Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.715.500 [Categoria DeCS]
Referências encontradas : 56 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 6 ir para página                

  1 / 56 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28476963
[Au] Autor:Prabhu S; Vaideki K; Anitha S; Rajendran R
[Ad] Endereço:Thinfilm Center of Excellence, Department of Applied Science, PSG College of Technology, Peelamedu, Coimbatore 641004,Tamil Nadu, India.
[Ti] Título:Synthesis of ZnO nanoparticles using leaf extract and its characterisation.
[So] Source:IET Nanobiotechnol;11(1):62-65, 2017 Feb.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present work deals with the synthesis of zinc oxide (ZnO) nanoparticles (Nps) using the biocompounds extracted from leaves (MD L.) and zinc acetate as precursors. The choice of the precursors was based on the intention to use the synthesised ZnO Nps for the healthcare applications. In this line, the antimicrobial property of ethanolic extract of MD L., uncalcined ZnO Nps and calcined ZnO Nps has been assessed and compared. The prepared particles have been characterised by comparing their Fourier transform infrared spectrum, X-ray diffraction (XRD) diffractogram and TEM images. The presence of ZnO has been confirmed using IR spectrum. The crystal structure and crystallite size have been found out using XRD diffractogram, and the obtained crystallite size was confirmed using TEM images. Finally, an attempt has been made to correlate the structure with the antimicrobial property of the material.
[Mh] Termos MeSH primário: Fenômenos Fisiológicos Bacterianos/efeitos dos fármacos
Nanopartículas Metálicas/administração & dosagem
Nanopartículas Metálicas/química
Extratos Vegetais/administração & dosagem
Folhas de Planta/química
Óxido de Zinco/administração & dosagem
Óxido de Zinco/síntese química
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Antibacterianos/síntese química
Sobrevivência Celular/efeitos dos fármacos
Melia/química
Nanopartículas Metálicas/ultraestrutura
Tamanho da Partícula
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0073


  2 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27667515
[Au] Autor:Zhang Q; Zheng QH; Liang JY; Li QS; Min ZD
[Ad] Endereço:Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China. Electronic address: zhangqiong_83@hotmail.com.
[Ti] Título:Two new limonoids isolated from the fuits of Melia toosendan.
[So] Source:Chin J Nat Med;14(9):692-696, 2016 Sep.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12ß-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their antibacterial activities. Compound 4 exhibited significant antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.2 µg·mL(-1). Compound 2 was also active against P. gingivalis ATCC 33277, with an MIC value of 31.25 µg·mL(-1). In conlcusion, our resutls indicate that these compounds may provide a basis for future development of novel antibiotics.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Limoninas/isolamento & purificação
Melia/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Medicamentos de Ervas Chinesas/química
Frutas/química
Limoninas/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Porphyromonas gingivalis/efeitos dos fármacos
Porphyromonas gingivalis/crescimento & desenvolvimento
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drugs, Chinese Herbal); 0 (Limonins)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170923
[Lr] Data última revisão:
170923
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


