Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.685.500 [Categoria DeCS]
Referências encontradas : 430 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 43 ir para página                         

  1 / 430 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28746938
[Au] Autor:Shen J; Ma H; Zhang T; Liu H; Yu L; Li G; Li H; Hu M
[Ad] Endereço:Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
[Ti] Título:Magnolol Inhibits the Growth of Non-Small Cell Lung Cancer via Inhibiting Microtubule Polymerization.
[So] Source:Cell Physiol Biochem;42(5):1789-1801, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The tubulin/microtubule system, which is an integral component of the cytoskeleton, plays an essential role in mitosis. Targeting mitotic progression by disturbing microtubule dynamics is a rational strategy for cancer treatment. METHODS: Microtubule polymerization assay was performed to examine the effect of Magnolol (a novel natural phenolic compound isolated from Magnolia obovata) on cellular microtubule polymerization in human non-small cell lung cancer (NSCLC) cells. Cell cycle analysis, mitotic index assay, cell proliferation assay, colony formation assay, western blotting analysis of cell cycle regulators, Annexin V-FITC/PI staining, and live/dead viability staining were carried out to investigate the Magnolol's inhibitory effect on proliferation and viability of NSCLS cells in vitro. Xenograft model of human A549 NSCLC tumor was used to determine the Magnolol's efficacy in vivo. RESULTS: Magnolol treatment effectively inhibited cell proliferation and colony formation of NSCLC cells. Further study proved that Magnolol induced the mitotic phase arrest and inhibited G2/M progression in a dose-dependent manner, which were mechanistically associated with expression alteration of a series of cell cycle regulators. Furthermore, Magnolol treatment disrupted the cellular microtubule organization via inhibiting the polymerization of microtubule. We also found treatment with NSCLC cells with Magnolol resulted in apoptosis activation through a p53-independent pathway, and autophgy induction via down-regulation of the Akt/mTOR pathway. Finally, Magnolol treatment significantly suppressed the NSCLC tumor growth in mouse xenograft model in vivo. CONCLUSION: These findings identify Magnolol as a promising candidate with anti-microtubule polymerization activity for NSCLC treatment.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Compostos de Bifenilo/farmacologia
Proliferação Celular/efeitos dos fármacos
Lignanas/farmacologia
Microtúbulos/metabolismo
[Mh] Termos MeSH secundário: Células A549
Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/uso terapêutico
Apoptose/efeitos dos fármacos
Compostos de Bifenilo/química
Compostos de Bifenilo/uso terapêutico
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Carcinoma Pulmonar de Células não Pequenas/metabolismo
Carcinoma Pulmonar de Células não Pequenas/patologia
Linhagem Celular Tumoral
Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos
Seres Humanos
Lignanas/química
Lignanas/uso terapêutico
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/patologia
Pontos de Checagem da Fase M do Ciclo Celular/efeitos dos fármacos
Magnolia/química
Magnolia/metabolismo
Masculino
Camundongos Nus
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais/efeitos dos fármacos
Serina-Treonina Quinases TOR/metabolismo
Transplante Heterólogo
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Biphenyl Compounds); 0 (Lignans); 0 (Tumor Suppressor Protein p53); 001E35HGVF (magnolol); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1159/000479458


