Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.773.374 [Categoria DeCS]
Referências encontradas : 38 [refinar]
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[PMID]:28598616
[Au] Autor:Kaneta Y; Arai MA; Ishikawa N; Toume K; Koyano T; Kowithayakorn T; Chiba T; Iwama A; Ishibashi M
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
[Ti] Título:Identification of BMI1 Promoter Inhibitors from Beaumontia murtonii and Eugenia operculata.
[So] Source:J Nat Prod;80(6):1853-1859, 2017 Jun 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:B-Cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) is a core component of the polycomb repressive complex 1 (PRC1). Abnormal expression of BMI1 is associated with a number of human malignances and cancer stem cells (CSCs), which cause chemotherapy resistance. Therefore, small molecules that inhibit BMI1 expression are potential candidates for cancer therapy. In this study, a cell-based reporter gene assay was developed that allowed BMI1 promoter activity to be measured in 293T human embryonic kidney cells based on luciferase expression levels. Using this screening assay, the methanol-soluble extracts of Beaumontia murtonii and Eugenia operculata were selected as leads. Bioassay-guided fractionation of the extracts led to the isolation of three known cardenolides (1-3) and one new compound (4) from B. murtonii and two known triterpenoids (5 and 6) and one new compound (7) from E. operculata. These seven compounds inhibited BMI1 promoter activity (IC range 0.093-23.0 µM), and the most active compound, wallichoside (1), was further evaluated. Western blot analysis revealed that wallichoside (1) decreases BMI1 protein levels in HCT116 human colon carcinoma cells, and flow cytometry analysis showed that it significantly reduced levels of the CSC biomarker epithelial cell adhesion molecule. Wallichoside (1) also inhibited sphere formation of Huh7 human hepatocellular carcinoma cells, indicating that it diminished the self-renewal capability of CSCs.
[Mh] Termos MeSH primário: Apocynaceae/química
Eugenia/química
Complexo Repressor Polycomb 1/metabolismo
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Antineoplásicos/farmacologia
Western Blotting
Carcinoma Hepatocelular/tratamento farmacológico
Cardenolídeos/química
Cardenolídeos/isolamento & purificação
Cardenolídeos/farmacologia
Linhagem Celular Tumoral
Células HCT116
Células HEK293
Seres Humanos
Concentração Inibidora 50
Neoplasias Hepáticas/tratamento farmacológico
Camundongos
Estrutura Molecular
Células-Tronco Neoplásicas/efeitos dos fármacos
Folhas de Planta/química
Tailândia
Triterpenos/química
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (BMI1 protein, human); 0 (Cardenolides); 0 (Triterpenes); EC 2.3.2.27 (Polycomb Repressive Complex 1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00138


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[PMID]:28541359
[Au] Autor:Teixeira LL; Costa GR; Dörr FA; Ong TP; Pinto E; Lajolo FM; Hassimotto NMA
[Ad] Endereço:Department of Food Science and Nutrition, School of Pharmaceutical Science, University of São Paulo, Av. Prof Lineu Prestes 580, Bloco 14, 05508-900 São Paulo, SP, Brazil. aymoto@usp.brphone.
[Ti] Título:Potential antiproliferative activity of polyphenol metabolites against human breast cancer cells and their urine excretion pattern in healthy subjects following acute intake of a polyphenol-rich juice of grumixama (Eugenia brasiliensis Lam.).
[So] Source:Food Funct;8(6):2266-2274, 2017 Jun 21.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The bioavailability and metabolism of anthocyanins and ellagitannins following acute intake of grumixama fruit, native Brazilian cherry, by humans, and its in vitro antiproliferative activity against breast cancer cells (MDA-MB-231) were investigated. A single dose of grumixama juice was administered to healthy women (n = 10) and polyphenol metabolites were analyzed in urine and plasma samples collected over 24 h. The majority of the metabolites circulating and excreted in urine were phenolic acids and urolithin conjugates, the gut microbiota catabolites of both classes of polyphenols, respectively. According to pharmacokinetic parameters, the subjects were divided into two distinct groups, high and low urinary metabolite excretors. The pool of polyphenol metabolites found in urine samples showed a significant inhibition of cell proliferation and G2/M cell cycle arrest in MDA-MB-231 cells. Our findings demonstrate the large interindividual variability concerning the polyphenol metabolism, which possibly could reflect in health promotion.
[Mh] Termos MeSH primário: Neoplasias da Mama/dietoterapia
Proliferação Celular
Eugenia/metabolismo
Sucos de Frutas e Vegetais/análise
Extratos Vegetais/metabolismo
Preparações de Plantas/metabolismo
Polifenóis/metabolismo
[Mh] Termos MeSH secundário: Adulto
Brasil
Neoplasias da Mama/metabolismo
Neoplasias da Mama/fisiopatologia
Neoplasias da Mama/urina
Linhagem Celular Tumoral
Cromatografia Líquida de Alta Pressão
Eugenia/química
Feminino
Seres Humanos
Extratos Vegetais/química
Polifenóis/química
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Plant Preparations); 0 (Polyphenols)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00076f


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Rosalen, Pedro Luiz
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[PMID]:28259673
[Au] Autor:Sardi JC; Freires IA; Lazarini JG; Infante J; de Alencar SM; Rosalen PL
[Ad] Endereço:Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
[Ti] Título:Unexplored endemic fruit species from Brazil: Antibiofilm properties, insights into mode of action, and systemic toxicity of four Eugenia spp.
[So] Source:Microb Pathog;105:280-287, 2017 Apr.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Brazilian endemic fruit species have aroused attention due to their highly valuable, yet unexplored, agro-industrial, food and therapeutic potential. Herein, we describe the antifungal activity of four Eugenia spp. against Candida albicans biofilms, and further demonstrate insights into their potential mode(s) of action and toxicity in vitro and in vivo. Extracts from different parts (seeds, pulps, leaves) of E. leitonii (EL), E. brasiliensis (EB), E. myrcianthes (EM) and E. involucrata (EI) were obtained (S23°23',W45°39') and chemically characterized by GC/MS. The active extracts were tested against C. albicans biofilm viability and architecture, as well as mode of action, and toxicology using RAW 264.7 macrophages and Galleria mellonella larvae. The MIC values ranged from 15.62 to >2000 µg/mL. The most active extracts were EL (seed, 15.62 µg/mL) and EB (leaf and seeds, 31.25 and 15.62 µg/mL, respectively). Treatment with these extracts at 10xMIC reduced biofilm viability by 54-55% (P < 0.0001) as compared to 42% by nystatin. At 10xMIC, all extracts caused damages to biofilm architecture and integrity, and fewer hyphae remained attached to treated biofilms. None of them was found to interfere with cell wall biosynthesis or complexation with ergosterol. The extracts had low toxicity against macrophages in vitro (P > 0.05) and G. mellonella larvae, with mean in vivo LD of 1500 mg/kg (EL, seeds); 2500 mg/kg (EB, seeds); and 1250 mg/kg (EB, leaf). The phenolic compounds epicatechin and gallic acid were the major constituents in the extracts. Our findings may open avenues for the application of these yet unexplored native fruits in the food and pharmaceutical industry.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Eugenia/química
Frutas/química
Extratos Vegetais/farmacologia
Extratos Vegetais/toxicidade
Plantas Tóxicas/química
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Antifúngicos/farmacologia
Brasil
Candida albicans/efeitos dos fármacos
Parede Celular/metabolismo
Ergosterol/metabolismo
Ácido Gálico/química
Camundongos
Testes de Sensibilidade Microbiana
Nistatina/farmacologia
Fenóis/química
Extratos Vegetais/química
Folhas de Planta/química
Plantas Medicinais/química
Células RAW 264.7
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Phenols); 0 (Plant Extracts); 1400-61-9 (Nystatin); 632XD903SP (Gallic Acid); Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE


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[PMID]:28115317
[Au] Autor:Lima JS; Telles MP; Chaves LJ; Lima-Ribeiro MS; Collevatti RG
[Ad] Endereço:Laboratório de Genética & Biodiversidade, Instituto de Ciências Biológicas, Universidade Federal de Goiás, PO Box 131, 74001-970, Goiânia, Brazil.
[Ti] Título:Demographic stability and high historical connectivity explain the diversity of a savanna tree species in the Quaternary.
[So] Source:Ann Bot;119(4):645-657, 2017 Mar 01.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background and Aims: Cyclic glaciations were frequent throughout the Quaternary and this affected species distribution and population differentiation worldwide. The present study reconstructed the demographic history and dispersal routes of Eugenia dysenterica lineages and investigated the effects of Quaternary climate change on its spatial pattern of genetic diversity. Methods: A total of 333 individuals were sampled from 23 populations and analysed by sequencing four regions of the chloroplast DNA and the internal transcribed spacer of the nuclear DNA. The analyses were performed using a multi-model inference approach based on ecological niche modelling and statistical phylogeography. Key Results: Coalescent simulation showed that population stability through time is the most likely scenario. The palaeodistribution dynamics predicted by the ecological niche models revealed that the species was potentially distributed across a large area, extending over Central-Western Brazil through the last glaciation. The lineages of E. dysenterica dispersed from Central Brazil towards populations at the northern, western and south-eastern regions. A historical refugium through time may have favoured lineage dispersal and the maintenance of genetic diversity. Conclusions: The results suggest that the central region of the Cerrado biome is probably the centre of distribution of E. dysenterica and that the spatial pattern of its genetic diversity may be the outcome of population stability throughout the Quaternary. The lower genetic diversity in populations in the south-eastern Cerrado biome is probably due to local climatic instability during the Quaternary.
[Mh] Termos MeSH primário: Biodiversidade
Eugenia
Pradaria
Árvores
[Mh] Termos MeSH secundário: Brasil
DNA de Cloroplastos/genética
DNA Intergênico/genética
DNA de Plantas/genética
Demografia
Eugenia/genética
Filogeografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (DNA, Intergenic); 0 (DNA, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcw257


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[PMID]:27951494
[Au] Autor:Acosta-Motos JR; Hernández JA; Álvarez S; Barba-Espín G; Sánchez-Blanco MJ
[Ad] Endereço:Irrigation Department, CEBAS-CSIC, Campus Universitario de Espinardo, Murcia, P.O. Box 164, E-30100, Spain.
[Ti] Título:The long-term resistance mechanisms, critical irrigation threshold and relief capacity shown by Eugenia myrtifolia plants in response to saline reclaimed water.
[So] Source:Plant Physiol Biochem;111:244-256, 2017 Feb.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Salts present in irrigation water are serious problems for commercial horticulture, particularly in semi-arid regions. Reclaimed water (RW) typically contains, among others elements, high levels of salts, boron and heavy metal. Phytotoxic ion accumulation in the substrate has been linked to different electric conductivities of the treatments. Based on these premises, we studied the long-term effect of three reclaimed water treatments with different saline concentrations on Eugenia myrtifolia plants. We also looked at the ability of these plants to recover when no drainage was applied. The RW with the highest electric conductivity (RW3, EC = 6.96 dS m ) provoked a number of responses to salinity in these plants, including: 1) accumulation and extrusion of phytotoxic ions in roots; 2) a decrease in the shoot/root ratio, leaf area, number of leaves; 3) a decrease in root hydraulic conductivity, leaf water potential, the relative water content of leaves, leaf stomatal conductance, the leaf photosynthetic rate, water-use efficiency and accumulated evapotranspiration in order to limit water loss; and 4) changes in the antioxidant defence mechanisms. These different responses induced oxidative stress, which can explain the damage caused in the membranes, leading to the death of RW3 plants during the relief period. The behaviour observed in RW2 plants was slightly better compared with RW3 plants, although at the end of the experiment about 55% of the RW2 plants also died, however RW containing low salinity level (RW1, EC = 2.97 dS m ) can be effective for plant irrigation.
[Mh] Termos MeSH primário: Irrigação Agrícola
Eugenia/fisiologia
Salinidade
Água/metabolismo
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Eugenia/enzimologia
Eugenia/crescimento & desenvolvimento
Gases/metabolismo
Íons
Fenômenos Fisiológicos da Nutrição
Desenvolvimento Vegetal
Folhas de Planta/enzimologia
Folhas de Planta/fisiologia
Raízes de Plantas/fisiologia
Estresse Fisiológico
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Gases); 0 (Ions); 0 (Thiobarbituric Acid Reactive Substances); 059QF0KO0R (Water)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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Borojevic, Radovan
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[PMID]:27744523
[Au] Autor:Denardin CC; Martins LA; Parisi MM; Vieira MQ; Terra SR; Barbé-Tuana FM; Borojevic R; Vizzotto M; Emanuelli T; Guma FC
[Ad] Endereço:Programa de Pós-Graduação em Ciências Biológicas-Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
[Ti] Título:Autophagy induced by purple pitanga (Eugenia uniflora L.) extract triggered a cooperative effect on inducing the hepatic stellate cell death.
[So] Source:Cell Biol Toxicol;33(2):197-206, 2017 Apr.
[Is] ISSN:1573-6822
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Activated hepatic stellate cells (HSC) are the major source of collagen I in liver fibrosis. Eugenia uniflora L. is a tree species that is widely distributed in South America. E. uniflora L. fruit-popularly known as pitanga-has been shown to exert beneficial properties. Autophagy contributes to the maintenance of cellular homeostasis and survival under stress situation, but it has also been suggested to be an alternative cell death pathway. Mitochondria play a pivotal role on signaling cell death. Mitophagy of damaged mitochondria is an important cell defense mechanism against organelle-mediated cell death signaling. We previously found that purple pitanga extract induced mitochondrial dysfunction, cell cycle arrest, and death by apoptosis and necrosis in GRX cells, a well-established activated HSC line. We evaluated the effects of 72-h treatment with crescent concentrations of purple pitanga extract (5 to 100 µg/mL) on triggering autophagy in GRX cells, as this is an important mechanism to cells under cytotoxic conditions. We found that all treated cells presented an increase in the mRNA expression of autophagy-related protein 7 (ATG7). Concomitantly, flow cytometry and ultrastructural analysis of treated cells revealed an increase of autophagosomes/autolysosomes that consequentially led to an increased mitophagy. As purple pitanga extract was previously found to be broadly cytotoxic to GRX cells, we postulated that autophagy contributes to this scenario, where cell death seems to be an inevitable fate. Altogether, the effectiveness on inducing activated HSC death can make purple pitanga extract a good candidate on treating liver fibrosis.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Eugenia/química
Células Estreladas do Fígado/patologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Autofagossomos/efeitos dos fármacos
Autofagossomos/metabolismo
Autofagossomos/ultraestrutura
Linhagem Celular
Células Estreladas do Fígado/efeitos dos fármacos
Cirrose Hepática/tratamento farmacológico
Cirrose Hepática/patologia
Lisossomos/efeitos dos fármacos
Lisossomos/metabolismo
Camundongos
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Fitoterapia
Extratos Vegetais/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161017
[St] Status:MEDLINE
[do] DOI:10.1007/s10565-016-9366-5


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[PMID]:27664610
[Au] Autor:da Silva MMM; da Silva EP; da Silva FA; Ogando FIB; de Aguiar CL; Damiani C
[Ad] Endereço:Departamento de Engenharia de Alimentos, Escola de Agronomia, Universidade Federal de Goiás, Rodovia GO-462 (Goiânia - Nova Veneza), km zero, Campus Samambaia, CEP 74690-900 Goiânia, Goiás, Brazil.
[Ti] Título:Physiological development of cagaita (Eugenia dysenterica).
[So] Source:Food Chem;217:74-80, 2017 Feb 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:It was evaluated the physiological aspects of the cagaita (Eugenia dysenterica) development, from anthesis to ripening. The fruits have been subjected to physical and chemical analysis during the fruit life cycle. The total fruit development comprised 37days. There was a steady increase in the total mass of the fruits and significant increase in transverse and longitudinal diameter, adjusting the double sigmoidal behavior in response to changes in the time. From the 23rd DAA, it was observed the beginning of loss of firmness, increase in total and soluble pectin content and a decrease in starch content. It occurred degradation of total chlorophyll and unmasking of carotenoids from 31st days after anthesis. A decrease in pH and, therefore, increase in acidity, low soluble solids content. The sucrose content was extremely low during the cycle. At the end of development, the respiratory and ethylene production peak was observed, suggesting climacteric behavior.
[Mh] Termos MeSH primário: Etilenos/metabolismo
Eugenia/fisiologia
Frutas/química
[Mh] Termos MeSH secundário: Carotenoides/análise
Clorofila/análise
Frutas/crescimento & desenvolvimento
Frutas/metabolismo
Sacarose/análise
Syzygium
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylenes); 1406-65-1 (Chlorophyll); 36-88-4 (Carotenoids); 57-50-1 (Sucrose); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


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[PMID]:27094237
[Au] Autor:Calvi GP; Aud FF; Ferraz ID; Pritchard HW; Kranner I
[Ad] Endereço:National Institute for Amazonian Research (INPA), Manaus, Brazil.
[Ti] Título:Analyses of several seed viability markers in individual recalcitrant seeds of Eugenia stipitata McVaugh with totipotent germination.
[So] Source:Plant Biol (Stuttg);19(1):6-13, 2017 Jan.
[Is] ISSN:1438-8677
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The use of biochemical seed viability markers is often compromised by the unknown partitioning of analytes in bulk seed lots consisting of inseparable populations of viable and nonviable seeds. We took advantage of an unusual morphological syndrome found in the recalcitrant, undifferentiated seeds of Eugenia stipitata: one seed can be cut into several parts, each of which can germinate and develop into seedlings. We used four seed parts from one individual seed to analyse seed moisture content (MC), seed viability and the antioxidant glutathione (γ-glutamyl-cysteinyl-glycine; GSH), glutathione disulphide (GSSG) and intermediates of glutathione synthesis and breakdown. Seeds were exposed to different environmental MC to induce various levels of desiccation stress. Upon storage at high seed MC, seed viability was maintained, while GSH concentration increased and the glutathione half-cell reduction potential (E ) was less negative than -215 mV, indicating GSH production and highly reducing conditions. Storage at low seed MC led to loss of GSH, resulting in a shift in E , and seed death. In contrast, the cyst(e)ine half-cell reduction potential (E ) could not distinguish between the viability categories. Previous studies on seed populations revealed that the probability for a seed being alive is 50% at E values between -180 and -160 mV. The single seed approach revealed that the window in which seed viability was lost could be slightly shifted towards more negative values. We discuss the contribution of cellular pH to E and recommend E. stipitata as a recalcitrant seed model to study stress response on a single seed basis.
[Mh] Termos MeSH primário: Biomarcadores/análise
Eugenia/fisiologia
Germinação
Sementes/fisiologia
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Dessecação
Glutationa/metabolismo
Plântulas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE
[do] DOI:10.1111/plb.12466


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[PMID]:27974324
[Au] Autor:de Oliveira Bünger M; Fernanda Mazine F; Forest F; Leandro Bueno M; Renato Stehmann J; Lucas EJ
[Ad] Endereço:Laboratório de Sistemática Vegetal, Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil maribunger@gmail.com.
[Ti] Título:The evolutionary history of Eugenia sect. Phyllocalyx (Myrtaceae) corroborates historically stable areas in the southern Atlantic forests.
[So] Source:Ann Bot;118(7):1209-1223, 2016 Dec.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Eugenia sect. Phyllocalyx Nied. includes 14 species endemic to the Neotropics, mostly distributed in the Atlantic coastal forests of Brazil. Here the first comprehensive phylogenetic study of this group is presented, and this phylogeny is used as the basis to evaluate the recent infrageneric classification in Eugenia sensu lato (s.l.) to test the history of the evolution of traits in the group and test hypotheses associated with the history of this clade. METHODS: A total of 42 taxa were sampled, of which 14 were Eugenia sect. Phyllocalyx for one nuclear (ribosomal internal transcribed spacer) and four plastid markers (psbA-trnH, rpl16, trnL-rpl32 and trnQ-rps16). The relationships were reconstructed based on Bayesian analysis and maximum likelihood. Additionally, ancestral area analysis and modelling methods were used to estimate species dispersal, comparing historically climatic stable (refuges) and unstable areas. KEY RESULTS: Maximum likelihood and Bayesian inferences indicate that Eugenia sect. Phyllocalyx is paraphyletic and the two clades recovered are characterized by combinations of morphological characters. Phylogenetic relationships support a link between Cerrado and south-eastern species and a difference in the composition of species from north-eastern and south-eastern Atlantic forest. Refugia and stable areas identified within unstable areas suggest that these areas were important to maintain diversity in the Atlantic forest biodiversity hotspot. CONCLUSION: This study provides a robust phylogenetic framework to address important historical questions for Eugenia s.l. within an evolutionary context, supporting the need for better taxonomic study of one of the largest genera in the Neotropics. Furthermore, valuable insight is offered into diversification and biome shifts of plant species in the highly environmentally impacted Atlantic forest of South America. Evidence is presented that climate stability in the south-eastern Atlantic forest during the Quaternary contributed to the highest levels of plant diversity in this region that acted as a refugium.
[Mh] Termos MeSH primário: Eugenia/genética
[Mh] Termos MeSH secundário: Teorema de Bayes
Evolução Biológica
Brasil
DNA Espaçador Ribossômico/genética
Ecossistema
Eugenia/classificação
Florestas
Marcadores Genéticos/genética
Filogenia
Plastídeos/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Ribosomal Spacer); 0 (Genetic Markers)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE


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[PMID]:27813583
[Au] Autor:Silveira RM; Machado RM; Forni-Martins ER; Verola CF; Costa IR
[Ad] Endereço:Laboratório de Citotaxonomia e Evolução de Plantas, Departamento de Biologia, Centro de Ciências, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
[Ti] Título:Environmental variations drive polyploid evolution in neotropical Eugenia species (Myrtaceae).
[So] Source:Genet Mol Res;15(4), 2016 Oct 24.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Polyploidy is one of the most important mechanisms of speciation and diversification in plant evolution. Polyploidy results in genetic variation among individuals of the same species and even between populations, and may be responsible for differences in environmental tolerance between populations of the same species. This study determined chromosome numbers of Eugenia L. (Myrtaceae, x = 11) for 26 populations of 14 species by conventional cytogenetic techniques. Nine species (13 populations) were diploid (2n = 2x = 22), but diploid and/or polyploid cytotypes were found in the other five species (13 populations), with 2n = 33, 2n = 44, and 2n = 55. Data on chromosome number/ploidy level for other Eugenia species/populations were collected from the literature and included in this cytogeographic analysis. For each collection point (32 species and 62 populations), environmental variables were recorded using georeferencing techniques through the DIVA-GIS v.7.5 program. Environmental variables such as temperature, altitude, rainfall, solar radiation, soil type, and vegetation were analyzed with the R program, using Mann-Whitney and chi-square tests, principal component analysis, and graphic analyses, such as scatterplots, boxplots, and barplot. Polyploid and diploid populations had different spatial distribution patterns and were found in areas subjected to different environmental conditions. Polyploid individuals were collected from locations with more adverse environmental conditions, usually at higher elevations than the diploid individuals. Polyploidy allows species to occur at locations with varying environmental conditions. As diploidy and polyploidy occur under different environmental conditions, species with cytotypes exhibit wide environmental tolerance.
[Mh] Termos MeSH primário: Eugenia/genética
Especiação Genética
Genética Populacional
Poliploidia
[Mh] Termos MeSH secundário: Cromossomos de Plantas
Análise Citogenética
Diploide
Ecossistema
Meio Ambiente
Eugenia/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE
[do] DOI:10.4238/gmr15048842



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