  3 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26679526
[Au] Autor:Anbu P; Murugan K; Madhiyazhagan P; Dinesh D; Subramaniam J; Panneerselvam C; Suresh U; Alarfaj AA; Munusamy MA; Higuchi A; Hwang JS; Kumar S; Nicoletti M; Benelli G
[Ad] Endereço:a Division of Entomology, Department of Zoology , School of Life Sciences, Bharathiar University , Coimbatore , India.
[Ti] Título:Green-synthesised nanoparticles from Melia azedarach seeds and the cyclopoid crustacean Cyclops vernalis: an eco-friendly route to control the malaria vector Anopheles stephensi?
[So] Source:Nat Prod Res;30(18):2077-84, 2016 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The impact of green-synthesised mosquitocidal nanoparticles on non-target aquatic predators is poorly studied. In this research, we proposed a single-step method to synthesise silver nanoparticles (Ag NP) using the seed extract of Melia azedarach. Ag NP were characterised using a variety of biophysical methods, including UV-vis spectrophotometry, scanning electron microscopy, energy-dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy. In laboratory assays on Anopheles stephensi, Ag NP showed LC50 ranging from 2.897 (I instar larvae) to 14.548 ppm (pupae). In the field, the application of Ag NP (10 × LC50) lead to complete elimination of larval populations after 72 h. The application of Ag NP in the aquatic environment did not show negative adverse effects on predatory efficiency of the mosquito natural enemy Cyclops vernalis. Overall, this study highlights the concrete possibility to employ M. azedarach-synthesised Ag NP on young instars of malaria vectors.
[Mh] Termos MeSH primário: Anopheles
Química Verde/métodos
Controle de Insetos/métodos
Inseticidas/síntese química
Inseticidas/toxicidade
Malária/transmissão
Melia/química
Minociclina
Nanopartículas/química
[Mh] Termos MeSH secundário: Animais
Larva/efeitos dos fármacos
Dose Letal Mediana
Extratos Vegetais/química
Comportamento Predatório/efeitos dos fármacos
Sementes/química
Prata/química
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Espectroscopia por Absorção de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Plant Extracts); 3M4G523W1G (Silver); FYY3R43WGO (Minocycline)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151219
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1114935


  4 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26517430
[Au] Autor:Kamau RW; Juma BF; Baraza LD
[Ad] Endereço:a Department of Pure and Applied Chemistry , Masinde Muliro University of Science and Technology , Kakamega , Kenya.
[Ti] Título:Antimicrobial compounds from root, stem bark and seeds of Melia volkensii.
[So] Source:Nat Prod Res;30(17):1984-7, 2016 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three compounds, toosendanin (1), kulactone (2) and scopoletin (3), were isolated from either the root bark and/or the stem bark of Melia volkensii. Their structures were determined on the basis of spectroscopic data generated and by comparison with data from the literature. 1 and 2, isolated for the first time from M. volkensii, exhibited significant (p < 0.05) activity against Escherichia coli with minimum inhibitory concentration of 12.5 µg/mL, close to that of neomycin (6.25 µg/mL). The compounds also exhibited high activity against Aspergillus niger (MIC 6.25 µg/mL compared to 2.5 µg/mL for clotrimazole). Dichloromethane and methanol seed, hexane stem bark and methanol root bark extracts exhibited activities towards Escherichia coli, Staphylococcus aureus, Aspergillus niger and Plasmodium falciparum, respectively. Antimicrobial activity of the plant towards A. niger, P. falciparum and S. aureus is reported for the first time in the current work.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Melia/química
Estruturas Vegetais/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Aspergillus niger/efeitos dos fármacos
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Escherichia coli/efeitos dos fármacos
Lactonas
Testes de Sensibilidade Microbiana
Estrutura Molecular
Plasmodium falciparum/efeitos dos fármacos
Escopoletina/química
Escopoletina/isolamento & purificação
Escopoletina/farmacologia
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Drugs, Chinese Herbal); 0 (Lactones); 0 (kulactone); 79304-40-8 (toosendanin); KLF1HS0SXJ (Scopoletin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151031
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1101104


  5 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26383159
[Au] Autor:Liu XL; Wang H; Zhang L; Wang YL; Wang J; Wang P; He X; He YJ
[Ad] Endereço:Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine (Ministry of Education), Chongqing Medical University, Chongqing, 400016, China.
[Ti] Título:Anticancer effects of crude extract from Melia toosendan Sieb. et Zucc on hepatocellular carcinoma in vitro and in vivo.
[So] Source:Chin J Integr Med;22(5):362-9, 2016 May.
[Is] ISSN:1672-0415
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the anti-cancer effects of crude extract from Melia toosendan Sieb. et Zucc and its possible molecular mechanisms in vitro and in vivo. METHODS: Transonic alcohol-chloroform extraction method was used to extract toosendanin from the bark of Melia toosendan Sieb. et Zucc, and the content of toosendanin in the crude extract was measured by high performance liquid chromatography (HPLC). Anti-cancer effects of crude extract from Melia toosendan Sieb. et Zucc were investigated in in vivo and in vitro studies. In the in vitro experiment, human hepatocellular carcinoma cell lines SMMC-7721 and Hep3B were co-incubated with toosendanin crude extract of different concentrations, respectively. In the in vivo experiment, BALB/c mice were subcutaneously inoculated with mouse hepatocellular carcinoma H22 cells and treated with crude extract. RESULTS: HPLC revealed the content of toosendanin was about 15%. Crude extract from Melia toosendan Sieb. et Zucc inhibited cancer cells growth in a dose- and time-dependent manner. The 50% inhibitory concentration (IC50, 72 h) was 0.6 mg/L for SMMC-7721 cells and 0.8 mg/L for Hep3B cells. Both high-dose [0.69 mg/(kg d)] and low-dose [0.138 mg/(kg d)] crude extract could markedly suppress cancer growth, and the inhibition rate was greater than 50%. Hematoxylin and eosin staining showed necrotic area in cancers and transmission electron microscopy displayed necrotic and apoptotic cancer cells with apoptotic bodies. Immunohistochemistry showed that the expression of Bax and Fas increased and the expression of Bcl-2 reduced. CONCLUSIONS: Toosendanin extract has potent anti-cancer effects via suppressing proliferation and inducing apoptosis of cancer cells in vivo and in vitro. The mechanism of apoptosis involves in mitochondrial pathway and death receptor pathway.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Carcinoma Hepatocelular/tratamento farmacológico
Medicamentos de Ervas Chinesas/uso terapêutico
Neoplasias Hepáticas/tratamento farmacológico
Melia/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/patologia
Carcinoma Hepatocelular/ultraestrutura
Proliferação Celular/efeitos dos fármacos
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Feminino
Imuno-Histoquímica
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/ultraestrutura
Masculino
Camundongos Endogâmicos BALB C
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Transplante de Neoplasias
Padrões de Referência
Proteína X Associada a bcl-2/metabolismo
Receptor fas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Drugs, Chinese Herbal); 0 (Fas protein, mouse); 0 (Plant Extracts); 0 (bcl-2-Associated X Protein); 0 (fas Receptor); 79304-40-8 (toosendanin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150919
[St] Status:MEDLINE
[do] DOI:10.1007/s11655-015-2084-7


  6 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26085048
[Au] Autor:Wang H; Geng CA; Xu HB; Huang XY; Ma YB; Yang CY; Zhang XM; Chen JJ
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
[Ti] Título:Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1.
[So] Source:Planta Med;81(10):847-54, 2015 Jul.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Investigation on the fruits of Melia toosendan afforded seven new lignans (1-7), along with seventeen known compounds (8-24). The structures of the new compounds, involving four neo-lignans (1-4), two sesquilignans (5-6), and a nor-lignan (7), were elucidated based on extensive spectroscopic analyses (high-resolution electrospray ionization mass spectra, ultraviolet, infrared, one-dimensional and two-dimensional nuclear magnetic resonance). Compound 24 exhibited activity on melatonin receptor type 1 with an agonistic rate of 57.77% at 1.02 mM according to the assay on HEK293 cell lines in vitro.
[Mh] Termos MeSH primário: Furanos/farmacologia
Lignanas/química
Lignanas/farmacologia
Melia/química
Receptor MT1 de Melatonina/agonistas
[Mh] Termos MeSH secundário: Avaliação Pré-Clínica de Medicamentos/métodos
Furanos/química
Células HEK293/efeitos dos fármacos
Seres Humanos
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/farmacologia
Plantas Medicinais/química
Receptor MT1 de Melatonina/metabolismo
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Furans); 0 (Lignans); 0 (Neuroprotective Agents); 0 (Receptor, Melatonin, MT1); V4N1UDY811 (pinoresinol)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150710
[Lr] Data última revisão:
150710
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150619
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1546127


  7 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25482401
[Au] Autor:Peters RL; Groenendijk P; Vlam M; Zuidema PA
[Ad] Endereço:Forest Ecology & Forest Management group, Wageningen University, P.O. Box 47, 6700AA, Wageningen, The Netherlands; Landscape Dynamics, Swiss Federal Research Institute for Forest, Snow and Landscape Research (WSL), Zürcherstrasse 111, CH-8903, Birmensdorf, Switzerland.
[Ti] Título:Detecting long-term growth trends using tree rings: a critical evaluation of methods.
[So] Source:Glob Chang Biol;21(5):2040-54, 2015 May.
[Is] ISSN:1365-2486
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tree-ring analysis is often used to assess long-term trends in tree growth. A variety of growth-trend detection methods (GDMs) exist to disentangle age/size trends in growth from long-term growth changes. However, these detrending methods strongly differ in approach, with possible implications for their output. Here, we critically evaluate the consistency, sensitivity, reliability and accuracy of four most widely used GDMs: conservative detrending (CD) applies mathematical functions to correct for decreasing ring widths with age; basal area correction (BAC) transforms diameter into basal area growth; regional curve standardization (RCS) detrends individual tree-ring series using average age/size trends; and size class isolation (SCI) calculates growth trends within separate size classes. First, we evaluated whether these GDMs produce consistent results applied to an empirical tree-ring data set of Melia azedarach, a tropical tree species from Thailand. Three GDMs yielded similar results - a growth decline over time - but the widely used CD method did not detect any change. Second, we assessed the sensitivity (probability of correct growth-trend detection), reliability (100% minus probability of detecting false trends) and accuracy (whether the strength of imposed trends is correctly detected) of these GDMs, by applying them to simulated growth trajectories with different imposed trends: no trend, strong trends (-6% and +6% change per decade) and weak trends (-2%, +2%). All methods except CD, showed high sensitivity, reliability and accuracy to detect strong imposed trends. However, these were considerably lower in the weak or no-trend scenarios. BAC showed good sensitivity and accuracy, but low reliability, indicating uncertainty of trend detection using this method. Our study reveals that the choice of GDM influences results of growth-trend studies. We recommend applying multiple methods when analysing trends and encourage performing sensitivity and reliability analysis. Finally, we recommend SCI and RCS, as these methods showed highest reliability to detect long-term growth trends.
[Mh] Termos MeSH primário: Feixe Vascular de Plantas/anatomia & histologia
Árvores/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Fatores Etários
Acurácia dos Dados
Melia/crescimento & desenvolvimento
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Tailândia
Árvores/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150420
[Lr] Data última revisão:
150420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141209
[St] Status:MEDLINE
[do] DOI:10.1111/gcb.12826


  8 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25281546
[Au] Autor:Cho WH; Park JC; Kim DH; Kim MS; Lee SY; Park H; Kang JH; Yeon SW; Han JS
[Ad] Endereço:Department of Biological Sciences, Konkuk University, Seoul 143-701, Republic of Korea.
[Ti] Título:ID1201, the ethanolic extract of the fruit of Melia toosendan ameliorates impairments in spatial learning and reduces levels of amyloid beta in 5XFAD mice.
[So] Source:Neurosci Lett;583:170-5, 2014 Nov 07.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:A previous study has demonstrated the anti-amyloidogenic effects of the ethanolic extract of Meliae Fructus (ID1201) using cell lines with stably expressed human Swedish mutant APP695 and ß-secretase 1, and 5Xfamilial AD (FAD) mice carrying five mutations. Here, we investigated the effects of ID1201 on cognitive impairment in 5XFAD mice. Daily administration of ID1201 was commenced at 3 months of age and continued for 3 months. Mice were serially trained in cued/response and place/spatial training tasks in the Morris water maze. After this training, testing for strategy preference was conducted. Non-transgenic control mice with vehicle treatment, vehicle-treated 5XFAD, and ID1201-treated 5XFAD mice showed equivalent performance in cued/response training. However, as training progressed to the subsequent place/spatial learning, vehicle-treated control and ID1201-treated 5XFAD mice differed significantly from vehicle-treated 5XFAD mice in measures of spatial learning (search error and adaptive spatial learning strategy). In the strategy preference test that followed, control mice preferred a place/spatial strategy relative to vehicle-treated 5XFAD mice, but differences between ID1201-treated 5XFAD mice and vehicle-treated 5XFAD mice were not significant. Additionally, ID1201 treatment reduced hippocampal levels of insoluble Aß42 and increased cortical levels of soluble amyloid precursor protein α. These results indicate that ID1201 may possess potential as a therapeutic agent for Alzheimer's disease by decreasing Aß deposits.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/metabolismo
Frutas/química
Melia/química
Extratos Vegetais/farmacologia
Aprendizagem Espacial/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Etanol
Feminino
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Camundongos Mutantes
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Plant Extracts); 0 (Solvents); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141005
[St] Status:MEDLINE


  9 / 56 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25250895
[Au] Autor:Wang L; Li F; Yang CY; Khan AA; Liu X; Wang MK
[Ad] Endereço:Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijin
[Ti] Título:Neolignans, lignans and glycoside from the fruits of Melia toosendan.
[So] Source:Fitoterapia;99:92-8, 2014 Dec.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four new neolignans, meliasendanins A-D (1-4), and a new glycoside, toosenoside A (5), together with ten known ones (6-15), were isolated from a n-BuOH partition of the fruits of Melia toosendan. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously. Meliasendanin A (1) was a rare neolignan containing isochroman moiety, and its absolute configuration was determined using a CD spectrum. Toosenoside A (5) was an unusual glycoside with a rare naturally occurring aglycone and its structure was confirmed by X-ray single crystal diffraction analysis. The antioxidant activity of the isolated neolignans and lignans was evaluated by ABTS radical-scavenging assay. Compounds 1 and 13 exhibited strong antioxidant activity, with IC50 values of 62.8 and 45.1 µM, respectively.
[Mh] Termos MeSH primário: Antioxidantes/química
Glicosídeos/química
Lignanas/química
Melia/química
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Frutas/química
Glicosídeos/isolamento & purificação
Lignanas/isolamento & purificação
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glycosides); 0 (Lignans); 0 (toosenoside A)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:141216
[Lr] Data última revisão:
141216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140925
[St] Status:MEDLINE


  10 / 56 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25189120
[Au] Autor:Zhu GY; Bai LP; Liu L; Jiang ZH
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China.
[Ti] Título:Limonoids from the fruits of Melia toosendan and their NF-κB modulating activities.
[So] Source:Phytochemistry;107:175-81, 2014 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eight ring C-seco and ring-intact limonoids, and 25 known limonoids were isolated from the fruits of Melia toosendan (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic evidence including HRMS, 1D and 2D NMR spectroscopic data. A total of 29 isolated limonoids was evaluated for NF-κB activities. Among them, eight compounds significantly enhanced the TNFα-induced NF-κB luciferase activity at 10µM, while 10 compounds suppressed the NF-κB activation.
[Mh] Termos MeSH primário: Frutas/química
Limoninas/isolamento & purificação
Limoninas/farmacologia
Melia/química
NF-kappa B/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células Hep G2
Hong Kong
Seres Humanos
Limoninas/química
Luciferases/metabolismo
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Fator de Necrose Tumoral alfa/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Limonins); 0 (NF-kappa B); 0 (Tumor Necrosis Factor-alpha); EC 1.13.12.- (Luciferases)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:141007
[Lr] Data última revisão:
141007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140906
[St] Status:MEDLINE



página 1 de 6 ir para página                
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde