Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.665.750 [Categoria DeCS]
Referências encontradas : 18 [refinar]
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  1 / 18 MEDLINE  
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[PMID]:27931157
[Au] Autor:Mishra S; Aeri V
[Ad] Endereço:a Department of Pharmacognosy and Phytochemistry , Jamia Hamdard , New Delhi , India.
[Ti] Título:Biotransformation of lignan glycoside to its aglycone by Woodfordia fruticosa flowers: quantification of compounds using a validated HPTLC method.
[So] Source:Pharm Biol;55(1):360-366, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Saraca asoca Linn. (Caesalpiniaceae) is an important traditional remedy for gynaecological disorders and it contains lyoniside, an aryl tetralin lignan glycoside. The aglycone of lyoniside, lyoniresinol possesses structural similarity to enterolignan precursors which are established phytoestrogens. OBJECTIVES: This work illustrates biotransformation of lyoniside to lyoniresinol using Woodfordia fruticosa Kurz. (Lythraceae) flowers and simultaneous quantification of lyoniside and lyoniresinol using a validated HPTLC method. MATERIALS AND METHODS: The aqueous extract prepared from S. asoca bark was fermented using W. fruticosa flowers. The substrate and fermented product both were simultaneously analyzed using solvent system:toluene:ethyl acetate:formic acid (4:3:0.4) at 254 nm. The method was validated for specificity, accuracy, precision, linearity, sensitivity and robustness as per ICH guidelines. RESULTS: The substrate showed the presence of lyoniside, however, it decreased as the fermentation proceeded. On 3rd day, lyoniresinol starts appearing in the medium. In 8 days duration most of the lyoniside converted to lyoniresinol. The developed method was specific for lyoniside and lyoniresinol. Lyoniside and lyoniresinol showed linearity in the range of 250-3000 and 500-2500 ng. The method was accurate as resulted in 99.84% and 99.83% recovery, respectively, for lyoniside and lyoniresinol. CONCLUSION: Aryl tetralin lignan glycoside, lyoniside was successfully transformed into lyoniresinol using W. fruticosa flowers and their contents were simultaneously analyzed using developed validated HPTLC method.
[Mh] Termos MeSH primário: Anisóis/metabolismo
Cromatografia Líquida de Alta Pressão
Flores/metabolismo
Glicosídeos/metabolismo
Lignanas/metabolismo
Naftalenos/metabolismo
Sitosteroides/metabolismo
Woodfordia/metabolismo
[Mh] Termos MeSH secundário: Biotransformação
Calibragem
Cromatografia Líquida de Alta Pressão/normas
Densitometria
Fermentação
Modelos Lineares
Fitoterapia
Casca de Planta
Plantas Medicinais
Padrões de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anisoles); 0 (Glycosides); 0 (Lignans); 0 (Naphthalenes); 0 (Sitosterols); 0 (lyoniresinol); U45VN859W3 (lyoniside)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE


  2 / 18 MEDLINE  
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[PMID]:27780146
[Au] Autor:Nagar HK; Srivastava AK; Srivastava R; Ranawat MS
[Ad] Endereço:Bhupal Nobles' College of Pharmacy, Udaipur 313002, India. Electronic address: hemant_nagar81@yahoo.co.in.
[Ti] Título:Evaluation of potent phytomedicine for treatment of psoriasis using UV radiation induced psoriasis in rats.
[So] Source:Biomed Pharmacother;84:1156-1162, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The aim of present study was to determine the effect of newly formulated gels and suspensions of extractive Phytoconstituents of Woodfordia fructicosa flowers and Gardenia gummifera leaves by using UV Radiation induced psoriasis in rats. Both plants are traditionally claimed to be useful in treatment of number of skin diseases. However, there are no established scientific reports for their potential in psoriasis. Formulated Gels and Suspensions of ethanolic extract of both plants were tested for acute dermal and oral toxicity study respectively. The results of acute dermal toxicity at concentration 1% w/w and oral toxicity at dose 1000mg/kg showed that the gels and suspensions were safe. Psoriasis was induced in Wistar rats by espousing 10% area of total body by UV radiations. Anti-psoriatic activity was performed by applying 0.1% gel and orally at a dose 100mg/kg body weight in rats. Severity Index, histological study and biochemical estimation were analyzed. The results of our studies showed that the test formulations (Gels and Suspensions) of both plant extracts exhibited potential effect in anti-psoriatic activity.
[Mh] Termos MeSH primário: Fármacos Dermatológicos/farmacologia
Extratos Vegetais/farmacologia
Psoríase/prevenção & controle
Pele/efeitos dos fármacos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Administração Cutânea
Administração Oral
Animais
Fármacos Dermatológicos/isolamento & purificação
Fármacos Dermatológicos/toxicidade
Modelos Animais de Doenças
Etanol/química
Feminino
Gardenia
Géis
Hidroxiprolina/metabolismo
Masculino
Soluções Farmacêuticas
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Psoríase/metabolismo
Psoríase/patologia
Ratos Wistar
Índice de Gravidade de Doença
Pele/metabolismo
Pele/patologia
Solventes/química
Woodfordia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dermatologic Agents); 0 (Gels); 0 (Pharmaceutical Solutions); 0 (Plant Extracts); 0 (Solvents); 3K9958V90M (Ethanol); RMB44WO89X (Hydroxyproline)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  3 / 18 MEDLINE  
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[PMID]:27721539
[Au] Autor:Srivastava AK; Nagar HK; Chandel HS; Ranawat MS
[Ad] Endereço:Department of Pharmacology, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, India.
[Ti] Título:Antipsoriatic activity of ethanolic extract of (L.) Kurz flowers in a novel screening model.
[So] Source:Indian J Pharmacol;48(5):531-536, 2016 Sep-Oct.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to investigate the antipsoriatic activity of ethanolic extract of flowers (EEWF) using a novel screening model. MATERIALS AND METHODS: For induction of psoriasis, 0.1 ml of prepared complete Freund's adjuvant (CFA) and formaldehyde mixture (1:10 ratio) was topically applied for 7 days on the dorsum surface of the skin of Swiss albino mice. Psoriasis severity index (PSI) was evaluated by phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Therapeutic effect of 0.05% and 0.1% (w/w) ointments of EEWF was evaluated after the induction of psoriasis. Ointments of EEWF flowers were applied once daily for 3 weeks, and antipsoriatic activity was evaluated by scoring the PSI and histological examination. RESULTS: We observed the phenotypic and histological features and found a progressive reduction ( < 0.05) in the severity of psoriatic lesions (redness, erythema, and scales) from day 7 to 21 day and decreased epidermal thickness in animals treated with 0.05% and 0.1% (w/w) ointments of EEWF. CONCLUSIONS: The results showed that 0.05% and 0.1% (w/w) ointments of EEWF have dose-dependent beneficial effects in CFA and formaldehyde-induced psoriasis. The present investigation revealed that flowers possess potent antipsoriatic activity and can be used for psoriasis treatment.
[Mh] Termos MeSH primário: Fármacos Dermatológicos/uso terapêutico
Modelos Animais de Doenças
Extratos Vegetais/uso terapêutico
Psoríase/tratamento farmacológico
Woodfordia
[Mh] Termos MeSH secundário: Animais
Fármacos Dermatológicos/química
Fármacos Dermatológicos/toxicidade
Etanol
Feminino
Flavonoides/análise
Flores/química
Formaldeído
Adjuvante de Freund
Masculino
Camundongos
Fenóis/análise
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Psoríase/induzido quimicamente
Psoríase/patologia
Pele/efeitos dos fármacos
Pele/patologia
Solventes
Testes de Toxicidade Aguda
Woodfordia/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dermatologic Agents); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Solvents); 1HG84L3525 (Formaldehyde); 3K9958V90M (Ethanol); 9007-81-2 (Freund's Adjuvant)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  4 / 18 MEDLINE  
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[PMID]:25415873
[Au] Autor:Nitha A; Prabha SP; Ansil PN; Latha MS
[Ad] Endereço:Biochemistry and Pharmacognosy Research Laboratory, School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India.
[Ti] Título:Methanolic extract of Woodfordia fruticosa Kurz flowers ameliorates carbon tetrachloride-induced chronic hepatic fibrosis in rats.
[So] Source:Toxicol Ind Health;32(7):1224-36, 2016 Jul.
[Is] ISSN:1477-0393
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hepatic fibrosis, characterized by extracellular matrix accumulation, is the common cause of chronic liver failure and is a leading cause of morbidity and mortality worldwide. The aim of the present study was to evaluate the effect of dried flowers of Woodfordia fruticosa on carbon tetrachloride (CCl4)-induced hepatic fibrosis in rat model. Hepatic fibrosis was induced in male Wistar rats by CCl4 administration (150 µl/100 g rat weight, oral) twice a week for 10 weeks. In preventive model, administration of daily doses of methanolic extract of W. fruticosa (MEWF) at two different doses (100 mg/kg, body weight (b.w.) and 200 mg/kg, b.w.) was started 1 week before the onset of CCl4 administration and continued for 10 weeks. In curative model, MEWF at 100 and 200 mg/kg were given for last 2 weeks after the establishment of fibrosis. MEWF at a dose of 200 mg/kg was able to exert a more pronounced effect as evidenced histologically by significant reduction in fibrotic septa formation in liver tissue, immunohistochemically by abridged expression of collagen III, and also biochemically by serum and tissue antioxidant status, lipid peroxidation, and hydroxyproline level. Liquid chromatography-mass spectrometry analysis revealed the presence of confertin, quercetin methyl ether, ellagic acid, and stigmasterol in MEWF, which could be responsible for its antifibrotic activity. These results indicate the effective protection exerted by MEWF against CCl4-induced hepatic fibrosis in a dose-dependent manner.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Flores/química
Cirrose Hepática/tratamento farmacológico
Extratos Vegetais/farmacologia
Woodfordia/química
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Aspartato Aminotransferases/sangue
Tetracloreto de Carbono/toxicidade
Relação Dose-Resposta a Droga
Imuno-Histoquímica
L-Lactato Desidrogenase/sangue
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Cirrose Hepática/induzido quimicamente
Masculino
Tamanho do Órgão/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); CL2T97X0V0 (Carbon Tetrachloride); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141122
[St] Status:MEDLINE
[do] DOI:10.1177/0748233714552120


  5 / 18 MEDLINE  
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[PMID]:26342523
[Au] Autor:Arya A; Al-Obaidi MM; Karim RB; Taha H; Khan AK; Shahid N; Sayem AS; Looi CY; Mustafa MR; Mohd MA; Ali HM
[Ad] Endereço:Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: aditya@um.edu.my.
[Ti] Título:Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves ß-cell function in streptozotocin-nicotinamide induced diabetic rats.
[So] Source:J Ethnopharmacol;175:229-40, 2015 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The art of Ayurveda and the traditional healing system in India have reflected the ethnomedicinal importance of the plant Woodfordia fruticosa Kurtz, which demonstrates its vast usage in the Ayurvedic preparations as well as in the management of diabetes by the traditional healers. AIMS OF STUDY: The study aimed to ascertain the antidiabetic potential of W. fruticosa flower methanolic extract (WF) on Streptozotocin (STZ)-nicotinamide-induced diabetic rat model. MATERIALS AND METHODS: Diabetes was induced in Sprague Dawley (SD) rats by STZ-nicotinamide and thereafter diabetic rats were treated with three different doses of WF (100, 200 and 400mg/kg body weight) respectively and glibenclamide as a positive control. Biochemical parameters such as blood glucose, serum insulin and C-peptide levels were measured with oxidative stress markers. Furthermore, histology of liver and pancreas was carried out to evaluate glycogen content and ß-cell structures. Moreover, immunohistochemistry and western blot analysis were performed on kidney and pancreas tissues to determine renal Bcl-2, pancreatic insulin and glucose transporter (GLUT-2, 4) protein expression in all the experimental groups. RESULTS: The acute toxicity study showed non-toxic nature of all the three doses of WF. Further, studies on diabetic rats exhibited anti-hyperglycemic effects by upregulating serum insulin and C-peptide levels. Similarly, WF shown to ameliorate oxidative stress by downregulating LPO levels and augmenting the antioxidant enzyme (ABTS). Furthermore, histopathological analysis demonstrate recovery in the structural degeneration of ß-cells mass of pancreas tissue with increase in the liver glycogen content of the diabetic rats. Interestingly, protective nature of the extract was further revealed by the immunohistochemical study result which displayed upregulation in the insulin and renal Bcl-2 expression, the anti apoptosis protein. Moreover, western blot result have shown slight alteration in the GLUT-2 and GLUT-4 protein expression with the highest dose of WFc treatment, that might have stimulated glucose uptake in the pancreas and played an important role in attenuating the blood glucose levels. CONCLUSION: The overall study result have demonstrated the potential of WF in the management of diabetes and its related complications, thus warrants further investigation on its major compounds with in depth mechanistic studies at molecular level.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Extratos Vegetais/uso terapêutico
Woodfordia
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Experimental/patologia
Flores
Transportador de Glucose Tipo 2/metabolismo
Transportador de Glucose Tipo 4/metabolismo
Glicogênio/metabolismo
Hiperglicemia/tratamento farmacológico
Hiperglicemia/metabolismo
Hiperglicemia/patologia
Hipoglicemiantes/farmacologia
Insulina/metabolismo
Rim/efeitos dos fármacos
Rim/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Niacinamida
Estresse Oxidativo/efeitos dos fármacos
Pâncreas/efeitos dos fármacos
Pâncreas/metabolismo
Pâncreas/patologia
Compostos Fitoquímicos/análise
Extratos Vegetais/farmacologia
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Ratos Sprague-Dawley
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucose Transporter Type 2); 0 (Glucose Transporter Type 4); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Slc2a2 protein, rat); 0 (Slc2a4 protein, rat); 25X51I8RD4 (Niacinamide); 5W494URQ81 (Streptozocin); 9005-79-2 (Glycogen)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150907
[St] Status:MEDLINE


  6 / 18 MEDLINE  
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[PMID]:24405177
[Au] Autor:Hiralal Ghante M; Bhusari KP; Duragkar NJ; Ghiware NB
[Ad] Endereço:Department of Pharmacy, Sharad Pawar College of Pharmacy , Nagpur, Maharashtra , India and.
[Ti] Título:Pharmacological evaluation for anti-asthmatic and anti-inflammatory potential of Woodfordia fruticosa flower extracts.
[So] Source:Pharm Biol;52(7):804-13, 2014 Jul.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Woodfordia fruticosa Kurz. (Lythraceae) flowers are ethnopharmacologically acclaimed in the Indian medicinal system to treat asthma. OBJECTIVE: To evaluate W. fruticosa flower extracts for anti-asthmatic effect. MATERIALS AND METHODS: Ethyl acetate, acetone, methanol, and hydro-alcohol extracts of W. fruticosa flowers were obtained successively and standardized. Ability of extracts to stabilize free radicals and compound-48/80-induced mast cell degranulation was evaluated. In vitro anti-inflammatory potential of extracts at 100 and 200 µg/ml by membrane stabilization and in vivo inhibition of rat paw edema up to 5 h (100 and 200 mg/ml; p.o.) was evaluated. In vitro bronchorelaxant effect was examined against histamine- and acetylcholine (1 µg/ml; independently)-induced guinea pig tracheal contraction. Extracts were evaluated for bronchoprotection (in vivo) ability against 0.1% histamine- and 2% acetylcholine-induced bronchospasm in guinea pigs at 100 and 200 mg/ml; p.o. RESULTS: Standardization studies revealed that the methanol extract exhibited highest polyphenolic (62.66 GAE), and flavonoid (6.32 RE) content and HPLC fingerprinting confirmed the presence of gallic acid (Rt 1.383). IC50 values for DPPH scavenging and metal chelation by the methanol extract were 40.42 and 31.50 µg/ml. Methanol and ethyl acetate extracts at 100 µg/ml exhibited 06.52 and 07.12% of histamine release. Methanol, ethyl acetate, and hydro alcohol extracts at 200 mg/kg demonstrated 32.73, 29.83, 26.75% and 32.46, 9.38, 26.75% inhibition of egg albumin and carrageenan-induced inflammation, respectively. Methanol extract exhibited 100% bronchorelaxation and 48.83% bronchoprotection. CONCLUSION: Woodfordia fruticosa flower (WFF) extracts exhibited anti-asthmatic effect by demonstrating bronchoprotection, bronchorelaxation, anti-inflammatory, antioxidant, and mast cell stabilization ability.
[Mh] Termos MeSH primário: Antiasmáticos/farmacologia
Anti-Inflamatórios/farmacologia
Flores/química
Mastócitos/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/farmacologia
Woodfordia/química
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Animais
Antioxidantes/farmacologia
Broncodilatadores/farmacologia
Edema/tratamento farmacológico
Cobaias
Histamina/metabolismo
Histamina/farmacologia
Mastócitos/metabolismo
Extratos Vegetais/uso terapêutico
Ratos
Solventes/química
Traqueia/efeitos dos fármacos
p-Metoxi-N-metilfenetilamina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Bronchodilator Agents); 0 (Plant Extracts); 0 (Solvents); 4091-50-3 (p-Methoxy-N-methylphenethylamine); 820484N8I3 (Histamine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:140612
[Lr] Data última revisão:
140612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140111
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.869232


  7 / 18 MEDLINE  
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[PMID]:24211394
[Au] Autor:Bhondave PD; Devarshi PP; Mahadik KR; Harsulkar AM
[Ad] Endereço:Department of Pharmaceutical Biotechnology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune 411038, Maharashtra, India. Electronic address: prashantbhondave@gmail.com.
[Ti] Título:'Ashvagandharishta' prepared using yeast consortium from Woodfordia fruticosa flowers exhibit hepatoprotective effect on CCl4 induced liver damage in Wistar rats.
[So] Source:J Ethnopharmacol;151(1):183-90, 2014.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: [corrected] Consortium of yeasts sourced from traditionally used Woodfordia fruticosa flowers proved to be beneficial for fermenting Ashvagandharishta. It resulted in faster fermentation, acceptable organoleptic properties and demonstrable hepatoprotective potential in CCl4 induced hepatotoxicity. To formulate Ashvagandharishta using consortium of yeasts and to investigate its physiochemical parameters. Standardize the formulation with the help of standard withaferin-A and withanolide-A and to evaluate its hepatoprotective potential in CCl4 induced hepatotoxicity in the rat model. MATERIAL AND METHODS: Ashvagandharishta was prepared using a 5% consortium of yeasts and ascertained its quality through physiochemical and phytochemical investigation. Withaferin-A and withanolide-A was simultaneously estimated by HPLC for standardization. Hepatoprotective potential was evaluated by administering 2.31 and 1.15 ml/kg doses while considering biochemical parameters like serum AST, ALT, ALP and lipid profile. Gene expression study was carried out for the expression of antioxidant and inflammatory genes such as CAT, GPx and proinflammatory gene IL-6. Histopathology of liver was also studied with the help of H&E staining. RESULTS: Ashvagandharishta was found organolepticaly acceptable with optimized physiochemical parameters. Withaferin-A and withanolide-A in Ashvagandharishta estimated as 0.3711, 0.7426 (%w/v), respectively. In the CCl4 induced hepato-toxicity model, Ashvagandharishta-2.31ml/kg dose showed significant decrease in elevated hepatic level of AST(p<0.001), ALT(p<0.01) and ALP(p<0.001). Both doses of Ashvagandharishta showed significant reduction of TG, Cholesterol, VLDL and LDL in serum, with corresponding reduction of (p<0.001) serum-HDL. Ashvagandharishta also showed increased serum protein (p<0.05) and albumin (p<0.01) with decrease in bilirubin (p<0.01). Additionally, Ashvagandharishta administration revealed up-regulation in antioxidant genes such as CAT and GPx in liver with concomitant down-regulation in proinflammatory IL-6gene (p<0.01). Histopathological parameters revealed restoration of normal tissue architecture by both doses of Ashvagandharishta. CONCLUSIONS: Consortium of yeasts from Woodfordia fruticosa flowers showed better fermentation pattern for Ashvagandharishta produced with acceptable organoleptic properties. Hepatoprotection shown by Ashvagandharishta was mainly through prevention of oxidative damage. Up-regulation of CAT and GPx genes and corresponding down regulation of proinflammatory IL6 gene was revealed as possible mechanism of its action.
[Mh] Termos MeSH primário: Intoxicação por Tetracloreto de Carbono/prevenção & controle
Tetracloreto de Carbono/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Flores/microbiologia
Woodfordia/microbiologia
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Animais
Intoxicação por Tetracloreto de Carbono/patologia
Catalase/genética
Catalase/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Fermentação
Regulação da Expressão Gênica/efeitos dos fármacos
Interleucina-6/genética
Interleucina-6/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Lipídeos/sangue
Medicina Ayurvédica
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Interleukin-6); 0 (Lipids); CL2T97X0V0 (Carbon Tetrachloride); EC 1.11.1.6 (Catalase)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131112
[St] Status:MEDLINE


  8 / 18 MEDLINE  
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[PMID]:24772949
[Au] Autor:Verma N; Amresh G; Sahu PK; Mishra N; Rao ChV; Singh AP
[Ti] Título:Wound healing potential of flowers extracts of Woodfordia fruticosa Kurz.
[So] Source:Indian J Biochem Biophys;50(4):296-304, 2013 Aug.
[Is] ISSN:0301-1208
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Wound healing or repair is the body's natural process of regenerating dermal and epidermal tissue. Woodfordia fruticosa Kurz (Family: Lythraceae) is used traditionally in wound healing by the tribals of Chhattisgarh district. However, there is a paucity of scientific data in support. In this study, we evaluated antimicrobial activity of petroleum ether, chloroform, ethanolic and aqueous extracts against a diverse range of gram +ve and gram -ve bacteria along with pathogenic fungi. The wound healing activity of ethanolic extract was also evaluated at dose levels of 250 and 500 mg/kg body wt in rats by excision, incision and dead space wound healing models along with histopathology of wound area of skin. The ethanolic extract showed potent wound healing activity, as evident from the increase in the wound contraction and breaking strength in dose-dependent manner. Treatment with ethanolic extract (250 and 500 mg/kg body wt) showed significant dose-dependently decrease in epithelization period and scar area. Hydroxyproline, hexuronic acid and hexosamine contents, the important constituents of extracellular matrix of healing were also correlated with the observed healing pattern. During early wound healing phase, pro-inflammatory cytokines TNF-alpha, IL-6 and anti-inflammatory cytokine IL-10 levels were found to be upregulated by the ethanolic extract treatment. The ethanolic extract exhibited a strong and broad spectrum antimicrobial activity, as compared to other extracts. It showed very low Minimum inhibitory concentration (MIC) values and inhibited the growth of E. coli, Staphylococcus aureus and Candida albicans in concentration of 2.5 microg/disc. Thus, the results of the present study demonstrated the strong wound healing potential and antimicrobial activities of W. fruticosa, flowers, supporting the folklore use of the plant by the tribal people of Chhattisgarh district.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Flores/química
Extratos Vegetais/farmacologia
Woodfordia/química
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Etanol/química
Interleucina-10/biossíntese
Interleucina-6/biossíntese
Masculino
Ratos
Ratos Wistar
Fator de Necrose Tumoral alfa/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Interleukin-6); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:140429
[Lr] Data última revisão:
140429
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140430
[St] Status:MEDLINE


  9 / 18 MEDLINE  
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[PMID]:22803325
[Au] Autor:Verma N; Amresh G; Sahu PK; Rao ChV; Singh AP
[Ad] Endereço:Department of Pharmacology, Goel Institute of Pharmacy & Sciences, Faizabad Road (Near Indira Canal), Lucknow 227 105, India. neerajcology@gmail.com
[Ti] Título:Antihyperglycemic activity of Woodfordia fruticosa (Kurz) flowers extracts in glucose metabolism and lipid peroxidation in streptozotocin-induced diabetic rats.
[So] Source:Indian J Exp Biol;50(5):351-8, 2012 May.
[Is] ISSN:0019-5189
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The ethanolic extract of W. fruticosa flowers (250 and 500 mg/kg) significantly reduced fasting blood glucose level and increased insulin level after 21 days treatment in streptozotocin diabetic rats. The extract also increased catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase activities significantly and reduced lipid peroxidation. Glycolytic enzymes showed a significant increase in their levels while a significant decrease was observed in the levels of the gluconeogenic enzymes in ethanolic extract treated diabetic rats. The extract has a favourable effect on the histopathological changes of the pancreatic beta-cells in streptozotocin induced diabetic rats. The results suggest that W. fruticosa possess potential antihyperglycemic effect by regulating glucose homeostasis and antioxidant efficacy in streptozotocin-induced diabetic rats.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Glucose/metabolismo
Hipoglicemiantes/administração & dosagem
Extratos Vegetais/administração & dosagem
Woodfordia
[Mh] Termos MeSH secundário: Animais
Flores/química
Hipoglicemiantes/química
Inativação Metabólica
Células Secretoras de Insulina/efeitos dos fármacos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Extratos Vegetais/química
Ratos
Ratos Wistar
Woodfordia/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Extracts); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120719
[St] Status:MEDLINE


  10 / 18 MEDLINE  
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[PMID]:21771673
[Au] Autor:Baravalia Y; Vaghasiya Y; Chanda S
[Ad] Endereço:Phytochemical, Pharmacological and Microbiological Laboratory, Department of Biosciences, Saurashtra University, Rajkot-360 005, Gujarat, India.
[Ti] Título:Hepatoprotective effect of Woodfordia fruticosa Kurz flowers on diclofenac sodium induced liver toxicity in rats.
[So] Source:Asian Pac J Trop Med;4(5):342-6, 2011 May.
[Is] ISSN:2352-4146
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the protective effect of Woodfordia fruticosa Kurz flowers against experimentally induced liver toxicity in rats. METHODS: Two different doses of methanol extract of Woodfordia fruticosa (WFM) were evaluated for the hepatoprotective activity against diclofenac sodium induced hepatotoxicity in rats. Various biochemical parameters like alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), blood urea nitrogen (BUN) from serum; total protein (TP), glutathione (GSH) levels, catalase (CAT) and glutathione peroxidase (GPx) activities from liver were studied; histopathologic changes of liver were also evaluated. RESULTS: WFM effectively reduced the elevated levels of serum ALT, AST, ALP and BUN, enhanced the reduced TP, ALB and hepatic GSH, CAT, GPx activity. The histopathological analysis suggested that WFM decreased the degree of liver fibrosis induced by diclofenac. CONCLUSIONS: This study demonstrates the hepatoprotective activity of WFM and thus scientifically support the use of this plant in traditional medicine for the treatment of liver disorders.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/toxicidade
Diclofenaco/toxicidade
Flores
Fígado/efeitos dos fármacos
Extratos Vegetais/farmacologia
Woodfordia
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Aspartato Aminotransferases/sangue
Feminino
Glutationa/metabolismo
Fígado/metabolismo
Fígado/patologia
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Plant Extracts); 144O8QL0L1 (Diclofenac); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:160519
[Lr] Data última revisão:
160519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110721
[St] Status:MEDLINE
[do] DOI:10.1016/S1995-7645(11)60100-4



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