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[PMID]:28578903
[Au] Autor:Navanesan S; Abdul Wahab N; Manickam S; Cheow YL; Sim KS
[Ad] Endereço:Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
[Ti] Título:Intrinsic capabilities of Leptospermum javanicum in inducing apoptosis and suppressing the metastatic potential of human lung carcinoma cells.
[So] Source:Chem Biol Interact;273:37-47, 2017 Aug 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The active isolate of LF1 in Leptospermum javanicum was further looked into its capabilities in provoking an apoptotic reaction and suppressing the metastasis process in treated non-small lung cancer cells. LF1 underwent isolation and purification to yield a white powder which was identified as Betulinic acid (BA) via NMR, LCMS and IR spectroscopy. The isolate, BA, which produced an encouraging cytotoxic effect against non-small lung cancer cells (A549 and NCI-H1299) through the MTT assay, was further assessed with TUNEL, Sub-G1 population quantification, acridine orange/ethidium bromide staining as well as activated caspase-3 detection. The results pointed towards the induction of apoptosis as a result of increasing doses of BA, regardless of the p53 status in both cell lines. Treatment with BA also prevented an effective attachment of the invasive A549 cells onto a new culture surface in addition to diminishing the migratory potential of treated cells across a porous membrane. Further investigation through the ELISA detection and gelatin zymography showed an adverse effect to production of matrix metalloproteinase-2 (MMP-2) while the levels of matrix metalloproteinase-9 (MMP-9) were not negatively affected. The findings from this study validate the potential of L. javanicum as a potential anti-cancer treatment as stated in our previous study. The isolate, BA not only showed a capacity in inducing apoptotic cell death in non-small lung cancer cells, but managed to distort the ability of the cancer cells in effectively undergoing the metastasis process.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Carcinoma Pulmonar de Células não Pequenas/patologia
Leptospermum/química
Neoplasias Pulmonares/patologia
Metástase Neoplásica/prevenção & controle
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Morte Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Estrutura Molecular
Relação Estrutura-Atividade
Triterpenos/química
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Triterpenes); 4G6A18707N (betulinic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


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[PMID]:28490123
[Au] Autor:Grainger MNC; Owens A; Manley-Harris M; Lane JR; Field RJ
[Ad] Endereço:Chemistry, School of Science University of Waikato, Private Bag 3105, Hamilton, New Zealand.
[Ti] Título:Kinetics of conversion of dihydroxyacetone to methylglyoxal in New Zealand manuka honey: Part IV - Formation of HMF.
[So] Source:Food Chem;232:648-655, 2017 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:During a study of the conversion of dihydroxyacetone (DHA) to methylglyoxal (MGO) in maturing New Zealand manuka honey, the kinetics of formation of 5-(hydroxymethyl)furfural (HMF) was studied at temperatures from 4 to 37°C. Formation of HMF was first-order during an induction period and zero-order thereafter indicating that the mechanism includes the formation of certain critical intermediates and that these require time to build up; the duration of the induction period depended primarily upon temperature. The zero-order rate constant at 37°C was the same for manuka honey and clover honey doped with 2000 or 10,000mg/kg DHA and for artificial honey with 2000mg/kg of DHA and either alanine or proline and alanine added. Zero-order rate constants for artificial honey with added amino acids were less than for a control without amino acids. A simulation was created to predict the formation of HMF over time at 37°C in manuka honey.
[Mh] Termos MeSH primário: Di-Hidroxiacetona
Mel
Aldeído Pirúvico
[Mh] Termos MeSH secundário: Cinética
Leptospermum
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
722KLD7415 (Pyruvaldehyde); O10DDW6JOO (Dihydroxyacetone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


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[PMID]:28415841
[Au] Autor:Hellwig M; Rückriemen J; Sandner D; Henle T
[Ad] Endereço:Chair of Food Chemistry, Technische Universität Dresden , D-01062 Dresden, Germany.
[Ti] Título:Unique Pattern of Protein-Bound Maillard Reaction Products in Manuka (Leptospermum scoparium) Honey.
[So] Source:J Agric Food Chem;65(17):3532-3540, 2017 May 03.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As a unique feature, honey from the New Zealand manuka tree (Leptospermum scoparium) contains substantial amounts of dihydroxyacetone (DHA) and methylglyoxal (MGO). Although MGO is a reactive intermediate in the Maillard reaction, very little is known about reactions of MGO with honey proteins. We hypothesized that the abundance of MGO should result in a particular pattern of protein-bound Maillard reaction products (MRPs) in manuka honey. A protein-rich high-molecular-weight fraction was isolated from 12 manuka and 8 non-manuka honeys and hydrolyzed enzymatically. By HPLC-MS/MS, 8 MRPs, namely, N-ε-fructosyllysine, N-ε-maltulosyllysine, carboxymethyllysine, carboxyethyllysine (CEL), pyrraline, formyline, maltosine, and methylglyoxal-derived hydroimidazolone 1 (MG-H1), were quantitated. Compared to non-manuka honeys, the manuka honeys were characterized by high concentrations of CEL and MG-H1, whereas the formation of N-ε-fructosyllysine was suppressed, indicating concurrence reactions of glucose and MGO at the ε-amino group of protein-bound lysine. Up to 31% of the lysine and 8% of the arginine residues, respectively, in the manuka honey protein can be modified to CEL and MG-H1, respectively. CEL and MG-H1 concentrations correlated strongly with the MGO concentration of the honeys. Manuka honey possesses a special pattern of protein-bound MRPs, which might be used to prove the reliability of labeled MGO levels in honeys and possibly enable the detection of fraudulent MGO or DHA addition to honey.
[Mh] Termos MeSH primário: Di-Hidroxiacetona/química
Mel/análise
Leptospermum/química
Proteínas de Plantas/química
Aldeído Pirúvico/química
[Mh] Termos MeSH secundário: Flores/química
Reação de Maillard
Ligação Proteica
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 722KLD7415 (Pyruvaldehyde); O10DDW6JOO (Dihydroxyacetone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00797


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[PMID]:28379400
[Au] Autor:Hogg BN; Mills NJ; Daane KM
[Ad] Endereço:Department of Environmental Science Policy and Management, University of California, Berkeley, CA 94720-3114 ( brian.hogg@ars.usda.gov ; nmills@berkeley.edu ; kdaane@ucanr.edu ).
[Ti] Título:Temporal Patterns in the Abundance and Species Composition of Spiders on Host Plants of the Invasive Moth Epiphyas postvittana (Lepidoptera: Tortricidae).
[So] Source:Environ Entomol;46(3):502-510, 2017 06 01.
[Is] ISSN:1938-2936
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Generalist predators such as spiders may help mitigate the spread and impact of exotic herbivores. The lack of prey specificity and long generation times of spiders may allow them to persist when pests are scarce, and to limit the growth of pest populations before they reach damaging levels. We examined whether resident spiders are likely to play a role in maintaining populations of the invasive light brown apple moth, Epiphyas postvittana (Walker) (Lepidoptera: Tortricidae), below outbreak levels in California. We surveyed the spider community on two E. postvittana host plants, the ornamental Australian tea tree, Leptospermum laevigatum, and the weed French broom, Genista monspessulana, to characterize spider and larval E. postvittana abundance and spider species composition throughout the year. Spider densities and species composition showed slight seasonal changes. Spiders were present during periods of high and low E. postvittana abundance. Anyphaenid hunting spiders, Anyphaena aperta Banks in Australian tea tree and Anyphaena pacifica Banks in French broom, dominated spider species composition at four of five sampled sites, and underwent only slight seasonal variation in abundance. Adult A. aperta were rare at all times of the year, suggesting that high mortality among juvenile A. aperta limits the potential of this species as a predator of E. postvittana. Nevertheless, the continued presence of spiders throughout the year indicates that the resident spider community is likely to play a key role in reducing E. postvittana populations in California.
[Mh] Termos MeSH primário: Cadeia Alimentar
Genista/fisiologia
Leptospermum/fisiologia
Mariposas/fisiologia
Aranhas/fisiologia
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal
California
Espécies Introduzidas
Larva/crescimento & desenvolvimento
Larva/fisiologia
Mariposas/crescimento & desenvolvimento
Controle Biológico de Vetores
Dinâmica Populacional
Estações do Ano
Especificidade da Espécie
Aranhas/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1093/ee/nvx065


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[PMID]:28326322
[Au] Autor:Hixon KR; Lu T; McBride-Gagyi SH; Janowiak BE; Sell SA
[Ad] Endereço:Department of Biomedical Engineering, Parks College of Engineering, Aviation, and Technology, Saint Louis University, St. Louis, MO, USA.
[Ti] Título:A Comparison of Tissue Engineering Scaffolds Incorporated with Manuka Honey of Varying UMF.
[So] Source:Biomed Res Int;2017:4843065, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:. Manuka honey (MH) is an antibacterial agent specific to the islands of New Zealand containing both hydrogen peroxide and a Unique Manuka Factor (UMF). Although the antibacterial properties of MH have been studied, the effect of varying UMF of MH incorporated into tissue engineered scaffolds have not. Therefore, this study was designed to compare silk fibroin cryogels and electrospun scaffolds incorporated with a 5% MH concentration of various UMF. . Characteristics such as porosity, bacterial clearance and adhesion, and cytotoxicity were compared. . Pore diameters for all cryogels were between 51 and 60 m, while electrospun scaffolds were 10 m. Cryogels of varying UMF displayed clearance of approximately 0.16 cm for and . In comparison, the electrospun scaffolds clearance ranged between 0.5 and 1 cm. A glucose release of 0.5 mg/mL was observed for the first 24 hours by all scaffolds, regardless of UMF. With respect to cytotoxicity, neither scaffold caused the cell number to drop below 20,000. . Overall, when comparing the effects of the various UMF within the two scaffolds, no significant differences were observed. This suggests that the fabricated scaffolds in this study displayed similar bacterial effects regardless of the UMF value.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Mel/microbiologia
Leptospermum/química
Engenharia Tecidual
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/química
Adesão Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Escherichia coli/patogenicidade
Seres Humanos
Peróxido de Hidrogênio/química
Peróxido de Hidrogênio/farmacologia
Microscopia Eletrônica de Varredura
Nova Zelândia
Porosidade
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/patogenicidade
Tecidos Suporte/química
Tecidos Suporte/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1155/2017/4843065


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[PMID]:28287469
[Au] Autor:Afrin S; Forbes-Hernandez TY; Gasparrini M; Bompadre S; Quiles JL; Sanna G; Spano N; Giampieri F; Battino M
[Ad] Endereço:Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, via Ranieri 65, Ancona 60131, Italy. dolla.bihs@gmail.com.
[Ti] Título:Strawberry-Tree Honey Induces Growth Inhibition of Human Colon Cancer Cells and Increases ROS Generation: A Comparison with Manuka Honey.
[So] Source:Int J Mol Sci;18(3), 2017 Mar 11.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Honey is a natural product known to modulate several biological activities including cancer. The aim of the present study was to examine the phytochemical content and the antioxidant activity of Strawberry tree ( ) honey (STH) and its cytotoxic properties against human colon adenocarcinoma (HCT-116) and metastatic (LoVo) cell lines in comparison with Manuka ( ) honey (MH). Several unifloral STH and MH were analyzed for their phenolic, flavonoid, amino acid and protein contents, as well as their radical scavenging activities. STH from the Berchidda area showed the highest amount of phenolic, flavonoid, amino acid and protein content, and antioxidant capacity compared to MH. Both STH and MH induced cytotoxicity and cell death in a dose- and time-dependent manner in HCT-116 and LoVo cells, with less toxicity on non-cancer cells. Compared to MH, STH showed more effect at lower concentrations on HCT-116 and LoVo cells. In addition, both honeys increased intracellular reactive oxygen species (ROS) generation. In HCT-116 cells, STH and MH induced similar ROS production but in LoVo cells STH induced a higher percentage of ROS compared to MH. Our results indicate that STH and MH can induce cell growth inhibition and ROS generation in colon adenocarcinoma and metastatic cells, which could be due to the presence of phytochemicals with antioxidant properties. These preliminary results are interesting and suggest a potential chemopreventive action which could be useful for further studies in order to develop chemopreventive agents for colon cancer.
[Mh] Termos MeSH primário: Antineoplásicos/química
Antineoplásicos/farmacologia
Fragaria
Mel
Leptospermum
Espécies Reativas de Oxigênio/metabolismo
Árvores
[Mh] Termos MeSH secundário: Aminoácidos/química
Antioxidantes/química
Antioxidantes/farmacologia
Linhagem Celular Tumoral
Neoplasias do Colo/metabolismo
Flavonoides/química
Células HCT116
Mel/análise
Seres Humanos
Compostos Fitoquímicos/química
Polifenóis/química
Proteínas/química
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Flavonoids); 0 (Phytochemicals); 0 (Polyphenols); 0 (Proteins); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:28244415
[Au] Autor:Fogh SE; Deshmukh S; Berk LB; Dueck AC; Roof K; Yacoub S; Gergel T; Stephans K; Rimner A; DeNittis A; Pablo J; Rineer J; Williams TM; Bruner D
[Ad] Endereço:University of California San Francisco, San Francisco, California. Electronic address: Shannon.Fogh@ucsf.edu.
[Ti] Título:A Randomized Phase 2 Trial of Prophylactic Manuka Honey for the Reduction of Chemoradiation Therapy-Induced Esophagitis During the Treatment of Lung Cancer: Results of NRG Oncology RTOG 1012.
[So] Source:Int J Radiat Oncol Biol Phys;97(4):786-796, 2017 Mar 15.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Randomized trials have shown that honey is effective for the prevention of radiation-induced mucositis in head and neck cancer patients. Because there is no efficacious preventative for radiation esophagitis in lung cancer patients, this trial compared liquid honey, honey lozenges, and standard supportive care for radiation esophagitis. METHODS: The patients were stratified by percentage of esophagus receiving specific radiation dose (V60 Gy esophagus <30% or ≥30%) and were then randomized between supportive care, 10 mL of liquid manuka honey 4 times a day, and 2 lozenges (10 mL of dehydrated manuka honey) 4 times a day during concurrent chemotherapy and radiation therapy. The primary endpoint was patient-reported pain on swallowing, with the use of an 11-point (0-10) scale at 4 weeks (Numerical Rating Pain Scale, NRPS). The study was designed to detect a 15% relative reduction of change in NRPS score. The secondary endpoints were trend of pain over time, opioid use, clinically graded and patient-reported adverse events, weight loss, dysphagia, nutritional status, and quality of life. RESULTS: 53 patients were randomized to supportive care, 54 were randomized to liquid honey, and 56 were randomized to lozenge honey. There was no significant difference in the primary endpoint of change in the NRPS at 4 weeks between arms. There were no differences in any of the secondary endpoints except for opioid use at 4 weeks during treatment between the supportive care and liquid honey arms, which was found to be significant (P=.03), with more patients on the supportive care arm taking opioids. CONCLUSION: Honey as prescribed within this protocol was not superior to best supportive care in preventing radiation esophagitis. Further testing of other types of honey and research into the mechanisms of action are needed.
[Mh] Termos MeSH primário: Quimiorradioterapia/efeitos adversos
Dietoterapia/métodos
Esofagite/prevenção & controle
Mel
Neoplasias Pulmonares/radioterapia
Lesões por Radiação/prevenção & controle
[Mh] Termos MeSH secundário: Idoso
Esofagite/etiologia
Feminino
Seres Humanos
Leptospermum
Masculino
Meia-Idade
Lesões por Radiação/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE


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[PMID]:28024521
[Au] Autor:Fratini F; Mancini S; Turchi B; Friscia E; Pistelli L; Giusti G; Cerri D
[Ad] Endereço:Department of Veterinary Sciences, Viale delle Piagge 2, University of Pisa, Italy; Interdepartmental Research Center "Nutraceuticals and Food for Health", Via del Borghetto 80, University of Pisa, Italy. Electronic address: filippo.fratini@unipi.it.
[Ti] Título:A novel interpretation of the Fractional Inhibitory Concentration Index: The case Origanum vulgare L. and Leptospermum scoparium J. R. et G. Forst essential oils against Staphylococcus aureus strains.
[So] Source:Microbiol Res;195:11-17, 2017 Jan.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Origanum vulgare (oregano) and Leptospermum scoparium (manuka) were traditionally employed as natural remedies for infected wounds and skin injuries where Staphylococcus aureus is mainly involved. The first aim of this study was to investigate oregano and manuka essential oils (EOs) chemical compositions and evaluate their antibacterial activity (MIC, Minimum Inhibitory Concentration) against fourteen S. aureus wild strains. The second aim was to evaluate the antibacterial activities of oregano and manuka EOs mixed in different combination (FIC, Fractional Inhibitory Concentration) with an improved chequerboard technique. This allowed to avoid the usual uncertainty in the determination of MIC and FIC values and to obtain a more precise interpretation of FIC indexes (FICIs). Moreover, FICIs were discussed on the basis of a novel interpretation method to evaluate the synergistic/antagonistic effect of EOs mixtures. The most representative compounds in oregano EO were Carvacrol (65.93%), p-Cymene (9.33%) and γ-Terpinene (5.25%), while in manuka EO were Leptospermone (31.65%), cis-Calamenene (15.93%) and Flavesone (6.92%). EOs presented MIC values ranging from 1:2048 to 1:4096 v/v and FIC values ranging from 0.125 to 1. According to our interpretation, a synergistic effect (34.68%), a commutative effect (15.32%) and an indifferent effect (50.00%) and no antagonistic effect were observed. Conversely, according to two previously proposed FICI interpretation models, 1.80% synergistic effect could be observed and, respectively, 98.20% indifferent effect or 48.20% additive effect and 50.00% indifferent effect. As practical results, oregano and manuka EOs may be an effective alternative to chemotherapic drugs in staphylococcal infections and useful tools to enhance food security.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Leptospermum/química
Óleos Voláteis/farmacologia
Origanum/química
Compostos Fitoquímicos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Sinergismo Farmacológico
Testes de Sensibilidade Microbiana
Óleos Voláteis/isolamento & purificação
Compostos Fitoquímicos/isolamento & purificação
Staphylococcus aureus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 0 (Phytochemicals)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE


  9 / 120 MEDLINE  
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[PMID]:27611017
[Au] Autor:Esser M
[Ad] Endereço:Children's Hospital of Wisconsin, Milwaukee, Wisconsin; and St Mary's Hospital, Madison, Wisconsin.
[Ti] Título:Leptospermum Honey for Wound Care in an Extremely Premature Infant.
[So] Source:Adv Neonatal Care;17(1):27-32, 2017 Feb.
[Is] ISSN:1536-0911
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/INTRODUCTION TO CASE: Neonatal wound care is challenging due to the fragility and vulnerable skin structure. Neonates are often left susceptible to the forces of their environment, leaving them open to infection when skin injury occurs. Leptospermum honey has been used successfully in adult patients, with evidence lacking in the neonatal population. This case demonstrates the management of a difficult-to-heal wound in a 23-week gestation infant. PURPOSE: Selecting the proper treatment and products for wound healing is challenging, with little evidence-based research available for the treatment of neonatal wounds. Leptospermum honey and other adult-driven dressings have been used for neonatal wound care as well as other adult-driven dressings. This case demonstrates the benefits of Leptospermum honey as an option for neonatal wounds. CASE FINDINGS/RESULTS: This case presents the treatment and healing of an extensive wound of a 23-week gestation neonate using a hydrogel product initially and then transitioning to a Leptospermum honey dressing due to suboptimal healing. Results of this treatment included quick healing time, little to no scarring, and no loss of movement or function to the affected extremities. IMPLICATIONS FOR PRACTICE: The incorporation of Leptospermum honey for wound care has the potential to promote faster wound healing, with less scarring in the neonatal population. IMPLICATIONS FOR RESEARCH: Adult wound care principles have been applied in the face of a weak evidence base relating to neonatal-specific cases. There is a need for continued research related to moist wound healing in the neonatal population, with resulting product and practice recommendations.
[Mh] Termos MeSH primário: Bandagens
Mel
Ferimentos e Lesões/enfermagem
[Mh] Termos MeSH secundário: Curativos Hidrocoloides
Seres Humanos
Lactente Extremamente Prematuro
Recém-Nascido
Leptospermum
Masculino
Resultado do Tratamento
Cicatrização
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE
[do] DOI:10.1097/ANC.0000000000000331


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[PMID]:27507454
[Au] Autor:Bong J; Prijic G; Braggins TJ; Schlothauer RC; Stephens JM; Loomes KM
[Ad] Endereço:School of Biological Sciences and Institute for Innovation in Biotechnology, University of Auckland, PB92019 Auckland, New Zealand.
[Ti] Título:Leptosperin is a distinct and detectable fluorophore in Leptospermum honeys.
[So] Source:Food Chem;214:102-109, 2017 Jan 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:New Zealand manuka (Leptospermum scoparium) honey exhibits two unique fluorescence signatures that distinguish it from other honey types. One of these is the MM1 fluorescence marker (270-365nm excitation-emission) which we show is due to a Leptospermum nectar-derived compound, leptosperin. Synthetic or honey-purified leptosperin not only displayed an identical fluorescence spectrum, but supplementation of leptosperin into clover or artificial honeys generated the MM1 fluorescence signature. There was a quenching effect of the honey matrix on leptosperin fluorescence but otherwise leptosperin was chemically stable over prolonged storage at 37°C. Leptosperin was also present in the woody-fruited Australian Leptospermum species at elevated concentrations but virtually absent in Leptospermum subtenue suggesting its elevated expression developed following the mid-Miocene separation of the genus. These findings suggest that fluorescence spectroscopy could offer a rapid and high-throughput screening method for identification of Leptospermum honeys using the MM1 fluorescence marker.
[Mh] Termos MeSH primário: Mel/análise
Leptospermum/química
Néctar de Plantas/química
[Mh] Termos MeSH secundário: Austrália
Fluorescência
Corantes Fluorescentes
Ensaios de Triagem em Larga Escala
Espectrometria de Fluorescência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes); 0 (Plant Nectar)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE



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