixie-related herbs, in this study, seven sorts of representative Bixie herbs (Dioscorea collettii, D. zingiberensis, D. nipponica, D. septemloba, Smilax china, S. glabra, and Heterosmilax japonica) were characterized based on the microscopic examination of their powders and cryotomed transverse sections. This is not only the first attempt to distinguish Bixie herbs by a comprehensive microscopic techniques, including common light microscopy, fluorescence microscopy, and polarized light microscopy, but also it is the first research to observe characteristics of transections of crude drugs under polarized lighting for the purpose of authentication. Polarized light has been found to provide a number of unique characteristics. The results indicate that starch granules, stone cells, vascular bundles, and other significant tissue features can be used to authenticate "Bixie" herbs. The method was proven to be quick, handy, specific, and simple. It should be widely applicable to other herbal materials.
[Mh] Termos MeSH primário: Dioscorea/química
Microscopia/métodos
Plantas Medicinais/química
Smilacaceae/química
Smilax/química
[Mh] Termos MeSH secundário: China
Análise Discriminante
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140304
[Lr] Data última revisão:
140304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131115
[St] Status:MEDLINE
[do] DOI:10.1002/jemt.22313


  5 / 14 MEDLINE  
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[PMID]:23973725
[Au] Autor:Do HD; Kim JS; Kim JH
[Ad] Endereço:Department of Life Science, Gachon University, Seongnam, Gyeonggi-do 461-701, Republic of Korea. Electronic address: dohoangdangkhoa@yahoo.com.
[Ti] Título:Comparative genomics of four Liliales families inferred from the complete chloroplast genome sequence of Veratrum patulum O. Loes. (Melanthiaceae).
[So] Source:Gene;530(2):229-35, 2013 Nov 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The sequence of the chloroplast genome, which is inherited maternally, contains useful information for many scientific fields such as plant systematics, biogeography and biotechnology because its characteristics are highly conserved among species. There is an increase in chloroplast genomes of angiosperms that have been sequenced in recent years. In this study, the nucleotide sequence of the chloroplast genome (cpDNA) of Veratrum patulum Loes. (Melanthiaceae, Liliales) was analyzed completely. The circular double-stranded DNA of 153,699 bp consists of two inverted repeat (IR) regions of 26,360 bp each, a large single copy of 83,372 bp, and a small single copy of 17,607 bp. This plastome contains 81 protein-coding genes, 30 distinct tRNA and four genes of rRNA. In addition, there are six hypothetical coding regions (ycf1, ycf2, ycf3, ycf4, ycf15 and ycf68) and two open reading frames (ORF42 and ORF56), which are also found in the chloroplast genomes of the other species. The gene orders and gene contents of the V. patulum plastid genome are similar to that of Smilax china, Lilium longiflorum and Alstroemeria aurea, members of the Smilacaceae, Liliaceae and Alstroemeriaceae (Liliales), respectively. However, the loss rps16 exon 2 in V. patulum results in the difference in the large single copy regions in comparison with other species. The base substitution rate is quite similar among genes of these species. Additionally, the base substitution rate of inverted repeat region was smaller than that of single copy regions in all observed species of Liliales. The IR regions were expanded to trnH_GUG in V. patulum, a part of rps19 in L. longiflorum and A. aurea, and whole sequence of rps19 in S. china. Furthermore, the IGS lengths of rbcL-accD-psaI region were variable among Liliales species, suggesting that this region might be a hotspot of indel events and the informative site for phylogenetic studies in Liliales. In general, the whole chloroplast genome of V. patulum, a potential medicinal plant, will contribute to research on the genetic applications of this genus.
[Mh] Termos MeSH primário: Cloroplastos/genética
Genoma de Cloroplastos
Genômica
Filogenia
RNA de Plantas/genética
Veratrum/genética
[Mh] Termos MeSH secundário: Cloroplastos/classificação
Mapeamento Cromossômico
DNA Circular
Sequências Repetidas Invertidas
Liliaceae/classificação
Liliaceae/genética
RNA de Plantas/classificação
RNA Ribossômico/classificação
RNA Ribossômico/genética
RNA de Transferência/classificação
RNA de Transferência/genética
Smilacaceae/classificação
Smilacaceae/genética
Veratrum/classificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Circular); 0 (RNA, Plant); 0 (RNA, Ribosomal); 9014-25-9 (RNA, Transfer)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:130930
[Lr] Data última revisão:
130930
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130827
[St] Status:MEDLINE