  2 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28919305
[Au] Autor:Suh KS; Chon S; Jung WW; Choi EM
[Ad] Endereço:Dept. of Endocrinology & Metabolism, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
[Ti] Título:Magnolol protects pancreatic ß-cells against methylglyoxal-induced cellular dysfunction.
[So] Source:Chem Biol Interact;277:101-109, 2017 Nov 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Chronic hyperglycemia aggravates insulin resistance, in part due to increased formation of advanced glycation end-products (AGEs). Methylglyoxal (MG), a major precursor of AGEs, accumulates abnormally in various tissues and organs and participates in oxidative damage. We investigated the insulinotropic benefits of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, in pancreatic ß-cells exposed to MG in vitro. When exposed to cytotoxic levels of MG for 48 h, RIN-m5F ß-cells exhibited a significant loss of viability and impaired insulin secretion, whereas pretreatment with magnolol protected against MG-induced cell death and decreased insulin secretion. Moreover, magnolol increased the expression of genes involved in ß-cell survival and function, including Ins2 and PDX1. Furthermore, magnolol increased the levels of AMPK phosphorylation, SIRT1, and PGC1α in RIN-5F ß-cells. In addition, magnolol increased the activity of glyoxalase I and decreased the levels of MG-modified protein adducts, which suggests that magnolol protects against MG-induced protein glycation. Taken together, the results indicate the potential application of magnolol as an intervention against MG-induced hyperglycemia.
[Mh] Termos MeSH primário: Compostos de Bifenilo/farmacologia
Citoproteção/efeitos dos fármacos
Células Secretoras de Insulina/efeitos dos fármacos
Lignanas/farmacologia
Substâncias Protetoras/farmacologia
Aldeído Pirúvico/metabolismo
[Mh] Termos MeSH secundário: Animais
Compostos de Bifenilo/química
Compostos de Bifenilo/isolamento & purificação
Morte Celular/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Insulina/metabolismo
Células Secretoras de Insulina/citologia
Células Secretoras de Insulina/metabolismo
Lignanas/química
Lignanas/isolamento & purificação
Magnolia/química
Substâncias Protetoras/química
Substâncias Protetoras/isolamento & purificação
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Insulin); 0 (Lignans); 0 (Protective Agents); 001E35HGVF (magnolol); 722KLD7415 (Pyruvaldehyde)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


  3 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28854218
[Au] Autor:Sun L; Liao K; Wang D
[Ad] Endereço:Department of Pharmacology, Medical School of Southeast University, Nanjing, China.
[Ti] Título:Honokiol induces superoxide production by targeting mitochondrial respiratory chain complex I in Candida albicans.
[So] Source:PLoS One;12(8):e0184003, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Honokiol, a compound extracted from Magnolia officinalis, has antifungal activities by inducing mitochondrial dysfunction and triggering apoptosis in Candida albicans. However, the mechanism of honokiol-induced oxidative stress is poorly understood. The present investigation was designed to determine the specific mitochondrial reactive oxygen species (ROS)-generation component. METHODS/RESULTS: We found that honokiol induced mitochondrial ROS accumulation, mainly superoxide anions (O2•-) measured by fluorescent staining method. The mitochondrial respiratory chain complex I (C I) inhibitor rotenone completely blocked O2•- production and provided the protection from the killing action of honokiol. Moreover, respiratory activity and the C I enzyme activity was significantly reduced after honokiol treatment. The differential gene-expression profile also showed that genes involved in oxidoreductase activity, electron transport, and oxidative phosphorylation were upregulated. CONCLUSIONS: The present work shows that honokiol may bind to mitochondrial respiratory chain C I, leading to mitochondrial dysfunction, accompanied by increased cellular superoxide anion and oxidative stress. GENERAL SIGNIFICANCE: This work not only provides insights on the mechanism by which honokiol interferes with fungal cell, demonstrating previously unknown effects on mitochondrial physiology, but also raises a note of caution on the use of M. officinalis as a Chinese medicine due to the toxic for mitochondria and suggests the possibility of using honokiol as chemosensitizer.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Compostos de Bifenilo/farmacologia
Candida albicans/efeitos dos fármacos
Complexo I de Transporte de Elétrons/antagonistas & inibidores
Proteínas Fúngicas/antagonistas & inibidores
Lignanas/farmacologia
Superóxidos/metabolismo
[Mh] Termos MeSH secundário: Antifúngicos/química
Antifúngicos/isolamento & purificação
Compostos de Bifenilo/química
Compostos de Bifenilo/isolamento & purificação
Candida albicans/citologia
Candida albicans/genética
Candida albicans/metabolismo
Candidíase/tratamento farmacológico
Candidíase/microbiologia
Complexo I de Transporte de Elétrons/genética
Complexo I de Transporte de Elétrons/metabolismo
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Regulação Fúngica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Lignanas/química
Lignanas/isolamento & purificação
Magnolia/química
Estresse Oxidativo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Biphenyl Compounds); 0 (Fungal Proteins); 0 (Lignans); 11062-77-4 (Superoxides); 11513CCO0N (honokiol); EC 1.6.5.3 (Electron Transport Complex I)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184003


  4 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28621040
[Au] Autor:Latif A; Du Y; Dalal SR; Fernández-Murga ML; Merino EF; Cassera MB; Goetz M; Kingston DGI
[Ad] Endereço:Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA.
[Ti] Título:Bioactive Neolignans and Other Compounds from Magnolia grandiflora L.: Isolation and Antiplasmodial Activity.
[So] Source:Chem Biodivers;14(9), 2017 Sep.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bioassay-guided fractionation of a methanol extract of Magnolia grandiflora against Plasmodium falciparum yielded two new (1 and 2) and six known (3 - 8) bioactive compounds. The structures of the new compounds were assigned by mass spectrometric and 1D- and 2D-NMR data. Known compounds were identified by comparison of H-NMR and MS data with literature data. The two known neolignans 3 and 4 showed moderate antiplasmodial activity with the IC values of 2.8 ± 0.1 and 3.4 ± 0.1 µm, respectively. Weak antiplasmodial activity was recorded for compounds 1, 2, 5, 6, 7, and 8, with the IC values of 38 ± 2, 23 ± 2, 16.5 ± 0.2, 86 ± 1, 44 ± 4, and 114 ± 9 µm, respectively.
[Mh] Termos MeSH primário: Antimaláricos/química
Antimaláricos/farmacologia
Lignanas/química
Lignanas/farmacologia
Magnolia/química
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antimaláricos/isolamento & purificação
Seres Humanos
Lignanas/isolamento & purificação
Malária Falciparum/tratamento farmacológico
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Lignans); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700209


  5 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28585905
[Au] Autor:Kato N; Kawabe S; Ganeko N; Yoshimura M; Amakura Y; Ito H
[Ad] Endereço:a Faculty of Health and Welfare Science, Department of Nutritional Science , Okayama Prefectural University , Okayama , Japan.
[Ti] Título:Polyphenols from flowers of Magnolia coco and their anti-glycation effects.
[So] Source:Biosci Biotechnol Biochem;81(7):1285-1288, 2017 Jul.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the inhibitory effects of several plant extracts on advanced glycation end-products (AGEs) formation. Among tested samples, the flower extract of Magnolia coco showed significant inhibition of AGE formation. We isolated and characterized procyanidin oligomer and four other compounds from the flowers, and evaluated their inhibitory effects on AGE formation and the AGE-derived crosslink-cleaving activity of the isolated compounds.
[Mh] Termos MeSH primário: Biflavonoides/química
Catequina/química
Flores/química
Produtos Finais de Glicação Avançada/antagonistas & inibidores
Magnolia/química
Polifenóis/química
Proantocianidinas/química
[Mh] Termos MeSH secundário: Biflavonoides/isolamento & purificação
Catequina/isolamento & purificação
Frutose/química
Glucose/química
Glicosilação
Seres Humanos
Extratos Vegetais/química
Polifenóis/isolamento & purificação
Proantocianidinas/isolamento & purificação
Albumina Sérica/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Glycation End Products, Advanced); 0 (Plant Extracts); 0 (Polyphenols); 0 (Proanthocyanidins); 0 (Serum Albumin); 30237-26-4 (Fructose); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1292837


  6 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28271656
[Au] Autor:Poivre M; Duez P
[Ad] Endereço:Unit of Therapeutic Chemistry and Pharmacognosy, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, University of Mons-UMONS, Mons, Belgium.
[Ti] Título:Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents.
[So] Source:J Zhejiang Univ Sci B;18(3):194-214, 2017 Mar..
[Is] ISSN:1862-1783
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Magnolia/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Ansiedade/tratamento farmacológico
Asma/tratamento farmacológico
Depressão/tratamento farmacológico
Medicamentos de Ervas Chinesas/toxicidade
Gastroenteropatias/tratamento farmacológico
Cefaleia/tratamento farmacológico
Seres Humanos
Parassimpatolíticos/farmacologia
Casca de Planta/química
Extratos Vegetais/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Drugs, Chinese Herbal); 0 (Parasympatholytics); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1631/jzus.B1600299


  7 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28252172
[Au] Autor:Wang L; Xiao AH; Ma LY; Chen FJ; Sang ZY; Duan J
[Ad] Endereço:Key Laboratory for Silviculture and Conservation of the Ministry of Education, Beijing Forestry University, Beijing, China.
[Ti] Título:Identification of Magnolia wufengensis (Magnoliaceae) cultivars using phenotypic traits, SSR and SRAP markers: insights into breeding and conservation.
[So] Source:Genet Mol Res;16(1), 2017 Feb 23.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:A combination of phenotypic characterization and molecular markers may provide reliable information on new plant varieties and elucidate the conservation status of rare species. Five newly developed Magnolia wufengensis cultivars, an endangered plant species endemic to Hubei Province, China, possess more distinctive phenotypes than common Magnolia cultivars. With reference to a wild species population of M. wufengensis and a population of Magnolia denudata, morphological traits of flower organs, simple sequence repeat (SSR), and sequence-related amplified polymorphism (SRAP) markers were used. In the morphological study, six traits of floral organs were investigated and their relationships were analyzed between cultivars. In the genetic study, 9 SSR primer pairs and 10 SRAP primer combinations were screened. The five cultivars maintained a high level of genetic diversity. Genetic diversity of each M. wufengensis cultivar was much lower than that of the wild population, but was slightly higher than that of the M. denudata population. Analysis of molecular variance (AMOVA) revealed that genetic variation among populations was 20% (SRAP) and 30% (SSR), which showed a high degree of genetic differentiation among populations of the five cultivars. The dendrograms illustrated a clear separation between M. wufengensis populations and outer species, and identified two major groups among cultivars. Correlation analysis indicated a good fit between the two marker systems, but a relatively low fit between morphological and genetic traits (SRAP: r = 0.60, SSR: r = 0.52). These findings provide reliable references for the application of these molecular markers in the breeding and conservation of M. wufengensis.
[Mh] Termos MeSH primário: Conservação dos Recursos Naturais/métodos
Marcadores Genéticos/genética
Variação Genética
Magnolia/genética
Repetições de Microssatélites/genética
Melhoramento Vegetal/métodos
[Mh] Termos MeSH secundário: Análise de Variância
Antocianinas/análise
Antocianinas/metabolismo
China
Cromatografia Líquida de Alta Pressão
Análise por Conglomerados
Cor
Espécies em Perigo de Extinção
Flores/genética
Flores/metabolismo
Magnolia/classificação
Magnolia/metabolismo
Fenótipo
Filogenia
Pigmentação/genética
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Genetic Markers)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16019473


  8 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28232195
[Au] Autor:Chen X; Hu Y; Shan L; Yu X; Hao K; Wang GX
[Ad] Endereço:College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
[Ti] Título:Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells.
[So] Source:Fish Shellfish Immunol;63:245-254, 2017 Apr.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Medicinal plants have been widely used for a long history. Exploration of pharmacologically active compounds from medicinal plants present a broad prevalent of application. By examining viral mRNA expression in GCRV-infected Ctenopharyngodon idella kidney (CIK) cells treated with thirty kinds of plant extracts, we identified Magnolia officinalis Rehd et Wils. was able to preferably suppress viral replication. Further studies demonstrated that the main ingredients of magnolia bark, namely, magnolol and honokiol presented protective pharmacological function when treated GCRV-infected CIK cells with a concentration of 2.00 µg/ml and 1.25 µg/ml, respectively. Furthermore, reverse transcript quantitative polymerase chain reaction (RT-qPCR) and western blot showed that both magnolol and honokiol were efficient to restrain the replication of GCRV in CIK cells at non-toxic concentration (2.51 ± 0.51 µg/ml for magnolol, and 3.18 ± 0.61 µg/ml for honokiol). Moreover, it was found that magnolol and honokiol promoted the expression of immune-related genes. Magnolol obviously significantly increased the expression of interferon (IFN) regulatory factor (IRF)7 rather than that of IRF3 in the GCRV-infected cells, leading to the activation of type I IFN (IFN-I). Simultaneously, magnolol drastically facilitated the expression of interleukin (IL)-1ß, but failed to induce the molecules in nuclear factor (NF)-κB pathways. Differently, honokiol strikingly motivated not only the expression of IL-1ß, but also those of tumor necrosis factor α (TNFα) and NF-κB. Interestingly, though honokiol motivated the expression of IFN-ß promoter stimulator 1 (IPS-1), IRF3 and IRF7, it failed to up-regulate the expression of IFN-I, indicating that honokiol enhanced the host innate antiviral response to GCRV infection via NF-κB pathways. Collectively, the present study revealed that magnolol and honokiol facilitated the expression of innate immune-related genes to strengthen the innate immune signaling responses to resist GCRV infection, which contributed to understanding the mechanisms by which small-molecule drugs possessed antiviral activities. In addition, these results lay a foundation for the development of broad-spectrum antiviral compounds in aquaculture industry.
[Mh] Termos MeSH primário: Compostos de Bifenilo/farmacologia
Carpas
Doenças dos Peixes/imunologia
Imunidade Inata
Lignanas/farmacologia
Magnolia/química
Infecções por Reoviridae/veterinária
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Colorimetria
Efeito Citopatogênico Viral
Doenças dos Peixes/virologia
Reoviridae/fisiologia
Infecções por Reoviridae/imunologia
Infecções por Reoviridae/virologia
Sais de Tetrazólio/química
Tiazóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Lignans); 0 (Tetrazolium Salts); 0 (Thiazoles); 001E35HGVF (magnolol); 11513CCO0N (honokiol); EUY85H477I (thiazolyl blue)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE


  9 / 430 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28209193
[Au] Autor:Yimam M; Jiao P; Hong M; Brownell L; Lee YC; Hyun EJ; Kim HJ; Nam JB; Kim MR; Jia Q
[Ad] Endereço:Unigen, Inc., 3005 1st Avenue, Seattle, WA, 98121, USA. myimam@unigen.net.
[Ti] Título:UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss.
[So] Source:BMC Complement Altern Med;17(1):114, 2017 Feb 16.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too expensive, their long term usages are hindered by their severe adverse effects. Here we describe the effect of UP601, a standardized blend of extracts from Morus alba, Yerba mate and Magnolia officinalis, in modulating a number of obesity-related phenotypic and biochemical markers in a high-fat high-fructose (HFF)-induced C57BL/6J mouse model of obesity. METHOD: Adipogenesis activity of the composition was assessed in 3T3-L1 cells in vitro. Effects of UP601 on body weight and metabolic markers were evaluated. It was administered at oral doses of 300 mg/kg, 450 mg/kg and 600 mg/kg for 7 weeks. Orlistat (40 mg/kg/day) was used as a positive control. Body compositions of mice were assessed using dual energy X-ray absorptiometry (DEXA). Serum biomarkers were measured for liver function and lipid profiling. Relative organ weights were determined. Histopathological analysis was performed for non-alcoholic steatohepatitis (NASH) scoring. RESULTS: UP601 at 250 µg/ml resulted in 1.8-fold increase in lipolysis. Statistically significant changes in body weight (decreased by 9.1, 19.6 and 25.6% compared to the HFF group at week-7) were observed for mice treated with UP601 at 300, 450 and 600 mg/kg, respectively. Reductions of 9.1, 16.9, and 18.6% in total cholesterol; 45.0, 55.0, 63.6% in triglyceride; 34.8, 37.1 and 41.6% in LDL; 3.2, 21.6 (P = 0.03) and 33.7% (P = 0.005) in serum glucose were observed for UP601 at 300, 450 and 600 mg/kg, respectively. Body fat distribution was found reduced by 31.6 and 17.2% for the 450 mg/kg UP601 and orlistat, respectively, from the DEXA scan analysis. Up to an 89.1% reduction in mesenteric fat deposit was observed for UP601 in relative organ weight. Statistically significant improvements in NASH scores were observed for mice treated with UP601. CONCLUSION: UP601, a standardized botanical composition from Morus alba, Yerba mate and Magnolia officinalis could potentially be used for achieving healthy weight loss and maintenance.
[Mh] Termos MeSH primário: Ilex
Magnolia
Morus
Obesidade/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Perda de Peso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipogenia/efeitos dos fármacos
Animais
Glicemia/metabolismo
Distribuição da Gordura Corporal
Dieta
Modelos Animais de Doenças
Hipoglicemiantes/farmacologia
Hipoglicemiantes/uso terapêutico
Hipolipemiantes/farmacologia
Hipolipemiantes/uso terapêutico
Lactonas/farmacologia
Lactonas/uso terapêutico
Lipídeos/sangue
Lipólise/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/patologia
Camundongos
Camundongos Endogâmicos C57BL
Hepatopatia Gordurosa não Alcoólica/prevenção & controle
Obesidade/sangue
Obesidade/etiologia
Obesidade/patologia
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Hypolipidemic Agents); 0 (Lactones); 0 (Lipids); 0 (Plant Extracts); 95M8R751W8 (orlistat)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170226
[Lr] Data última revisão:
170226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1627-1


  10 / 430 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28208808
[Au] Autor:De Franciscis P; Grauso F; Luisi A; Schettino MT; Torella M; Colacurci N
[Ad] Endereço:Department of Woman, Child and General and Specialized Surgery-Second University of Naples, Largo Madonna delle Grazie, 1, 80138 Naples, Italy. pasquale.defranciscis@unina2.it.
[Ti] Título:Adding Agnus Castus and Magnolia to Soy Isoflavones Relieves Sleep Disturbances Besides Postmenopausal Vasomotor Symptoms-Long Term Safety and Effectiveness.
[So] Source:Nutrients;9(2), 2017 Feb 13.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The effectiveness for vasomotor symptoms and sleep disorders plus the long-term safety of a nutraceutical combination of and magnolia extracts combined with soy isoflavones (SI) and lactobacilli were assessed in postmenopausal women. A controlled study was carried out in menopausal women comparing this nutraceutical combination (ESP group) with a formulation containing isoflavones alone (C group) at the dosage recommended. The Kuppermann index, The Pittsburgh Sleep Quality Index (PSQI), and Short Form 36 (SF-36) were determined at baseline, three, six and 12 months. Endometrial thickness, mammary density and liver function were evaluated at baseline and after 12 months. One hundred and eighty women were enrolled in the study (100 in the ESP group and 80 in the C group). At the end of the treatment, mammary density, endometrial thickness, and hepatic function did not show substantial differences between groups. The Kuppermann index and particularly the tendency for hot flashes progressively and significantly decreased in frequency and severity during ESP versus C treatment. At the same time, a significant increase in sleep quality and psychophysical wellness parameters was observed in the ESP versus C groups. No adverse events were observed. and magnolia, combined with SI + lactobacilli, can effectively and safely be used in symptomatic postmenopausal women, mainly when quality of sleep is the most disturbing complaint. The endometrium, mammary glands and liver function were unaffected after 12 months of treatment.
[Mh] Termos MeSH primário: Isoflavonas/administração & dosagem
Magnolia/química
Fitoterapia
Pós-Menopausa/efeitos dos fármacos
Sono/efeitos dos fármacos
Feijão de Soja/química
Vitex/química
[Mh] Termos MeSH secundário: Idoso
Suplementos Nutricionais
Endométrio/efeitos dos fármacos
Endométrio/metabolismo
Feminino
Fogachos/tratamento farmacológico
Seres Humanos
Lactobacillus/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Glândulas Mamárias Humanas/efeitos dos fármacos
Glândulas Mamárias Humanas/metabolismo
Meia-Idade
Preparações de Plantas/farmacologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Isoflavones); 0 (Plant Preparations)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE



página 1 de 43 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde