Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.685 [Categoria DeCS]
Referências encontradas : 108 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 11 ir para página                         

  1 / 108 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28867711
[Au] Autor:Nguyen TTM; Lee HS; Nguyen TT; Ngo TQM; Jun CD; Min BS; Kim JA
[Ad] Endereço:College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University.
[Ti] Título:Four New Lignans and IL-2 Inhibitors from Magnoliae Flos.
[So] Source:Chem Pharm Bull (Tokyo);65(9):840-847, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Four new lignans, a furofuran lignan medioresinol B (10) and three tetrahydrofuran lignans kobusinol C (16), 7'-methoxy magnostellin A (21), and mangnostellin D (23), along with 19 known lignans, were isolated from the flower buds of Magnolia biondii PAMP. The structures of the isolates were elucidated using spectroscopic analysis, mainly one- and two-dimensional NMR, high resolution-MS, and circular dichroism techniques as well as Mosher's esterification method. The anti-allergic effects of the isolated compounds were evaluated by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T-cells. Compounds 11-14 reduced IL-2 expression in a dose-dependent manner.
[Mh] Termos MeSH primário: Interleucina-2/metabolismo
Lignanas/química
Magnoliaceae/química
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Dicroísmo Circular
Análise Citogenética
Ensaio de Imunoadsorção Enzimática
Expressão Gênica/efeitos dos fármacos
Seres Humanos
Interleucina-2/análise
Interleucina-2/antagonistas & inibidores
Células Jurkat
Lignanas/isolamento & purificação
Lignanas/farmacologia
Espectroscopia de Ressonância Magnética
Magnoliaceae/metabolismo
Espectrometria de Massas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-2); 0 (Lignans); 0 (medioresinol B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00314


  2 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27177332
[Au] Autor:Pan CC; Shah N; Kumar S; Wheeler SE; Cinti J; Hoyt DG; Beattie CE; An M; Mythreye K; Rakotondraibe LH; Lee NY
[Ad] Endereço:Division of Pharmacology, College of Pharmacy, The Ohio State University, OH, USA.
[Ti] Título:Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy.
[So] Source:Oncotarget;8(8):12675-12685, 2017 Feb 21.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Angiogenesis is the formation of new blood vessels from existing vasculature critical for embryonic development and vascular remodeling. Its dysregulation underlies numerous pathologic states ranging from ischemia to tumor growth and as such identifying new targeted- therapies is of significant interest for angiogenesis-based medicine. Here we evaluated the potential angiostatic properties of capsicodendrin (CPCD), a natural compound isolated from Cinnamosma macrocarpa, a plant belonging to the Malagasy Cinnamosma. CPCD potently inhibits endothelial proliferation, migration and capillary tube formation at nanomolar to low micromolar concentrations without inducing cytotoxic effects. We show that CPCD directly inactivates VEGFR2 and downstream AKT signaling, thereby strongly inducing autophagy as determined by increased expression of beclin1, autophagy-related gene (Atg) 3, Atg5 and LC3 cleavage. Ectopic AKT overexpression counteracts the inhibitory effects of CPCD on proliferation and capillary tubule formation. Importantly, CPCD treatment in vivo inhibits sprouting angiogenesis as evidenced by strongly reduced intersegmental vessel (ISV) sprouting and subintestinal vessel (SIV) formation during zebrafish embryonic development, and correlates with increased presence of LC3II along the ISVs despite overall reduced vasculature. These findings demonstrate CPCD as a potent inhibitor of the VEGFR2/AKT pathway at nanomolar concentrations and inducer of autophagy-related angiostatic effects.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Neovascularização Fisiológica/efeitos dos fármacos
Extratos Vegetais/farmacologia
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Autofagia/efeitos dos fármacos
Linhagem Celular
Células Endoteliais/efeitos dos fármacos
Imunofluorescência
Seres Humanos
Magnoliaceae
Camundongos
Camundongos Endogâmicos C57BL
Transdução de Sinais/efeitos dos fármacos
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Plant Extracts); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.9307