  6 / 14 MEDLINE  
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[PMID]:23578597
[Au] Autor:Zhao Y; Qi Z; Ma W; Dai Q; Li P; Cameron KM; Lee J; Xiang QY; Fu C
[Ad] Endereço:The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education, College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China.
[Ti] Título:Comparative phylogeography of the Smilax hispida group (Smilacaceae) in eastern Asia and North America--implications for allopatric speciation, causes of diversity disparity, and origins of temperate elements in Mexico.
[So] Source:Mol Phylogenet Evol;68(2):300-11, 2013 Aug.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Smilax hispida group (Smilacaceae) exhibits a discontinuous distribution in eastern Asia, eastern and western United States, and Mexico. A broad scale phylogeographic analysis was conducted for this group to evaluate the hypotheses of accelerated allopatric divergence in eastern Asia and a northern origin of the temperate elements in Mexico. Phylogeny was inferred using seven plastid and nuclear DNA sequences. Species delineation was assessed using genealogical sorting indices (GSI). Lineage divergence time, haplotype diversification rates, and ancestral distributions were estimated using Bayesian methods. Phylogeographic patterns in eastern Asia and North America were compared by analyzing 539 individuals from 64 populations to assess allopatric diversification. Results strongly supported delineation of six allopatric species, the origin of this group from a Mexican ancestor around 11.42mya, and Mexican origins of the temperate species in Mexico. Significant geographic structure of haplotypes was found in eastern Asia, and greater haplotype diversification rate was observed for the North American lineage. Our data support allopatric speciation in eastern Asia but do not find evidence of an elevated diversification rate. Greater species diversity of the study system in eastern Asia may be due to a longer evolutionary history. Our results do not support northern origins of the Mexican temperate species.
[Mh] Termos MeSH primário: Evolução Molecular
Genes de Plantas
Filogenia
Smilacaceae/genética
[Mh] Termos MeSH secundário: DNA de Cloroplastos/genética
Extremo Oriente
Especiação Genética
Variação Genética
Genomas de Plastídeos
Haplótipos
México
Modelos Genéticos
Tipagem de Sequências Multilocus
Filogeografia
Smilacaceae/classificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:130520
[Lr] Data última revisão:
130520
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130413
[St] Status:MEDLINE


  7 / 14 MEDLINE  
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[PMID]:22474949
[Au] Autor:Li X; Zhang YF; Yang L; Feng Y; Deng YH; Liu YM; Zeng X
[Ad] Endereço:Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
[Ti] Título:Chemical profiling of constituents of Smilacis glabrae using ultra-high pressure liquid chromatography coupled with LTQ Orbitrap mass spectrometry.
[So] Source:Nat Prod Commun;7(2):181-4, 2012 Feb.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A reliable LC-MS method has been applied for the separation and identification of major constituents of the rhizome of Smilacis glabrae. Identification of the constituents was carried out by interpretation of their retention time, and MS and MS/MS data, especially by comparing these with Sarcandra glabra under the same LC-MS conditions, as well as the data provided by the literature. Thirty-three compounds, including catechin derivatives, flavanonols, phenolic acid derivatives and phenylpropanoid glycosides were either identified or tentatively characterized. Among them, compound 12 was deduced to be a new phenylpropanoid-substituted catechin. Fragmentation behaviors of the three major categories of compounds were also investigated. This UPLC-PDA/ESI-MS(n) method was effective for the separation and identification of the constituents and could be the basis for the comprehensive quality control of Smilacis glabrae.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Espectrometria de Massas/métodos
Smilacaceae/química
[Mh] Termos MeSH secundário: Ácidos Cafeicos/química
Catequina/análogos & derivados
Catequina/química
Flavonoides/química
Glicosídeos/química
Hidroxibenzoatos/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Flavonoids); 0 (Glycosides); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1204
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120406
[St] Status:MEDLINE


