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Pesquisa : B01.650.940.800.575.912.250.715.124 [Categoria DeCS]
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[PMID]:27776244
[Au] Autor:Goswami KK; Sarkar M; Ghosh S; Saha A; Ghosh T; Guha I; Barik S; Banerjee S; Roy S; Bose A; Dasgupta P; Baral R
[Ad] Endereço:Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India.
[Ti] Título:Neem leaf glycoprotein regulates function of tumor associated M2 macrophages in hypoxic tumor core: Critical role of IL-10/STAT3 signaling.
[So] Source:Mol Immunol;80:1-10, 2016 12.
[Is] ISSN:1872-9142
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Heterogeneous tumor microenvironment (TME), broadly divided into tumor core and peripheral sub-microenvironments, differentially polarize normal macrophages into a different form known as tumor associated M2 macrophages (M2TAMs) to promote tumor growth. In view of the extensive immune-editing role of NLGP, here, we have observed that NLGP is effective to convert M2TAMs (CD11b F4/80 ) to M1 (CD11b F4/80 ) more prominently in tumor core, along with downregulation of other M2 associated markers, like, ManR, Ym1, Fizz1. High IL-10:IL-12 ratio at tumor core was downregulated in NLGP treated melanoma bearing mice. Decrease in IL-10 by NLGP is again associated with the decrease in hypoxia, as indicated by prominent downregulation of HIF1α and VEGF, particularly at tumor core. Macrophages exposed to hypoxic tumor core lysates in vitro exhibited high IL-10, HIF1α and VEGF expression that was significantly downregulated by NLGP. Further evidences suggest M2TAM to M1 conversion by NLGP is associated with STAT3-regulated IL-10 dependent pathway without affecting the IL-4 dependent one. Such TAM modulatory functions of NLGP might help in the restriction of melanoma growth by increasing the proportion of M1 TAMs in tumor core that helps in prevention of tumor relapse and dissemination of the tumor mass.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Macrófagos/imunologia
Melanoma Experimental/imunologia
Proteínas de Plantas/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Azadirachta
Western Blotting
Hipóxia Celular/efeitos dos fármacos
Citometria de Fluxo
Glicoproteínas/farmacologia
Imuno-Histoquímica
Interleucina-10/imunologia
Macrófagos/efeitos dos fármacos
Melanoma Experimental/patologia
Camundongos
Camundongos Endogâmicos C57BL
Extratos Vegetais/farmacologia
Folhas de Planta
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Fator de Transcrição STAT3/imunologia
Transdução de Sinais/imunologia
Microambiente Tumoral/efeitos dos fármacos
Microambiente Tumoral/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Glycoproteins); 0 (IL10 protein, mouse); 0 (Plant Extracts); 0 (Plant Proteins); 0 (STAT3 Transcription Factor); 0 (Stat3 protein, mouse); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28797303
[Au] Autor:Heyman L; Houri-Haddad Y; Heyman SN; Ginsburg I; Gleitman Y; Feuerstein O
[Ad] Endereço:Department of Prosthodontics, Hebrew University-Hadassah Faculty of Dental Medicine, P.O.B. 12272, 91120, Jerusalem, Israel.
[Ti] Título:Combined antioxidant effects of Neem extract, bacteria, red blood cells and Lysozyme: possible relation to periodontal disease.
[So] Source:BMC Complement Altern Med;17(1):399, 2017 Aug 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The common usage of chewing sticks prepared from Neem tree (Azadirachta indica) in India suggests its potential efficacy in periodontal diseases. The objective of this study is to explore the antibacterial effects of Neem leaf extract on the periodontophatic bacteria Porphyromonas gingivalis and Fusobacterium nucleatum, and its antioxidant capacities alone and in combination with bacteria and polycationic peptides that may be at the site of inflammation. METHODS: Neem leaf extract was prepared by ethanol extraction. The growth kinetics of P. gingivalis and F. nucleatum under anaerobic conditions in the presence of Neem leaf extract were measured. Broth microdilution test was used to determine the Minimal Inhibitory Concentration (MIC) of Neem leaf extract against each bacterial strain. The effect of Neem leaf extract on the coaggregation of the bacteria was assessed by a visual semi-quantitative assay. The antioxidant capacities of Neem leaf extract alone and in combination with bacteria, with the addition of red blood cells or the polycationic peptides chlorhexidine and lisozyme, were determined using a chemiluminescence assay. RESULTS: Neem leaf extract showed prominent dose-dependent antibacterial activity against P. gingivalis, however, had no effect on the growth of F. nucleatum nor on the coaggregation of the two bacteria. Yet, it showed intense antioxidant activity, which was amplified following adherence to bacteria and with the addition of red blood cells or the polycationic peptides. CONCLUSIONS: Neem leaf extract, containing polyphenols that adhere to oral surfaces, have the potential to provide long-lasting antibacterial as well as synergic antioxidant activities when in complex with bacteria, red blood cells and lisozyme. Thus, it might be especially effective in periodontal diseases.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antioxidantes/farmacologia
Azadirachta/química
Eritrócitos
Muramidase/metabolismo
Doenças Periodontais/microbiologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos Locais
Clorexidina
Fusobacterium/efeitos dos fármacos
Fusobacterium nucleatum/efeitos dos fármacos
Fusobacterium nucleatum/crescimento & desenvolvimento
Seres Humanos
Índia
Medicina Tradicional
Testes de Sensibilidade Microbiana
Peptídeos
Doenças Periodontais/tratamento farmacológico
Doenças Periodontais/metabolismo
Fitoterapia
Folhas de Planta
Poliaminas
Polifenóis/farmacologia
Porphyromonas/efeitos dos fármacos
Porphyromonas gingivalis/efeitos dos fármacos
Porphyromonas gingivalis/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Local); 0 (Antioxidants); 0 (Peptides); 0 (Plant Extracts); 0 (Polyamines); 0 (Polyphenols); 0 (polycations); EC 3.2.1.17 (Muramidase); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1900-3


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[PMID]:28530186
[Au] Autor:Avinash B; Venu R; Prasad TNVKV; Alpha Raj M; Srinivasa Rao K; Srilatha C
[Ad] Endereço:Department of Veterinary Parasitology, Sri Venkateswara Veterinary University, College of Veterinary Science, Tirupati-517502, Andhra Pradesh, India.
[Ti] Título:Synthesis and characterisation of neem leaf extract, 2, 3-dehydrosalanol and quercetin dihydrate mediated silver nano particles for therapeutic applications.
[So] Source:IET Nanobiotechnol;11(4):383-389, 2017 Jun.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The utility of green silver nanoparticles (AgNPs) in veterinary medicine is steadily increasing as they have many therapeutic applications against pathogens and arthropods of livestock. In this study, green AgNPs using neem (N-AgNPs), 2,3-dehydrosalanol (2,3-DHS-AgNPs) and quercetin dihydrate (QDH-AgNPs) were synthesised and characterised. Synthesised compounds were characterised by UV-Vis spectroscopy and the peak absorbance was recorded at 370 nm for neem extract. For N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs, the maximum absorbance peaks were at 430, 230 and 220 nm, respectively. The FTIR analysis confirmed the synthesis of green AgNPs. The XRD pattern of N-AgNPs showed the peaks corresponding to whole spectra of 2 values ranging from 10-80. The relatively higher intensity of (111, 222) planes in face centred cubic crystalline structure supports the formation of synthesised AgNPs. In DLS analysis, the hydrodynamic diameter of neem leaf extract was found to be 259.8 nm, followed by 5.3, 6.7 and 261.8 nm for 2,3-DHS-AgNPs, N-AgNPs and QDH-AgNPs, respectively. Based on the transmission electron microscopy and scanning electron microscopy image analyses, confirmed the formation of N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs. These eco-friendly phyto-AgNPs may be of use as an effective alternative to chemical control methods against the arthropods of livestock.
[Mh] Termos MeSH primário: Acaricidas/administração & dosagem
Azadirachta/química
Benzotiadiazinas/administração & dosagem
Nanopartículas Metálicas/administração & dosagem
Quercetina/administração & dosagem
Prata/administração & dosagem
[Mh] Termos MeSH secundário: Acaricidas/química
Benzotiadiazinas/química
Química Verde/métodos
Teste de Materiais
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Tamanho da Partícula
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Folhas de Planta/química
Quercetina/química
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Benzothiadiazines); 0 (Plant Extracts); 3M4G523W1G (Silver); 9IKM0I5T1E (Quercetin); EZN4D2O31B (dehydrosanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0095


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[PMID]:28493718
[Au] Autor:Yadav DK; Bharitkar YP; Hazra A; Pal U; Verma S; Jana S; Singh UP; Maiti NC; Mondal NB; Swarnakar S
[Ti] Título:Tamarixetin 3-O-ß-d-Glucopyranoside from Azadirachta indica Leaves: Gastroprotective Role through Inhibition of Matrix Metalloproteinase-9 Activity in Mice.
[So] Source:J Nat Prod;80(5):1347-1353, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neem (Azadirachta indica) is a well-known medicinal and insecticidal plant. Although previous studies have reported the antiulcer activity of neem leaf extract, the lead compound is still unidentified. The present study reports tamarixetin 3-O-ß-d-glucopyranoside (1) from a methanol extract of neem leaves and its gastroprotective activity in an animal model. Compound 1 showed significant protection against indomethacin-induced gastric ulceration in mice in a dose-dependent manner. Moreover, ex vivo and circular dichroism studies confirmed that 1 inhibited the enzyme matrix metalloproteinase-9 (MMP-9) activity with an IC value of ca. 50 µM. Molecular docking and dynamics showed the binding of 1 into the pocket of the active site of MMP-9, forming a coordination complex with the catalytic zinc, thus leading to inhibition of MMP-9 activity.
[Mh] Termos MeSH primário: Antiulcerosos/farmacologia
Azadirachta/química
Dissacarídeos/isolamento & purificação
Dissacarídeos/farmacologia
Indometacina/farmacologia
Metaloproteinase 9 da Matriz/química
Quercetina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Antiulcerosos/química
Dissacarídeos/química
Indometacina/química
Metaloproteinase 9 da Matriz/metabolismo
Camundongos
Simulação de Acoplamento Molecular
Estrutura Molecular
Fitoterapia
Folhas de Planta
Quercetina/química
Quercetina/isolamento & purificação
Quercetina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Disaccharides); 73WRA8Z8M8 (tamarixetin); 9IKM0I5T1E (Quercetin); EC 3.4.24.35 (Matrix Metalloproteinase 9); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00957


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[PMID]:28476978
[Au] Autor:Ahmad H; Rajagopal K; Shah AH; Bhat AH; Venugopal K
[Ad] Endereço:School of Life Sciences, Department of Biotechnology, Vels University Chennai, Chennai 600117, India. hhiillaallbiotech@gmail.com.
[Ti] Título:Study of bio-fabrication of iron nanoparticles and their fungicidal property against phytopathogens of apple orchards.
[So] Source:IET Nanobiotechnol;11(3):230-235, 2017 Apr.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Current research trends on iron nanoparticles (FeNPs) are extensively focused because of their unique magnetic and electrical properties mostly applicable in essential medical devices. However, their fungicidal property against plant pathogens is very less known until date. Present study demonstrates a green technique for blending of FeNPs by utilising aqueous extract of neem leaf ( A Juss.) as reducing agent. Various characterisation techniques such as ultraviolet (UV)-visible spectroscopy, Fourier transform infrared spectroscopy transmission electron microscopy, scanning electron microscopy and X-ray diffraction were performed for FeNPs. The authors' results demonstrate the more cluster formation of FeNPs with size distribution of 20-80 nm. The bio-fabricated FeNPs showed enhanced biocidal activity against economically important phytopathogens of apple such as , and . From the obtained results, it can be suggested that further delve into green synthesis of FeNPs can address future biotechnology concerns to limit the synthesis of FeNPs by conventional methods. Furthermore, the field study on pathogenic fungi can be an effective step to verify their agricultural applications.
[Mh] Termos MeSH primário: Antifúngicos/administração & dosagem
Azadirachta/química
Fungos/efeitos dos fármacos
Nanopartículas de Magnetita/administração & dosagem
Malus/microbiologia
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Antifúngicos/síntese química
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Relação Dose-Resposta a Droga
Fungos/fisiologia
Química Verde/métodos
Nanopartículas de Magnetita/química
Nanopartículas de Magnetita/ultraestrutura
Teste de Materiais
Tamanho da Partícula
Extratos Vegetais/química
Folhas de Planta/química
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Magnetite Nanoparticles); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2015.0061


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[PMID]:28419927
[Au] Autor:Ashok Yadav P; Pavan Kumar C; Siva B; Suresh Babu K; Allanki AD; Sijwali PS; Jain N; Veerabhadra Rao A
[Ad] Endereço:Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
[Ti] Título:Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives.
[So] Source:Eur J Med Chem;134:242-257, 2017 Jul 07.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Epoxyazadiradione (1), a major compound derived from Neem oil, showed modest anti-plasmodial activity against CQ-resistant and CQ-sensitive strains of the most virulent human malaria parasite P. falciparum. A series of analogues were synthesized by modification of the key structural moieties of this high yield natural product. Out of the library of all compounds tested, compounds 3c and 3g have showed modest anti-plasmodial activity against CQ-sensitive (IC 2.8 ± 0.29 µM and 1.5 ± 0.01 µM) and CQ-resistant strains (IC 1.3 ± 1.08 µM and 1.2 ± 0.14), while compounds 3k, 3l and 3m showed modest activity against CQ-sensitive strain of P. falciparum with IC values of 2.3 ± 0.4 µM, 2.9 ± 0.1 µM and 1.7 ± 0.06 µM, respectively. Additionally, cytotoxic properties of these derivatives against SIHA, PANC 1, MDA-MB-231, and IMR-3 cancer cell lines were also studied and the results indicated that low cytotoxic potentials of all the derivatives which indicating the high selectivity index of the compounds.
[Mh] Termos MeSH primário: Antimaláricos/química
Antimaláricos/farmacologia
Antineoplásicos/química
Antineoplásicos/farmacologia
Azadirachta/química
Limoninas/química
Limoninas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antimaláricos/síntese química
Antimaláricos/isolamento & purificação
Antineoplásicos/síntese química
Antineoplásicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Limoninas/síntese química
Limoninas/isolamento & purificação
Malária/tratamento farmacológico
Malária Falciparum/tratamento farmacológico
Camundongos
Camundongos Endogâmicos BALB C
Neoplasias/tratamento farmacológico
Plasmodium berghei/efeitos dos fármacos
Plasmodium falciparum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Antineoplastic Agents); 0 (Limonins); 18385-59-6 (epoxyazadiradione)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28414726
[Au] Autor:Sarkar M; Ghosh S; Bhuniya A; Ghosh T; Guha I; Barik S; Biswas J; Bose A; Baral R
[Ad] Endereço:Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), Kolkata 700026, India.
[Ti] Título:Neem leaf glycoprotein prevents post-surgical sarcoma recurrence in Swiss mice by differentially regulating cytotoxic T and myeloid-derived suppressor cells.
[So] Source:PLoS One;12(4):e0175540, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Post-surgical tumor recurrence is a common problem in cancer treatment. In the present study, the role of neem leaf glycoprotein (NLGP), a novel immunomodulator, in prevention of post-surgical recurrence of solid sarcoma was examined. Data suggest that NLGP prevents tumor recurrence after surgical removal of sarcoma in Swiss mice and increases their tumor-free survival time. In NLGP-treated tumor-free mice, increased cytotoxic CD8+ T cells and a decreased population of suppressor cells, especially myeloid-derived suppressor cells (MDSCs) was observed. NLGP-treated CD8+ T cells showed greater cytotoxicity towards tumor-derived MDSCs and supernatants from the same CD8+ T cell culture caused upregulation of FasR and downregulation of cFLIP in MDSCs. To elucidate the role of CD8+ T cells, specifically in association with the downregulation in MDSCs, CD8+ T cells were depleted in vivo before NLGP immunization in surgically tumor removed mice and tumor recurrence was noted. These mice also exhibited increased MDSCs along with decreased levels of Caspase 3, Caspase 8 and increased cFLIP expression. In conclusion, it can be stated that NLGP, by activating CD8+ T cells, down regulates the proportion of MDSCs. Accordingly, suppressive effects of MDSCs on CD8+ T cells are minimized and optimum immune surveillance in tumor hosts is maintained to eliminate the residual tumor mass appearing during recurrence.
[Mh] Termos MeSH primário: Azadirachta/química
Glicoproteínas/farmacologia
Células Supressoras Mieloides/efeitos dos fármacos
Recidiva Local de Neoplasia/prevenção & controle
Folhas de Planta/química
Sarcoma/tratamento farmacológico
Linfócitos T Citotóxicos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD8-Positivos/efeitos dos fármacos
Linfócitos T CD8-Positivos/imunologia
Caspase 3/metabolismo
Caspase 8/metabolismo
Regulação para Baixo/efeitos dos fármacos
Regulação para Baixo/imunologia
Feminino
Glicoproteínas/imunologia
Camundongos
Células Supressoras Mieloides/imunologia
Proteínas de Plantas/imunologia
Proteínas de Plantas/farmacologia
Sarcoma/imunologia
Linfócitos T Citotóxicos/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycoproteins); 0 (Plant Proteins); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 8)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175540


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[PMID]:28246003
[Au] Autor:Avinash B; Venu R; Alpha Raj M; Srinivasa Rao K; Srilatha C; Prasad TN
[Ad] Endereço:Department of Veterinary Parasitology, College of Veterinary Science, S.V. Veterinary University, Tirupati 517502, A.P., India.
[Ti] Título:In vitro evaluation of acaricidal activity of novel green silver nanoparticles against deltamethrin resistance Rhipicephalus (Boophilus) microplus.
[So] Source:Vet Parasitol;237:130-136, 2017 Apr 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An investigation was undertaken to study, for the first time, in vitro acaricidal activity of green silver nanoparticles on deltamethrin resistance Rhipicephalus (Boophilus) microplus. The compounds tested were neem coated silver nanoparticles (N-Ag NPs), deltamethrin neem coated silver nanoparticles (DN-Ag NPs), 2, 3 dehydrosalannol (2,3 DHS), 2, 3 DHS coated silver nanoparticles (2, 3-DHS-Ag NPs), Quercetin dihydrate (QDH) and QDH coated silver nanoparticles (QDH-Ag NPs). Also included in this study, for the purpose of comparison, were neem leaf extract (NLE), silver nitrate (AgNO ) and deltamethrin (D). Acaricidal activity on larvae and adults of R. (B.) microplus was tested by larval packet test (LPT) and adult immersion test (AIT) respectively. In the LPT, 100% mortality was obtained at concentrations (ppm) of 360, 6000, 260, 200, 50, 300, 85, 600 and 200 for the compounds, D, NLE, Ag NO , N-Ag NPs, DN-Ag NPs, 2, 3 DHS, 2, 3 DHS-Ag NPs, QDH, QDH-Ag NPs respectively. In AIT, the proportions of mortality and oviposition inhibition were proportionate but the reproductive index was inversely proportional to the concentration of the compounds used. The effect of DN-Ag NPs on mortality was the highest (93.33%) at 50ppm concentration. The mean reproductive index (0.01) and oviposition inhibition (99.16%) values were statistically significant when compared to control group. DN-Ag NPs showed significantly (P<0.05) lower LC (3.87ppm; 21.95ppm) and LC (53.05ppm; 90.06ppm) values against both the larvae and adults of R. (B.) microplus. The oviposition inhibiting ability of various compounds was determined to assess the reproductive performance of adult female ticks. The DN-Ag NPs had potent oviposition inhibitory activity with significantly lower IC and IC values compared to the rest of the treatments at 0.034 and 51.07ppm respectively. These results showed that the DN-Ag NPs had significant acaricidal activity against R. (B.) microplus.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Azadirachta/química
Nitrilos/farmacologia
Extratos Vegetais/farmacologia
Piretrinas/farmacologia
Rhipicephalus/efeitos dos fármacos
Prata/farmacologia
[Mh] Termos MeSH secundário: Animais
Feminino
Larva/efeitos dos fármacos
Nanopartículas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Nitriles); 0 (Plant Extracts); 0 (Pyrethrins); 2JTS8R821G (decamethrin); 3M4G523W1G (Silver)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


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[PMID]:28145090
[Au] Autor:Akihisa T; Nishimoto Y; Ogihara E; Matsumoto M; Zhang J; Abe M
[Ad] Endereço:Research Institute for Science & Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
[Ti] Título:Nitric Oxide Production-Inhibitory Activity of Limonoids from Azadirachta indica and Melia azedarach.
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Seventy-three limonoids isolated from three Meliaceae plants, Azadirachta indica, A. indica var. siamensis, and Melia azedarach, or semi-synthesized from the Meliaceae limonoids, were evaluated for their inhibitory activity against nitric oxide (NO) production in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS), as a primary screening test for anti-inflammatory agents. Of the compounds tested, 21 compounds exhibited inhibitory activity (IC 4.6 - 58.6 µm) without any significant toxicity (IC > 100 µm) which were more potent than l-NMMA (NO-production inhibitory activity, IC 65.6 µm; cytotoxicity, IC > 100 µm), and among which, nine compounds, i.e., 17-hydroxy-15-methoxynimbocinol (6), ohchinin (20), 1-cis-cinnamoyl-1-decinnamoylohchinin (24), salannin (27), methyl nimbidate (32), isosalannin (55), nimbolinin D (58), mesendanin E (69), and 7-deacetylgedunin (73) exhibited potent inhibitory activity (IC 4.6 - 29.3 µm). In particular, compounds 6 (IC 7.3 µm), an azadirone-type limonoid, and 73 (IC 4.6 µm), a gedunin-type limonoid, exhibited remarkable activity. Western blot analysis revealed that 27 and 73 reduced the expression levels of the inducible NO synthase and cyclooxygenase-2 proteins in a concentration-dependent manner. These findings suggest that limonoids of A. indica, A. indica var. siamensis, and M. azedarach, and their semi-synthetic derivatives may be effective against inflammation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Azadirachta/química
Limoninas/farmacologia
Melia azedarach/química
Óxido Nítrico/biossíntese
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Inibidores de Ciclo-Oxigenase 2
Concentração Inibidora 50
Camundongos
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cyclooxygenase 2 Inhibitors); 0 (Limonins); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600468


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[PMID]:28091970
[Au] Autor:Datta A; Grün IU; Kwasniewski MT; Fernando LN
[Ad] Endereço:Department of Food Science, University of Missouri, 246 WC Stringer Wing, Eckles Hall, Columbia, MO, 65211, USA. ad8g4@mail.missouri.edu.
[Ti] Título:Comparison of Two Adsorbent Based de-Bittering Procedures for Neem (Azadirachta indica A. Juss) Tea- Effect on Polyphenols, Anti-Oxidant Capacity, Color and Volatile Profile.
[So] Source:Plant Foods Hum Nutr;72(1):88-95, 2017 Mar.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Bitterness reduction, especially of foods and beverages containing phytonutrients, is one of the biggest challenges in the food industry because bitterness has a deleterious effect on the taste profile of foods and beverages. Neem (Azadirachta indica A. Juss) is a medicinal tree, indigenous to the Indian-subcontinent, whose medicinal properties have led to it being heralded as the tree which is the "panacea for all diseases". However, neem leaf is extremely bitter, in large part due to its limonoid content, making it unpalatable. The objective of this study was to apply two adsorbent based strategies, namely solid phase extraction (SPE) and Amberlite XAD-16 (AMB) resin, to achieve de-bittering of neem tea and to determine the effects of the de-bittering on the bio-active, color and volatile properties. The solid SPE treatment completely removed the flavonol, quercetin, from neem tea while in Amberlite XAD-16 treated tea (AMB) it was only insignificantly (p > 0.05) reduced. We also observed decreases in total phenolic content and consequently anti-oxidant activities after de-bittering. A 62% mean reduction of limonoid aglycones indicated diminished levels of bitterness. The loss of phenolics lead to a visually appreciable color changes in the treated teas. The de-bittering also leads to a loss of sesquiterpenes, ketones and acids from neem tea. In conclusion, we found that while SPE cartridges were more efficient in removing bitterness, they caused a greater reduction in bio-active compounds than AMB XAD-16 resins, which may ultimately affect the health properties of neem tea.
[Mh] Termos MeSH primário: Antioxidantes/química
Azadirachta/química
Extratos Vegetais/química
Polifenóis/análise
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Cor
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Polímeros
Chá/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Polymers); 0 (Polyphenols); 0 (Tea); 104219-63-8 (Amberlite XAD-16)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-016-0595-9



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