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Pesquisa : B01.650.940.800.575.912.250.715 [Categoria DeCS]
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  1 / 725 MEDLINE  
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[PMID]:28864040
[Au] Autor:Dai YG; Wu J; Padmakumar KP; Shen L
[Ad] Endereço:Marine Drugs Research Center, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, PR China.
[Ti] Título:Sundarbanxylogranins A-E, five new limonoids from the Sundarban Mangrove, Xylocarpus granatum.
[So] Source:Fitoterapia;122:85-89, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new limonoids, named sundarbanxylogranins A-E (1-5), were isolated from the seeds of an Indian mangrove, Xylocarpus granatum, collected from mangrove swamps of the Sundarbans, India. The structures of these limonoids were established by HRESIMS and NMR spectroscopic data. Sundarbanxylogranin A (1) is a rare limonoid containing a bicyclo[5.2.1]dec-3-en-8-one scaffold as the ring A/B-fused core; whereas sundarbanxylogranin B (2) is a typical mexicanolide with an 8α, 30α-epoxy ring. Sundarbanxylogranins C-E (3-5), among which the former two possess a 29-OMe group with different orientation, belong to a small group of limonoids containing a C -O-C oxygen bridge. Sundarbanxylogranin B exhibited moderate anti-HIV activity with an IC value of 23.14±1.29µM and a CC value of 78.45±1.69µM, respectively.
[Mh] Termos MeSH primário: Limoninas/farmacologia
Meliaceae/química
Sementes/química
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/isolamento & purificação
Fármacos Anti-HIV/farmacologia
Células HEK293
HIV-1/efeitos dos fármacos
Seres Humanos
Índia
Limoninas/isolamento & purificação
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Limonins); 0 (mexicanolide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE


  2 / 725 MEDLINE  
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[PMID]:28829608
[Au] Autor:Wu YB; Wang YZ; Ni ZY; Qing X; Shi QW; Sauriol F; Vavricka CJ; Gu YC; Kiyota H
[Ti] Título:Xylomexicanins I and J: Limonoids with Unusual B/C Rings from Xylocarpus granatum.
[So] Source:J Nat Prod;80(9):2547-2550, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two tetranortriterpenoids with new skeletons, xylomexicanins I and J (1 and 2), were isolated during the investigation of chemical constituents from seeds of the Chinese mangrove, Xylocarpus granatum. Xylomexicanin I (1) is an unprecedented limonoid with bridged B- and C-rings. A biosynthesis pathway for 1 from xylomexicanin F is proposed.
[Mh] Termos MeSH primário: Limoninas/isolamento & purificação
Meliaceae/química
Sementes/química
[Mh] Termos MeSH secundário: Limoninas/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Limonins); 0 (xylomexicanin F); 0 (xylomexicanin I); 0 (xylomexicanin J)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00305


  3 / 725 MEDLINE  
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[PMID]:28739177
[Au] Autor:Zou YH; Liu WT; Zhang JX; Xiang DC
[Ad] Endereço:Department of Cardiology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
[Ti] Título:Triterpenoids from the bark of Dysoxylum hainanense and their anti-inflammatory and radical scavenging activity.
[So] Source:Fitoterapia;121:159-163, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation on the 70% EtOH extract of the bark of Dysoxylum hainanense resulted in the isolation of four new triterpenoids, dysoxyhaines A-D (1-4). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D ( H H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-inflammatory activities for Cox-1 and Cox-2, and radical scavenging potential using ABTS and DPPH test. As a result, nor seco-olean type triterpenoid 1 exhibited significant anti-inflammatory potential, while tirucallane triterpenoids 3 and 4 showed radical scavenging activities.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Depuradores de Radicais Livres/química
Meliaceae/química
Triterpenos/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/isolamento & purificação
Depuradores de Radicais Livres/isolamento & purificação
Estrutura Molecular
Casca de Planta/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Free Radical Scavengers); 0 (Triterpenes); 0 (tirucallane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  4 / 725 MEDLINE  
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[PMID]:28673807
[Au] Autor:Geng YD; Zhang C; Lei JL; Yu P; Xia YZ; Zhang H; Yang L; Kong LY
[Ad] Endereço:Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer.
[So] Source:Biochem Pharmacol;142:71-86, 2017 Oct 15.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Walsuronoid B is a limonoid compound extracted from Walsura robusta. Previous studies have shown that limonoid compounds possess anti-cancer potential, although the molecular mechanism of this activity remains elusive. In this study, we demonstrated for the first time that walsuronoid B inhibited cell proliferation in several human cancer lines. Liver cancer cells (HepG2 and Bel-7402) were chosen for their high sensitivity to walsuronoid B. Walsuronoid B induced cell death through G /M phase arrest and apoptosis and induced the accumulation of autophagosomes through the suppression of mTOR signaling, which serves as a cell survival mechanism and prevents cell death. We further examined the molecular mechanisms and found that walsuronoid B-induced dysfunction of the mitochondria and lysosomes rather than the endoplasmic reticulum contributed to its cell death effect. Walsuronoid B enhanced the generation of hydrogen peroxide, nitric oxide and superoxide anion radical, resulting in elevated levels of reactive oxygen species (ROS). In addition, ROS induced by walsuronoid B upregulated p53 levels; conversely, p53 stimulated ROS. These results suggested that ROS and p53 reciprocally promoted each other's production and cooperated to induce liver cancer cell death. We found that the induction of ROS and p53 significantly triggered G /M phase arrest and mitochondrial and lysosomal apoptosis. Finally, walsuronoid B suppressed tumor growth in vivo with few side effects. In summary, our findings demonstrated that walsuronoid B caused G /M phase arrest and induced mitochondrial and lysosomal apoptosis through the ROS/p53 signaling pathway in human liver cancer cells in vitro and in vivo.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Hidrocarbonetos Aromáticos com Pontes/farmacologia
Limoninas/farmacologia
Neoplasias Hepáticas
Lisossomos/metabolismo
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Proteína Supressora de Tumor p53/metabolismo
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/uso terapêutico
Autofagia/efeitos dos fármacos
Hidrocarbonetos Aromáticos com Pontes/isolamento & purificação
Hidrocarbonetos Aromáticos com Pontes/uso terapêutico
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Células Hep G2
Seres Humanos
Limoninas/isolamento & purificação
Limoninas/uso terapêutico
Neoplasias Hepáticas/metabolismo
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas Experimentais/tratamento farmacológico
Neoplasias Hepáticas Experimentais/metabolismo
Neoplasias Hepáticas Experimentais/patologia
Lisossomos/fisiologia
Meliaceae/química
Camundongos Endogâmicos BALB C
Camundongos Nus
Transdução de Sinais
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Bridged-Ring Compounds); 0 (Limonins); 0 (Reactive Oxygen Species); 0 (Tumor Suppressor Protein p53); 0 (walsuronoid B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  5 / 725 MEDLINE  
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Zanoni, Jacqueline Nelisis
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[PMID]:28662504
[Au] Autor:Gomes RM; de Paulo LF; Bonato Panizzon CPDN; Neves CQ; Cordeiro BC; Zanoni JN; Francisco FA; Piovan S; de Freitas Mathias PC; Longhini R; de Mello JCP; de Oliveira JC; Pedrino GR; da Silva Reis AA; Cecchini AL; Marçal Natali MR
[Ad] Endereço:Department of Physiological Sciences, Federal University of Goiás, Goiânia, Brazil.
[Ti] Título:Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats.
[So] Source:Cell Physiol Biochem;42(3):1087-1097, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. METHODS: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. RESULTS: EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic ß-cells and the size of the islets had increased by ß-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZ-induced diabetic rats by reduction of renal fibrosis. CONCLUSION: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabetic rats.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Tipo 1/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Meliaceae/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Acetatos/química
Animais
Diabetes Mellitus Experimental/patologia
Diabetes Mellitus Tipo 1/patologia
Hiperglicemia/tratamento farmacológico
Hiperglicemia/patologia
Hipoglicemiantes/química
Células Secretoras de Insulina/efeitos dos fármacos
Células Secretoras de Insulina/patologia
Masculino
Extratos Vegetais/química
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1159/000478761


  6 / 725 MEDLINE  
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[PMID]:28402310
[Au] Autor:Yavari S; Malakahmad A; Sapari NB; Yavari S
[Ad] Endereço:Department of Civil and Environmental Engineering, Universiti Teknologi PETRONAS, 32610 Bandar Seri Iskandar, Malaysia E-mail: amirhossein@utp.edu.my; amalakahmad@gmail.com.
[Ti] Título:Treatment of urea manufacturing facility effluent by Hopea odorata and Khaya ivorensis.
[So] Source:Water Sci Technol;75(7-8):1684-1692, 2017 Apr.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytoremediation is an environmentally friendly and sustainable alternative for treatment of nitrogen-enriched wastewaters. In this study, Ta-khian (Hopea odorata) and Lagos mahogany (Khaya ivorensis), two tropical timber plants, were investigated for their performances in treatment of urea manufacturing factory effluent with high nitrogen (N) content. Plant seedlings received four concentrations of N (190, 240, 290 and 340 mg/L N) in laboratory-scale constructed wetlands every 4 days for a duration of 8 weeks. The solution volumes supplied to each container, amount of N recovered by plants and plant growth characteristics were measured throughout the experiment. Results showed that Ta-khian plants were highly effective at reducing N concentration and volume of water. A maximum of 63.05% N recovery was obtained by Ta-khian plants grown in 290 mg/L N, which was assimilated in the chlorophyll molecule structure and shoot biomass. Significant positive correlations have been shown between N recovery percentages and plant growth parameters. Ta-Khian plants can be applied as suitable phytoremediators for mitigating N pollution in water sources.
[Mh] Termos MeSH primário: Dipterocarpaceae/metabolismo
Meliaceae/metabolismo
Ureia/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Resíduos Industriais/análise
Nigéria
Nitrogênio/metabolismo
Águas Residuais/química
Purificação da Água/instrumentação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Industrial Waste); 0 (Waste Water); 8W8T17847W (Urea); N762921K75 (Nitrogen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2017.043


  7 / 725 MEDLINE  
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[PMID]:28327530
[Au] Autor:Higuchi K; Miyake T; Ohmori S; Tani Y; Minoura K; Kikuchi T; Yamada T; Tanaka R
[Ad] Endereço:Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. rikiaifuni815@yahoo.co.jp.
[Ti] Título:Carapanosins A-C from Seeds of Andiroba (Carapa guianensis, Meliaceae) and Their Effects on LPS-Activated NO Production.
[So] Source:Molecules;22(3), 2017 Mar 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Two new phragmalin-type limonoids, Carapanosins A and B ( and ), and a new gedunin-type limonoid, Carapansin C ( ), together with five known limonoids ( - ) were isolated from the oil of A (Meliaceae) seeds, a traditional medicine in Brazil and Latin American countries. Their structures were elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and HRFABMS. Compounds - were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages. The NO inhibitory assay suggested that Compounds , , and may be valuable as potential inhibitors of macrophage activation.
[Mh] Termos MeSH primário: Limoninas/química
Limoninas/farmacologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Meliaceae/química
Óxido Nítrico/metabolismo
Sementes/química
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Lipopolissacarídeos/imunologia
Ativação de Macrófagos/efeitos dos fármacos
Ativação de Macrófagos/imunologia
Macrófagos/imunologia
Espectroscopia de Ressonância Magnética
Camundongos
Estrutura Molecular
Óxido Nítrico/biossíntese
Óleos Vegetais/química
Óleos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Limonins); 0 (Lipopolysaccharides); 0 (Plant Oils); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


  8 / 725 MEDLINE  
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[PMID]:28257660
[Au] Autor:Leong KH; Mahdzir MA; Din MF; Awang K; Tanaka Y; Kulkeaw K; Ishitani T; Sugiyama D
[Ad] Endereço:Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Centre of Natural Products and Drug Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: leongkh@um.edu.my.
[Ti] Título:Induction of intrinsic apoptosis in leukaemia stem cells and in vivo zebrafish model by betulonic acid isolated from Walsura pinnata Hassk (Meliaceae).
[So] Source:Phytomedicine;26:11-21, 2017 Mar 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Leukaemia stem cells (LSC) have been associated with disease relapse and chemotherapy resistance. Betulonic acid (BA), a pentacyclic lupane-type triterpenoid, was reported to exhibit cytotoxicity toward various cancer cells and to be capable of inducing intrinsic apoptosis in solid tumours. However, the in vitro and in vivo apoptotic effects of BA against LSC remain unknown. HYPOTHESIS/PURPOSE: We aimed to determine whether BA isolated from bark of Walsura pinnata Hassk (Meliaceae) has pro-apoptotic effects on LSC in in vitro and in vivo models. STUDY DESIGN/METHODS: The population of high purity LSC was isolated from the Kasumi-1 cell line using magnetic sorting and characterised by flow cytometry. Cell viability was assessed using the MTS assay to examine dose- and time-dependent effects. The colony formation assay was performed in MethoCult® H4435 enriched media. Apoptosis was analysed using Annexin-V and propidium iodide staining, mitochondrial transmembrane potential was studied using JC-1 staining, and expression of apoptosis related genes (BAX, Bcl-2 and survivin) was evaluated by real time-polymerase chain reaction (RT-PCR). Caspase 3/7 and 9 activities were monitored through Promega Caspase-Glo® over a period of 24h. The in vivo antileukaemia activity was evaluated using LSC xenotransplanted zebrafish, observed for DNA fragmentation from apoptosis by TUNEL assay. RESULTS: BA maintained its potency against the LSC population in comparison to parental Kasumi-1 cells (fold differences ≤ 1.94) over various treatment time points and significantly inhibited the formation of colonies by LSC. Apoptosis was triggered by BA through the upregulation of BAX and suppression of Bcl-2 and survivin genes with the loss of mitochondrial transmembrane potential, leading to the activation of caspase 9 followed by downstream caspase 3/7. BA was able to suppressed leukaemia formation and induced apoptosis in LSC xenotransplanted zebrafish. CONCLUSIONS: The results demonstrate that BA inhibited the proliferative and colonogenic properties of LSC. BA induced apoptosis in LSC through the mitochondria pathway and was effective in the in vivo zebrafish model. Therefore, BA could be a lead compound for further development into a chemotherapy agent against LSC.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Leucemia/metabolismo
Meliaceae/química
Ácido Oleanólico/análogos & derivados
Células-Tronco/efeitos dos fármacos
Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Malásia
Ácido Oleanólico/metabolismo
Ácido Oleanólico/toxicidade
Casca de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (betulonic acid); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


  9 / 725 MEDLINE  
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[PMID]:28198502
[Au] Autor:Li WZ; Han WN; Liu B; Ding SH; Zhang XK; Wang RS
[Ad] Endereço:College of Pharmacy, Weifang Medical University, Weifang, People's Republic of China wanzhong_06@163.com.
[Ti] Título:Extraction of proteins and preliminary characterization of physicochemical properties in Toona sinensis fruit.
[So] Source:Genet Mol Res;16(1), 2017 Feb 08.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:We investigated the extraction of Toona sinensis fruit proteins and preliminarily characterized their physicochemical properties. The results showed that optimal extraction occurred under conditions of pH 10.5, a duration of 40 min, a liquid-to-solid ratio of 25:1, and a temperature of 40°C by an orthogonal design using T. sinensis fruit protein as the index and single factor. The total nitrogen content was 13.8 g/100 g and included 17 different amino acids. The glutamate level was highest at 35.37%, followed by arginine at 15.31%. The isoelectric point of T. sinensis fruit protein was between 6.8 and 10.0 with a typical absorption peak by infrared chromatography. Three protein bands were analyzed using SDS-polyacrylamide gel electrophoresis, with relative molecular weights of 55, 51, and 22 kDa. This study provides a theoretical basis for the comprehensive utilization of T. sinensis fruit by further investigating the biological activity of its proteins.
[Mh] Termos MeSH primário: Frutas/química
Meliaceae/química
Extratos Vegetais/química
Proteínas de Plantas/química
[Mh] Termos MeSH secundário: Proteômica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Plant Proteins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16019177


  10 / 725 MEDLINE  
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[PMID]:28129886
[Au] Autor:Zhang Y; An FL; Huang SS; Yang L; Gu YC; Luo J; Kong LY
[Ad] Endereço:State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China.
[Ti] Título:Diverse tritepenoids from the fruits of Walsura robusta and their reversal of multidrug resistance phenotype in human breast cancer cells.
[So] Source:Phytochemistry;136:108-118, 2017 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four 18 (13 â†’ 14)-abeo limonoids, five cedrelone limonoids, and five walsurin limonoids were isolated from the fruits of Walsura robusta together with 21 known compounds. Their structures were determined by extensive studies of their one- and two-dimensional NMR spectra and mass spectroscopy results. Among all the isolated compounds, the absolute configurations of 11-oxo-dihydrocedrelone, walsuronoid B, dysoxylumosin G, and walsunoid H were confirmed by single crystal X-ray diffraction. Selected compounds were evaluated for their reversal of multidrug resistance (MDR) phenotype in human breast cancer cells in vitro. Walsurin A showed significant effect in sensitization of these resistant cancer cells at non-toxic concentration to doxorubicin with the modulation factor of 62.76.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Resistência a Múltiplos Medicamentos/efeitos dos fármacos
Frutas/química
Limoninas/isolamento & purificação
Limoninas/farmacologia
Meliaceae/química
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Neoplasias da Mama/tratamento farmacológico
Cristalografia por Raios X
Feminino
Seres Humanos
Limoninas/química
Conformação Molecular
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Limonins); 0 (Triterpenes); 0 (cedrelone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE



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