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[PMID]:28946886
[Au] Autor:Endharti AT; Permana S
[Ad] Endereço:Department of Parasitology, Faculty of Medicine, Brawijaya University, Veteran Road, Malang, East Java, 65145, Indonesia. tinapermana@yahoo.com.
[Ti] Título:Extract from mango mistletoes Dendrophthoe pentandra ameliorates TNBS-induced colitis by regulating CD4+ T cells in mesenteric lymph nodes.
[So] Source:BMC Complement Altern Med;17(1):468, 2017 Sep 25.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects. The aim of this study was to investigate whether MMDP extract could increase Foxp3 regulatory T cells and inhibits development of Th17 cells. METHODS: Colitis was induced in Balb/c mice by rectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS). The mice were randomly divided into five groups comprising group1 receiving vehicle (the negative control), group 2-5 receiving TNBS, group 3-5 orally receiving either MMDP extract 150, 300 and 600 mg/kgBW for 7 days after TNBS administration. On day 8 of the experiment, the colon tissues were removed for histological examination, cytokine and myeloperoxidase (MPO) measurement. T-cells sub-population in mesenteric lymph nodes were analyzed by flow cytometer. RESULTS: MMDP extract potently suppressed colon shortening and MPO in mice with TNBS-induced colitis. Administration of the extract significantly decreased the severity of TNBS-induced colitis in a dose-dependent manner. The extract significantly attenuated the loss of body weight (p < 0.05). These effects were associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of the colonic MPO (p < 0.05). The extract lowered the levels of Th17-associated cytokines but increased the production of Treg-associated cytokines in mesenteric lymph node cells. CONCLUSION: Our results suggest that MMDP has the therapeutic potential to ameliorate TNBS-induced colitis symptoms revealed by histological change and inhibit IL-17 production.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/efeitos dos fármacos
Colite/metabolismo
Loranthaceae/química
Linfonodos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD4-Positivos/citologia
Linfócitos T CD4-Positivos/metabolismo
Colite/induzido quimicamente
Colite/patologia
Colo/efeitos dos fármacos
Colo/patologia
Modelos Animais de Doenças
Feminino
Interleucina-10/metabolismo
Interleucina-17/metabolismo
Linfonodos/citologia
Camundongos Endogâmicos BALB C
Peroxidase/metabolismo
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Células Th17/efeitos dos fármacos
Células Th17/metabolismo
Ácido Trinitrobenzenossulfônico/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL10 protein, mouse); 0 (Interleukin-17); 0 (Plant Extracts); 130068-27-8 (Interleukin-10); 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1973-z


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[PMID]:28330723
[Au] Autor:Bezerra AN; Massing LT; de Oliveira RB; Mourão RH
[Ad] Endereço:Graduate Program in Amazonian Natural Resources, Bioprospection and Experimental Biology Laboratory, Federal University of Western Pará, UFOPA, Rua Vera Paz, s/n, Salé, Santarém, PA 68035-110, Brazil. Electronic address: adriellensb@gmail.com.
[Ti] Título:Standardization and anti-inflammatory activity of aqueous extract of Psittacanthus plagiophyllus Eichl. (Loranthaceae).
[So] Source:J Ethnopharmacol;202:234-240, 2017 Apr 18.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL IMPORTANCE: The hemiparasitic species Psittacanthus plagiophyllus Eichl. (Loranthaceae), also known as erva de passarinho, is used in folk medicine in the Santarém region in the state of Pará, Brazil, to treat gastritis and a variety of inflammatory disorders. In view of the lack of pharmacological studies on this species in the literature and the fact that it is used constantly by the local population, this study sought to standardize the extract of the leaves of P. plagiophyllus (AEPp) and to assess its anti-inflammatory potential in in vivo tests. MATERIAL AND METHODS: Quality control and standardization of AEPp were performed following the 5th edition of the Brazilian Pharmacopeia. To assess the in vivo anti-inflammatory activity of AEPp, the carrageenan-induced and dextran-induced rat paw edema models were initially used. To investigate the effect of AEPp on carrageenan-induced leukocyte recruitment and exudate production, the air pouch inflammation model was used. In addition, the antioxidant activity of AEPp was assessed in vitro by the DPPH radical scavenging method. RESULTS: The chromatographic profile of AEPp indicated the presence of flavonoids, coumarins and hydrolyzable and condensed tannins. Measurement of phenolics revealed the following percentages in the extract: 12.62±0.18% total phenolics, 5.39±0.01% total tannins, 12.54±0.24% hydrolyzable tannins, 8.37±0.32% condensed tannins and 1.23±0.02% total flavonoids. In 500 and 1000mg/kg doses (p.o.) AEPp had significant edema-inhibiting activity (p<0.01) in both the models used, suggesting that the extract may act in vascular and cell events in the inflammatory response and exert an inhibitory effect on mediators responsible for edema. In all the doses tested [250, 500 and 1000mg/kg (p.o.)], AEPp inhibited total leukocyte and neutrophil migration and reduced the amount of exudate in the air pouch in a dose-dependent manner. Both effects were statistically significant (p<0.01). The extract also reduced the DPPH radical (maximum reduction 93.13±1.71% at a concentration of 75µg/mL), indicating that it has antioxidant activity. AEPp, therefore, exhibited considerable in vivo anti-inflammatory activity and in vitro antioxidant activity. This may be due to its high phenolics content. CONCLUSION: These findings provide evidence to support the use of P. plagiophyllus in folk medicine to treat inflammatory disorders.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/normas
Loranthaceae/química
Extratos Vegetais/farmacologia
Extratos Vegetais/normas
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Brasil
Carragenina
Edema/induzido quimicamente
Edema/prevenção & controle
Exsudatos e Transudatos
Inflamação/tratamento farmacológico
Inflamação/patologia
Contagem de Leucócitos
Masculino
Infiltração de Neutrófilos/efeitos dos fármacos
Folhas de Planta/química
Controle de Qualidade
Ratos
Ratos Wistar
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Plant Extracts); 9000-07-1 (Carrageenan)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE


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[PMID]:28090664
[Au] Autor:Dobrecky CB; Flor SA; López PG; Wagner ML; Lucangioli SE
[Ad] Endereço:Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Cátedra de Farmacobotánica, Buenos Aires, Argentina.
[Ti] Título:Development of a novel dual CD-MEKC system for the systematic flavonoid fingerprinting of Ligaria cuneifolia (R. et P.) Tiegh.-Loranthaceae-extracts.
[So] Source:Electrophoresis;38(9-10):1292-1300, 2017 05.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The present work deals with the development and validation of a novel dual CD-MEKC system for the systematic flavonoid fingerprinting of Ligaria cuneifolia (R. et P.) Tiegh.-Loranthaceae-extracts. The BGE consisted of 20 mM pH 8.3 borate buffer, 50 mM SDS, a dual CD system based on the combination of 5 mM ß-CD and 2% w/v S-ß-CD, and 10% v/v methanol. The proposed method has been successfully applied to the comparative analysis of extracts from aerial parts and different hosts, geographical areas, and extraction procedures in order to establish the flavonoid fingerprint of L. cuneifolia. The method was validated according to international guidelines. LOD and LOQ, intra and interday precision, and linearity were determined for catechin, epicatechin, procyanidin B2, rutin, quercetin-3-O-glucoside, quercetin-3-O-xyloside, quercetin-3-O-rhamnoside, quercetin-3-O-arabinofuranoside, quercetin-3-O-arabinopyranoside, and quercetin. The CD-MEKC methodology emerges as a suitable alternative to the traditional HPLC for quality control, fingerprinting, and standardization of L. cuneifolia extracts from different sources.
[Mh] Termos MeSH primário: Cromatografia Capilar Eletrocinética Micelar/métodos
Flavonoides/análise
Loranthaceae/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600533


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[PMID]:28057689
[Au] Autor:Suaza-Gaviria V; González F; Pabón-Mora N
[Ad] Endereço:Universidad de Antioquia, Instituto de Biología, Medellín, AA 1226, Colombia.
[Ti] Título:Comparative inflorescence development in selected Andean Santalales.
[So] Source:Am J Bot;104(1):24-38, 2017 Jan.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Loranthaceae, Santalaceae, and Viscaceae are the most diversified hemiparasitic families of Santalales in the Andes. Their partial inflorescences (PIs) vary from solitary flowers, or dichasia in most Santalales, to congested floral groups along articles in most Viscaceae. The atypical articled inflorescences in Phoradendreae (Viscaceae), a phylogenetic novelty restricted to this tribe, have been variously described as racemes, spikes, fascicles, or as intercalary inflorescences, but no developmental studies have been performed to compare them with the construction of PIs across Santalales. METHODS: We used standard light microscopy and scanning electron microscopy to record the inflorescence development in members of Phoradendreae (Viscaceae) in comparison to those in species of Aetanthus, Gaiadendron, Oryctanthus, Passovia, and Peristethium (Loranthaceae) and Antidaphne (Santalaceae). KEY RESULTS: Morphological and developmental comparisons as well as optimization onto a phylogenetic framework indicate that individual inflorescences in Santalales are indeterminate and are formed by axillary cymose PIs. The latter correspond to dichasia, either simple, compound, or variously reduced by abortion of lateral flowers, abortion of the terminal flower, or loss of bracteoles. CONCLUSIONS: Dichasia are plesiomorphic in Santalales. These results favor the interpretation that inflorescences in Phoradendreae are formed by the fusion of serial dichasia (=floral rows) with the main inflorescence axis via syndesmy. We compared this interpretation with the competing one based on the co-occurrence of collateral and serial floral buds.
[Mh] Termos MeSH primário: Flores/anatomia & histologia
Inflorescência/anatomia & histologia
Magnoliopsida/anatomia & histologia
[Mh] Termos MeSH secundário: Flores/crescimento & desenvolvimento
Flores/ultraestrutura
Inflorescência/crescimento & desenvolvimento
Inflorescência/ultraestrutura
Loranthaceae/anatomia & histologia
Loranthaceae/classificação
Loranthaceae/ultraestrutura
Magnoliopsida/classificação
Magnoliopsida/ultraestrutura
Microscopia Eletrônica de Varredura
Santalaceae/anatomia & histologia
Santalaceae/classificação
Santalaceae/ultraestrutura
Especificidade da Espécie
Viscaceae/anatomia & histologia
Viscaceae/classificação
Viscaceae/ultraestrutura
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1600253


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[PMID]:28046012
[Au] Autor:Wei S; Ma X; Pan L; Miao J; Fu J; Bai L; Zhang Z; Guan Y; Mo C; Huang H; Chen M
[Ad] Endereço:Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
[Ti] Título:Transcriptome Analysis of Taxillusi chinensis (DC.) Danser Seeds in Response to Water Loss.
[So] Source:PLoS One;12(1):e0169177, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Taxillus chinensis (DC.) Danser, the official species of parasitic loranthus that grows by parasitizing other plants, is used in various traditional Chinese medicine prescriptions. ABA-dependent and ABA-independent pathways are two major pathways in response to drought stress for plants and some genes have been reported to play a key role during the dehydration including dehydration-responsive protein RD22, late embryogenesis abundant (LEA) proteins, and various transcription factors (TFs) like MYB and WRKY. However, genes responding to dehydration are still unknown in loranthus. METHODS AND RESULTS: Initially, loranthus seeds were characterized as recalcitrant seeds. Then, biological replicates of fresh loranthus seeds (CK), and seeds after being dehydrated for 16 hours (Tac-16) and 36 hours (Tac-36) were sequenced by RNA-Seq, generating 386,542,846 high quality reads. A total of 164,546 transcripts corresponding to 114,971 genes were assembled by Trinity and annotated by mapping them to NCBI non-redundant (NR), UniProt, GO, KEGG pathway and COG databases. Transcriptome profiling identified 60,695, 56,027 and 66,389 transcripts (>1 FPKM) in CK, Tac-16 and Tac-36, respectively. Compared to CK, we obtained 2,102 up-regulated and 1,344 down-regulated transcripts in Tac-16 and 1,649 up-regulated and 2,135 down-regulated transcripts in Tac-36 by using edgeR. Among them some have been reported to function in dehydration process, such as RD22, heat shock proteins (HSP) and various TFs (MYB, WRKY and ethylene-responsive transcription factors). Interestingly, transcripts encoding ribosomal proteins peaked in Tac-16. It is indicated that HSPs and ribosomal proteins may function in early response to drought stress. Raw sequencing data can be accessed in NCBI SRA platform under the accession number SRA309567. CONCLUSIONS: This is the first time to profile transcriptome globally in loranthus seeds. Our findings provide insights into the gene regulations of loranthus seeds in response to water loss and expand our current understanding of drought tolerance and germination of seeds.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica
Loranthaceae/fisiologia
Água/fisiologia
[Mh] Termos MeSH secundário: Desidratação/genética
Desidratação/metabolismo
Secas
Regulação da Expressão Gênica de Plantas
Biblioteca Gênica
Genes de Plantas
Germinação
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
RNA de Plantas/genética
Sementes/fisiologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (RNA, Plant); 059QF0KO0R (Water)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169177


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[PMID]:27845891
[Au] Autor:Al Musayeib NM; Ibrahim SRM; Amina M; Al Hamoud GA; Mohamed GA
[Ad] Endereço:Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451.
[Ti] Título:Curviflorside and curviflorin, new naphthalene glycoside and flavanol from Plicosepalus curviflorus.
[So] Source:Z Naturforsch C;72(5-6):197-201, 2017 May 01.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The naphthalene glycosidecurviflorside [1,5-dihydroxy-8-methoxynaphthalene-2-O-ß-D-xylopyranoside] (3) and the flavanol curviflorin [(+)-catechin-7-O-3″,4″-dihydroxybenzoate] (4), along with two known flavonoids: (+)-catechin (1) and quercetin (2) were isolated from the shoots of Plicosepalu scurviflorus Benth. (Loranthaceae) growing in Saudi Arabia and the chemical structures were elucidated by 2D-NMR spectroscopy.
[Mh] Termos MeSH primário: Flavonóis/isolamento & purificação
Glicosídeos/isolamento & purificação
Loranthaceae/química
Naftalenos/isolamento & purificação
Naftóis/isolamento & purificação
[Mh] Termos MeSH secundário: Loranthaceae/crescimento & desenvolvimento
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Brotos de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonols); 0 (Glycosides); 0 (Naphthalenes); 0 (Naphthols)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE


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[PMID]:27295355
[Au] Autor:Yang L; Lin J; Zhou B; Liu Y; Zhu B
[Ad] Endereço:a School of Pharmacy , Shanghai Jiao Tong University , Shanghai , China.
[Ti] Título:Activity of compounds from Taxillus sutchuenensis as inhibitors of HCV NS3 serine protease.
[So] Source:Nat Prod Res;31(4):487-491, 2017 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to isolate active compounds from traditional Chinese medicinal Taxillus sutchuenensis to inhibit hepatitis C virus (HCV) NS3 protease activity. Under the guidance of bioassay, 10 compounds were isolated from the EtOAc extract fraction, which were identified as inhibitors of HCV NS3 protease. IC values of these compounds were obtained, and a broad degree of anti-HCV activity was observed. The most active compounds were kaempferol-3,7-bisrhamnoside (19.4 µM) and (3S)-3-hydroxy-1,7-bis(4-hydroxy-phenyl)-6E-hepten-5-one (28.7 µM). In conclusion, flavonoids and diarylheptanoids were responsible for the anti-HCV constitution of Taxilli Herba. These inhibitors of HCV NS3 protease might serve as potential candidate of anti-HCV agents.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Loranthaceae/química
Extratos Vegetais/farmacologia
Inibidores de Serino Proteinase/farmacologia
Proteínas não Estruturais Virais/antagonistas & inibidores
[Mh] Termos MeSH secundário: Flavonoides/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Flavonoids); 0 (NS3 protein, hepatitis C virus); 0 (Plant Extracts); 0 (Serine Proteinase Inhibitors); 0 (Viral Nonstructural Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1190719


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[PMID]:28862823
[Au] Autor:Robles A; Raz L; Marquínez X
[Ti] Título:[Floral anatomy of Peristethium leptostachyum (Loranthaceae)].
[Ti] Título:Anatomía Floral de Peristethium leptostachyum (Loranthaceae)..
[So] Source:Rev Biol Trop;64(1):341-52, 2016 03.
[Is] ISSN:0034-7744
[Cp] País de publicação:Costa Rica
[La] Idioma:spa
[Ab] Resumo:Peristethium leptostachyum is a hemiparasite species of the family Loranthaceae, distributed in Colombia, Costa Rica, Ecuador, Peru, Venezuela and Panama. Previously treated as Struthanthus leptostachyus, the species was recently transferred to Peristethium together with other species of Cladocolea and Struthanthus. The present research describes the inflorescence and floral morphoanatomy of Peristethium leptostachyum, detailing the structure of the androecium and gynoecium and the processes of microgametogenesis and megagametogenesis, thus allowing comparison with Struthanthus and Cladocolea. Flowering material was collected in February and August 2012, in Santa María, Boyacá, Colombia. Histological sections were prepared and stained with astrablue-fuchsin and floral dissections were performed under a stereomicroscope. Peristethium leptostachyum shares inflorescence characters with Cladocolea (determinate inflorescence, ebracteate terminal flower), but also with Struthanthus (pairs of triads along the axis, deciduous bracts and actinomorphic flowers). The flowers of P. leptostachyum from Santa María are clearly hermaphrodites with androecium and gynoecium fully developed. This observation contradicts the description by Kuijt who reported this species to be dioecious. The androecium was observed to be similar to that of Struthanthus vulgaris, with a glandular tapetum and simultaneous microsporogenesis; in contrast, Cladocolea loniceroides has a periplasmodial tapetum and successive microsporogenesis. The gynoecium of P. leptostachyum, like that of Cladocolea, Struthanthus and Phthirusa, has a unilocular ovary with a mamelon and arquesporial tissue isoriented towards the style, which in turn is solid and amyliferous. Peristethium leptostachyum is similar to Cladocolea loniceroides and differs from Strutanthus vulgaris in presenting multiple embryo sacs and an unlignified pelvis (hipostase). The presence of a solid stylar canal is proposed as a synapomorphy of the tribe Psittacanthinae. Given that P. leptostachyum shares characters with both Cladocolea and Struthanthus generic placement cannot be clearly determined on the basis of anatomical evidence. Phylogenetic studies that include representative species of all three genera are desirable to test hypotheses of monophyly. The sexual system observed here in P. leptostachyum is different from that reported by Kuijt and more studies are needed to identify the factors (geographic, ecological, etc.) that influence this variation.
[Mh] Termos MeSH primário: Flores/anatomia & histologia
Flores/classificação
Loranthaceae/anatomia & histologia
Loranthaceae/classificação
[Mh] Termos MeSH secundário: Flores/fisiologia
Inflorescência
Loranthaceae/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


  9 / 115 MEDLINE  
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[PMID]:27761061
[Au] Autor:Yoo JM; Yang JH; Kim YS; Cho WK; Ma JY
[Ad] Endereço:Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Republic of Korea.
[Ti] Título:Inhibitory Effect of on IgE-Mediated Allergic Responses in RBL-2H3 Cells.
[So] Source:Mediators Inflamm;2016:8742562, 2016.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The mistletoe has been used as a compound for traditional medicine in Northeast Asia for a long time and is known to possess neuroprotective action. Nonetheless, the effect of on allergic responses remains unknown. In the present study, we evaluated whether the water extract of (LPE) could inhibit IgE-mediated allergic responses in RBL-2H3 cells. LPE inhibited the release of -hexosaminidase (IC , 184.5 g/mL) and the formation of tumor necrosis factor- (IC , 84.27 g/mL), interleukin-4 (IC , 93.43 g/mL), prostaglandin E (IC , 84.10 g/mL), prostaglandin D , and leukotriene C (IC , 43.27 g/mL) in a concentration-dependent manner. Moreover, LPE inhibited phosphorylation of Syk, PLC 1/2, PKC , ERK, JNK, p38, and Akt. In the late phase, LPE decreased 5-lipoxygenase phosphorylation and COX-2 expression but not cPLA phosphorylation. Additionally, LPE included total phenolic compounds (10.72 mg/g dry weight) and total flavonoids (56.20 mg/g dry weight). These results suggest that the phenolic compounds or flavonoids contained in LPE may be associated with antiallergic activity. The phenolic compounds and flavonoids in LPE are antiallergic phytochemicals capable of inhibiting the activation of the Fc RI signaling cascade in mast cells. Such effects may provide further information for the development of a phytomedicine for allergic diseases.
[Mh] Termos MeSH primário: Hipersensibilidade/metabolismo
Imunoglobulina E/metabolismo
Loranthaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Eicosanoides/metabolismo
Flavonoides/metabolismo
Immunoblotting
Técnicas Imunoenzimáticas
Interleucina-4/metabolismo
Fenol/metabolismo
Extratos Vegetais/química
Ratos
Fator de Necrose Tumoral alfa/metabolismo
beta-N-Acetil-Hexosaminidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Eicosanoids); 0 (Flavonoids); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 207137-56-2 (Interleukin-4); 339NCG44TV (Phenol); 37341-29-0 (Immunoglobulin E); EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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[PMID]:27329781
[Au] Autor:Dos Santos Gramma LS; Marques FM; Vittorazzi C; de Andrade TA; Frade MA; de Andrade TU; Endringer DC; Scherer R; Fronza M
[Ad] Endereço:Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
[Ti] Título:Struthanthus vulgaris ointment prevents an over expression of inflammatory response and accelerates the cutaneous wound healing.
[So] Source:J Ethnopharmacol;190:319-27, 2016 Aug 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Struthanthus vulgaris (Vell.) Mart. (Loranthaceae) has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and to treat various skin disorders, including wounds. AIMS OF THE STUDY: To investigated the influence of 5% Struthanthus vulgaris ointment during cutaneous wound healing in rats. MATERIALS AND METHODS: Twenty Wistar rats were used in each group according the daily treatment, S. vulgaris 5% ointment (SV 5%) and vehicle control groups. Four full thicknesses wounds were punched in back side skin of each animal, and five animals were sacrificed after 2, 7, 14 and 21 days after surgery for histological, immunological and biochemical analysis. RESULTS: A significant wound closured area in the S. vulgaris 5% group of about 38% and 35% as compared to 19% and 21% in the control group was observed after 2 and 5 days, respectively. Histological and biochemical analysis of the skin biopsies showed that S. vulgaris treated wounds exhibited increased granulation tissue and regulated the inflammatory response by modulating the release of pro and anti-inflammatory cytokines like IL-1α, TNF-α and IL-10, nitric oxide and, growth factors like TGF-ß. Moreover, S. vulgaris showed a marked and robust increase in the deposition and organization of collagen fibers in the wounds, and improve the quality of the scar tissue. CONCLUSIONS: Altogether these data revealed that S. vulgaris seems to prevent an over expression of inflammation and accelerates wound epithelialization and might be beneficial for treating healing disorders.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Citocinas/metabolismo
Mediadores da Inflamação/metabolismo
Loranthaceae/química
Extratos Vegetais/farmacologia
Pele/efeitos dos fármacos
Cicatrização/efeitos dos fármacos
Ferimentos Penetrantes/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Cutânea
Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Biópsia
Cicatriz/metabolismo
Cicatriz/patologia
Modelos Animais de Doenças
Colágenos Fibrilares/metabolismo
Tecido de Granulação/efeitos dos fármacos
Tecido de Granulação/metabolismo
Tecido de Granulação/patologia
Masculino
Pomadas
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plantas Medicinais
Ratos Wistar
Reepitelização/efeitos dos fármacos
Pele/lesões
Pele/metabolismo
Pele/patologia
Fatores de Tempo
Ferimentos Penetrantes/metabolismo
Ferimentos Penetrantes/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Fibrillar Collagens); 0 (Inflammation Mediators); 0 (Ointments); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE



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