Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.725.124 [Categoria DeCS]
Referências encontradas : 17 [refinar]
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  1 / 17 MEDLINE  
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[PMID]:25095346
[Au] Autor:Liao J; Lei Y; Wang JZ
[Ti] Título:[Chemical constituents of Cocculus orbiculatus var. mollis root].
[So] Source:Zhong Yao Cai;37(2):254-7, 2014 Feb.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the chemical constituents in the root of Cocculus orbiculatus var. mollis. METHODS: The compounds were isolated by silica gel chromatography, their structures were established by spectroscopic methods. RESULTS: Eleven compounds were isolated and identified as wattisine A (I), O-methylcocsoline (II), (+) cocsoline (III), (+) cocsuline (IV), magnoflorine (V), sino-coculine (VI), isosinococuline (VII), (-) coclaurine (VIII), daucosterol (IX), beta-sitosterol (X) and 1-oleioyl-3-(9Z, 12Z-arachoyl) glycerol (XI). CONCLUSION: Compound I is isolated from this genus for the first time,and compound II - XI are isolated from this plant for the first time.
[Mh] Termos MeSH primário: Alcaloides/química
Cocculus/química
Raízes de Plantas/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Aporfinas/química
Aporfinas/isolamento & purificação
Benzilisoquinolinas/química
Benzilisoquinolinas/isolamento & purificação
Etanol/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Sitosteroides/química
Sitosteroides/isolamento & purificação
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Aporphines); 0 (Benzylisoquinolines); 0 (Sitosterols); 0 (wattisine A); 3K9958V90M (Ethanol); NI8K6962K4 (magnoflorine); U45VN859W3 (lyoniside)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140806
[Lr] Data última revisão:
140806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140807
[St] Status:MEDLINE


  2 / 17 MEDLINE  
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[PMID]:24920232
[Au] Autor:Thavamani BS; Mathew M; Palaniswamy DS
[Ad] Endereço:Department of Pharmacognosy, PSG College of Pharmacy , Peelamedu, Coimbatore, Tamil Nadu , India .
[Ti] Título:Anticancer activity of Cocculus hirsutus against Dalton's lymphoma ascites (DLA) cells in mice.
[So] Source:Pharm Biol;52(7):867-72, 2014 Jul.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Cocculus hirsutus (L.) Diels (Menispermaceae) is used in Indian folk system of alternative medicine for rheumatism, eczema, diabetics, inflammation, and neuralgia. OBJECTIVE: To evaluate antitumor activities of C. hirsutus in vitro and in vivo. MATERIALS AND METHODS: C. hirsutus was successively extracted using hexane, petroleum ether, chloroform, ethyl acetate, methanol, and water. In vitro cytotoxicity was assessed by the MTT assay. Phytochemical analyses were conducted with methanol extract of C. hirsutus (MECH) and in vivo antitumor activity was carried out with MECH using Dalton's lymphoma ascites (DLA) mouse model. Antioxidant properties were assessed by estimating superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation. RESULTS AND DISCUSSION: Phytochemical studies indicated a high content of total alkaloid (165.6 mg/100 g), total phenolic (43.5 GAE mg/g), and total flavanoid (4.97 RE mg/g) in MECH. Anti-proliferative activity against the breast cancer cell line MCF-7 showed IC50 values of 221.5 ± 16.68, 255 ± 17.88, 213 ± 8.4, 147 ± 7.9, and 229 ± 8.02 µg/ml with hexane, petroleum ether, chloroform, ethyl acetate, methanol, and aqueous extracts, respectively. A significant (p < 0.01) decrease in packed cell volume, viable cell count, and increased lifespan (58 and 77%) was observed. Hematological and serum biochemical profiles were restored to normal levels in MECH-treated mice. MECH-treated group significantly (p < 0.001) decreased SOD, lipid peroxidation, and CAT towards normal. CONCLUSION: C. hirsutus exhibited significant in vitro and in vivo antitumor activities that are reasonably attributed to endogenous antioxidant mechanisms.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Cocculus/química
Linfoma/patologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/análise
Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/toxicidade
Antioxidantes/farmacologia
Catalase/metabolismo
Contagem de Células
Morte Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Feminino
Flavonoides/análise
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Linfoma/tratamento farmacológico
Masculino
Camundongos
Fenóis/análise
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Solventes/química
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Solvents); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:140612
[Lr] Data última revisão:
140612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140613
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.871642


  3 / 17 MEDLINE  
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[PMID]:23973403
[Au] Autor:Zubedat S; Freed Y; Eshed Y; Cymerblit-Sabba A; Ritter A; Nachmani M; Harush R; Aga-Mizrachi S; Avital A
[Ad] Endereço:The Rappaport Faculty of Medicine, Behavioural Neuroscience Lab, Technion - Israel Institute of Technology, Haifa, Israel.
[Ti] Título:Plant-derived nanoparticle treatment with cocc 30c ameliorates attention and motor abilities in sleep-deprived rats.
[So] Source:Neuroscience;253:1-8, 2013 Dec 03.
[Is] ISSN:1873-7544
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sleep is an essential physiological process that underlies crucial cognitive functions as well as emotional reactivity. Thus, sleep deprivation (SD) may exert various deleterious effects. In this study, we aimed to examine the adverse behavioral and hormonal effects of SD and a potential treatment with Plant-derived nanoparticle treatment - cocc 30c. The study was a 4-arm trial with randomization and double-blinding of verum and placebo treatments. SD was induced by using the Multiple Platform Method for 48 h. The effects of SD were evaluated behaviorally (pre-pulse inhibition (PPI), startle response and rotor-rod) at baseline as well as at 6, 12, 24h, and 14 days post deprivation. cocc 30c treatment was administrated Per Os every three hours starting immediately after baseline tests and for a period of 24h. On day 14, blood samples were taken and serum levels of corticosterone, testosterone, serotonin and leptin were tested. We found that cocc 30c improved PPI 12 and 24h post deprivation, likewise, cocc 30c improved motor learning. On day 14 SD led to increased startle response that was ameliorated by cocc 30c. Likewise, SD led to increased levels of corticosterone and serotonin while decreasing testosterone and leptin. Interestingly, cocc 30c treatment has moderated these hormonal alterations. We conclude that the treatment with cocc 30c recovers both short-term behavioral and the long-term hormonal modulations following SD.
[Mh] Termos MeSH primário: Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico
Transtornos dos Movimentos/tratamento farmacológico
Nanopartículas/uso terapêutico
Fitoterapia/métodos
Privação do Sono/complicações
[Mh] Termos MeSH secundário: Estimulação Acústica
Animais
Transtorno do Deficit de Atenção com Hiperatividade/etiologia
Cocculus/química
Modelos Animais de Doenças
Método Duplo-Cego
Masculino
Transtornos dos Movimentos/etiologia
Extratos Vegetais/uso terapêutico
Ratos
Ratos Wistar
Tempo de Reação/efeitos dos fármacos
Reflexo de Sobressalto/efeitos dos fármacos
Privação do Sono/sangue
Sono REM/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130827
[St] Status:MEDLINE


  4 / 17 MEDLINE  
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[PMID]:23729561
[Au] Autor:Gadapuram TK; Murthy JS; Rajannagari RR; Kandati V; Choda PK; Shukla R
[Ti] Título:Nephroprotective activity of Cocculus hirsutus leaf extract in 5/6 nephrectomized rat model.
[So] Source:J Basic Clin Physiol Pharmacol;24(4):299-306, 2013.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cocculus hirsutus, commonly known as broom creeper, belongs to the family Menispermaceae. It is widely used in folk medicine to treat leprosy, skin diseases, dyspepsia, etc. Hence, an effort has been made to investigate the nephroprotective potential of C. hirsutus. METHODS: The nephroprotective activity of ethanolic C. hirsutus leaf extract (ECHE) in the 5/6 nephrectomized rat model was investigated. Different parameters like postoperative survival rate, change in body weight and levels of red blood corpuscles (RBCs), hemoglobin (Hb), triglyceride, cholesterol, creatinine, urea and uric acid were estimated in experimental rats. RESULTS: The findings revealed the postoperative survival rate of rats in the investigated novel method to be 100%. Change in the body weight of ECHE-treated groups I and II was found to be 32 and 30 g, respectively. These values suggested that ECHE treatment normalized the elevated body weight levels in experimental rats. Furthermore, ECHE treatment normalized the decreased RBC levels and the elevated Hb, triglyceride, cholesterol, creatinine, urea and uric acid levels in experimental rats. CONCLUSIONS: The results indicate that C. hirsutus has strong nephroprotective activity. However, further scrutiny is essential for isolation and characterization of the active components that can be employed to allay various human maladies.
[Mh] Termos MeSH primário: Cocculus/química
Extratos Vegetais/uso terapêutico
Substâncias Protetoras/uso terapêutico
Insuficiência Renal Crônica/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Etanol/química
Testes de Função Renal
Masculino
Medicina Ayurvédica
Nefrectomia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Folhas de Planta/química
Substâncias Protetoras/administração & dosagem
Substâncias Protetoras/isolamento & purificação
Substâncias Protetoras/toxicidade
Ratos
Ratos Wistar
Insuficiência Renal Crônica/sangue
Insuficiência Renal Crônica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Protective Agents); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:131104
[Lr] Data última revisão:
131104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130605
[St] Status:MEDLINE


  5 / 17 MEDLINE  
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[PMID]:23652992
[Au] Autor:Sim HJ; Kim JH; Lee KR; Hong J
[Ad] Endereço:College of Pharmacy, Kyung Hee University, Hoegi-dong, Dongdaemoon-gu, Seoul 130-701, Korea.
[Ti] Título:Simultaneous determination of structurally diverse compounds in different Fangchi species by UHPLC-DAD and UHPLC-ESI-MS/MS.
[So] Source:Molecules;18(5):5235-50, 2013 May 07.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Two bisbenzylisoquinoline alkaloids, two morphine alkaloids, one aporphine alkaloid, syringaresinol and aristolochic acid І were selected as marker compounds and simultaneously analyzed using an ultra-high pressure liquid chromatography-diode array detection (UHPLC-DAD) method. These marker compounds were used for the quality control of Fangchi species of different origins, including Sinomenium acutum, Stephania tetrandra, Cocculus trilobus and Aristolochia fangchi. A reversed-phase UHPLC-DAD method was developed and validated for the simultaneous quantification of structurally diverse markers in different Fangchi species. In addition, an UHPLC-electrospray ionization tandem mass spectrometry (ESI-MS/MS) method was used for marker identification in Fangchi species, which provided diagnostic MS/MS spectral patterns that were dependent upon the marker structures. The UHPLC-MS/MS data were used to confirm and complement the UHPLC-DAD quality evaluation results. Additionally, magnoflorine and syringaresinol were observed for the first time in S. tetrandra and C. trilobus, respectively. Twenty different Fangchi species samples were analyzed for aristolochic acid I, syringaresinol and the alkaloids using the UHPLC-DAD and MS/MS method. Based on the levels of markers and principal component analysis (PCA), this method allowed for the clear classification of the samples into four different groups representing samples originating from the four species.
[Mh] Termos MeSH primário: Alcaloides/análise
Aristolochia/química
Cocculus/química
Plantas Medicinais/química
Sinomenium/química
Stephania tetrandra/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Medicina Tradicional Chinesa
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:130508
[Lr] Data última revisão:
130508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130509
[St] Status:MEDLINE
[do] DOI:10.3390/molecules18055235


  6 / 17 MEDLINE  
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[PMID]:20480375
[Au] Autor:Elango G; Rahuman AA; Zahir AA; Kamaraj C; Bagavan A; Rajakumar G; Jayaseelan C; Santhoshkumar T; Marimuthu S
[Ad] Endereço:Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, Vellore District, Tamil Nadu, India.
[Ti] Título:Evaluation of repellent properties of botanical extracts against Culex tritaeniorhynchus Giles (Diptera: Culicidae).
[So] Source:Parasitol Res;107(3):577-84, 2010 Aug.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In recent times, there were considerable efforts made to promote the use of environmentally friendly and biodegradable natural insecticides and repellents, particularly from botanical sources. The present study explored the effects of crude leaf ethyl acetate, acetone, and methanol extracts of Aegle marmelos (L.) Correa ex Roxb, Andrographis lineata Wallich ex Nees., Andrographis paniculata (Burm.f.) Wallich ex Nees., Cocculus hirsutus (L.) Diels, Eclipta prostrata L., and Tagetes erecta L. on repellent activity against Culex tritaeniorhynchus Giles. The maximum repellent activity was observed at 500 ppm in methanol extracts of A. marmelos, ethyl acetate extracts of A. lineata, C. hirsutus, and E. prostrata and the mean complete protection time ranged from 120 to 150 min with the different extracts tested. The ethyl acetate extract of A. lineata showed 100% repellency in 120 min; acetone extracts of A. marmelos and C. hirsutus and methanol extract of T. erecta showed complete protection in 90 min at 250 ppm, respectively. These results suggest that the leaf extracts of A. marmelos, A. lineata, and C. hirsutus have the potential to be used as an ideal eco-friendly approach for the control of the C. tritaeniorhynchus. Therefore, this study provides first report on the repellent activity against Japanese encephalitis, C. tritaeniorhynchus of plant extracts from Southern India.
[Mh] Termos MeSH primário: Culex/efeitos dos fármacos
Repelentes de Insetos/farmacologia
Insetos Vetores/efeitos dos fármacos
Magnoliopsida/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Aegle/química
Andrographis/química
Animais
Cocculus/química
Culex/classificação
Eclipta/química
Encefalite Japonesa/transmissão
Índia
Insetos Vetores/classificação
Magnoliopsida/classificação
Plantas Medicinais/química
Plantas Medicinais/classificação
Tagetes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Plant Extracts)
[Em] Mês de entrada:1011
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100519
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-010-1897-8


  7 / 17 MEDLINE  
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[PMID]:19953270
[Au] Autor:Elango G; Rahuman AA; Bagavan A; Kamaraj C; Zahir AA; Rajakumar G; Marimuthu S; Santhoshkumar T
[Ad] Endereço:Unit of Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, 632509 Vellore District, Tamil Nadu, India.
[Ti] Título:Efficacy of botanical extracts against Japanese encephalitis vector, Culex tritaeniorhynchus.
[So] Source:Parasitol Res;106(2):481-92, 2010 Jan.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The purpose of the present study was to assess the effect of leaf hexane and chloroform extracts of Aegle marmelos, Andrographis lineata, Andrographis paniculata, Cocculus hirsutus, Eclipta prostrata, and Tagetes erecta on repellent, ovicidal, and oviposition-deterrent activities against Culex tritaeniorhynchus Giles (Diptera: Culicidae). The repellent action of the plant extracts tested varied depending on the plant species, part, solvent used in extraction, and the extract dose. The hexane extract of A. paniculata was more effective in exhibiting the repellent action against the mosquito as compared with A. lineata extract. Complete protections for 150 min were found in hexane extract of A. paniculata at 500 ppm against mosquito bites. Mean percent hatchability of the ovicidal activity was observed 24 h after treatment. The percent hatchability was inversely proportional to the concentration of extract and directly proportional to the eggs. No hatchability was observed with hexane, and chloroform extracts of A. lineata, A. paniculata, and hexane extract of T. erecta were exerted at 1,000 ppm. The percentage of effective oviposition repellency were 95.90, 94.75, 95.04, 90.58, 87.93, 87.14, 94.82, 95.71, 92.26, 90.58, 83.35, and 78.16 at 500 ppm, and the lowest repellency was 69.93, 53.06, 64.81, 70.06, 51.82, 54.54, 48.31, 66.71, 68.82, 61.85, 34.84, and 39.53 at 31.25 ppm in hexane and chloroform extracts of A. marmelos, A. lineata, A. paniculata, C. hirsutus, E. prostrata, and T. erecta, respectively. The oviposition activity index values revealed that the solvent plant extracts have deterrent effect, and they caused a remarkable negative response resulting in oviposition of very few eggs. These results clearly reveal that the hexane extracts of A. marmelos and A. paniculata served as a potential repellent, ovicidal, and oviposition deterrent against Japanese encephalitis vector, C. tritaeniorhynchus.
[Mh] Termos MeSH primário: Culex/efeitos dos fármacos
Vetores de Doenças
Repelentes de Insetos/farmacologia
Inseticidas/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Aegle/química
Andrographis/química
Animais
Cocculus/química
Feminino
Seres Humanos
Repelentes de Insetos/isolamento & purificação
Inseticidas/isolamento & purificação
Extratos Vegetais/isolamento & purificação
Tagetes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Insecticides); 0 (Plant Extracts)
[Em] Mês de entrada:1003
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091203
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-009-1690-8


  8 / 17 MEDLINE  
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[PMID]:19707789
[Au] Autor:Elango G; Bagavan A; Kamaraj C; Abduz Zahir A; Abdul Rahuman A
[Ad] Endereço:Unit of Bioactive Natural Products, P.G & Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, 632 509, Tamil Nadu, India.
[Ti] Título:Oviposition-deterrent, ovicidal, and repellent activities of indigenous plant extracts against Anopheles subpictus Grassi (Diptera: Culicidae).
[So] Source:Parasitol Res;105(6):1567-76, 2009 Nov.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. The leaf acetone, ethyl acetate, and methanol extracts of Aegle marmelos (Linn.) Correa ex Roxb, Andrographis lineata Wallich ex Nees, and Cocculus hirsutus (L.) Diels were tested for oviposition-deterrent, ovicidal, and repellent activities against Anopheles subpictus Grassi (Diptera: Culicidae). The percentage of effective oviposition repellency of 92.60 , 93.04, 95.20, 88.26, 92.80, 94.01, 95.77, 96.93, and 92.54 at 500 ppm and the lowest repellency of 47.14, 58.00, 56.52, 64.93, 71.09, 66.42, 50.62, 57.62, and 65.73 at 31.25 ppm in acetone, ethyl acetate, and methanol extracts of Aegle marmelos, Andrographis lineata, and Cocculus hirsutus, respectively. The oviposition activity index (OAI) value of acetone, ethyl acetate, and methanol extracts of Aegle marmelos, Andrographis lineata, and Cocculus hirsutus at 500 ppm were -0.86, -0.87, -0.90, -0.78, -0.87, -0.86, -0.91, -0.94, and -0.86 respectively. The OAI values revealed that the solvent plant extracts have deterrent effect, and they caused a remarkable negative response resulting in oviposition of very few eggs. Mean percent hatchability of the ovicidal activity was observed 24 h after treatment. The percent hatchability was inversely proportional to the concentration of extract and directly proportional to the eggs. Mortality of 100% with ethyl acetate extract of Aegle marmelos, methanol extracts Aegle marmelos, Andrographis lineata, and Cocculus hirsutus were exerted at 1,000 ppm. The maximum repellent activity was observed at 500 ppm in methanol extracts of Aegle marmelos, Andrographis lineata, and ethyl acetate extract of Cocculus hirsutus, and the mean complete protection time ranged from 90 to 120 min with the different extracts tested. These results suggest that the leaf extracts of Aegle marmelos, Andrographis lineata, and Cocculus hirsutus have the potential to be used as an ideal ecofriendly approach for the control of the Anopheles subpictus. Therefore, this study provides first report on the oviposition, ovicidal, and repellent activities against malaria vector, Anopheles subpictus of plant extracts from Southern India.
[Mh] Termos MeSH primário: Aegle/química
Andrographis/química
Anopheles/efeitos dos fármacos
Cocculus/química
Repelentes de Insetos/farmacologia
Inseticidas/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Índia
Repelentes de Insetos/isolamento & purificação
Inseticidas/isolamento & purificação
Oviposição/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Insecticides); 0 (Plant Extracts)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090827
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-009-1593-8


  9 / 17 MEDLINE  
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[PMID]:19479625
[Au] Autor:Atta-ur-Rahman; Atia-tul-Wahab; Zia Sultani S; Nawaz SA; Choudhary MI
[Ad] Endereço:H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
[Ti] Título:Bisbenzylisoquinoline alkaloids from Cocculus pendulus.
[So] Source:Nat Prod Res;23(14):1265-73, 2009.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new bisbenzylisoquinoline alkaloid, 1,2-dihydrokurramine (1), and four known bisbenzylisoquinoline alkaloids 2-5, along with a morphinan alkaloid 6 were isolated from Cocculus pendulus. The structures for these compounds were deduced by spectroscopic methods. All bisbenzylisoquinoline alkaloids showed inhibitory activities against acetyl- and butyrylcholinesterases.
[Mh] Termos MeSH primário: Alcaloides/química
Benzilisoquinolinas/química
Inibidores da Colinesterase/química
Cocculus/química
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Alcaloides/farmacologia
Benzilisoquinolinas/farmacologia
Butirilcolinesterase/metabolismo
Inibidores da Colinesterase/farmacologia
Ativação Enzimática/efeitos dos fármacos
Concentração Inibidora 50
Espectroscopia de Ressonância Magnética
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Cholinesterase Inhibitors); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:0911
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090530
[St] Status:MEDLINE
[do] DOI:10.1080/14786410500185303


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[PMID]:19222913
[Au] Autor:Badole SL; Bodhankar SL; Patel NM; Bhardwaj S
[Ad] Endereço:Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune, India.
[Ti] Título:Acute and chronic diuretic effect of ethanolic extract of leaves of Cocculus hirsutus (L.) Diles in normal rats.
[So] Source:J Pharm Pharmacol;61(3):387-93, 2009 Mar.
[Is] ISSN:0022-3573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this study was to evaluate the acute and chronic diuretic effect of the ethanolic extract of the leaves of Cocculus hirsutus (L.) Diles. METHODS: The ethanolic extract was administered (100, 200 and 400 mg/kg, p.o.) in Wistar rats. In the acute study, rats received drugs orally and urine was collected after 1, 2, 3, 4, 5 and 6 h. The chronic study involved repeated administration of ethanolic extract for 28 days and urine was collected on day 1, 7, 14, 21 and 28. The parameters were total urine volume, concentration of Na+, K+ and Cl- ions, creatinine in urine and serum. Urine output, electrolytes (Na+, K+ and Cl- ions) and creatinine were determined on day 7, 14, 21 and 28. KEY FINDINGS: The highest dose (400 mg/kg) of the ethanolic extract significantly (P < 0.01) enhanced urine output. Excretion of cations (Na+ and K+ ions) and anions (Cl- ions) increased significantly with respect to the control (gum acacia 2% dissolved in saline, 10 ml/kg) group. The increase of cations in the urine after treatment with ethanolic extract was dose dependent. The ethanolic extract of the leaves of C. hirsutus (100, 200 and 400 mg/kg) and furosemide (10 mg/kg) did not significantly change the concentration of Na+, K+ and Cl- ions in serum. The ethanolic extract of the leaves of C. hirsutus (100, 200 and 400 mg/kg) and furosemide (10 mg/kg) increased the excretion of creatinine in urine but with a corresponding decrease in serum. CONCLUSIONS: It was concluded that the ethanolic extract of the leaves of C. hirsutus (400 mg/kg) had significant diuretic effect in rats.
[Mh] Termos MeSH primário: Cocculus/química
Diuréticos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Cloretos/sangue
Cloretos/urina
Diuréticos/administração & dosagem
Diuréticos/toxicidade
Relação Dose-Resposta a Droga
Esquema de Medicação
Furosemida/farmacologia
Masculino
Extratos Vegetais/administração & dosagem
Extratos Vegetais/toxicidade
Folhas de Planta
Potássio/sangue
Potássio/urina
Ratos
Ratos Wistar
Sódio/sangue
Sódio/urina
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Diuretics); 0 (Plant Extracts); 7LXU5N7ZO5 (Furosemide); 9NEZ333N27 (Sodium); RWP5GA015D (Potassium)
[Em] Mês de entrada:0904
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090219
[St] Status:MEDLINE
[do] DOI:10.1211/jpp/61.03.0015



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