  8 / 14 MEDLINE  
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[PMID]:21315392
[Au] Autor:Wungsintaweekul B; Umehara K; Miyase T; Noguchi H
[Ad] Endereço:School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.
[Ti] Título:Estrogenic and anti-estrogenic compounds from the Thai medicinal plant, Smilax corbularia (Smilacaceae).
[So] Source:Phytochemistry;72(6):495-502, 2011 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From the rhizomes of Smilax corbularia Kunth. (Smilacaceae), 11 compounds, (2R,3R)-2″-acetyl astilbin, (2R,3R)-3″-acetyl astilbin, (2R,3R)-4″-acetyl astilbin, (2R,3R)-3″-acetyl engeletin, (2R,3S)-4″-acetyl isoastilbin, 2-(4-hydroxyphenyl)-3,4,9,10-tetrahydro-3,5-dihydroxy-10-(3,4-dihydroxyphenyl)-(2R,3R,10R)-2H,8H-benzo [1,2-b:3,4-b'] dipyran-8-one, 2-(4-hydroxyphenyl)-3,4,9,10-tetrahydro-3,5-dihydroxy-10-(3,4-dihydroxyphenyl)-(2R,3R,10S)-2H, 8H-benzo [1,2-b:3,4-b'] dipyran-8-one, 3,4-dihydro-7-hydroxy-4-(3,4-dihydroxyphenyl)-5-[(1E)-2-(4-hydroxyphenyl) ethenyl]-2H-1-benzopyran-2-one, 3,4-dihydro-7-hydroxy-4-(3,4-dihydroxy-phenyl)-5-[(1E)-2-(3,4-dihydroxyphenyl) ethenyl]-2H-1-benzopyran-2-one, 3,4-dihydro-7-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-5-[(1E)-2-(4-hydroxyphenyl) ethenyl]-2H-1-benzopyran-2-one, and 5,7,3',4'-tetrahydroxy-3-phenylcoumarin along with 34 known compounds were isolated and characterized as 19 flavonoids, 14 catechin derivatives, 6 stilbene derivatives, and 6 miscellaneous substances. All isolates had their estrogenic and anti-estrogenic activities determined using the estrogen-responsive human breast cancer cell lines MCF-7 and T47D. The major constituents were recognized as flavanonol rhamnosides by the suppressive effect on estradiol induced cell proliferation at a concentration of 1µM. Meanwhile, flavanonol rhamnoside acetates demonstrated estrogenic activity in both MCF-7 and T47D cells at a concentration of 100µM, and they enhanced the effects of co-treated E2 on T47D cell proliferation at concentrations of more than 0.1µM.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Antagonistas de Estrogênios/farmacologia
Estrogênios/farmacologia
Plantas Medicinais/química
Smilacaceae/química
[Mh] Termos MeSH secundário: Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Antagonistas de Estrogênios/química
Antagonistas de Estrogênios/isolamento & purificação
Estrogênios/química
Estrogênios/isolamento & purificação
Seres Humanos
Estrutura Molecular
Estereoisomerismo
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Estrogen Antagonists); 0 (Estrogens)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:110322
[Lr] Data última revisão:
110322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110215
[St] Status:MEDLINE
[do] DOI:10.1016/j.phytochem.2010.12.018


  9 / 14 MEDLINE  
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[PMID]:19898799
[Au] Autor:Nhiem NX; Van Kiem P; Minh CV; Ban NK; Cuong NX; Tai BH; Kim YH
[Ad] Endereço:Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi, Vietnam.
[Ti] Título:Phenylpropanoid glycosides from Heterosmilax erythrantha and their antioxidant activity.
[So] Source:Arch Pharm Res;32(10):1373-7, 2009 Oct.
[Is] ISSN:0253-6269
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:By various chromatographic methods, one new phenylpropanoid glycoside, heterosmilaside (1), two known phenylpropanoid glycosides, helonioside B (2), and 2',6'-diacetyl-3,6-diferuloyl sucrose (3), and three known flavonoids, isoquercetin (4), quercetin-3-O-beta-D-glucuronopyranoside (5), and quercetin-3-O-(2''-alpha-L-rhamnopyranosyl)-beta-D-glucuronopyranoside (6) were isolated from the methanolic extract of the aerial part of Heterosmilax erythrantha Baill. Their structures were elucidated on the basis of spectroscopic analyses. All the isolated compounds were tested for antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 5 and 6 showed significant antioxidant activity with SC(50) values of 3.7 and 6.5 microg/mL, respectively.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Glicosídeos/farmacologia
Propanóis/química
Smilacaceae/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/química
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Glicosídeos/química
Glicosídeos/isolamento & purificação
Estrutura Molecular
Picratos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Glycosides); 0 (Picrates); 0 (Propanols); 0F897O3O4M (1-phenylpropanol); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1001
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091110
[St] Status:MEDLINE
[do] DOI:10.1007/s12272-009-2005-4


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[PMID]:19033282
[Au] Autor:Peruzzi L; Leitch IJ; Caparelli KF
[Ad] Endereço:Dipartimento di Biologia, Unità di Botanica Generale e Sistematica, Università di Pisa, Pisa, Italy. lperuzzi@biologia.unipi.it
[Ti] Título:Chromosome diversity and evolution in Liliaceae.
[So] Source:Ann Bot;103(3):459-75, 2009 Feb.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: There is an extensive literature on the diversity of karyotypes found in genera within Liliaceae, but there has been no attempt to analyse these data within a robust phylogenetic framework. In part this has been due to a lack of consensus on which genera comprise Liliaceae and the relationships between them. Recently, however, this changed with the proposal for a relatively broad circumscription of Liliaceae comprising 15 genera and an improved understanding of the evolutionary relationships between them. Thus there is now the opportunity to examine patterns and trends in chromosome evolution across the family as a whole. METHODS: Based on an extensive literature survey, karyo-morphometric features for 217 species belonging to all genera in Liliaceae sensu the APG (Angiosperm Phylogeny Group) were obtained. Included in the data set were basic chromosome number, ploidy, chromosome total haploid length (THL) and 13 different measures of karyotype asymmetry. In addition, genome size estimates for all species studied were inferred from THLs using a power regression model constructed from the data set. Trends in karyotype evolution were analysed by superimposing the karyological data onto a phylogenetic framework for Liliaceae. KEY RESULTS AND CONCLUSIONS: Combining the large amount of data enabled mean karyotypes to be produced, highlighting marked differences in karyotype structure between the 15 genera. Further differences were noted when various parameters for analysing karyotype asymmetry were assessed. By examining the effects of increasing genome size on karyotype asymmetry, it was shown that in many but not all (e.g. Fritillaria and all of Tulipeae) species, the additional DNA was added preferentially to the long arms of the shorter chromosomes rather than being distributed across the whole karyotype. This unequal pattern of DNA addition is novel, contrasting with the equal and proportional patterns of DNA increase previously reported. Overall, the large-scale analyses of karyotype features within a well-supported phylogenetic framework enabled the most likely patterns of chromosome evolution in Liliaceae to be reconstructed, highlighting diverse modes of karyotype evolution, even within this comparatively small monocot family.
[Mh] Termos MeSH primário: Cromossomos de Plantas/genética
Evolução Molecular
Variação Genética
Liliaceae/genética
[Mh] Termos MeSH secundário: Centrômero/genética
Análise por Conglomerados
Genoma de Planta/genética
Haploidia
Cariotipagem
Filogenia
Poliploidia
Análise de Regressão
Smilacaceae/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:0903
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081127
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcn230



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