  3 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27927052
[Au] Autor:Samakradhamrongthai R; Thakeow P; Kopermsub P; Utama-Ang N
[Ad] Endereço:a Division of Product Development Technology, Faculty of Agro-Industry , Chiang Mai University , Chiang Mai , Thailand.
[Ti] Título:Microencapsulation of white champaca (Michelia alba D.C.) extract using octenyl succinic anhydride (OSA) starch for controlled release aroma.
[So] Source:J Microencapsul;33(8):773-784, 2016 Dec.
[Is] ISSN:1464-5246
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of the study was to optimise the encapsulation of Michelia alba D.C. (MAD) extract using octenyl succinic anhydride (OSA) starch. The MAD extract (5-10 g/100 g of dry starch) and the OSA starch (25-100 g/100 ml of water) was used in microcapsule preparation and analysed for the physicochemical and encapsulation properties. The optimised formula using the MAD extract and the OSA starch were 15.00 g/100 g of dry starch and 96.32 g/100 g water, which provided the highest in yield recovery (40.65% ± 0.99) and encapsulation efficiency (68.91% ± 1.50), with the lowest moisture content (3.19% ± 0.06) and water activity (0.236 ± 0.004). The aroma release from the optimum encapsulated powder in simulated artificial saliva fluid (SSF) suggested that linalool retention in microcapsules was higher than verbenone and 2-methyl butanoic acid. This study shows that the optimised formulation of MAD encapsulated flavour powder was found to be effective for controlling the aroma release.
[Mh] Termos MeSH primário: Preparações de Ação Retardada/química
Aromatizantes/administração & dosagem
Magnoliaceae/química
Odorantes
Extratos Vegetais/administração & dosagem
Amido/análogos & derivados
Anidridos Succínicos/química
[Mh] Termos MeSH secundário: Aromatizantes/química
Odorantes/análise
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Flavoring Agents); 0 (Plant Extracts); 0 (Succinic Anhydrides); 9005-25-8 (Starch)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161209
[St] Status:MEDLINE
[do] DOI:10.1080/02652048.2016.1264493


  4 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27420958
[Au] Autor:Zhong YD; Sun XY; Liu EY; Li YQ; Gao Z; Yu FX
[Ad] Endereço:The Key Laboratory of Horticultural Plant Genetic and Improvement of Jiangxi, Institute of Biology and Resources, Jiangxi Academy of Sciences, Nanchang, China.
[Ti] Título:Expressed sequence tag analysis of functional genes associated with adventitious rooting in Liriodendron hybrids.
[So] Source:Genet Mol Res;15(2), 2016 Jun 24.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Liriodendron hybrids (Liriodendron chinense x L. tulipifera) are important landscaping and afforestation hardwood trees. To date, little genomic research on adventitious rooting has been reported in these hybrids, as well as in the genus Liriodendron. In the present study, we used adventitious roots to construct the first cDNA library for Liriodendron hybrids. A total of 5176 expressed sequence tags (ESTs) were generated and clustered into 2921 unigenes. Among these unigenes, 2547 had significant homology to the non-redundant protein database representing a wide variety of putative functions. Homologs of these genes regulated many aspects of adventitious rooting, including those for auxin signal transduction and root hair development. Results of quantitative real-time polymerase chain reaction showed that AUX1, IRE, and FB1 were highly expressed in adventitious roots and the expression of AUX1, ARF1, NAC1, RHD1, and IRE increased during the development of adventitious roots. Additionally, 181 simple sequence repeats were identified from 166 ESTs and more than 91.16% of these were dinucleotide and trinucleotide repeats. To the best of our knowledge, the present study reports the identification of the genes associated with adventitious rooting in the genus Liriodendron for the first time and provides a valuable resource for future genomic studies. Expression analysis of selected genes could allow us to identify regulatory genes that may be essential for adventitious rooting.
[Mh] Termos MeSH primário: Etiquetas de Sequências Expressas
Genes de Plantas
Magnoliaceae/genética
Raízes de Plantas/genética
[Mh] Termos MeSH secundário: Magnoliaceae/crescimento & desenvolvimento
Repetições de Microssatélites
Raízes de Plantas/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15027606


  5 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27210247
[Au] Autor:Bao Y; Wang W; Wu H; Qi M; Li J; Yang Y
[Ad] Endereço:a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
[Ti] Título:A new sesquiterpene from the barks of Manglietia hookeri.
[So] Source:Nat Prod Res;30(21):2396-401, 2016 Nov.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new sesquiterpene manghookerins A (1) was isolated from the barks of Manglietia hookeri (Magnoliaceae) together with five known eudesmane-type sesquiterpenes. The structure of manghookerins A (1) was elucidated by physical and spectroscopic data analysis, including 1D and 2D NMR, HR-ESI-MS and X-ray diffraction. The structures of known sesquiterpenes were established by comparing their spectroscopic data with those in literatures.
[Mh] Termos MeSH primário: Magnoliaceae/química
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Casca de Planta/química
Sesquiterpenos/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sesquiterpenes); 0 (manghookerins A)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1188097


  6 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27164073
[Au] Autor:Pereira JM; Lopes-Rodrigues V; Xavier CP; Lima MJ; Lima RT; Ferreira IC; Vasconcelos MH
[Ad] Endereço:Department of Biological Sciences, FFUP-Faculty of Pharmacy of the University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal. joanita_12@live.com.pt.
[Ti] Título:An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells.
[So] Source:Molecules;21(5), 2016 May 06.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Tuberaria lignosa (Sweet) Samp. is found in European regions, and has antioxidant properties due to its composition in ascorbic acid and phenolic compounds. Given its traditional use and antioxidant properties, the tumor cell growth inhibitory potential of aqueous extracts from T. lignosa (prepared by infusion and decoction) was investigated in three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and HCT-15 (human colorectal adenocarcinoma). Both extracts inhibited the growth of these cell lines; the most potent one being the T. lignosa extract obtained by infusion in the NCI-H460 cells (GI50 of approximately 50 µg/mL). Further assays were carried out with this extract in NCI-H460 cells. At 100 µg/mL or 150 µg/mL it caused an increase in the percentage of cells in the G0/G1 phase and a decrease of cells in S phase of the cell cycle. Additionally, these concentrations caused an increase in the percentage of apoptotic cells. In agreement, a decrease in total poly (ADP-ribose) polymerase (PARP) and pro-caspase 3 levels was found. In conclusion, the T. lignosa extract obtained by infusion was more potent in NCI-H460 cells, altering the cell cycle progression and inducing apoptosis. This work highlights the importance of T. lignosa as a source of bioactive compounds with tumor cell growth inhibitory potential.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Ciclo Celular/efeitos dos fármacos
Magnoliaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Apoptose
Caspase 3/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Células MCF-7
Extratos Vegetais/química
Poli(ADP-Ribose) Polimerases/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE


  7 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26943243
[Au] Autor:Pina ES; Silva DB; Teixeira SP; Coppede JS; Furlan M; França SC; Lopes NP; Pereira AM; Lopes AA
[Ad] Endereço:Unidade de Biotecnologia, Universidade de Ribeirão Preto, Av. Costábile Romano, 2201, 14096-900, Ribeirão Preto, SP, Brazil.
[Ti] Título:Mevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging.
[So] Source:Sci Rep;6:22627, 2016 Mar 04.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Biosynthetic investigation of quinonemethide triterpenoid 22ß-hydroxy-maytenin (2) from in vitro root cultures of Peritassa laevigata (Celastraceae) was conducted using (13)C-precursor. The mevalonate pathway in P. laevigata is responsible for the synthesis of the quinonemethide triterpenoid scaffold. Moreover, anatomical analysis of P. laevigata roots cultured in vitro and in situ showed the presence of 22ß-hydroxy-maytenin (2) and maytenin (1) in the tissues from transverse or longitudinal sections with an intense orange color. MALDI-MS imaging confirmed the distribution of (2) and (1) in the more distal portions of the root cap, the outer cell layers, and near the vascular cylinder of P. laevigata in vitro roots suggesting a role in plant defense against infection by microorganisms as well as in the root exudation processes.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Magnoliaceae
Exsudatos de Plantas/metabolismo
Raízes de Plantas/metabolismo
Espermidina/análogos & derivados
[Mh] Termos MeSH secundário: Antioxidantes/química
Células Cultivadas
Técnicas In Vitro
Indolquinonas/química
Redes e Vias Metabólicas
Ácido Mevalônico/metabolismo
Exsudatos de Plantas/química
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Espermidina/química
Espermidina/metabolismo
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Indolequinones); 0 (Plant Exudates); 0 (Triterpenes); 138230-21-4 (quinone methide); 41590-65-2 (maytenine); S5UOB36OCZ (Mevalonic Acid); U87FK77H25 (Spermidine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE
[do] DOI:10.1038/srep22627


  8 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26732234
[Au] Autor:Yang YQ
[Ad] Endereço:a School of Pharmacy , Jiangsu University , Zhenjiang , China.
[Ti] Título:Synthesis and disproof of the structure proposed for the tetrahydrofuranol isolated from Michelia compressa var. lanyuensis (Magnoliaceae).
[So] Source:Nat Prod Res;30(14):1628-32, 2016 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The previously proposed structure for a tetrahydrofuranol isolated from the leaves of Michelia compressa var. lanyuensis (Magnoliaceae) was synthesised in an enantiopure form using diethyl D-tartarate as the starting material. The synthetic sample showed spectroscopic data incompatible with those for the natural product and thus unequivocally disproved the previously assigned structure.
[Mh] Termos MeSH primário: Furanos/química
Magnoliaceae/química
[Mh] Termos MeSH secundário: Indicadores e Reagentes
Espectroscopia de Ressonância Magnética
Conformação Molecular
Folhas de Planta/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furans); 0 (Indicators and Reagents)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1129331


  9 / 108 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26709074
[Au] Autor:Lee J; Choi JW; Sohng JK; Pandey RP; Park YI
[Ad] Endereço:Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, 420-743, Republic of Korea.
[Ti] Título:The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway.
[So] Source:Int Immunopharmacol;31:88-97, 2016 Feb.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Quercetin is a natural plant flavonoid that has been reported to possess a wide range of beneficial health effects, including anti-cancer and anti-inflammatory activities. Glycosylation of natural flavonoids with various sugar moieties can affect their physical, chemical, and biological properties. In this study, quercetin 3-O-xyloside (Quer-xyl) was enzymatically synthesized, and the immunomodulatory activities of quercetin and Quer-xyl were evaluated and compared. The results showed that Quer-xyl more effectively induced the secretion of TNF-α and IL-6 than quercetin by 2.5 and 1.5-fold, respectively. Quer-xyl dose-dependently induced the inducible nitric oxide synthase (iNOS) expression and increased the production of nitric oxide (NO) 1.3-fold more than quercetin. Quer-xyl also increased the phosphorylation of ASK1 and MAPKs (JNK and p38). Treatment with NQDI-1 (an inhibitor of ASK1) significantly attenuated the Quer-xyl-induced up-regulation of TNF-α secretion. The activation and subsequent nuclear translocation of NF-κB were substantially enhanced upon treatment with Quer-xyl (2.5-20 µM), while NQDI-1 treatment blocked the nuclear translocation of NF-κB. These results demonstrated that Quer-xyl can enhance the early innate immunity more effectively than quercetin by activating macrophages to secrete TNF-α and IL-6 through up-regulation of the redox-dependent ASK1/MAPK/NF-κB signaling pathway, suggesting for the first time that Quer-xyl may represent a new immunostimulator.
[Mh] Termos MeSH primário: MAP Quinases Reguladas por Sinal Extracelular/metabolismo
MAP Quinase Quinase Quinase 5/metabolismo
Macrófagos/efeitos dos fármacos
NF-kappa B/metabolismo
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Animais
Aporfinas/farmacologia
Linhagem Celular
Citocinas/metabolismo
Glicosilação
Imunização
Macrófagos/imunologia
Magnoliaceae/imunologia
Camundongos
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Quercetina/análogos & derivados
Quercetina/química
Quinolinas/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2,7-dioxo-2,7-dihydro-3H-naphtho(1,2,3-de)quinoline-1-carboxylate); 0 (Aporphines); 0 (Cytokines); 0 (NF-kappa B); 0 (Quinolines); 9IKM0I5T1E (Quercetin); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.25 (MAP Kinase Kinase Kinase 5)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151229
[St] Status:MEDLINE


  10 / 108 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26609630
[Au] Autor:Hu X; Sui X; Wang Y; Wang W; Wu H; Zhang F; Tan Y; Zhang F
[Ad] Endereço:a College of Life and Environmental Sciences , Minzu University of China , Beijing , P.R. China.
[Ti] Título:Sesquiterpene-neolignans from Manglietia hookeri.
[So] Source:Nat Prod Res;30(13):1477-83, 2016 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The comet assay-guided fractionation of the twigs of Manglietia hookeri resulted in the isolation of three sesquiterpene-neolignans, including a new one 5-allyl-2-(4-allyl-phenoxy)-3-[7-(1-hydroxy-1-methyl-ethyl)-1, 4a-dimethyl-decahydro-naphthalen-1-yloxy]-phenol (1), and eudesobovatol A (2) and eudesobovatol B (3), together with three lignans, obovatol (4), honokiol (5) and magnolol (6). Their structures were elucidated on the basis of spectral analysis and by comparison with related literature data. Compounds 1, 4-6 showed a protective effect on UV inductive DNA damage in mice lymphocyte cells, while compound 1 indicated the smallest Olive Tail Moment 7.34 ± 2.09 at 6 × 10(-6) µM.
[Mh] Termos MeSH primário: Lignanas/isolamento & purificação
Magnoliaceae/química
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Lignanas/química
Lignanas/farmacologia
Camundongos
Sesquiterpenos/química
Sesquiterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); 0 (Sesquiterpenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1110703



página 1 de 11 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde