Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.685.249 [Categoria DeCS]
Referências encontradas : 73 [refinar]
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[PMID]:29324847
[Au] Autor:Wu Y; Ma W; Liu J; Zhu L; Cong L; Zhai J; Wang Y; Zhang Z
[Ad] Endereço:College of Nature Conservation, Beijing Forestry University, Beijing, China.
[Ti] Título:Sabina chinensis and Liriodendron chinense improve air quality in Beijing, China.
[So] Source:PLoS One;13(1):e0189640, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Urban forests have been shown to be efficient for reducing air pollutants especially for particulate matters (PMs). This study aims to reveal the PM blocking capacity of two common artificial landscape species, Sabina chinensis and Liriodendron chinense and to investigate spatial-temporal heterogeneities by estimating the vegetation collection velocity of coarse (PM10) and fine particles (PM2.5) during different seasons and heights. PM concentration and meteorological data were collected on both leeward and windward sides of trees during the daytime in both summers and winters from 2013 to 2015. Concentration and meteorological monitors were installed at three heights, bottom (1.5 m), middle (3.5 m), and top (5.5 m) of the canopy. The results showed: During daytime, the collection velocity changed and PM2.5 collection velocity was much higher than that of PM10. Furthermore, the maximum collection velocities of L. chinense and S. chinensis occurred at 14:00-16:00 both in summer and winter. Moreover, the collection velocity had a positive correlation with wind speed and temperature. The blocking capacities of L. chinense and S. chinensis varied from season to season, and the concentrations of particulate matter indicate the middle canopy of both species as the most effective part for TSP blocking. Furthermore, these two species are more effective blocking in PM2.5 than PM10. The blocking capacity of S. chinensis is generally better. The vegetation collection is the major process of PM removal near the ground and sedimentation was not taken into consideration near the ground.
[Mh] Termos MeSH primário: Poluição do Ar
Florestas
Liriodendron/metabolismo
[Mh] Termos MeSH secundário: Pequim
Modelos Teóricos
Material Particulado/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Particulate Matter)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189640


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[PMID]:28550774
[Au] Autor:Choi WI; Ryu HJ; Kim SJ; Oh KK
[Ad] Endereço:R&D Center, SugarEn Co., Ltd., Yongin, Gyeonggi 16890, Republic of Korea.
[Ti] Título:Thermo-mechanical fractionation of yellow poplar sawdust with a low reaction severity using continuous twin screw-driven reactor for high hemicellulosic sugar recovery.
[So] Source:Bioresour Technol;241:63-69, 2017 Oct.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Yellow poplar sawdust (YPS), a wood waste that can be easily collected from a local furniture factory, was fractionated using continuous twin screw-driven reactor for high hemicellulosic sugar recovery. The highest total sugar yields were attained under the following conditions: a barrel temperature of 127°C, sulfuric acid concentration of 0.8wt%, liquid feeding rate of 25mL/min, solid feeding rate of 2.0g/min, screw rotation speed of 25rpm, and residence time of 14.5min. The glucan and hemicellulose contents of the CTSR-fractionated YPS were 47.8% and 10.4%, respectively, and these results indicated that 44.9% of cellulose and 76.3% of the hemicellulose were extracted into liquid hydrolyzate. Meanwhile, the batch fractionation of YPS at the same reaction conditions showed a little fractionation effect, i.e., only 20.5% of hemicellulosic sugar yield was obtained.
[Mh] Termos MeSH primário: Reatores Biológicos
Liriodendron
[Mh] Termos MeSH secundário: Carboidratos
Hidrólise
Sacarose
Madeira
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 57-50-1 (Sucrose)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170528
[St] Status:MEDLINE


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[PMID]:28323890
[Au] Autor:Huo A; Chen Z; Wang P; Yang L; Wang G; Wang D; Liao S; Cheng T; Chen J; Shi J
[Ad] Endereço:Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
[Ti] Título:Establishment of transient gene expression systems in protoplasts from Liriodendron hybrid mesophyll cells.
[So] Source:PLoS One;12(3):e0172475, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Liriodendron is a genus of the magnolia family comprised of two flowering tree species that produce hardwoods of great ecological and economic value. However, only a limited amount of genetic research has been performed on the Liriodendron genus partly because transient or stable transgenic trees have been difficult to produce. In general, transient expression systems are indispensable for rapid, high-throughput screening and systematic characterization of gene functions at a low cost; therefore, development of such a system for Liriodendron would provide a necessary step forward for research on Magnoliaceae and other woody trees. Herein, we describe an efficient and rapid protocol for preparing protoplasts from the leaf mesophyll tissue of a Liriodendron hybrid and an optimized system for polyethylene glycol-mediated transient transfection of the protoplasts. Because the leaves of the Liriodendron hybrid are waxy, we formulated an enzyme mix containing 1.5% (w/v) Cellulase R-10, 0.5% (w/v) Macerozyme R-10, and 0.1% (w/v) Pectolyase Y-23 to efficiently isolate protoplasts from the Liriodendron hybrid leaf mesophyll tissue in 3 h. We optimized Liriodendron protoplast transfection efficiency by including 20 µg plasmid DNA per 104 protoplasts, a transformation time of 20 min, and inclusion of 20% (w/v) polyethylene glycol 4000. After integrating the Liriodendron WOX1 gene into pJIT166-GFP to produce a WOX1-GFP fusion product and transfecting it into isolated protoplasts, LhWOX1-GFP was found to localize to the nucleus according to its green fluorescence.
[Mh] Termos MeSH primário: Expressão Gênica
Liriodendron
Células do Mesofilo
Protoplastos
Transfecção
[Mh] Termos MeSH secundário: Técnicas de Cultura de Células
Vetores Genéticos
Proteínas Luminescentes/genética
Proteínas Luminescentes/metabolismo
Células do Mesofilo/metabolismo
Folhas de Planta
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Protoplastos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Luminescent Proteins); 0 (Plant Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172475


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[PMID]:27208738
[Au] Autor:Yoon J; Lee HW; Sim S; Myint AA; Park HJ; Lee YW
[Ad] Endereço:School of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744, Republic of Korea.
[Ti] Título:Hydrolysis kinetics of tulip tree xylan in hot compressed water.
[So] Source:Bioresour Technol;214:679-85, 2016 Aug.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lignocellulosic biomass, a promising renewable resource, can be converted into numerous valuable chemicals post enzymatic saccharification. However, the efficacy of enzymatic saccharification of lignocellulosic biomass is low; therefore, pretreatment is necessary to improve the efficiency. Here, a kinetic analysis was carried out on xylan hydrolysis, after hot compressed water pretreatment of the lignocellulosic biomass conducted at 180-220°C for 5-30min, and on subsequent xylooligosaccharide hydrolysis. The weight ratio of fast-reacting xylan to slow-reacting xylan was 5.25 in tulip tree. Our kinetic results were applied to three different reaction systems to improve the pretreatment efficiency. We found that semi-continuous reactor is promising. Lower reaction temperatures and shorter space times in semi-continuous reactor are recommended for improving xylan conversion and xylooligosaccharide yield. In the theoretical calculation, 95% of xylooligosaccharide yield and xylan conversion were achieved simultaneously with high selectivity (desired product/undesired product) of 100 or more.
[Mh] Termos MeSH primário: Biotecnologia/métodos
Liriodendron/química
Xilanos/química
[Mh] Termos MeSH secundário: Biomassa
Reatores Biológicos
Biotecnologia/instrumentação
Hidrólise
Cinética
Oligossacarídeos/química
Oligossacarídeos/metabolismo
Temperatura Ambiente
Água
Xilanos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oligosaccharides); 0 (Xylans); 059QF0KO0R (Water)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE


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[PMID]:26943934
[Au] Autor:Kundu C; Jeong SY; Lee JW
[Ad] Endereço:Department of Forest Products and Technology, College of Agriculture and Life Sciences, Chonnam National University, Gwang-ju 500-757, Republic of Korea.
[Ti] Título:Bioethanol production from deacetylated yellow poplar pretreated with oxalic acid recovered through electrodialysis.
[So] Source:Bioresour Technol;208:170-177, 2016 May.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrodialysis (ED) was used to develop a multistage oxalic acid recovery and pretreatment system to produce ethanol from deacetylated yellow poplar. Pretreatment of the biomass was performed at 150°C for 42 min using 0.16 M oxalic acid. The efficiency of oxalic acid recovery from the hydrolysate reached up to 92.32% in all the stages. Ethanol production and ethanol yield of ED-treated hydrolysate in each stage showed a uniform pattern ranging from 6.81 g/L to 7.21 g/L and 0.40 g/g to 0.43 g/g, respectively. The results showed that efficiency of ethanol production increased when deacetylated biomass and ED process was used. Ethanol yield from the pretreated biomass using simultaneous saccharification and fermentation (SSF) was in the range of 80.59-83.36% in all the stages. The structural characterization of the pretreated biomass at each stage was investigated and structural changes were not significantly different among the various pretreated biomass.
[Mh] Termos MeSH primário: Etanol/isolamento & purificação
Liriodendron/química
Ácido Oxálico/química
[Mh] Termos MeSH secundário: Acetilação
Biomassa
Diálise/métodos
Etanol/química
Fermentação
Hidrólise
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3K9958V90M (Ethanol); 9E7R5L6H31 (Oxalic Acid)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE


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[PMID]:26100445
[Au] Autor:Levia DF; Shiklomanov AN; Van Stan JT; Scheick CE; Inamdar SP; Mitchell MJ; McHale PJ
[Ad] Endereço:Departments of Geography and Plant and Soil Sciences, University of Delaware, Newark, DE, 19716, USA, dlevia@udel.edu.
[Ti] Título:Calcium and aluminum cycling in a temperate broadleaved deciduous forest of the eastern USA: relative impacts of tree species, canopy state, and flux type.
[So] Source:Environ Monit Assess;187(7):458, 2015 Jul.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ca/Al molar ratios are commonly used to assess the extent of aluminum stress in forests. This is among the first studies to quantify Ca/Al molar ratios for stemflow. Ca/Al molar ratios in bulk precipitation, throughfall, stemflow, litter leachate, near-trunk soil solution, and soil water were quantified for a deciduous forest in northeastern MD, USA. Data were collected over a 3-year period. The Ca/Al molar ratios in this study were above the threshold for aluminum stress (<1). Fagus grandifolia Ehrh. (American beech) had a median annual stemflow Ca/Al molar ratio of 15.7, with the leafed and leafless values of 12.4 and 19.2, respectively. The corresponding Ca/Al molar ratios for Liriodendron tulipifera L. (yellow poplar) were 11.9 at the annual time scale and 11.9 and 13.6 for leafed and leafless periods, respectively. Bayesian statistical analysis showed no significant effect of canopy state (leafed, leafless) on Ca/Al molar ratios. DOC was consistently an important predictor of calcium, aluminum, and Ca/Al ratios. pH was occasionally an important predictor of calcium and aluminum concentrations, but was not a good predictor of Ca/Al ratio in any of the best-fit models (of >500 examined). This study supplies new data on Ca/Al molar ratios for stemflow from two common deciduous tree species. Future work should examine Ca/Al molar ratios in stemflow of other species and examine both inorganic and organic aluminum species to better gauge the potential for, and understand the dynamics of, aluminum toxicity in the proximal area around tree boles.
[Mh] Termos MeSH primário: Alumínio/análise
Cálcio/análise
Monitoramento Ambiental/métodos
Fagus/fisiologia
Florestas
Liriodendron/fisiologia
[Mh] Termos MeSH secundário: Teorema de Bayes
Concentração de Íons de Hidrogênio
Modelos Lineares
Folhas de Planta/química
Chuvas
Solo
Especificidade da Espécie
Árvores
Estados Unidos
Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Soil); 059QF0KO0R (Water); CPD4NFA903 (Aluminum); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150624
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-015-4675-3


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[PMID]:26004723
[Au] Autor:Tan X; Yang D; Yang G; Chen J; Dong W; Shi J; Jia A
[Ad] Endereço:Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
[Ti] Título:The investigation of inhibiting quorum sensing and methicillin-resistant Staphylococcus aureus biofilm formation from Liriodendron hybrid.
[So] Source:Pak J Pharm Sci;28(3):903-8, 2015 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The quorum sensing (QS) of pathogens has been found to affect their biofilm forming ability, making it a potential target for anti-microbial therapy. The present research aimed to evaluate the anti-QS activities of different extracts and isolated phytochemicals from Liriodendron hybrid barks and their roles in the inhibition of the growth and biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA). The assays on the inhibition of QS by the five extracts (n-hexane, dichloromethane, ethyl acetate, acetone, and methanol) and eight isolated compounds were carried out by using both the indicator strains Chromobacrerium violaceum CV026 and C. violaceum ATCC12472. The in vitro effects of the five extracts and eight isolated compounds on MRSA biofilm were also preliminarily evaluated using crystal violet micro titer plate assays. The results suggested that the dichloromethane extract showed anti-QS and MRSA biofilm inhibitory activities and the n-hexane extract possessed only MRSA biofilm inhibitory effect. The dichloromethane extract could serve as a source for developing bacterial intervention strategies targeting microbial QS system. All eight isolated compounds showed no anti-QS and biofilm formation inhibiting activities. So further researches are still being required to purify and identify the compounds possessing anti-QS and biofilm inhibitory effects from the dichloromethane and n-hexane extracts.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Biofilmes/efeitos dos fármacos
Liriodendron
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Casca de Planta
Extratos Vegetais/farmacologia
Percepção de Quorum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Benzamidas/farmacologia
Cumarínicos/farmacologia
Testes de Sensibilidade Microbiana
Compostos Fitoquímicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Benzamides); 0 (Coumarins); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150525
[Lr] Data última revisão:
150525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150526
[St] Status:MEDLINE


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[PMID]:25963192
[Au] Autor:Fang Z; Jung KH; Yan HH; Kim SJ; Son MK; Rumman M; Lee H; Kim KW; Yoo HD; Hong SS
[Ad] Endereço:Department of Biomedical Sciences, College of Medicine, Inha University, Incheon 400-712, Republic of Korea.
[Ti] Título:CD-200 induces apoptosis and inhibits Bcr-Abl signaling in imatinib-resistant chronic myeloid leukemia with T315I mutation.
[So] Source:Int J Oncol;47(1):253-61, 2015 Jul.
[Is] ISSN:1791-2423
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Chronic myeloid leukemia (CML) is characterized by a constitutively active Bcr-Abl tyrosine kinase. Although Imatinib has been proven to be an effective drug against CML, its resistance has been observed with disease relapse due to T315I predominant point mutation. Liriodendron tulipifera L., one of the fastest growing hardwood tree species, exerts antioxidant activity and anti-inflammatory effects. However, its anticancer effect has been minimally reported. In this study, we extracted CD-200 from Liriodendron tulipifera L. and investigated its effect on cell survival or apoptosis in CML cells with Bcr-Abl/T315I (BaF3/T315I) as well as wild-type Bcr-Abl (BaF3/WT). CD-200 inhibited cell proliferation in the BaF3/WT cells, and also in the BaF3/T315I cells with Imatinib resistance. Moreover, it strongly inhibited Bcr-Abl signaling pathways in a dose-dependent manner. Also, it significantly increased the sub-G1 phase and the expression of cleaved PARP and caspase-3, as well as the TUNEL-positive apoptotic cells. In addition, we observed that CD-200 induced apoptosis with a loss of mitochondrial membrane potential by decreasing the expression of Mcl-1 and survivin. Furthermore, CD-200 showed a significant inhibition in tumor growth, compared to Imatinib in BaF3/T315I mouse xenograft models. Taken together, our study demonstrates that CD-200 exhibits apoptosis induction and anti-proliferative effect by blocking the Bcr-Abl signaling pathways in the Bcr-Abl/T315I with resistance to Imatinib. We suggest that CD-200 may be a natural product to target Bcr-Abl and overcome Imatinib resistance in CML patients.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Proteínas de Fusão bcr-abl/genética
Lactonas/administração & dosagem
Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico
Liriodendron/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/farmacologia
Apoptose
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Mesilato de Imatinib/farmacologia
Lactonas/química
Lactonas/farmacologia
Leucemia Mielogênica Crônica BCR-ABL Positiva/genética
Camundongos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Mutação Puntual
Transdução de Sinais/efeitos dos fármacos
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Lactones); 0 (Plant Extracts); 8A1O1M485B (Imatinib Mesylate); EC 2.7.10.2 (Fusion Proteins, bcr-abl)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150610
[Lr] Data última revisão:
150610
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150513
[St] Status:MEDLINE
[do] DOI:10.3892/ijo.2015.2994


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[PMID]:25817591
[Au] Autor:Yang DT; Lin SS; Chen JH; Yuan ST; Shi JS; Wang JS; Jia AQ
[Ad] Endereço:School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Xiaolingwei 200, Nanjing 210094, China; Luoyang Ruize Petrochemical Engineering Co. Ltd, Luoyang 471003, China.
[Ti] Título:(+)- and (-)-liriodenol, a pair of novel enantiomeric lignans from Liriodendron hybrid.
[So] Source:Bioorg Med Chem Lett;25(9):1976-8, 2015 May 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:(+)- and (-)-liriodenol, a pair of unprecedented enantiomeric lignans bearing a 1,1-disubstituted olefinic group, were isolated from the barks of Liriodendron hybrid. The structure and relative configurations were determined by comprehensive analysis of MS and NMR spectroscopy. The cytotoxicity of these three lignans ((±)-, (+)-, and (-)-liriodenol) was evaluated in vitro against four selected human tumor cell lines, where (+)-liriodenol showed more significant cytotoxic effects than the (±)- and (-)-liriodenol enantiomers.
[Mh] Termos MeSH primário: Lignanas/química
Lignanas/farmacologia
Liriodendron/química
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Colorimetria
Relação Dose-Resposta a Droga
Seres Humanos
Lignanas/isolamento & purificação
Estrutura Molecular
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lignans); 0 (liriodenol)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150423
[Lr] Data última revisão:
150423
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150331
[St] Status:MEDLINE


  10 / 73 MEDLINE  
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[PMID]:25747981
[Au] Autor:Jeong EJ; Kim NH; Heo JD; Lee KY; Rho JR; Kim YC; Sung SH
[Ad] Endereço:Department of Agronomy & Medicinal Plant Resources, College of Life Sciences and Natural Resources, Gyeongnam National University of Science and Technology.
[Ti] Título:Antifibrotic compounds from Liriodendron tulipifera attenuating HSC-T6 proliferation and TNF-α production in RAW264.7 cells.
[So] Source:Biol Pharm Bull;38(2):228-34, 2015.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The inhibition of hepatic stellate cell (HSC) proliferation has been considered as an effective therapeutic target for the treatment of liver fibrosis. The methanolic extract of Liriodendron tulipifera showed significant inhibitory activity against the proliferation of HSCs. Bioactivity-guided isolation afforded twelve compounds including (-)-sesamin (1), (-)-syringaresinol (2), (+)-dihydrodehydrodiconiferyl alcohol (3), salvinal (4), (+)-guaiacylglycerol-8-O-4'-dihydroconiferyl ether (5), (±)-guaiacylglycerol-8-O-4'-sinapyl alcohol ether (6), tanegool (7), (+)-5,5'-dimethoxy-7-oxolariciresinol (8), 3-hydroxy-4-methoxyacetophenone (9), 4-acetoxymethylphenol (10), (-)-paramicholide (11), and blumenol A (12). Among the compounds isolated, 2, 3 and 4 significantly attenuated the proliferation of the activated HSC-T6 cells. The maximal dose of these compounds, however, showed no cytotoxicity in primary cultured rat hepatocytes. Collagen deposition in the activated HSC-T6 cells was reduced by 2, 3 and 4. Also, the increased production of the pro-inflammatory cytokine tumor necrosis factor (TNF)-α induced by lipopolysaccharide was decreased by 3 and 4 in RAW264.7 macrophage cells. Collectively, (-)-syringaresinol (2), (+)-dihydrodehydrodiconiferyl alcohol (3), and salvinal (4) isolated from L. tulipifera leaves and twigs exhibited selective antifibrotic activities toward the activated HSCs and suppressed TNF-α production in RAW264.7 macrophages. These compounds may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis.
[Mh] Termos MeSH primário: Colágeno/metabolismo
Liriodendron
Extratos Vegetais/farmacologia
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Células Estreladas do Fígado/efeitos dos fármacos
Células Estreladas do Fígado/metabolismo
Hepatócitos/efeitos dos fármacos
Lipopolissacarídeos
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Folhas de Planta
Caules de Planta
Ratos
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 9007-34-5 (Collagen)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150309
[Lr] Data última revisão:
150309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150310
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b14-00583



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