Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.665.437 [Categoria DeCS]
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[PMID]:28476954
[Au] Autor:Jannathul Firdhouse M; Lalitha P
[Ad] Endereço:Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641043, Tamil Nadu, India.
[Ti] Título:Cytotoxicity of spherical gold nanoparticles synthesised using aqueous extracts of aerial roots of (Linden ex Andre) intertwined over and on MCF-7 cell line.
[So] Source:IET Nanobiotechnol;11(1):2-11, 2017 Feb.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A facile synthesis of gold nanoparticles (GNPs) using the aqueous extracts of the aerial roots of (Linden ex Andre) intertwined over and was carried out under different conditions, namely room temperature, higher temperature, sonication, solar irradiation and pH variation. The surface plasmon resonance (SPR) band at 536 and 575 nm obtained in UV-visible spectrum revealed the formation of AuNP's. The sharp SPR band of the synthesised nanogold indicates the formation of spherical-shaped and uniform-sized nanoparticles. The TEM analysis revealed spherical nanogold particles of size 35 and 10 nm for MM and MP extracts. The secondary metabolites present in the aqueous extract are suggested to be responsible for the reduction of metal ions to metal nanoparticles as evidenced from results of FTIR analysis. Rapid synthesis of GNPs by sunlight is the production of microscopic grains of gold due to the dissociation of gold chloride. This may induce the reaction between secondary metabolites and gold chloride solutions and results in GNPs. The cytotoxic activity of the synthesised nanogold studied against human breast cancer cells (MCF-7) by 3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide assay showed significant activity at higher concentration.
[Mh] Termos MeSH primário: Araceae/química
Sobrevivência Celular/efeitos dos fármacos
Ouro/administração & dosagem
Lawsonia (Planta)/química
Nanopartículas Metálicas/administração & dosagem
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Antineoplásicos/síntese química
Ouro/química
Química Verde/métodos
Teste de Materiais
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Nanosferas/administração & dosagem
Nanosferas/química
Nanosferas/ultraestrutura
Tamanho da Partícula
Extratos Vegetais/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); 059QF0KO0R (Water); 7440-57-5 (Gold)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0076


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[PMID]:28415483
[Au] Autor:Yousefi I; Pakravan M; Rahimi H; Bahador A; Farshadzadeh Z; Haririan I
[Ad] Endereço:School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran; Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran. Electronic address: iman_yousefi@ut.ac.ir.
[Ti] Título:An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:433-444, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Wound healing characteristics of some plant extracts have been well known for many years, and they have been utilized for such applications in traditional way. Recently electrospun nanofibrous mats showed promising properties for tissue engineering and especially for skin repair. It is expected that incorporation of plant extracts into such structures could provide higher performance and synergistic effect for biomedical and wound healing applications. The final purpose of this study is to fabricate chitosan based nanofiber mats loaded with a traditional plant extract of Lawsonia inermis (Henna) leaves to enhance the antibacterial efficacy and wound healing of the precursor nanofibers. The morphology, structure, mechanical properties and swelling and weight loss degree of the electrospun nanofibers have been investigated in this study. Antibacterial activity, cell biocompatibility evaluations and in vivo wound healing activity of the abovementioned mats were also studied. The FESEM images of Henna leaves extract-loaded nanofibers proved that homogeneous, smooth and defect free nanofibers of 64-87nm in diameter have been prepared. Presence of Henna extract in the electrospun fibers was approved by Fourier Transform Infrared spectroscopy. Incorporation of Henna extract into the nanofiber mats exhibited significant synergistic antibacterial activity against bacterial cells. It was well supported by the results of cell viability and proliferation of human foreskin fibroblast cells on the prepared scaffolds. Therefore, the results of this work showed that Henna leaves extract incorporated chitosan nonwoven mats have a great potential to be used as the biodegradable, biobased and antibacterial wound healing dressings.
[Mh] Termos MeSH primário: Quitosana
Lawsonia (Planta)/química
Nanofibras/química
Extratos Vegetais
Folhas de Planta/química
Pele Artificial
[Mh] Termos MeSH secundário: Animais
Quitosana/química
Quitosana/farmacologia
Seres Humanos
Masculino
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
Engenharia Tecidual/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28100199
[Au] Autor:Kumar M; Kaur P; Chandel M; Singh AP; Jain A; Kaur S
[Ad] Endereço:Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
[Ti] Título:Antioxidant and hepatoprotective potential of Lawsonia inermis L. leaves against 2-acetylaminofluorene induced hepatic damage in male Wistar rats.
[So] Source:BMC Complement Altern Med;17(1):56, 2017 Jan 18.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Lawsonia inermis (Lythraceae) is an ethnomedicinal plant, traditionally known for curing several ailments such as skin diseases, bacterial infections, jaundice, renal lithiases and inflammation etc. The present work deals with assessment of in vitro antioxidant and in vivo hepatoprotective potential of butanolic fraction (But-LI) of Lawsonia inermis L. leaves. METHODS: Antioxidant activity was evaluated using deoxyribose degradation, lipid peroxidation inhibition and ferric reducing antioxidant power (FRAP) assay. In vivo protective potential of But-LI was assessed at 3 doses [100, 200 & 400 mg/kg body weight (bw)] against 2-acetylaminofluorene (2-AAF) induced hepatic damage in male Wistar rats. RESULTS: But-LI effectively scavenged hydroxyl radicals in deoxyribose degradation assay (IC 149.12 µg/ml). Fraction also inhibited lipid peroxidation and demonstrated appreciable reducing potential in FRAP assay. Treatment of animals with 2-AAF resulted in increased hepatic parameters such as SGOT (2.22 fold), SGPT (1.72 fold), ALP (5.68 fold) and lipid peroxidation (2.94 fold). Different concentration of But-LI demonstrated pronounced protective effects via decreasing levels of SGOT, SGPT, ALP and lipid peroxidation altered by 2-AAF treatment. But-LI administration also restored the normal liver architecture as evident from histopathological studies. CONCLUSIONS: The present experimental findings revealed that phytoconstituents of Lawsonia inermis L. possess potential to effectively protect rats from the 2-AAF induced hepatic damage in vivo possibly by inhibition of reactive oxygen species and lipid peroxidation.
[Mh] Termos MeSH primário: Lawsonia (Planta)/química
Fígado/efeitos dos fármacos
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: 2-Acetilaminofluoreno
Animais
Antioxidantes/farmacologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Peroxidação de Lipídeos
Fígado/patologia
Masculino
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); 9M98QLJ2DL (2-Acetylaminofluorene)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1567-9


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[PMID]:27716154
[Au] Autor:Galehdari H; Negahdari S; Kesmati M; Rezaie A; Shariati G
[Ad] Endereço:Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. galehdari187@yahoo.com.
[Ti] Título:Effect of the herbal mixture composed of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha on wound healing in streptozotocin-induced diabetic rats.
[So] Source:BMC Complement Altern Med;16(1):386, 2016 Oct 06.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Wound healing is often impaired in diabetic animals and humans. Matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, IL6, IL1A and IL1B, and the tumor necrosis factor and transforming growth factor beta1. Botanicals are traditionally used to assist healing of different types of wounds, because they produce fewer side effects. Our specific aim here was to develop a plant-based recipe supporting effective wound healing in diabetic animals. METHODS: Plant materials from Adiantum capillus-veneris, Commiphora molmol, Aloe Vera, and henna were collected for this study, and oven-dried at 60 °C. The dried leaves and resins were then crumbled into a powder and mixed in equal parts with Vaseline as a preservative. This mixture was used as an ointment on wounds induced in 60 diabetic and non-diabetic rats that were divided into 6 subgroups receiving agent or control treatments. Necrotic tissue surrounding the wound was periodically removed during wound healing. RNA was extracted from the healing region of the wound at days 7, 14 and 21 for cDNA synthesis to monitor changes in Tgfb1, Mmp3, Mmp9, Il6 and Tnf α expression using real-time PCR. RESULTS: The expression of the Mmp3, the Tnf α, and the Tgfb1 genes from wound tissue were significantly different (p < 0.05) between diabetic and non-diabetic (control) rats treated with the herbal mixture after 14 and 21 days. There was no significant difference (p > 0.05) of the Mmp9 gene expression in diabetic and non-diabetic rats treated only with Vaseline after 7, 14, and 21 days. But, the expression of the Mmp9 gene decreased significantly (p < 0.05) in diabetic rats after 14 days in comparison to non-diabetic rats, when the herbal mixture was added to Vaseline. CONCLUSIONS: Our study presents an herbal treatment that alters the gene expression signature at wounds induced in the rat model for type I diabetes in a manner consistent with accelerated healing, and demonstrates that this herbal treatment might be effective to treat wounds in diabetic patients.
[Mh] Termos MeSH primário: Adiantum/química
Aloe/química
Diabetes Mellitus Experimental/metabolismo
Lawsonia (Planta)/química
Extratos Vegetais/farmacologia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Expressão Gênica/efeitos dos fármacos
Masculino
Metaloproteinases da Matriz/metabolismo
Extratos Vegetais/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


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[PMID]:27321410
[Au] Autor:Afolayan FID; Adegbolagun OM; Irungu B; Kangethe L; Orwa J; Anumudu CI
[Ad] Endereço:Department of Zoology, University of Ibadan, Ibadan, Nigeria; Centre for Traditional Medicine and Drugs Research, Kenya Medical Research Institute, (KEMRI), P.O. Box 54840 00200, Nairobi, Kenya. Electronic address: fidifede@gmail.com.
[Ti] Título:Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination.
[So] Source:J Ethnopharmacol;191:188-194, 2016 Sep 15.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Chromolaena odorata, Tithonia diversifolia and Lawsonia inermis are medicinal plants used in treating malaria in traditional medicine system. Previous studies however showed that their dichloromethane, methanol (1:1) extracts were more active against Plasmodium parasite than the aqueous extracts. AIM OF THE STUDY: To determine the in vitro and in vivo antiplasmodial activity of dichloromethane, methanol (1:1) extracts of Chromolaena odorata, Tithonia diversifolia and Lawsonia inermis in combination and evaluate their safety using acute limit toxicity test. MATERIALS AND METHODS: Dichloromethane, methanol (1:1) extracts of Chromolaena odorata, Tithonia diversifolia and Lawsonia inermis leaves were combined at ratios 1:1, 1:3, 3:1, 1:5 and 5:1 using in vitro semi-automated microdilution technique against P. falciparum Chloroquine sensitive (D6) and Chloroquine resistant (W2) strains, with chloroquine and artemisinin as controls. The in vivo antiplasmodial activity of the crude extracts was carried out singly, and in combination at the different combination ratios on Plasmodium berghei Anka infected Swiss albino mice using Peters' 4-day suppressive test. Acute toxicity test was done in mice at 5000mg/kg. RESULTS: The in vitro combination of L. inermis and T. diversifolia (1:1) extracts against P. falciparum showed the highest synergy with IC50 of 0.43±0.02µg/mL and 2.55±0.19µg/mL against D6 and W2 respectively; while the combination of C. odorata with T. diversifolia and L. inermis were antagonistic. A synergy with chemosuppression of 83.6% against P. berghei infected mice was observed in L. inermis and T. diversifolia (1:1) treated animals. In contrast to the in vitro result, combination of C. odorata with T. diversifolia and L. inermis showed some degrees of synergy in vivo. Extracts were not toxic at the concentration tested. CONCLUSION: These findings rationalized the use of these plants in combination as antimalarials in traditional medicine. However, the combination of Chromolaena odorata with other medicinal plants should be used with caution because of its possible antagonistic effect.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Asteraceae/química
Chromolaena/química
Lawsonia (Planta)/química
Malária/tratamento farmacológico
Extratos Vegetais/farmacologia
Plasmodium berghei/efeitos dos fármacos
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antimaláricos/isolamento & purificação
Antimaláricos/toxicidade
Asteraceae/toxicidade
Chromolaena/toxicidade
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Resistência a Medicamentos
Sinergismo Farmacológico
Quimioterapia Combinada
Lawsonia (Planta)/toxicidade
Malária/parasitologia
Metanol/química
Cloreto de Metileno/química
Camundongos
Testes de Sensibilidade Parasitária
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Folhas de Planta/química
Plantas Medicinais
Plasmodium berghei/crescimento & desenvolvimento
Plasmodium falciparum/crescimento & desenvolvimento
Solventes/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts); 0 (Solvents); 588X2YUY0A (Methylene Chloride); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:27142000
[Au] Autor:Ziaei A; Sahranavard S; Gharagozlou MJ; Faizi M
[Ad] Endereço:Traditional Medicine and Material Medical Research Center; Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Preliminary investigation of the effects of topical mixture of Lawsonia inermis L. and Ricinus communis L. leaves extract in treatment of osteoarthritis using MIA model in rats.
[So] Source:Daru;24(1):12, 2016 May 03.
[Is] ISSN:2008-2231
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many plants have been introduced in Iranian traditional medicine for treatment of different joint problems including knee pain. Topical application of the mixture of Lawsonia inermis L. leaves (Henna) with aqueous extract of Ricinus communis L. leaves have been mentioned to have significant effects on reducing knee pain. The present study was designed to evaluate the analgesic and anti-inflammatory effects of the mixture of these two herbs in male rats. METHODS: We induced knee osteoarthritis as a model of chronic pain by intra-articular injection of mono sodium iodoacetate (MIA). Mechanical allodynia, hotplate latency test, spontaneous movements and gait analysis were used for the evaluation of analgesic activity. Anti-inflammatory activity was evaluated by measuring the diameter and the volume of the injected paw compared to contralateral paw. These tests were monitored at days 1, 3, 7, 14 and 21 of MIA administration. Histopathological evaluations were also used to assess the efficacy of the treatment on inflammation and lesions in knee tissue. In all tests, diclofenac topical gel was used as a positive control. The herbal extracts, their mixture, and vehicle or diclofenac gel were administered daily for 14 days by topical route. RESULTS: The mixture of these two extracts significantly reduced the knee joint width and volume of the injected paws and also improved foot prints in gait analysis after 3 days of MIA injection. Analysis of mechanical allodynia (after 21 days), hotplate latency test (after 10 days), spontaneous movements (after 7 days) and in positive control group (after 3 days in all tests and in mechanical allodynia after 14 days) compared to the vehicle group, showed significant effects. Topical usage of the selected formulation made significant histopathological changes on the knee of the rats. Compared to the vehicle group, the tests and diclofenac groups showed less reactions characterized by negligible edema and a few scattered inflammatory lymphoid cells. CONCLUSION: The present findings showed that the present formulation not only was able to mitigate pain and inflammation in the paws but also made significant histopathological changes on the knee of the rats. Further studies are necessary to confirm the effect of the formulation.
[Mh] Termos MeSH primário: Analgésicos/administração & dosagem
Anti-Inflamatórios/administração & dosagem
Lawsonia (Planta)/química
Osteoartrite do Joelho/tratamento farmacológico
Extratos Vegetais/administração & dosagem
Ricinus/química
[Mh] Termos MeSH secundário: Administração Tópica
Analgésicos/farmacologia
Animais
Anti-Inflamatórios/farmacologia
Modelos Animais de Doenças
Esquema de Medicação
Combinação de Medicamentos
Marcha/efeitos dos fármacos
Ácido Iodoacético/efeitos adversos
Masculino
Osteoartrite do Joelho/induzido quimicamente
Osteoartrite do Joelho/patologia
Manejo da Dor
Extratos Vegetais/farmacologia
Folhas de Planta/química
Distribuição Aleatória
Ratos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Drug Combinations); 0 (Plant Extracts); WF5188V710 (Iodoacetic Acid)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160505
[St] Status:MEDLINE
[do] DOI:10.1186/s40199-016-0152-y


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[PMID]:27003793
[Au] Autor:Huang J; Zhou R; Chen J; Han W; Chen Y; Wen Y; Tang J
[Ad] Endereço:Institute of Environmental Science and Engineering, Hangzhou Dianzi University, Hangzhou 310018, PR China. Electronic address: hjg@hdu.edu.cn.
[Ti] Título:Volatile fatty acids produced by co-fermentation of waste activated sludge and henna plant biomass.
[So] Source:Bioresour Technol;211:80-6, 2016 Jul.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anaerobic co-fermentation of waste activated sludge (WAS) and henna plant biomass (HPB) for the enhanced production of volatile fatty acids (VFAs) was investigated. The results indicated that VFAs was the main constituents of the released organics; the accumulation of VFAs was much higher than that of soluble carbohydrates and proteins. HPB was an advantageous substrate compared to WAS for VFAs production; and the maximum VFAs concentration in an HPB mono-fermentation system was about 2.6-fold that in a WAS mono-fermentation system. In co-fermentation systems, VFAs accumulation was positively related to the proportion of HPB in the mixed substrate, and the accumulated VFAs concentrations doubled when HPB was increased from 25% to 75%. HPB not only adjust the C/N ratio; the associated and/or released lawsone might also have a positive electron-shuttling effect on VFAs production.
[Mh] Termos MeSH primário: Ácidos Graxos Voláteis/metabolismo
Fermentação/fisiologia
Lawsonia (Planta)/metabolismo
Esgotos
[Mh] Termos MeSH secundário: Anaerobiose
Reatores Biológicos
Carboidratos/química
Concentração de Íons de Hidrogênio
Lawsonia (Planta)/química
Proteínas/metabolismo
Esgotos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Fatty Acids, Volatile); 0 (Proteins); 0 (Sewage)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE


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[PMID]:26997722
[Au] Autor:Ravichandran S; Muthuraman S
[Ad] Endereço:Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
[Ti] Título:Examining the anti-candidal activity of 10 selected Indian herbs and investigating the effect of Lawsonia inermis extract on germ tube formation, protease, phospholipase, and aspartate dehydrogenase enzyme activity in Candida albicans.
[So] Source:Indian J Pharmacol;48(1):47-52, 2016 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of the study is to identify potential anti-candidal agents from natural resources and elucidate the effect of Lawsonia inermis extract on major virulent factors of Candida albicans. MATERIALS AND METHODS: Plants, the most abundant and readily available resource of diverse bioactives, were chosen for the anti-candidal screening study. Ten different plants that were proven to have antimicrobial activity but not explored much for anti-candidal activity were chosen for this study. Ethyl acetate extract of these plant leaves were tested for the anti-candidal activity. Extracts with good anti-candidal activity were further screened for its effect in C. albicans germ tube formation and enzyme (protease, phospholipase, and aspartate dehydrogenase) activity. RESULTS: Among 10 plants screened, L. inermis extract showed complete inhibition of C. albicans. On further evaluation, this extract completely inhibited C. albicans germ tube formation in serum until the end of incubation period (3 h). This extract also exhibited dose-dependent inhibitory activity against two major virulent enzymes of C. albicans, proteases (27-33%) and phospholipases (44.5%). In addition to it, this extract completely inhibited both the isoforms of constitutive candidal enzyme aspartate dehydrogenase, thereby affecting amino acid biosynthesis. CONCLUSION: Thus, this study confirms the anti-candidal potential of L. inermis and hence can be considered further for development of anti-candidal drug.
[Mh] Termos MeSH primário: Aminoácido Oxirredutases/metabolismo
Antifúngicos/farmacologia
Candida albicans/efeitos dos fármacos
Medicina Herbária
Lawsonia (Planta)/química
Peptídeo Hidrolases/metabolismo
Fosfolipases/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Candida albicans/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts); EC 1.4.- (Amino Acid Oxidoreductases); EC 1.4.1.- (aspartate dehydrogenase); EC 3.1.- (Phospholipases); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160322
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.174523


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[PMID]:26936787
[Au] Autor:Oda Y; Nakashima S; Nakamura S; Yano M; Akiyama M; Imai K; Kimura T; Nakata A; Tani M; Matsuda H
[Ad] Endereço:Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
[Ti] Título:New potent accelerator of neurite outgrowth from Lawsonia inermis flower under non-fasting condition.
[So] Source:J Nat Med;70(3):384-90, 2016 Jul.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The methanolic extract of Lawsonia inermis L. (henna) showed accelerative effects on nerve growth factor-induced neurite outgrowth in PC12 cells under non-fasting conditions. To elucidate the active constituents responsible for the neuronal differentiation, we conducted a search of the constituents and examined their accelerative effects on neurite outgrowth in PC12 cells. We isolated a new acetophenone glycoside, inermioside A, which exerted a significant accelerative effect on neurite outgrowth. We also confirmed the activities of nine known compounds, including quercetin and lalioside. In addition, we found that quercetin, one of the active constituents, increased Vav3 mRNA expression.
[Mh] Termos MeSH primário: Flores/química
Lawsonia (Planta)/química
Crescimento Neuronal/fisiologia
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Animais
Células PC12
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160304
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-016-0974-4


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[PMID]:26916211
[Au] Autor:Swan BC; Tam MM; Higgins CL; Nixon RL
[Ad] Endereço:Contact Dermatitis Clinic, Skin and Cancer Foundation Inc., Melbourne, Victoria, Australia.
[Ti] Título:Allergic contact dermatitis to substitute hair dyes in a patient allergic to para-phenylenediamine: Pure henna, black tea and indigo powder.
[So] Source:Australas J Dermatol;57(3):219-21, 2016 Aug.
[Is] ISSN:1440-0960
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:We report a case of a 50-year-old lady with allergic contact dermatitis to para-phenylenediamine, who in her quest to find a substitute hair dye, subsequently reacted to a number of plant-based hair dyes, including pure henna, black tea and indigo powder respectively. While these substances all contain tannins, testing to possible constituents tannic acid and gallic acid was negative.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Tinturas para Cabelo/efeitos adversos
Fenilenodiaminas/efeitos adversos
Dermatoses do Couro Cabeludo/etiologia
[Mh] Termos MeSH secundário: Alérgenos
Dermatite Alérgica de Contato/fisiopatologia
Feminino
Seres Humanos
Índigo Carmim/imunologia
Lawsonia (Planta)/imunologia
Meia-Idade
Testes do Emplastro
Prurido/diagnóstico
Prurido/etiologia
Dermatoses do Couro Cabeludo/diagnóstico
Índice de Gravidade de Doença
Chá/imunologia
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Allergens); 0 (Hair Dyes); 0 (Phenylenediamines); 0 (Tea); D3741U8K7L (Indigo Carmine); U770QIT64J (4-phenylenediamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160227
[St] Status:MEDLINE
[do] DOI:10.1111/ajd.12454



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