Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.725.249 [Categoria DeCS]
Referências encontradas : 8 [refinar]
Mostrando: 1 .. 8   no formato [Detalhado]

página 1 de 1

  1 / 8 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25856440
[Au] Autor:Wang JZ; Liao J; Xu WL; Chen XB
[Ad] Endereço:West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.
[Ti] Título:Bisbenzylisoquinoline alkaloids from the roots of cyclea tonkinensis.
[So] Source:Planta Med;81(7):600-5, 2015 May.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cissampentine A (1), an enantiomer of cissampentin, three new cycleatjehenine-type bisbenzylisoquinoline alkaloids, cissampentine B-D (2-4), and five known alkaloids were isolated from the roots of Cyclea tonkinensis. Their structures were established by interpretation of NMR, high-resolution ESI-MS data, and CD spectra. In vitro studies indicated that compounds 1 and 4 exhibited cytotoxicity against the HCT-8 tumor cell line (IC50 values of 8.97 and 9.73 µM, respectively), and compound 4 was also active against the Bel-7402 tumor cell line (IC50 value of 5.36 µM).
[Mh] Termos MeSH primário: Benzilisoquinolinas/isolamento & purificação
Cyclea/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Alcaloides/uso terapêutico
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Antineoplásicos Fitogênicos/uso terapêutico
Benzilisoquinolinas/química
Benzilisoquinolinas/farmacologia
Benzilisoquinolinas/uso terapêutico
Linhagem Celular Tumoral
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Benzylisoquinolines); 0 (Plant Extracts); 0 (cissampentin); 0 (cissampentine D)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150528
[Lr] Data última revisão:
150528
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150410
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1545882


  2 / 8 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:20795368
[Au] Autor:Kirana H; Srinivasan BP
[Ad] Endereço:Delhi Institute of Pharmaceutical Sciences and Research, Sector-III, Pushp Vihar, New Delhi 110017, India.
[Ti] Título:Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats.
[So] Source:Indian J Exp Biol;48(5):499-502, 2010 May.
[Is] ISSN:0019-5189
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:In view of multi-dimensional activity of plant drugs beneficial to complex disorders like diabetes, the present study has been undertaken to evaluate the effect of aqueous extract of C. peltata roots on serum glucose, lipid profile, insulin, inflammatory marker namely tumour necrosis factor (TNF)-alpha and muscle glycogen in type 2 diabetic rats. Aqueous extract of C. peltata at 40 and 60 mg/kg dose significantly decreased both the fasting and postprandial blood glucose of type 2 diabetic rats; 60 mg/kg dose having more pronounced effect on hyperglycemia. An enhanced insulin levels by the aqueous extract is primary for its glucose and lipid lowering activity. The extract significantly decreased the elevated TNF-alpha in type 2 diabetic rats. The extract at 40 and 60 mg/kg dose increased the glycogen levels in skeletal muscle by 58 and 60% respectively. Improved glycogen in peripheral tissue such as skeletal muscle indicates the ability of plant drug to combat insulin resistance of type 2 diabetes.
[Mh] Termos MeSH primário: Cyclea/química
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Tipo 2/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Glicemia/efeitos dos fármacos
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Avaliação Pré-Clínica de Medicamentos
Feminino
Glibureto/uso terapêutico
Glicogênio/análise
Hipoglicemiantes/administração & dosagem
Hipoglicemiantes/farmacologia
Insulina/sangue
Resistência à Insulina
Lipídeos/sangue
Masculino
Medicina Ayurvédica
Metformina/uso terapêutico
Camundongos
Músculo Esquelético/química
Músculo Esquelético/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Plantas Medicinais/química
Distribuição Aleatória
Ratos
Ratos Wistar
Solventes
Fator de Necrose Tumoral alfa/análise
Água
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Lipids); 0 (Plant Extracts); 0 (Solvents); 0 (Tumor Necrosis Factor-alpha); 059QF0KO0R (Water); 9005-79-2 (Glycogen); 9100L32L2N (Metformin); SX6K58TVWC (Glyburide)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100828
[St] Status:MEDLINE


  3 / 8 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:20606353
[Au] Autor:Wang JZ; Liu XY; Wang FP
[Ad] Endereço:Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.
[Ti] Título:Two new curine-type bisbenzylisoquinoline alkaloids from the roots of Cyclea wattii with cytotoxic activities.
[So] Source:Chem Pharm Bull (Tokyo);58(7):986-8, 2010 Jul.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Two new curine-type bisbenzylisoquinoline alkaloids, wattisines A (1) and B (2) along with three known alkaloids were isolated from the roots of Cyclea wattii. Their structures were established by interpretation of NMR and high-resolution electrospray ionization (ESI)-MS data. Absolute configuration of wattisines A and B were determined by single-crystal X-ray diffraction and circular dichroism (CD) spectra, respectively. In vitro, wattisine A (1) showed significant cytotoxic activities with IC(50) value of 1.74 microM against HCT-8, and 7.29 microM against Bel-7402.
[Mh] Termos MeSH primário: Alcaloides/química
Benzilisoquinolinas/química
Cyclea/química
Isoquinolinas/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Alcaloides/toxicidade
Benzilisoquinolinas/isolamento & purificação
Benzilisoquinolinas/toxicidade
Linhagem Celular Tumoral
Dicroísmo Circular
Cristalografia por Raios X
Seres Humanos
Espectroscopia de Ressonância Magnética
Conformação Molecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Isoquinolines); 0 (curine); 0 (wattisine A); 0 (wattisine B)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:130814
[Lr] Data última revisão:
130814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100708
[St] Status:MEDLINE


  4 / 8 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20593839
[Au] Autor:Wang JZ; Chen QH; Wang FP
[Ad] Endereço:Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, No. 17, Duan 3, Renmin Nan Road, Chengdu, People's Republic of China.
[Ti] Título:Cytotoxic bisbenzylisoquinoline alkaloids from the roots of Cyclea racemosa.
[So] Source:J Nat Prod;73(7):1288-93, 2010 Jul 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six new bisbenzylisoquinoline alkaloids, racemosidines A-C (1-3) and racemosinines A-C (4-6), and four known compounds were isolated from the roots of Cyclea racemosa. Compound 1 is the first bisbenzylisoquinoline alkaloid reported that has diphenyl ether bridges at C-11/C-7' and C-8/C-12' and a benzyl-phenyl ether bridge at C-7/C-11'. Structures and absolute configurations of 1-6 were established by interpretation of spectroscopic data and confirmed by X-ray crystallographic analysis of representative compounds. Compounds 1-3 exhibited significant cytotoxicity against HCT-8 and BEL-7402 tumor cells, and compound 1 was also cytotoxic against A2780 tumor cells.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Benzilisoquinolinas/isolamento & purificação
Benzilisoquinolinas/farmacologia
Cyclea/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Antineoplásicos Fitogênicos/química
Benzilisoquinolinas/química
Cristalografia por Raios X
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Seres Humanos
Isoquinolinas
Conformação Molecular
Estrutura Molecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Benzylisoquinolines); 0 (Drugs, Chinese Herbal); 0 (Isoquinolines); 0 (racemosidine A); 0 (racemosidine B); 0 (racemosidine C); 0 (racemosinine A); 0 (racemosinine B); 0 (racemosinine C)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:130814
[Lr] Data última revisão:
130814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100703
[St] Status:MEDLINE
[do] DOI:10.1021/np1001863


  5 / 8 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:19397987
[Au] Autor:Shine VJ; Latha PG; Shyamal S; Suja SR; Anuja GI; Sini S; Pradeep S; Rajasekharan S
[Ad] Endereço:Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Trivandrum 695 562, India.
[Ti] Título:Gastric antisecretory and antiulcer activities of Cyclea peltata (Lam.) Hook. f. & Thoms. in rats.
[So] Source:J Ethnopharmacol;125(2):350-5, 2009 Sep 07.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Cyclea peltata (Lam.) Hook. f. & Thoms. (Menispermaceae), locally called 'Padathaali/Padakizhangu' is used in Ayurvedic medicine to treat peptic ulcer. AIM OF THE STUDY: To evaluate the gastric antisecretory and antiulcer activity of Cyclea peltata. MATERIALS AND METHODS: The ethanolic extract of Cyclea peltata root was used to evaluate its gastric antisecretory and antiulcer effect in the pylorus-ligated rat model and gastric lesions induced by ethanol or ethanol and indomethacin respectively in rats. The levels of gastric wall mucus, non-protein sulfhydryl groups (NP-SH), malondialdehyde, protein and catalase activity in the stomach samples of Cyclea peltata treated and control groups of rats were also quantified. RESULTS: The ethanolic extract of Cyclea peltata roots showed significant antisecretory activity as evidenced by decreased pepsin secretion, gastric juice volume and acid output in pylorus-ligated rats. Pretreatment with Cyclea peltata extract provided significant protection against the peptic ulceration caused by ethanol administered individually, or in combination with indomethacin. Our studies also revealed that pretreatment with Cyclea peltata significantly increased the gastric protein and catalase concentration of ethanol treated rats. Further, it showed significant gastroprotective effects on the stomach wall of ethanol or ethanol and indomethacin treated rats by decreasing malondialdehyde level, increasing the gastric wall mucus and non-protein sulfhydryl groups. CONCLUSION: The present findings demonstrate that Cyclea peltata ethanolic extract has potent antisecretory and antiulcer effects and justify the traditional/ethnic usage of this herb to treat peptic ulcers and consequent stomach ache.
[Mh] Termos MeSH primário: Antiulcerosos/uso terapêutico
Cyclea
Mucosa Gástrica/efeitos dos fármacos
Úlcera Péptica/prevenção & controle
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antiulcerosos/farmacologia
Catalase/metabolismo
Modelos Animais de Doenças
Etanol
Suco Gástrico/secreção
Indometacina
Masculino
Malondialdeído/metabolismo
Muco/metabolismo
Pepsina A/secreção
Extratos Vegetais/farmacologia
Raízes de Plantas
Proteínas/metabolismo
Ratos
Ratos Wistar
Estômago/efeitos dos fármacos
Estômago/metabolismo
Compostos de Sulfidrila/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Ulcer Agents); 0 (Plant Extracts); 0 (Proteins); 0 (Sulfhydryl Compounds); 3K9958V90M (Ethanol); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.6 (Catalase); EC 3.4.23.1 (Pepsin A); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:0912
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090429
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2009.04.039


  6 / 8 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18620498
[Au] Autor:Kieley S; Dwivedi R; Monga M
[Ad] Endereço:Department of Urologic Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
[Ti] Título:Ayurvedic medicine and renal calculi.
[So] Source:J Endourol;22(8):1613-6, 2008 Aug.
[Is] ISSN:1557-900X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To explore the supportive evidence for the use of Ayurvedic medicine in the management of existing and recurrent nephrolithiasis. METHOD: Nine Ayurvedic medicines commonly utilized in the management of nephrolithiasis were identified by discussions with Ayurvedic practitioners in India. Mechanistic and clinical studies evaluating the use of these agents were identified using the Medline database and bibliographies suggested by Ayurvedic practitioners. The articles were then critically reviewed and summarized. RESULTS: Four in vitro mechanistic studies, eight animal studies, and seven human trials were identified. Phyllanthus niruri has undergone mechanistic in vitro, animal, and clinical trials that support its impact on calcium oxalate crystallization. Preliminary clinical trials have evaluated the role of Dolichos biflorus and Orthosiphon grandiflorus in the prevention of urolithiasis and fish stone as a method of stone expulsion, yet the treatment effect and mechanism of action remains to be elucidated. CONCLUSION: Ayurvedic medicine holds promise as a complementary approach to the management and prevention of nephrolithiasis. The best studied compound is P. niruri. Further controlled randomized clinical trials are justified to support or refute the potential benefits demonstrated in these initial studies.
[Mh] Termos MeSH primário: Cálculos Renais/tratamento farmacológico
Medicina Ayurvédica
[Mh] Termos MeSH secundário: Animais
Arctostaphylos
Capparaceae
Ensaios Clínicos como Assunto
Cyclea
Dolichos
Seres Humanos
Phyllanthus
Extratos Vegetais/uso terapêutico
Tribulus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:0810
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080716
[St] Status:MEDLINE
[do] DOI:10.1089/end.2008.0020


  7 / 8 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:17715566
[Au] Autor:Vijayan FP; Rani VK; Vineesh VR; Sudha KS; Michael MM; Padikkala J
[Ad] Endereço:Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India 680555.
[Ti] Título:Protective effect of Cyclea peltata Lam on cisplatin-induced nephrotoxicity and oxidative damage.
[So] Source:J Basic Clin Physiol Pharmacol;18(2):101-14, 2007.
[Is] ISSN:0792-6855
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of the present investigation was to evaluate the protective effect of a 70% methanolic leaf extract of Cyclea peltata Lam on cisplatin-induced renal toxicity. The concentration of creatinine, urea, sodium, and potassium in serum and levels of malonyldyaldehyde (MDA), glutathione (GSH), as well as gluathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities were determined in kidney tissue. The marked cisplatin-induced renal damage, characterized by a significant increase in creatinine and urea levels, decreased in extract-treated group, whereas sodium and potassium levels did not change significantly. C. peltata Lam extract significantly changed the increased MDA level and decreased GSH levels found in rats treated with cisplatin alone. The reduced activities of GSH-Px, SOD, and CAT in groups treated with cisplatin alone were significantly increased by the extract. The protective effect was greater in the post-treated than in the pre-treated group of animals. The results indicate that the post-treatment of C. peltata Lam extract might effectively ameliorate the oxidative stress parameters observed in cisplatin induced renal toxicity and could be used as a natural antioxidant against cisplatin-induced oxidative stress.
[Mh] Termos MeSH primário: Antineoplásicos/toxicidade
Antioxidantes/farmacologia
Cisplatino/toxicidade
Cyclea/química
Nefropatias/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Catalase/efeitos dos fármacos
Catalase/metabolismo
Relação Dose-Resposta a Droga
Feminino
Glutationa/efeitos dos fármacos
Glutationa/metabolismo
Glutationa Peroxidase/efeitos dos fármacos
Glutationa Peroxidase/metabolismo
Concentração Inibidora 50
Nefropatias/induzido quimicamente
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Folhas de Planta
Ratos
Ratos Wistar
Superóxido Dismutase/efeitos dos fármacos
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Plant Extracts); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:0709
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070825
[St] Status:MEDLINE


  8 / 8 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:12040886
[Au] Autor:Christina AJ; Packia Lakshmi M; Nagarajan M; Kurian S
[Ad] Endereço:Department of Pharmacology, K.M. College of Pharmacy, Tamil Nadu, India. tinatina38@rediffmail.com
[Ti] Título:Modulatory effect of Cyclea peltata Lam. on stone formation induced by ethylene glycol treatment in rats.
[So] Source:Methods Find Exp Clin Pharmacol;24(2):77-9, 2002 Mar.
[Is] ISSN:0379-0355
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:The inhibitory effect of the root of Cyclea peltata Lam. on nephrolithiasis induced in rats by feeding with ethylene glycolated water (1%) for 35 days was summarized. Ethylene glycol administration led to oxalate stone formation, as indicated by its high level in urine. Complementary to this anion, the cation calcium level in urine was elevated. These two ions may have contributed to the formation of calcium oxalate stones. In addition to high serum potassium, a low serum magnesium level contributed to stone formation. Simultaneous administration of the powdered root of Cyclea peltata resulted in decreased urinary oxalate and calcium. Likewise, serum potassium was lowered and magnesium was elevated. These observations provided the basis for the conclusion that this plant inhibits the stone formation induced by ethylene glycol treatment.
[Mh] Termos MeSH primário: Cyclea/química
Etilenoglicol/toxicidade
Cálculos Renais/tratamento farmacológico
Rim/patologia
[Mh] Termos MeSH secundário: Animais
Rim/efeitos dos fármacos
Cálculos Renais/induzido quimicamente
Masculino
Oxalatos/urina
Fitoterapia
Raízes de Plantas/química
Pós
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxalates); 0 (Powders); FC72KVT52F (Ethylene Glycol)
[Em] Mês de entrada:0211
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020604
[St] Status:MEDLINE



página 1 de 1
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde