Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.756 [Categoria DeCS]
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[Au] Autor:Sadgrove NJ; Hitchcock M; Watson K; Jones GL
[Ad] Endereço:University of New England, Pharmaceuticals, Nutraceuticals Group for Bioactive Discovery in Health and Ageing, Armidale, New South Wales, Australia.
[Ti] Título:Chemical and biological characterization of novel essential oils from Eremophila bignoniiflora (F. Muell) (Myoporaceae): a traditional Aboriginal Australian bush medicine.
[So] Source:Phytother Res;27(10):1508-16, 2013 Oct.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Essential oils were extracted by hydrodistillation from the traditional Australian medicinal plant Eremophila bignoniiflora, characterized chemically and then screened for bioactivity. Characterization and quantification were completed using gas chromatography-mass spectrometry (GC-MS) and GC-flame ionization detection, respectively. Antimicrobial capacity was assessed using disc diffusion and micro-titre plate broth dilution and further characterized using thin layer chromatography followed by bioautography to assign activity to separated individual active components. Antifungal capacity was investigated using micro-titre plate broth dilution against pathogenic Trichophyton species. Free radical scavenging ability was assessed using the diphenylpicrylhydradyl reaction in methanol. The predominant components of the essential oil were fenchyl-acetate and bornyl-acetate. However, bioautography indicated antimicrobial ability to be largely linked to the less abundant, more polar constituents. Oils displayed only modest antifungal ability against pathogenic Trichophyton species associated with dermatophytosis, but moderate to high antimicrobial activity, particularly against the yeast Candida albicans and the bacteria Staphylococcus epidermidis. Essential oils exhibited relatively low free radical scavenging ability. Speculation over the role of essential oils in the traditional medicinal applications of E. bignoniiflora follows, exploring correlations between traditional use and investigated bioactivities.
[Mh] Termos MeSH primário: Antibacterianos/química
Depuradores de Radicais Livres/química
Óleos Voláteis/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Acetatos/química
Acetatos/isolamento & purificação
Antibacterianos/isolamento & purificação
Antifúngicos/isolamento & purificação
Candida albicans/efeitos dos fármacos
Cromatografia em Camada Delgada
Depuradores de Radicais Livres/isolamento & purificação
Cromatografia Gasosa-Espectrometria de Massas
Medicina Tradicional
Testes de Sensibilidade Microbiana
Óleos Voláteis/isolamento & purificação
Staphylococcus epidermidis/efeitos dos fármacos
Trichophyton/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Free Radical Scavengers); 0 (Oils, Volatile)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:131008
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121130
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.4889

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[Au] Autor:Williams LA; Conrad J; Vogler B; Rösner H; Porter RB; Setzer W; Barton EN; Levy HG; Mika S; Klaiber I; Nkurunziza JP; Kraus W
[Ad] Endereço:The University of Hohenheim, Institutes for Bio-organic Chemistry , Garbenstr 30, D-70593 Stuttgart, Germany.
[Ti] Título:In vitro anti-proliferation/cytotoxic activity of epingaione and its derivatives on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells.
[So] Source:West Indian Med J;56(1):5-10, 2007 Jan.
[Is] ISSN:0043-3144
[Cp] País de publicação:Jamaica
[La] Idioma:eng
[Ab] Resumo:Epingaione (4-Methyl-1-(5-methyl-2, 3,4,5-tetrahydro-[2,3']bifuranyl-5-yl)-pentan-2-one) was isolated as one of the major lipophilic secondary metabolites from the leaves and stems of Bontia daphnoides L. The compound gave 79.24% and 50.83% anti-proliferation/cytotoxic activity on the human SH-SY5Y neuroblastoma and TE-671 sarcoma cells in vitro at 50 pg/mL, respectively. Epingaione was transformed into eleven derivatives under laboratory conditions using ethanol, some gave greater anti-proliferation/cytotoxic activity on the cancer cell lines tested. One of the derivatives (compound 2) with enhanced cytotoxic activity was elucidated as 5'-Ethoxy-5-methyl-5-(4-methyl-2-oxo-pentyl)-2,3,4,5-tetrahydro-5'H-[2,3']bifuranyl-2'-one. Both epingaione and compound 2 caused an accumulation of arrested or dead SH-SY5Y neuroblastoma in the m-phase of the cell cycle as revealed by the m-phase specific marker KE 67.
[Mh] Termos MeSH primário: Furanos/farmacologia
Neuroblastoma/tratamento farmacológico
Sarcoma/tratamento farmacológico
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Folhas de Planta
Caules de Planta
[Nm] Nome de substância:
0 (4-methyl-1-(5-methyl-2, 3,4,5-tetrahydro-(2,3')bifuranyl-5-yl)-pentan-2-one); 0 (Furans); 0 (Pentanones); 0 (Plant Extracts)
[Em] Mês de entrada:0708
[Cu] Atualização por classe:080310
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070712
[St] Status:MEDLINE

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[Au] Autor:Smith JE; Tucker D; Watson K; Jones GL
[Ad] Endereço:School of Biological, Biomedical and Molecular Sciences, University of New England, Armidale NSW 2351, Australia.
[Ti] Título:Identification of antibacterial constituents from the indigenous Australian medicinal plant Eremophila duttonii F. Muell. (Myoporaceae).
[So] Source:J Ethnopharmacol;112(2):386-93, 2007 Jun 13.
[Is] ISSN:0378-8741
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:This paper reports on the isolation and identification of antibacterial constituents from the indigenous Australian medicinal plant Eremophila duttonii F. Muell. (Myoporaceae). Preparations derived from this plant are used by indigenous populations in the topical treatment of minor wounds, otitis and ocular complaints, and as a gargle for sore throat. Several authors have reported extracts of this plant to effect rapid bacteriolysis and inhibit growth of a wide range of Gram-positive micro-organisms. In other studies involving screening of native medicinal plants for antibacterial activity, extracts of Eremophila duttonii have been reported to consistently exhibit the highest potency amongst all species included. From a hexane extract, we identified two diterpenes of the serrulatane class, the principal constituents responsible for antibacterial activity and present as major constituents of the resinous leaf cuticle: serrulat-14-en-7,8,20-triol (1) and serrulat-14-en-3,7,8,20-tetraol (2). In addition, a hydroxylated furanosesquiterpene with mild antibacterial activity which appeared to be a novel compound was isolated from the extract and tentatively identified as 4-hydroxy-4-methyl-1-(2,3,4,5-tetrahydro-5-methyl[2,3'-bifuran]-5-yl) pentan-2-one. Minimum inhibitory concentrations for each of the compounds against three Gram-positive bacteria: Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228) and Streptococcus pneumoniae (ARL 10582), were determined using a micro-titre plate broth dilution assay.
[Mh] Termos MeSH primário: Antibacterianos/química
[Mh] Termos MeSH secundário: Austrália
Cromatografia em Camada Delgada
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
Streptococcus pneumoniae/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hexanes); 0 (Solvents)
[Em] Mês de entrada:0708
[Cu] Atualização por classe:070522
[Lr] Data última revisão:
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070509
[St] Status:MEDLINE

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