Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.618.937.900.099 [Categoria DeCS]
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[PMID]:28800540
[Au] Autor:Cui Q; Wang LT; Liu JZ; Wang HM; Guo N; Gu CB; Fu YJ
[Ad] Endereço:Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, 150040 Harbin, PR China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, 150040 Harbin, PR China.
[Ti] Título:Rapid extraction of Amomum tsao-ko essential oil and determination of its chemical composition, antioxidant and antimicrobial activities.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1061-1062:364-371, 2017 Sep 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A simple, green and efficient extraction method named modified-solvent free microwave extraction (M-SFME) was employed for the extraction of essential oils (EOs) from Amomun tsao-ko. The process of M-SFME was optimized with the prominent preponderance of such higher extraction yield (1.13%) than those of solvent free microwave extraction (SFME, 0.91%) and hydrodistillation (HD, 0.84%) under the optimal parameters. Thirty-four volatile substances representing 95.4% were identified. The IC values of EOs determined by DPPH radical scavenging activity and ß-carotene/linoleic acid bleaching assay were 5.27 and 0.63mg/ml. Furthermore, the EOs exhibited moderate to potent broad-spectrum antimicrobial activity against all tested strains including five gram-positive and two gram-negative bacteria (MIC: 2.94-5.86mg/ml). In general, M-SFME is a potential and desirable alternative for the extraction of EOs from aromatic herbs, and the EOs obtained from A. tsao-ko can be explored as a potent natural antimicrobial and antioxidant preservative ingredient in food industry from the technological and economical points of view.
[Mh] Termos MeSH primário: Amomum/química
Anti-Infecciosos/análise
Anti-Infecciosos/isolamento & purificação
Antioxidantes/análise
Antioxidantes/isolamento & purificação
Óleos Voláteis/análise
Óleos Voláteis/isolamento & purificação
Extratos Vegetais/análise
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Bactérias/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE


  2 / 97 MEDLINE  
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[PMID]:27978472
[Au] Autor:Wang X; Chen H; Chang C; Jiang M; Wang X; Xu L
[Ad] Endereço:Inner Mongolia Key laboratory for the Natural Products Chemistry and Functional Molecular Synthesis, College of Chemistry and Chemical engineering, Inner Mongolia University for the Nationalities, Tongliao, 028000, China.
[Ti] Título:Study the therapeutic mechanism of Amomum compactum in gentamicin-induced acute kidney injury rat based on a back propagation neural network algorithm.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1040:81-88, 2017 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Acute kidney injury (AKI) is a major global public health problems, as it causes high morbidity and serious injury to renal function. However, the etiology for AKI is not very clear. In this study, a serum metabolite profile analysis was performed to identify potential biomarkers for gentamicin-induced AKI and to investigate the mechanism of action of Amomum compactum (AC) used for treatment. A metabonomics approach by ultra-performance liquid chromatography together with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was applied to perform the analysis. Back propagation (BP) neural network models were established for classifying data from the control, model, and AC-treated groups. Accuracy rate for classification was 91.7% in positive ion mode and 87.5% in negative ion mode. By orthogonal partial least squares discriminant analysis (OPLS-DA), 29 metabolites were identified as potential biomarkers of gentamicin-induced AKI. Most of them are related to phospholipid metabolism. After treatment with AC, the levels of sphingomyelin, sphingosine, phytosphingosine, and arachidonic acid were restored to normal. The results indicate that AC plays a protective role in rats with gentamicin-induced AKI via regulation of the phospholipid metabolic pathway. In this work, early biomarkers of AKI has been identified and underlying therapeutic mechanism of AC has been understood, therefore, AC can be further investigated and tested for clinical application.
[Mh] Termos MeSH primário: Lesão Renal Aguda/tratamento farmacológico
Lesão Renal Aguda/metabolismo
Amomum
Medicamentos de Ervas Chinesas/uso terapêutico
Rim/efeitos dos fármacos
Metabolômica/métodos
[Mh] Termos MeSH secundário: Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/patologia
Amomum/química
Animais
Antibacterianos
Biomarcadores/metabolismo
Cromatografia Líquida de Alta Pressão/métodos
Análise Discriminante
Modelos Animais de Doenças
Medicamentos de Ervas Chinesas/química
Gentamicinas
Rim/metabolismo
Rim/patologia
Masculino
Redes e Vias Metabólicas
Redes Neurais (Computação)
Fosfolipídeos/metabolismo
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biomarkers); 0 (Drugs, Chinese Herbal); 0 (Gentamicins); 0 (Phospholipids)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE


  3 / 97 MEDLINE  
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[PMID]:28852725
[Au] Autor:Lai YF; Chen LX; Chen YN; Zhao J; Leong F; Li XW; Yang Q; Li P; Hu H
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao.
[Ti] Título:SUSTAINABLE DEVELOPMENT OF A SYSTEMATIC INVESTIGATION ON THREE DIFFERENT PRODUCTION MODES.
[So] Source:Afr J Tradit Complement Altern Med;13(4):97-104, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: (A. ), called Chunsharen in Chinese, is widely used in treating gastrointestinal disease. Its clinical benefits have been confirmed by both and studies. Facing the shortage of wild , artificial cultivating and natural fostering have been practiced in recent years. Therefore, it would be wondered whether the three different types of A. Villosum are comparable or not, particularly the herbal qualities, technological challenges, ecological impacts and economic benefits. MATERIAL AND METHODS: In this study, we combined quality research by using GC-MS, and field investigation to provide a systematic assessment about the three types of from these four aspects. RESULTS: It found that the wild type had low output and was in an endangered situation. The artificial cultivation had larger agriculturing area with higher productivity, but faced the ecological challenges. Lastly, the natural fostering type generated the highest economic benefit and relatively low ecological impact. In addition, the natural fostering type had relatively better quality than the other types. CONCLUSION: Therefore, it suggests that natural fostering can be applied for long-term sustainable development of .
[Mh] Termos MeSH primário: Amomum/química
Medicamentos de Ervas Chinesas/química
[Mh] Termos MeSH secundário: Amomum/crescimento & desenvolvimento
Animais
China
Conservação dos Recursos Naturais
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i4.14


  4 / 97 MEDLINE  
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[PMID]:27452308
[Au] Autor:Zhang TT; Lu CL; Jiang JG
[Ad] Endereço:School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China.
[Ti] Título:Neuroprotective and Anti-Inflammatory Effects of Diphenylheptanes from the Fruits of Amomum tsaoko, a Chinese Spice.
[So] Source:Plant Foods Hum Nutr;71(4):450-453, 2016 Dec.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Two novel diphenylheptanes, 2,3- dihydro-2 - (4' - hydroxy-phenylethyl) - 6 - [(3″,4″ - dihydroxy-5" - methoxy) phenyl] -4 - pyrone (CG-A) and 4 - dihydro-2 - (4' - hydroxy-phenylmethyl) -6 - [(3",4″ - dihydroxy-5″ - methoxyphenyl) methylene]-pyran-3, 5 - dione (CG-B), were isolated from the dried fruits of Amomum tsaoko, a commercially important spice. This study was designed to investigate their protective effects against H O -induced nerve injury, using PC-12 cells to determine the cell cytotoxicity and cell viability. The inhibitory effect on (nitric oxide) NO production was also determined in (lipopolysaccharide) LPS-stimulated macrophage RAW 264.7 cells. The results showed that CG-A and CG-B displayed significant neuroprotective effect and exhibited anti-inflammatory activity in a dose-dependent manner. These findings suggest that CG-A and CG-B are very important nutritional ingredients responsible for the neuroprotective and anti-inflammatory health benefits of A. tsaoko.
[Mh] Termos MeSH primário: Amomum/química
Anti-Inflamatórios/farmacologia
Frutas/química
Heptanos/farmacologia
Fármacos Neuroprotetores/farmacologia
Especiarias/análise
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Catecóis/química
Catecóis/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Heptanos/química
Peróxido de Hidrogênio/toxicidade
Lipopolissacarídeos/toxicidade
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Fármacos Neuroprotetores/química
Óxido Nítrico/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Células PC12
Pironas/química
Pironas/farmacologia
Células RAW 264.7
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2,3-dihydro-2-(4'-hydroxyphenylethyl)-6-((3',4'- dihydroxy-5'-methoxy)phenyl)-4-pyrone); 0 (4-dihydro-2-(4'-hydroxyphenylmethyl)-6-((3',4'-dihydroxy-5'-methoxyphenyl)methylene)pyran-3,5-dione); 0 (Anti-Inflammatory Agents); 0 (Catechols); 0 (Heptanes); 0 (Lipopolysaccharides); 0 (Neuroprotective Agents); 0 (Pyrones); 31C4KY9ESH (Nitric Oxide); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE


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[PMID]:26610381
[Au] Autor:Kim MS; Ahn EK; Hong SS; Oh JS
[Ad] Endereço:Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan, 31116, Republic of Korea.
[Ti] Título:2,8-Decadiene-1,10-Diol Inhibits Lipopolysaccharide-Induced Inflammatory Responses Through Inactivation of Mitogen-Activated Protein Kinase and Nuclear Factor-κB Signaling Pathway.
[So] Source:Inflammation;39(2):583-91, 2016 Apr.
[Is] ISSN:1573-2576
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Amomum tsao-ko (A. tsao-ko) has been used as a traditional medicine for the treatment of infectious and digestive disorders. In the present study, we report the anti-inflammatory activity and molecular mechanism of 2,8-decadiene-1,10-diol (DDO) isolated from the extract of A. tsao-ko in lipopolysaccharide-stimulated RAW 264.7 cells. DDO treatment inhibited the production of nitric oxide and prostaglandin E2 by downregulating inducible nitric oxide synthase and cyclooxygenase-2 expression, respectively. Moreover, DDO suppressed the production of pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-α. These inhibitory effects of DDO on the expression of inflammatory proteins were found to be mediated through the inactivation of mitogen-activated protein kinases (MAPKs) such as extracellular signal-regulated kinase, c-Jun-N-terminal kinase and p38(MAPK), and inhibition of nuclear factor-κB (NF-κB) pathways including degradation of inhibitor of κB-α and nuclear localization of NF-κB. Taken together, these findings demonstrate the pharmacological roles and molecular mechanisms of DDO in regulating inflammatory responses, and suggest further evaluation and development of DDO as a potent therapeutic agent for the treatment of inflammatory disorders.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Álcoois Graxos/farmacologia
Inflamação/tratamento farmacológico
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Inibidor de NF-kappaB alfa/metabolismo
NF-kappa B/antagonistas & inibidores
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Mh] Termos MeSH secundário: Amomum/metabolismo
Animais
Linhagem Celular Transformada
Ciclo-Oxigenase 2/biossíntese
Dinoprostona/biossíntese
Regulação para Baixo/efeitos dos fármacos
Inflamação/patologia
Interleucina-6/biossíntese
Lipopolissacarídeos
Medicina Tradicional Coreana
Camundongos
NF-kappa B/metabolismo
Óxido Nítrico/biossíntese
Óxido Nítrico Sintase Tipo II/biossíntese
Extratos Vegetais/farmacologia
Células RAW 264.7
Fator de Necrose Tumoral alfa/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2,8-decadiene-1,10-diol); 0 (Anti-Inflammatory Agents); 0 (Fatty Alcohols); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 139874-52-5 (NF-KappaB Inhibitor alpha); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.99.- (Ptgs2 protein, mouse); EC 1.14.99.1 (Cyclooxygenase 2); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151128
[St] Status:MEDLINE
[do] DOI:10.1007/s10753-015-0283-1


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[PMID]:26518036
[Au] Autor:Ghosh A; Das A; Vijayanandraj S; Mandal B
[Ad] Endereço:Indian Agricultural Research Institute, Regional Station, Kalimpong 734 301, West Bengal, India (amal4ento@gmail.com; amritapatho@gmail.com).
[Ti] Título:Cardamom Bushy Dwarf Virus Infection in Large Cardamom Alters Plant Selection Preference, Life Stages, and Fecundity of Aphid Vector, Micromyzus kalimpongensis (Hemiptera: Aphididae).
[So] Source:Environ Entomol;45(1):178-84, 2016 Feb.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cardamom bushy dwarf virus (CBDV) causes foorkey disease of large cardamom (Ammomum subulatum Roxburgh) in the eastern sub-Himalayan mountains. Although the aphid Micromyzus kalimpongensis Basu (Hemiptera: Aphididae) is known as a vector of CBDV, its behavior in dissemination of CBDV has not been investigated. In the present study, M. kalimpongensis was observed to colonize in higher number on CBDV-infected large cardamom plants compared with the healthy plants in the several plantations in Sikkim and Darjeeling hills. The affinity of M. kalimpongensis to the diseased large cardamom plants was further confirmed in a contained field experiment with intact plant as well as in a laboratory bioassay with the plant extract, where significantly higher number of aphids settled on the diseased plants or extracts compared with the healthy counterparts. Aphids grown on CBDV-infected large cardamom plants had shortened nymphal period and increased longevity and fecundity compared with those grown on the healthy plants. In the contained field experiment, M. kalimpongensis migrated to the CBDV-infected plants, colonized there, acquired CBDV, and once the diseased plants withered, migrated to healthy plants, which eventually became diseased. Our results suggest a general pattern of spread of CBDV by M. kalimpongensis where CBDV-infected plants attract or arrest and stimulate emergence and migration of viruliferous aphids that otherwise are sedentary in the underground plant parts of large cardamom. To our knowledge, this is the first study that shows the influence of a plant virus from the family Nanoviridae in altering behavior of its insect vector that favors its dissemination.
[Mh] Termos MeSH primário: Amomum/virologia
Afídeos/virologia
Babuvirus/fisiologia
Insetos Vetores/virologia
Doenças das Plantas/virologia
[Mh] Termos MeSH secundário: Animais
Afídeos/crescimento & desenvolvimento
Afídeos/fisiologia
Comportamento Alimentar
Índia
Insetos Vetores/crescimento & desenvolvimento
Insetos Vetores/fisiologia
Ninfa/crescimento & desenvolvimento
Ninfa/fisiologia
Ninfa/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151101
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvv161


  7 / 97 MEDLINE  
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[PMID]:25963227
[Au] Autor:Dai M; Peng C; Peng F; Xie C; Wang P; Sun F
[Ad] Endereço:a School of Medical Laboratory Science, Chengdu Medical College , Chengdu , Sichuan , PR China .
[Ti] Título:Anti-Trichomonas vaginalis properties of the oil of Amomum tsao-ko and its major component, geraniol.
[So] Source:Pharm Biol;54(3):445-50, 2016.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Trichomonosis, caused by the flagellate protozoan Trichomonas vaginalis, is the most common non-viral sexually transmitted disease (STD) and 5-nitroimidazole drugs are used for the treatment. However, a growing number of T. vaginalis isolates are resistant to these drugs, which make it becomes an urgent issue. OBJECTIVE: The current study was designed to evaluate the anti-T. vaginalis activity of the essential oil from A. tsao-ko used in traditional Chinese medicine and as a spice and its main component, geraniol. MATERIALS AND METHODS: The anti-T. vaginalis activities of A. tsao-ko essential oil and geraniol were evaluated by the minimum lethal concentration (MLC) and 50% inhibitory concentration (IC50) in vitro. The morphological changes of T. vaginalis were observed by transmission electron microscopy (TEM). Additionally, sub-MLC concentration treatment with sub-MLC A. tsao-ko essential oil and geraniol was also performed. RESULTS: This study shows that MLC/IC50 of A. tsao-ko essential oil was 44.97 µg/ml/22.49 µg/ml for T. vaginalis isolate Tv1, and 89.93 µg/ml/44.97 µg/ml for T. vaginalis isolate Tv2. Those of geraniol were 342.96 µg/ml/171.48 µg/ml, respectively. After A. tsao-ko essential oil or geraniol treatment, obvious similar morphological changes of T. vaginalis were observed by TEM: the nuclear membrane was damaged, nuclei were dissolved, and the chromatin was accumulated; in the cytoplasm, numerous vacuoles appeared, rough endoplasmic reticulum dilated, the number of ribosomes were reduced, organelles disintegrated, the cell membrane was partially damaged, with cytoplasmic leakage, and cell disintegration was observed. The action time did not increase the effect of A. tsao-ko essential oil or geraniol against T. vaginalis, as no significant difference was observed after sub-MLC concentration treatment for 1, 3, and 5 h with A. tsao-ko essential oil and geraniol. DISCUSSION AND CONCLUSION: The study describes the first report on the activity and morphological changes of A. tsao-ko essential oil and geraniol against T. vaginalis. The results obtained herein presented new opportunities for antitrichomonal drugs.
[Mh] Termos MeSH primário: Amomum
Antiprotozoários/farmacologia
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
Terpenos/farmacologia
Trichomonas vaginalis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antiprotozoários/isolamento & purificação
Feminino
Seres Humanos
Testes de Sensibilidade Microbiana/métodos
Óleos Voláteis/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Trichomonas vaginalis/isolamento & purificação
Trichomonas vaginalis/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Terpenes); L837108USY (geraniol)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150513
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1044617


  8 / 97 MEDLINE  
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[PMID]:27356373
[Au] Autor:Peng JM; Wang YF; Zhang LX; Li RY; Ma XJ
[Ti] Título:[A New Pest of Amomum villosum in Xishuangbanna].
[So] Source:Zhong Yao Cai;38(11):2255-6, 2015 Nov.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To report a new pest of Amomum villosum and its distribution, occurrence regularity and damage situation, in order to provide reference for its control. METHODS: Reared the pest larvae, observed the morphological characters, and made a preliminary investigation on its distribution, occurrence regularity and damage situation. RESULTS: Through macroscopic examination, the pest was identified as Anisodera rugulosa, which distributed in the main producing areas of Amomum villosum in Xishuangbanna, the pest larvae ate the inside of Amomum villosum fruit, which made the fruit formed holes, more seriously, it made the whole fruit rot black. CONCLUSION: The pest causes the fruit yield reduction of Amomum villosum. Pest control work needs to be carry out as soon as possible.
[Mh] Termos MeSH primário: Amomum
Frutas
Insetos
[Mh] Termos MeSH secundário: Animais
Larva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE


  9 / 97 MEDLINE  
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[PMID]:26852687
[Au] Autor:Shin JS; Ryu S; Jang DS; Cho YW; Chung EK; Lee KT
[Ad] Endereço:Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Korea.
[Ti] Título:Amomum tsao-ko fruit extract suppresses lipopolysaccharide-induced inducible nitric oxide synthase by inducing heme oxygenase-1 in macrophages and in septic mice.
[So] Source:Int J Exp Pathol;96(6):395-405, 2015 Dec.
[Is] ISSN:1365-2613
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Amomum tsao-ko Crevost et Lemarié (Zingiberaceae) has traditionally been used to treat inflammatory and infectious diseases, such as throat infections, malaria, abdominal pain and diarrhoea. This study was designed to assess the anti-inflammatory effects and the molecular mechanisms of the methanol extract of A. tsao-ko (AOM) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and in a murine model of sepsis. In LPS-induced RAW 264.7 macrophages, AOM reduced the production of nitric oxide (NO) by inhibiting inducible nitric oxide synthase (iNOS) expression, and increased heme oxygenase-1 (HO-1) expression at the protein and mRNA levels. Pretreatment with SnPP (a selective inhibitor of HO-1) and silencing HO-1 using siRNA prevented the AOM-mediated inhibition of NO production and iNOS expression. Furthermore, AOM increased the expression and nuclear accumulation of NF-E2-related factor 2 (Nrf2), which enhanced Nrf2 binding to antioxidant response element (ARE). In addition, AOM induced the phosphorylation of extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) and generated reactive oxygen species (ROS). Furthermore, pretreatment with N-acetyl-l-cysteine (NAC; a ROS scavenger) diminished the AOM-induced phosphorylation of ERK and JNK and AOM-induced HO-1 expression, suggesting that ERK and JNK are downstream mediators of ROS during the AOM-induced signalling of HO-1 expression. In LPS-induced endotoxaemic mice, pretreatment with AOM reduced NO serum levels and liver iNOS expression and increased HO-1 expression and survival rates. These results indicate that AOM strongly inhibits LPS-induced NO production by activating the ROS/MAPKs/Nrf2-mediated HO-1 signalling pathway, and supports its pharmacological effects on inflammatory diseases.
[Mh] Termos MeSH primário: Amomum
Anti-Inflamatórios/farmacologia
Heme Oxigenase-1/biossíntese
Lipopolissacarídeos
Macrófagos/efeitos dos fármacos
Proteínas de Membrana/biossíntese
Óxido Nítrico Sintase Tipo II/biossíntese
Extratos Vegetais/farmacologia
Sepse/tratamento farmacológico
[Mh] Termos MeSH secundário: Amomum/química
Animais
Anti-Inflamatórios/isolamento & purificação
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Indução Enzimática
Inibidores Enzimáticos/farmacologia
MAP Quinases Reguladas por Sinal Extracelular/antagonistas & inibidores
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Frutas
Heme Oxigenase-1/antagonistas & inibidores
Heme Oxigenase-1/genética
Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Macrófagos/enzimologia
Masculino
Proteínas de Membrana/antagonistas & inibidores
Proteínas de Membrana/genética
Camundongos
Camundongos Endogâmicos C57BL
Fator 2 Relacionado a NF-E2/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Células RAW 264.7
Interferência de RNA
RNA Mensageiro/biossíntese
Espécies Reativas de Oxigênio/metabolismo
Sepse/induzido quimicamente
Sepse/enzimologia
Sepse/genética
Transdução de Sinais/efeitos dos fármacos
Fatores de Tempo
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Enzyme Inhibitors); 0 (Lipopolysaccharides); 0 (Membrane Proteins); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161201
[Lr] Data última revisão:
161201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160209
[St] Status:MEDLINE
[do] DOI:10.1111/iep.12159


  10 / 97 MEDLINE  
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Fotocópia
[PMID]:26749844
[Au] Autor:Wang C; Su W; Su X; Ni G; Liu T; Kong Y
[Ti] Título:Synergy Effects of Three Plant Extracts on Protection of Gastric Mucosa.
[So] Source:Nat Prod Commun;10(11):1989-91, 2015 Nov.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The gastric mucosa protection effect of three natural plant extracts, Hericium erinaceus (HE), Centella asiatica (CA) and Amomum villosum (AV), were evaluated using the indomethacin damage model. Compared with a single extract, a combination of HE/CA/AV, especially with the ratios of 80:10:10, 45:45:10 and 45:10:45, showed significant synergistic effects for protection of the gastric mucosa with gastric ulcer inhibition rates of 97.8 ± 0.7%, 86.5 ± 2.8% and 86.1 ± 3.6%, respectively. Microscopic appearances of the gastric mucosa were carried out to help confirm the results.
[Mh] Termos MeSH primário: Amomum/química
Antiulcerosos/administração & dosagem
Basidiomycota/química
Centella/química
Mucosa Gástrica/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Úlcera Gástrica/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Sinergismo Farmacológico
Quimioterapia Combinada
Mucosa Gástrica/patologia
Seres Humanos
Masculino
Fitoterapia
Ratos
Ratos Sprague-Dawley
Úlcera Gástrica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:160111
[Lr] Data última revisão:
160111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160112
[St] Status:MEDLINE



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