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  1 / 102 MEDLINE  
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[PMID]:28145090
[Au] Autor:Akihisa T; Nishimoto Y; Ogihara E; Matsumoto M; Zhang J; Abe M
[Ad] Endereço:Research Institute for Science & Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8510, Japan.
[Ti] Título:Nitric Oxide Production-Inhibitory Activity of Limonoids from Azadirachta indica and Melia azedarach.
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Seventy-three limonoids isolated from three Meliaceae plants, Azadirachta indica, A. indica var. siamensis, and Melia azedarach, or semi-synthesized from the Meliaceae limonoids, were evaluated for their inhibitory activity against nitric oxide (NO) production in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide (LPS), as a primary screening test for anti-inflammatory agents. Of the compounds tested, 21 compounds exhibited inhibitory activity (IC 4.6 - 58.6 µm) without any significant toxicity (IC > 100 µm) which were more potent than l-NMMA (NO-production inhibitory activity, IC 65.6 µm; cytotoxicity, IC > 100 µm), and among which, nine compounds, i.e., 17-hydroxy-15-methoxynimbocinol (6), ohchinin (20), 1-cis-cinnamoyl-1-decinnamoylohchinin (24), salannin (27), methyl nimbidate (32), isosalannin (55), nimbolinin D (58), mesendanin E (69), and 7-deacetylgedunin (73) exhibited potent inhibitory activity (IC 4.6 - 29.3 µm). In particular, compounds 6 (IC 7.3 µm), an azadirone-type limonoid, and 73 (IC 4.6 µm), a gedunin-type limonoid, exhibited remarkable activity. Western blot analysis revealed that 27 and 73 reduced the expression levels of the inducible NO synthase and cyclooxygenase-2 proteins in a concentration-dependent manner. These findings suggest that limonoids of A. indica, A. indica var. siamensis, and M. azedarach, and their semi-synthetic derivatives may be effective against inflammation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Azadirachta/química
Limoninas/farmacologia
Melia azedarach/química
Óxido Nítrico/biossíntese
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Inibidores de Ciclo-Oxigenase 2
Concentração Inibidora 50
Camundongos
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cyclooxygenase 2 Inhibitors); 0 (Limonins); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600468


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[PMID]:27599262
[Au] Autor:Cornelio VE; Forim MR; Perlatti B; Fernandes JB; Vieira PC; Napolitano MP; Yost RA; da Silva MF
[Ad] Endereço:Department of Chemistry, Federal University of São Carlos, São Carlos, SP, Brazil.
[Ti] Título:Identification of Meliatoxins in Melia azedarach Extracts Using Mass Spectrometry for Quality Control.
[So] Source:Planta Med;83(3-04):312-317, 2017 Feb.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Indiscriminate use of synthetic pesticides can be hazardous to both humans and the environment, but the use of natural products as a source of bio-based products, such as extracts, is an interesting approach to overcome these hazards. Unfortunately, the limonoids found in with desired insecticidal properties (e.g. azadirachtin) may also be present with limonoids toxic to mammals. The goal of this report was to develop a fast and reliable MS-based experiment to characterize meliatoxins in crude extracts of in order to provide unequivocal assessment of the safety for extracts for application in the field. MS and MS/MS experiments using MALDI ionization were evaluated as tools for the assignment of characteristic ions produced by each meliatoxin in crude extracts.The use of different experiments in combination, such as the analysis of fragment 557 and [M + Na] (adducts ions 681 and z 667), MALDI-MS can be used for detection of meliatoxins A /B or A /B in a crude extract and may be used to discriminate meliatoxins A from B, respectively. Subsequent MS/MS experiments can distinguish between the presence of group 1 and/or 2 in each class of meliatoxins classifying the proposed approach as a quick and efficient quality control method of meliatoxins in real samples.
[Mh] Termos MeSH primário: Limoninas/química
Melia azedarach/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Frutas/química
Limoninas/análise
Limoninas/toxicidade
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Controle de Qualidade
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Limonins); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-115773


  3 / 102 MEDLINE  
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[PMID]:27638563
[Au] Autor:Fernández FD; Galdeano E; Kornowski MV; Arneodo JD; Conci LR
[Ad] Endereço:1​Instituto de Patología Vegetal (IPAVE), CIAP-INTA, Camino 60 cuadras km 5 ½ (X5020ICA), Córdoba, Argentina.
[Ti] Título:Description of 'Candidatus Phytoplasma meliae', a phytoplasma associated with Chinaberry (Melia azedarach L.) yellowing in South America.
[So] Source:Int J Syst Evol Microbiol;66(12):5244-5251, 2016 Dec.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:China tree yellows (ChTY) phytoplasma is associated with the yellowing disease of the China tree (Melia azedarach) in Argentina. According to partial 16S rRNA gene analysis, ChTY phytoplasma belongs to the 16Sr XIII group, subgroup G. Strains of species of ChTY have 98-99 % 16S rDNA gene sequence similarity with 16SrXIII-group phytoplasmas, and less than 97.5 % when compared to all 'CandidatusPhytoplasma' described so far, except for the novel 'CandidatusPhytoplasma hispanicum'. However, strains of species of ChTY are differentiated from the latter due to having additional molecular and biological attributes. The presence of unique features in the 16S rDNA sequence distinguishes ChTY from all species of 'CandidatusPhytoplasma' currently described. The in silico RFLP profile of 16S rDNA (1.2 kb) and rpLV-rpsC (1.3 kb) genes distinguished ChTY, as in the 16SrXIII-G subgroup within the 16SrXIIII group. The phylogenetic analyses, based on 16S rDNA, rpLV-rpsC and secA gene sequences, in addition to the restricted host range, characteristic symptoms and geographical distribution, confirm that the collective strains of the species ChTY represent a distinct lineage within the phytoplasma clade and support the description of a novel species of 'CandidatusPhytoplasma meliae' with the reference strain being ChTY-Mo3 (Montecarlo, Argentina).
[Mh] Termos MeSH primário: Melia azedarach/microbiologia
Filogenia
Phytoplasma/classificação
Doenças das Plantas/microbiologia
[Mh] Termos MeSH secundário: Argentina
Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos
Genes Bacterianos
Phytoplasma/isolamento & purificação
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001503


  4 / 102 MEDLINE  
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[PMID]:27449157
[Au] Autor:Zhou F; Ma XH; Li ZJ; Li W; Zheng WM; Wang ZB; Zeng XM; Sun KH; Zhang YH
[Ad] Endereço:Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004, P. R. China.
[Ti] Título:Four New Tirucallane Triterpenoids from the Fruits of Melia azedarach and Their Cytotoxic Activities.
[So] Source:Chem Biodivers;13(12):1738-1746, 2016 Dec.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Four new tirucallane triterpenoids, (21S,23R,24R)-21,23-epoxy-21,24-dihydroxy-25-methoxytirucall-7-en-3-one (2), (3S,21S,23R,24S)-21,23-epoxy-21,25-dimethoxytirucall-7-ene-3,24-diol (8), (21S,23R,24R)-21,23-epoxy-24-hydroxy-21-methoxytirucalla-7,25-dien-3-one (11), and (21S,23R,24R)-21,23-epoxy-21,24-dihydroxytirucalla-7,25-dien-3-one (12), along with 16 known analogues, 1, 3 - 7, 9 - 10, and 13 - 20, were isolated from the fruits of Melia azedarach. Their structures were elucidated by spectroscopic methods including 1D- and 2D-NMR techniques and mass spectrometry. These compounds were evaluated for their cytotoxicities against HepG2 (liver), SGC7901 (stomach), K562 (leukemia), and HL60 (leukemia) cancer cell lines. Compound 20 exhibited potent cytotoxicity against HepG2 and SGC7901 cancer cells with the IC values of 6.9 and 6.9 µm, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Frutas/química
Melia azedarach/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Conformação Molecular
Relação Estrutura-Atividade
Triterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Triterpenes); 0 (tirucallane)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170120
[Lr] Data última revisão:
170120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600149


  5 / 102 MEDLINE  
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[PMID]:26727712
[Au] Autor:Ge JJ; Wang LT; Chen P; Zhang Y; Lei XX; Ye XX
[Ad] Endereço:a School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou 325035 , China.
[Ti] Título:Two new tetracyclic triterpenoids from the barks of Melia azedarach.
[So] Source:J Asian Nat Prod Res;18(1):20-5, 2016.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new tetracyclic triterpenoids, together with 21 known compounds, were isolated from the barks of Melia azedarach. The structures of new compounds were elucidated by the means of HRESIMS, 1D NMR, 2D NMR, and X-ray crystallography analysis.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Melia azedarach/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Cristalografia por Raios X
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Casca de Planta/química
Spodoptera/efeitos dos fármacos
Triterpenos/química
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (24-hydroperoxytirucalla-7,25(26)-diene-3,6-dion-21,16-olide); 0 (Drugs, Chinese Herbal); 0 (Triterpenes); 0 (tirucalla-5(6),7,24 (25)-triene-3-dion-21,16-olide)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160216
[Lr] Data última revisão:
160216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160105
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2015.1124866


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[PMID]:26687557
[Au] Autor:Liu Y; Yang MH; Wang XB; Li TX; Kong LY
[Ad] Endereço:State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
[Ti] Título:Caryophyllene sesquiterpenoids from the endophytic fungus, Pestalotiopsis sp.
[So] Source:Fitoterapia;109:119-24, 2016 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Eight new caryophyllene sesquiterpenoids named pestaloporinates A-G (1-7) and 14-acetylhumulane (8) have been isolated from the solid cultures of an endophytic fungus Pestalotiopsis sp., which was obtained from the fresh stem bark of Melia azedarach Linn. Their structures as well as absolute configurations were determined by spectroscopic data, ECD experimentation, and single-crystal X-ray diffraction. Among all the isolates, compound 2 displayed potent inhibitory activity with IC50 value of 19.0 µM during the evaluation of nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells.
[Mh] Termos MeSH primário: Sesquiterpenos/química
Xylariales/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Macrófagos/efeitos dos fármacos
Melia azedarach/microbiologia
Camundongos
Estrutura Molecular
Óxido Nítrico/metabolismo
Casca de Planta/microbiologia
Células RAW 264.7
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Sesquiterpenes); 0 (pestaloporinate B); 31C4KY9ESH (Nitric Oxide); BHW853AU9H (caryophyllene)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160301
[Lr] Data última revisão:
160301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE


  7 / 102 MEDLINE  
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[PMID]:26485025
[Au] Autor:Sanna G; Madeddu S; Giliberti G; Ntalli NG; Cottiglia F; De Logu A; Agus E; Caboni P
[Ad] Endereço:Department of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliari, Italy.
[Ti] Título:Limonoids from Melia azedarach Fruits as Inhibitors of Flaviviruses and Mycobacterium tubercolosis.
[So] Source:PLoS One;10(10):e0141272, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The biological diversity of nature is the source of a wide range of bioactive molecules. The natural products, either as pure compounds or as standardized plant extracts, have been a successful source of inspiration for the development of new drugs. The present work was carried out to investigate the cytotoxicity, antiviral and antimycobacterial activity of the methanol extract and of four identified limonoids from the fruits of Melia azedarach (Meliaceae). The extract and purified limonoids were tested in cell-based assays for antiviral activity against representatives of ssRNA, dsRNA and dsDNA viruses and against Mycobacterium tuberculosis. Very interestingly, 3-α-tigloyl-melianol and melianone showed a potent antiviral activity (EC50 in the range of 3-11µM) against three important human pathogens, belonging to Flaviviridae family, West Nile virus, Dengue virus and Yellow Fever virus. Mode of action studies demonstrated that title compounds were inhibitors of West Nile virus only when added during the infection, acting as inhibitors of the entry or of a very early event of life cycle. Furthermore, 3-α-tigloyl-melianol and methyl kulonate showed interesting antimycobacterial activity (with MIC values of 29 and 70 µM respectively). The limonoids are typically lipophilic compounds present in the fruits of Melia azeradach. They are known as cytotoxic compounds against different cancer cell lines, while their potential as antiviral and antibacterial was poorly investigated. Our studies show that they may serve as a good starting point for the development of novel drugs for the treatment of infections by Flaviviruses and Mycobacterium tuberculosis, for which there is a continued need.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antivirais/farmacologia
Flavivirus/efeitos dos fármacos
Frutas/química
Limoninas/farmacologia
Melia azedarach/química
Mycobacterium tuberculosis/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Infecções por Flavivirus/tratamento farmacológico
Infecções por Flavivirus/virologia
Seres Humanos
Limoninas/química
Limoninas/isolamento & purificação
Tuberculose/tratamento farmacológico
Tuberculose/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antiviral Agents); 0 (Limonins); 0 (Plant Extracts)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151021
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0141272


  8 / 102 MEDLINE  
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[PMID]:26013136
[Au] Autor:Souza BH; Costa EN; Forim MR; Costa ES; Boiça Júnior AL
[Ad] Endereço:Depto de Fitossanidade, Fac de Ciências Agrárias e Veterinárias, UNESP, Via de Acesso Prof. Paulo Donato Castellane, s/n, Jaboticabal, SP, 14884-900, Brasil, souzabhs@gmail.com.
[Ti] Título:Formulations of Melia azedarach to Control Diabrotica speciosa (Germar) (Coleoptera: Chrysomelidae) Larvae in Corn and Plant Enhancement.
[So] Source:Neotrop Entomol;44(2):173-9, 2015 Apr.
[Is] ISSN:1678-8052
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We evaluated oil and powder formulations of Melia azedarach for controlling larvae of Diabrotica speciosa (Germar) in corn and plant enhancement. Five concentrations of each formulation were evaluated and compared to fipronil (negative control) and distilled water (positive control). After treatment, the number of surviving insects (larvae, pupae, and adults), the adult body weight, the sex ratio, and the longevity were recorded, while the height, dry weight of aerial part and roots, and number of leaves of plants were measured. The oil formulation at 4.0 mL reduced the larvae population of D. speciosa similarly to the insecticide fipronil, which resulted in greater height, dry weight of the root system, and number of leaves. Powder formulation at concentrations of 40, 80, and 160 mg caused larval mortality above 80%; however, these concentrations did not prevent reduction of plant height and dry weight of aerial part. Further studies assessing the residual period of M. azedarach control against D. speciosa larvae and its phytotoxicity, which are common traits associated with azadirachtin application, are necessary to subsidize the next steps of this alternative control strategy.
[Mh] Termos MeSH primário: Coleópteros/efeitos dos fármacos
Coleópteros/fisiologia
Controle de Insetos/métodos
Larva/efeitos dos fármacos
Melia azedarach
Extratos Vegetais/farmacologia
Zea mays/parasitologia
[Mh] Termos MeSH secundário: Animais
Composição de Medicamentos
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150528
[St] Status:MEDLINE
[do] DOI:10.1007/s13744-014-0268-z


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[PMID]:25935845
[Au] Autor:Abiy E; Gebre-Michael T; Balkew M; Medhin G
[Ad] Endereço:The Carter Center Ethiopia, North Wollo Zone Health Department, Malaria and Trachoma project office, PO Box 69, Woldia, Northeast Amhara region, Ethiopia. ephremabiy1@gmail.com.
[Ti] Título:Repellent efficacy of DEET, MyggA, neem (Azedirachta indica) oil and chinaberry (Melia azedarach) oil against Anopheles arabiensis, the principal malaria vector in Ethiopia.
[So] Source:Malar J;14:187, 2015 May 03.
[Is] ISSN:1475-2875
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Ethiopia, Anopheles arabiensis is the main vector responsible for the transmission of malaria in the country and its control mainly involves application of indoor residual spraying (IRS) and use of insecticide-treated bed nets (ITNs). OBJECTIVE: Although the role of repellents for reducing man-vector contact is documented in the literature, the response of An. arabiensis to repellents was not previously evaluated under field conditions in Ethiopia. METHOD: The trial was conducted in Sodere village assessing the repellent activities of four repellents, of which, two of them were commercially available DEET (N, N-diethyl-1,3-methylbenzamide) and MyggA (p-methane diol) and the other two were laboratory- produced, 20% neem oil and 20% chinaberry oil. A 6 by 6 Latin square design was employed by involving six volunteers who received rotated treatments of repellents and the Ethiopian Niger seed, noog abyssinia (Guizotia abyssinia), and locally called as noog oil (diluents to the two plant oils). Each volunteer also served as control. Volunteers were positioned at a distance of 20-40 m from each other and each was treated with one of the repellents, Niger seed/noog/ oil or untreated. Landing mosquitoes were collected from dusk to down using tests tubes. The tests were done in three replicates. RESULTS: Both DEET and MyggA provided more than 96% protection. The mean protection time for DEET was 8 hrs while the time for MyggA was 6 hrs. Protection obtained from neem oil and chinaberry oil was almost similar (more than 70%), however, the complete protection time for neem was 3 hrs, while that of chinaberry oil was one hour. CONCLUSION: The commercial products and laboratory-produced repellents can be utilized by individuals to avoid contact with An. arabiensis in Ethiopia.
[Mh] Termos MeSH primário: Anopheles
Repelentes de Insetos
Insetos Vetores
Malária/prevenção & controle
Controle de Mosquitos
[Mh] Termos MeSH secundário: Adulto
Animais
Criança
DEET
Etiópia
Glicerídeos
Seres Humanos
Masculino
Melia azedarach/química
Óleos Vegetais
Terpenos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycerides); 0 (Insect Repellents); 0 (Plant Oils); 0 (Terpenes); 134-62-3 (DEET); 4DKJ9B3K2T (neem oil)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150504
[St] Status:MEDLINE
[do] DOI:10.1186/s12936-015-0705-4


  10 / 102 MEDLINE  
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[PMID]:25758585
[Au] Autor:Rutkauskis JR; Jacomini D; Temponi LG; Sarragiotto MH; da Silva EA; Jorge TC; Jorge TC
[Ad] Endereço:Center of Medical Sciences and Pharmaceutical, UNIOESTE, Cascavel, Brazil.
[Ti] Título:Pediculicidal treatment using ethanol and Melia azedarach L.
[So] Source:Parasitol Res;114(6):2085-91, 2015 Jun.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pediculosis is an infestation of the scalp caused by Pediculus humanus capitis, known as lice, which affects thousands of people throughout the world. Disease control is achieved by topical insecticides, whose indiscriminate use has led to the emergence of resistant populations of lice. Melia azedarach L. (Meliaceae) is an Asian tree that is found in Brazil, where it is popularly known as cinnamon or santa-bárbara. This study aimed to evaluate a pediculicidal treatment, made from a hydroethanolic extract of M. azedarach, and to study the effect of extraction solvents (ethanol and water) on insect mortality. The chemical composition of crude extract was studied by gas chromatography, identifying 32 methyl esters of fatty acids, with esters of heneicosanoic, palmitic, and arachidic acids present in greatest abundance. The (1)H and (13)C nuclear magnetic resonance (NMR) spectra suggested the presence of flavonoids and terpenes. Quercetin-3-O-ß-D-glucopyranoside (1) and quercetin-3-O-ß-D-glucopyranosyl-(1 → 6)-O-ß-D-glucopyranoside (2) were isolated from the extract. The bioassay of pediculicidal activity shows that the M. azedarach extract had a pediculicidal activity, inducing the death of all lice faster than 1% permethrin, a topical insecticide commonly used to control lice.
[Mh] Termos MeSH primário: Antiparasitários/farmacologia
Infestações por Piolhos/tratamento farmacológico
Melia azedarach/química
Pediculus/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antiparasitários/química
Antiparasitários/isolamento & purificação
Bioensaio
Brasil
Etanol/farmacologia
Feminino
Seres Humanos
Inseticidas/farmacologia
Pediculus/fisiologia
Permetrina/farmacologia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Insecticides); 0 (Plant Extracts); 3K9958V90M (Ethanol); 509F88P9SZ (Permethrin)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150312
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-015-4394-2



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