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Pesquisa : B01.650.940.800.575.912.250.618.937.900.333 [Categoria DeCS]
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[PMID]:29343256
[Au] Autor:Aghasi M; Ghazi-Zahedi S; Koohdani F; Siassi F; Nasli-Esfahani E; Keshavarz A; Qorbani M; Khoshamal H; Salari-Moghaddam A; Sotoudeh G
[Ad] Endereço:Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial.
[So] Source:BMC Complement Altern Med;18(1):18, 2018 Jan 17.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. This study was planned to determine the effects of green cardamom on blood glucose, lipids and oxidative stress status in type 2 diabetic patients. METHODS/DESIGN: Eighty overweight or obese patients with type 2 diabetes will be selected. They will be randomly assigned to receive 3 g/d green cardamom or placebo for 10 weeks. The socio demographic, physical activity and 24-h food recall questionnaires will be collected for each subject. Weight, height and waist circumference will be measured. Determination of blood glucose, lipid profile, and oxidative stress biomarkers including serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), and glutathione peroxidase (GPx) and superoxide dismutase (SOD) in red blood cells will be performed. The homeostasis model assessment-estimated insulin resistance (HOMA-IR) index and the quantitative insulin-sensitivity check index (QUICKI) will be calculated. Also, serum levels of irisin, and Sirtuin1 (SIRT1) will be measured. DISCUSSION: This trial will be the first study to explore the effects of green cardamom supplementation on glycemic control, lipid profile and oxidative stress in patients with type 2 diabetes mellitus. The results from this trial will provide evidence on the efficacy of green cardamom in type 2 diabetes mellitus. TRIAL REGISTRATION NUMBER: ( http://www.irct.ir , identifier: IRCT2016042717254N5), Registration date: 23.11.2016.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/tratamento farmacológico
Elettaria/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Glicemia/efeitos dos fármacos
Registros de Dieta
Seres Humanos
Lipídeos/sangue
Meia-Idade
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Sirtuína 1/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Lipids); 0 (Plant Extracts); EC 3.5.1.- (Sirtuin 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2068-6


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[PMID]:28468697
[Au] Autor:Jadhav M; Thekkumpurath AS; Nakade M; Gadgil M; Oulkar D; Arimboor R; Ramakrishna M; Banerjee K
[Ad] Endereço:Indian Council of Agricultural Research, National Research Centre for Grapes, National Referral Laboratory, PO Manjri Farm, Pune 412 307, Maharashtra, India.
[Ti] Título:Multiresidue Method for Targeted Screening of Pesticide Residues in Spice Cardamom ( ) by Liquid Chromatography with Tandem Mass Spectrometry.
[So] Source:J AOAC Int;100(3):603-609, 2017 May 01.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A QuEChERS technique-based sample preparation method was optimized and validated in small cardamom to monitor the residues of 154 pesticides by LC with tandem MS. The proposed multiresidue method involved soaking powdered cardamom (2 g) in water (8 mL) for 30 min, followed by extraction with acetonitrile (10 mL). Cleanup by dispersive SPE was performed using primary secondary amine (25 mg/mL), C18 (25 mg/mL), and anhydrous magnesium sulfate (150 mg/mL). The method was validated as per the SANTE/11945/2015 guidelines at 5, 10, 50, and 100 ng/g spiking levels, and most of the analytes showed recoveries between 70 and 120% (with RSDs ≤20%). The LOQ of ≤10 ng/g was achieved for almost 90% of the target pesticides. The measurement uncertainties were evaluated at 100 ng/g, and the global uncertainty values were below 22% for all the analytes.
[Mh] Termos MeSH primário: Elettaria/química
Contaminação de Alimentos/análise
Resíduos de Praguicidas/análise
Especiarias/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida
Extração em Fase Sólida
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticide Residues)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.17-0061


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[PMID]:28701653
[Au] Autor:Asakawa Y; Ludwiczuk A; Sakurai K; Tomiyama K; Kawakami Y; Yaguchi Y
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
[Ti] Título:Comparative Study on Volatile Compounds of Alpinia japonica and Elettaria cardamomum.
[So] Source:J Oleo Sci;66(8):871-876, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The volatile compounds obtained from the ether extracts, headspace gases and steam distillates of Alpinia japonica and Elettaria cardamomum were analyzed by GC/MS. Both species were rich sources of naturally rare fenchane-type monoterpenoids, fenchene, fenchone, fenchyl alcohol and its acetate, together with 1,8-cineole. The distributions of volatile sesquiterpenoids were very poor in both species. Chiralities of fenchone in A. japonica and E. cardamomum were 99% of (1S,4R)-(+)-form. Camphor in A. japonica is composed of a mixture of (1R,4R)-(+)-form (94.3%) and (1S,4S)-(-)-form (5.7%). On the other hand, E. cardamomum produced only (1R,4R)-(+)-camphor (99%).
[Mh] Termos MeSH primário: Alpinia/química
Elettaria/química
Monoterpenos/análise
Extratos Vegetais/química
Sesquiterpenos/análise
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Cânfora/análise
Cicloexanóis/análise
Éter
Cromatografia Gasosa-Espectrometria de Massas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexanols); 0 (Monoterpenes); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Volatile Organic Compounds); 0F5N573A2Y (Ether); 76-22-2 (Camphor); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17048


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[PMID]:28073098
[Au] Autor:Masoumi-Ardakani Y; Mahmoudvand H; Mirzaei A; Esmaeilpour K; Ghazvini H; Khalifeh S; Sepehri G
[Ad] Endereço:Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
[Ti] Título:The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder.
[So] Source:Biomed Pharmacother;87:489-495, 2017 Mar.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition which develops in 6-8% of the general population. Current standard pharmacological treatments for PTSD cannot be widely used due to having various side effects. Nowadays, various pharmacological properties have been related to Elettaria cardamomum L. (family of Zingiberaceae). The present study aims to evaluate the efficacy of E. cardamomum methanolic extract on anxiety-like behavior in a rat model of PTSD. Adult male Wistar rats (200-250gr) were used in this study. The rats underwent single prolonged stress (SPS) or control and intraperitoneally received either saline or different dosages (200, 400, and 800mg/kg) of E. cardamomum methanolic extract before and after stress sessions. Moreover, open field, elevated plus-maze, and rotarod tests were used to evaluate locomotion and anxiety-like behavior in the rats. Findings demonstrated that E. Cardamomum methanolic extract, particularly at the dose of 400mg/kg, significantly (P<0.05) improved anxiety-like behavior in a rat model of PTSD, as examined by the open field, elevated plus-maze, and rotarod tests. Administration of E. cardamomum methanolic extract after stress might help to prevent the formation of anxiety-like behavior in the animals. However, further studies are requiredto clarify the exact mechanisms involved.
[Mh] Termos MeSH primário: Ansiedade/tratamento farmacológico
Elettaria/química
Extratos Vegetais/farmacologia
Transtornos de Estresse Pós-Traumáticos/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Locomoção/efeitos dos fármacos
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE


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[PMID]:28487896
[Au] Autor:Al-Haidari RA; Shaaban MI; Ibrahim SRM; Mohamed GA
[Ad] Endereço:Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia.
[Ti] Título:ANTI-QUORUM SENSING ACTIVITY OF SOME MEDICINAL PLANTS.
[So] Source:Afr J Tradit Complement Altern Med;13(5):67-71, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Quorum sensing is the key regulator of virulence factors of such as biofilm formation, motility, productions of proteases, hemolysin, pyocyanin, and toxins. The aim of this study was to explore the effect of the extracts from some medicinal plants on quorum sensing and related virulence factors of . MATERIAL AND METHODS: Quorum sensing inhibitory (OSI) effect of the alcohol extracts of 20 medicinal plants was evaluated by reporter using agar cup diffusion method. The efficient QSI extracts were tested for their activity against biofilm synthesis, motility, and synthesis of pyocyanin from PA14. RESULTS: The extracts of , and exhibited potent quorum quenching effect. On the other hand, and extracts showed lower QSI activity. These extracts exhibited significant elimination of pyocyanin formation and biofilm development of PA14. In addition, they significantly inhibited twitching and swimming motilities of PA14. CONCLUSION: This study illustrated, for the first time, the importance of , and as quorum sensing inhibitors and virulence suppressors of . Thus, these plants could provide a natural source for the elimination of pathogenesis.
[Mh] Termos MeSH primário: Magnoliopsida/química
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Pseudomonas aeruginosa/efeitos dos fármacos
Percepção de Quorum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Camellia sinensis/química
Chromobacterium/patogenicidade
Coriandrum/química
Elettaria/química
Laurus/química
Cebolas/química
Pseudomonas aeruginosa/patogenicidade
Fatores de Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Virulence Factors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i5.10


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[PMID]:27558433
[Au] Autor:Lee YG; Park JH; Jeon ES; Kim JH; Lim BK
[Ad] Endereço:Department of Biomedical Science, Jungwon University, Goesan 28024, Republic of Korea.
[Ti] Título: Extract Inhibit Coxsackievirus-B3 Induced Myocarditis in Murine Myocarditis Model.
[So] Source:J Microbiol Biotechnol;26(11):2012-2018, 2016 Nov 28.
[Is] ISSN:1738-8872
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Coxsackievirus B3 (CVB3) is the main cause of acute myocarditis and dilated cardiomyopathy. Plant extracts are considered as useful materials to develop new antiviral drugs. We had previously selected candidate plant extracts, which showed anti-inflammatory effects. We examined the antiviral effects by using a HeLa cell survival assay. Among these extracts, we chose the ( ) extract, which showed strong antiviral effect and preserved cell survival in CVB3 infection. We investigated the mechanisms underlying the ability of extract to inhibit CVB3 infection and replication. HeLa cells were infected by CVB3 with or without extract. Erk and Akt activities, and their correlation with virus replication were observed. Live virus titers in cell supernatants and viral positive- and negative-strand RNA amplification were measured. extract significantly increased HeLa cell survival in different concentrations (100-10 µg/ml). CVB3 capsid protein VP1 expression (76%) and viral protease 2A-induced eIF4G1 cleavage (70%) were significantly decreased in extract (100 µg/ml) treated cells. The levels of positive- (20%) and negative-strand (80%) RNA were dramatically decreased compared with the control, as revealed by reverse transcription-PCR. In addition, extract improved mice survival (51% vs 26%) and dramatically reduced heart inflammation in a CVB3-induced myocarditis mouse model. These results suggested that extract significantly inhibited replication and myocarditis damage. may be developed as a therapeutic drug for .
[Mh] Termos MeSH primário: Antivirais/administração & dosagem
Infecções por Coxsackievirus/tratamento farmacológico
Elettaria/química
Enterovirus Humano B/efeitos dos fármacos
Miocardite/tratamento farmacológico
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Infecções por Coxsackievirus/virologia
Modelos Animais de Doenças
Enterovirus Humano B/fisiologia
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Miocardite/virologia
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE
[do] DOI:10.4014/jmb.1605.05056


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[PMID]:27433883
[Au] Autor:Masoumi-Ardakani Y; Mandegary A; Esmaeilpour K; Najafipour H; Sharififar F; Pakravanan M; Ghazvini H
[Ad] Endereço:Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
[Ti] Título:Chemical Composition, Anticonvulsant Activity, and Toxicity of Essential Oil and Methanolic Extract of Elettaria cardamomum.
[So] Source:Planta Med;82(17):1482-1486, 2016 Nov.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:is an aromatic spice (cardamom) native to the humid Asian areas, which contains some compounds with a potential anticonvulsant activity. Various pharmacological properties such as anti-inflammatory, analgesic, antioxidant, and antimicrobial effects have been related to this plant. This research was conducted to examine the probable protective impact of the essential oil and methanolic extract of against chemically (pentylentetrazole)- and electrically (maximal electroshock)-induced seizures in mice. In addition, neurotoxicity, acute lethality, and phytochemistry of the essential oil and methanolic extract were estimated. The TLC method showed the presence of kaempferol, rutin, and quercetin in the extract, and the concentration of quercetin in the extract was 0.5 µg/mL. The major compounds in the essential oil were 1,8-cineole (45.6 %), -terpinyl acetate (33.7 %), sabinene (3.8 %), 4-terpinen-4-ol (2.4 %), and myrcene (2.2 %), respectively. The extract and essential oil showed significant neurotoxicity in the rotarod test at the doses of 1.5 g/kg and 0.75 mL/kg, respectively. No mortalities were observed up to the doses of 2 g/kg and 0.75 mL/kg for the extract and essential oil. The essential oil was effective in both the pentylentetrazole and maximal electroshock models; however, the extract was only effective in the pentylentetrazole model. The study suggested that methanolic extract had no significant lethality in mice. Both the essential oil and methanolic extract showed movement toxicity. Anticonvulsant effects of were negligible against the seizures induced by pentylentetrazole and maximal electroshock.
[Mh] Termos MeSH primário: Anticonvulsivantes/farmacologia
Elettaria/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alcenos/análise
Animais
Cicloexanóis/análise
Eletrochoque/efeitos adversos
Masculino
Metanol
Camundongos Endogâmicos
Monoterpenos/análise
Óleos Voláteis/toxicidade
Pentilenotetrazol/toxicidade
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Convulsões/induzido quimicamente
Convulsões/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Anticonvulsants); 0 (Cyclohexanols); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 3M39CZS25B (myrcene); 7D1TL44GPC (sabinene); RV6J6604TK (eucalyptol); WM5Z385K7T (Pentylenetetrazole); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE


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[PMID]:27246748
[Au] Autor:Lim DW; Kim H; Park JY; Kim JE; Moon JY; Park SD; Park WH
[Ad] Endereço:Department of Pathology, College of Korean Medicine, Dongguk University, Dongguk-Ro 32, Goyang, 10326, Republic of Korea.
[Ti] Título:Amomum cardamomum L. ethyl acetate fraction protects against carbon tetrachloride-induced liver injury via an antioxidant mechanism in rats.
[So] Source:BMC Complement Altern Med;16:155, 2016 May 31.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Medicinal herb-derived drug development has become important in the relief of liver pathology. Amomun cardamomum is traditionally used therapeutically in Korea to treat various human ailments including dyspepsia, hiccupping, and vomiting. We investigated to assess the protective effect of A. cardamomum on carbon tetrachloride (CCl4)-induced liver damage through antioxidant activity in hepatic tissues of Sprague-Dawley rats. METHODS: Antioxidant properties of different fractions from A. cardamomum from ethanol extracts were evaluated by an in vitro free radical scavenging systems. The protective effect of the ethyl acetate fraction from A. cardamomum (EAAC) against CCl4-induced cytotoxicity was determined by a cell viability assay using HepG2 hepatocarcinoma cells. In vivo study, the influence of EAAC concentrations of 100 and 200 mg/kg following CCl4-induced hepatic injury was assessed. Serum levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and alkaline phosphatase (ALP) were determined, as was lipid peroxidation (malondialdehyde, MDA). Effect of EAAC on liver detoxification enzymes including superoxide dismutase (SOD), total glutathione (GSH), and glutathione S-transferase (GST) activity was measured in rat liver homogenates. Liver cytochrome P450 (CYP2E1) expression level was determined by quantification of mRNA. RESULTS: Phytochemical analysis of A. cardamomum indicated that EAAC was enriched in total polyphenol and total flavonoid. Most of the tannins were confined to the hexane fraction. Hepatoprotective properties of EAAC were evident, with significantly reduced serum levels of GOT, GPT, and ALP compared with the control group. Improved hepatic antioxidant status was evident by increased SOD, GSH, and GST enzymes in rat liver tissue. Liver lipid peroxidation induced by CCl4 was apparent by increased intracellular MDA level. EAAC suppressed lipid peroxidation as evidenced by the significant decrease in MDA production. Expression of CYP2E1 was also significantly decreased at the higher concentration of EAAC, indicating the hepatoprotective efficacy of EAAC on acute liver damage. CONCLUSION: These results indicated that EAAC has a significant hepatoprotective activity on CCl4-induced acute hepatic injury in rats, which might be derived from its antioxidant properties and CYP2E1 downregulation.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Elettaria/química
Fígado/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetatos
Animais
Tetracloreto de Carbono
Citocromo P-450 CYP2E1/biossíntese
Células Hep G2
Seres Humanos
Lipídeos
Fígado/enzimologia
Masculino
Ratos
Ratos Sprague-Dawley
República da Coreia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Antioxidants); 0 (Lipids); 0 (Plant Extracts); 76845O8NMZ (ethyl acetate); CL2T97X0V0 (Carbon Tetrachloride); EC 1.14.13.- (Cytochrome P-450 CYP2E1)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1121-1


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[PMID]:26925555
[Au] Autor:Omar J; Olivares M; Alonso I; Vallejo A; Aizpurua-Olaizola O; Etxebarria N
[Ad] Endereço:Dept. of Analytical Chemistry, Faculty of Science and Technology, Univ. of the Basque Country (UPV-EHU), P.O. Box 644, Bilbao, 48080, Basque Country, Spain.
[Ti] Título:Quantitative Analysis of Bioactive Compounds from Aromatic Plants by Means of Dynamic Headspace Extraction and Multiple Headspace Extraction-Gas Chromatography-Mass Spectrometry.
[So] Source:J Food Sci;81(4):C867-73, 2016 Apr.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seven monoterpenes in 4 aromatic plants (sage, cardamom, lavender, and rosemary) were quantified in liquid extracts and directly in solid samples by means of dynamic headspace-gas chromatography-mass spectrometry (DHS-GC-MS) and multiple headspace extraction-gas chromatography-mass spectrometry (MHSE), respectively. The monoterpenes were 1st extracted by means of supercritical fluid extraction (SFE) and analyzed by an optimized DHS-GC-MS. The optimization of the dynamic extraction step and the desorption/cryo-focusing step were tackled independently by experimental design assays. The best working conditions were set at 30 °C for the incubation temperature, 5 min of incubation time, and 40 mL of purge volume for the dynamic extraction step of these bioactive molecules. The conditions of the desorption/cryo-trapping step from the Tenax TA trap were set at follows: the temperature was increased from 30 to 300 °C at 150 °C/min, although the cryo-trapping was maintained at -70 °C. In order to estimate the efficiency of the SFE process, the analysis of monoterpenes in the 4 aromatic plants was directly carried out by means of MHSE because it did not require any sample preparation. Good linearity (r2) > 0.99) and reproducibility (relative standard deviation % <12) was obtained for solid and liquid quantification approaches, in the ranges of 0.5 to 200 ng and 10 to 500 ng/mL, respectively. The developed methods were applied to analyze the concentration of 7 monoterpenes in aromatic plants obtaining concentrations in the range of 2 to 6000 ng/g and 0.25 to 110 µg/mg, respectively.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Magnoliopsida/química
Monoterpenos/análise
Óleos Voláteis/análise
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Cromatografia com Fluido Supercrítico/métodos
Elettaria/química
Lavandula/química
Reprodutibilidade dos Testes
Rosmarinus/química
Salvia/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160302
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13257


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[PMID]:26758574
[Au] Autor:Azimi P; Ghiasvand R; Feizi A; Hosseinzadeh J; Bahreynian M; Hariri M; Khosravi-Boroujeni H
[Ad] Endereço:a Food Security Research Center ;
[Ti] Título:Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial.
[So] Source:Blood Press;25(3):133-40, 2016 Jun.
[Is] ISSN:1651-1999
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Herbal medicines with high amounts of phytochemicals have been shown to have beneficial effects on blood pressure (BP), endothelial function and anthropometric measures. This study aimed to determine the effect of herbal treatment on BP, endothelial function and anthropometric measures in patients with type 2 diabetes mellitus (T2DM). This clinical trial included 204 T2DM patients randomly assigned to four intervention groups receiving 3 g cinnamon, 3 g cardamom, 1 g saffron or 3 g ginger with three glasses of black tea, and one control group consuming only three glasses of tea without any herbals, for 8 weeks. Intercellular adhesion molecule-1 (ICAM-1), systolic and diastolic BP and anthropometric measures were collected at baseline and after 8 weeks. No significant difference was found between various medicinal plants in terms of influencing BP, serum soluble (s)ICAM-1 concentrations and anthropometric measures. However, in within-group comparison saffron and ginger intakes significantly reduced sICAM-1 concentrations (340.9 ± 14.4 vs 339.69 ± 14.4 ng/ml, p = 0.01, and 391.78 ± 16.0 vs 390.97 ± 15.8 ng/ml, p = 0.009, respectively) and ginger intake affected systolic BP (143.06 ± 0.2 vs 142.07 ± 0.2 mmHg, p = 0.02). Although administration of these herbal medicines as supplementary remedies could affect BP and sICAM-1 concentrations, there was no significant difference between the plants in terms of influencing anthropometric measures, BP and endothelial function.
[Mh] Termos MeSH primário: Pressão Sanguínea
Cinnamomum zeylanicum
Crocus
Diabetes Mellitus Tipo 2/terapia
Elettaria
Alimento Funcional
Gengibre
[Mh] Termos MeSH secundário: Determinação da Pressão Arterial
Cinnamomum zeylanicum/química
Crocus/química
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/fisiopatologia
Elettaria/química
Endotélio/fisiopatologia
Feminino
Alimento Funcional/análise
Gengibre/química
Seres Humanos
Hipertensão/complicações
Hipertensão/prevenção & controle
Molécula 1 de Adesão Intercelular/sangue
Masculino
Meia-Idade
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
126547-89-5 (Intercellular Adhesion Molecule-1)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160114
[St] Status:MEDLINE
[do] DOI:10.3109/08037051.2015.1111020



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