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Pesquisa : B01.650.940.800.575.912.250.773.777 [Categoria DeCS]
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[PMID]:28222179
[Au] Autor:Zuntini Viscardi D; Arrigo JD; Correia CA; Kassuya CA; Cardoso CA; Maldonade IR; Argandoña EJ
[Ad] Endereço:College of Exact and Technological Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Brazil.
[Ti] Título:Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents.
[So] Source:PLoS One;12(2):e0157107, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Campomanesia adamantium (Myrtaceae) is popularly known as "gabiroba" and has been used in folk medicine as antirheumatic, antidiarrheal, hypocholesterolemic and anti-inflammatory. This study evaluated the anti-inflammatory and antinociceptive activities and toxicology of essential oils from peel (EOP) and seed (EOS) of C. adamantium fruits in animal models. Different groups were treated with doses of 100 and 300 mg/kg and the inflammatory parameters were evaluated in carrageenan induced paw oedema and leukocyte migration in pleurisy model, while antinociceptive activity was evaluated using formalin method in rodents. The major constituent of EOP and EOS was limonene with 13.07% and 20.89%, respectively. No clinical signs of toxicity have been observed in animals. It was observed a significant decreased (P<0.01) in leukocyte migration at the dose of 300 mg/kg of EOP and EOS, with maximal inhibition of 89±3% for EOP and 80±6% for EOS. Paw oedema was inhibited at all times, and maximal inhibition was at the dose of 100 mg/kg at 2 h after carrageenan injection with 72±2% for EOP and 74±2% for EOS. EOS and EOP also reduced the first and second phases of formalin-induced nociception test. In the first formalin-phase, maximal inhibitions were at 48±5% for EOP and 66±4% for EOS (300 mg/kg). At the inflammatory phase induced by formalin, maximal inhibitions were 72±2% for EOP and 80±2% for EOS at the dose of 100 mg/kg. Seed and peel essential oils from C. adamantium fruit inhibited leukocyte migration, inflammatory and neurogenic pain and oedema suggesting their use as nutraceutical or pharmacological agent.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Óleos Voláteis/farmacologia
Pimenta/química
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Animais
Anti-Inflamatórios/isolamento & purificação
Carragenina/toxicidade
Quimiotaxia de Leucócito/efeitos dos fármacos
Temperatura Baixa/efeitos adversos
Avaliação Pré-Clínica de Medicamentos
Edema/tratamento farmacológico
Feminino
Formaldeído/toxicidade
Frutas/química
Hiperalgesia/tratamento farmacológico
Hiperalgesia/etiologia
Masculino
Camundongos
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/toxicidade
Dor/induzido quimicamente
Dor/tratamento farmacológico
Dor/etiologia
Plantas Medicinais/química
Pleurisia/tratamento farmacológico
Ratos
Ratos Wistar
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Oils, Volatile); 1HG84L3525 (Formaldehyde); 9000-07-1 (Carrageenan)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0157107


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[PMID]:27480402
[Au] Autor:Senthil Kumar CM; Jacob TK; Devasahayam S; D'Silva S; Nandeesh PG
[Ad] Endereço:Division of Crop Protection, ICAR - Indian Institute of Spices Research, Marikunnu P.O., Kozhikode 673 012, Kerala, India. Electronic address: senthilkumarcm@spices.res.in.
[Ti] Título:Characterization and virulence of Beauveria bassiana associated with auger beetle (Sinoxylon anale) infesting allspice (Pimenta dioica).
[So] Source:J Invertebr Pathol;139:67-73, 2016 Sep.
[Is] ISSN:1096-0805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The incidence of auger beetle, Sinoxylon anale Lesne (Bostrichidae: Coleoptera), a destructive pest of cosmopolitan occurrence is reported for the first time on allspice trees, Pimenta dioica (L.) Merr. in Kerala, India. The insects bored through the basal region of fresh twigs resulting in dieback symptoms. Morphological characterization and sequencing of a partially amplified fragment of the mitochondrial CO1 gene (696bp) revealed the insect to be Sinoxylon anale. An entomopathogenic fungus was isolated from infected cadavers of S. anale that was identified as Beauveria bassiana (Bals.-Criv.) Vuill., sensu stricto (s.s.) (Ascomycota: Hypocreales) based on morphological and molecular studies. The partial sequences of the ITS, TUB, TEF and Bloc gene regions were sequenced. The fungus grew well in ambient room temperature conditions (28-32±2°C; 60-70% relative humidity) and the infection process on the insect was documented by scanning electron microscopy. Bioassay studies with the isolate indicated that the fungus was virulent against adult beetles as evidenced by the LC50 (3.6×10(6)conidia/ml) and ST50 values (6.8days at a dose of 1×10(7)conidia/ml and 5.8days at a dose of 1×10(8)conidia/ml, respectively). This is the first record of B. bassiana naturally infecting S. anale and the fungus holds promise to be developed as a mycoinsecticide.
[Mh] Termos MeSH primário: Beauveria/patogenicidade
Coleópteros/parasitologia
Controle Biológico de Vetores/métodos
[Mh] Termos MeSH secundário: Animais
Microscopia Eletrônica de Varredura
Filogenia
Pimenta
Reação em Cadeia da Polimerase
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE


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[PMID]:27318791
[Au] Autor:Gao Y; Zhaoyu L; Xiangming F; Chunyi L; Jiayu P; Lu S; Jitao C; Liangcai C; Jifang L
[Ad] Endereço:Department of Respiratory Medicine and Central Laboratory, The 5th Affiliated Hospital of Guangzhou Medical University, Guangzhou 517007, PR China.
[Ti] Título:Abietic acid attenuates allergic airway inflammation in a mouse allergic asthma model.
[So] Source:Int Immunopharmacol;38:261-6, 2016 Sep.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Abietic acid (AA), one of the terpenoids isolated from Pimenta racemosa var. grissea, has been reported to have anti-inflammatory and immunomodulatory effects. However, the anti-allergic effects of AA remain unclear. The aim of this study was to investigate the anti-allergic effects of AA in an ovalbumin (OVA)-induced asthma murine model. The model of mouse asthma was established by induction of OVA. AA (10, 20, 40mg/kg) was administered by oral gavage 1h after the OVA treatment on days 21 to 23. At 24h after the last challenge, bronchoalveolar lavage fluid (BALF) and lung tissues were collected to assess pathological changes, cytokines production, and NF-κB expression. The results showed that AA attenuated lung histopathologic changes, inflammatory cells infiltration, and bronchial hyper-responsiveness. AA also inhibited OVA-induced the nitric oxide (NO), IL-4, IL-5, IL-13, and OVA-specific IgE production, as well as NF-κB activation. In conclusion, the current study demonstrated that AA exhibited protective effects against OVA-induced allergic asthma in mice and the possible mechanism was involved in inhibiting NF-κB activation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Asma/tratamento farmacológico
Hiper-Reatividade Brônquica/tratamento farmacológico
Diterpenos Abietanos/uso terapêutico
Pulmão/efeitos dos fármacos
Pimenta/imunologia
Pneumonia/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Animais
Movimento Celular/efeitos dos fármacos
Citocinas/metabolismo
Modelos Animais de Doenças
Feminino
Seres Humanos
Imunoglobulina E/sangue
Pulmão/patologia
Pulmão/fisiologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Meia-Idade
NF-kappa B/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Diterpenes, Abietane); 0 (NF-kappa B); 37341-29-0 (Immunoglobulin E); V3DHX33184 (abietic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160620
[St] Status:MEDLINE


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[PMID]:26778678
[Au] Autor:Ferrari FC; Lemos Lima Rde C; Schimith Ferraz Filha Z; Barros CH; de Paula Michel Araújo MC; Antunes Saúde-Guimarães D
[Ad] Endereço:Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais 35400-000, Brazil.
[Ti] Título:Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action.
[So] Source:J Ethnopharmacol;180:37-42, 2016 Mar 02.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Leaves infusion of Pimenta pseudocaryophyllus (Gomes) Landrum is used in Brazilian folk medicine to treat the predisposition to arthritical and gouty affections of the joints, fever and other diseases. A refreshing drink prepared with the specie is also used due to its diuretic, sedative and aphrodisiac actions. AIM OF THE STUDY: The study was undertaken to investigate the mechanisms of anti-hyperuricemic effect and anti-inflammatory activity of P. pseudocaryophyllus extracts. MATERIALS AND METHODS: Anti-hyperuricemic effect was investigated using xanthine oxidase assay and uricosuric studies with rats in which hyperuricemia was induced by potassium oxonate and uric acid. Anti-inflammatory activity was investigated on MSU crystal-induced paw edema model. Ethyl acetate extracts of the leaves (EAL) and branches (EAB), ethanolic extracts of leaves (EEL) and branches (EEB) and aqueous extracts of leaves (AL) and branches (AB) were evaluated. RESULTS: The extracts of P. pseudocaryophyllus evaluated showed expressive results regarding the inhibition of xanthine oxidase enzyme in vitro and they were also able to reduce serum uric acid levels in hyperuricemic rats. The investigation of the mechanism of action, it was found that EAL, EAB, EEB, AB (125 and 250 mg/kg) and AL (250 mg/kg) promoted an increase on the urinary excretion of uric acid and EEL, EEB, AB (125 and 250 mg/kg) and EAB (250 mg/kg) were capable to inhibit liver xanthine oxidase. Treatments with EEL (125 and 250 mg/kg) and EEB (250 mg/kg) were able to reduce edema at 48 th h. EAL and EAB (125 and 250 mg/kg) showed significant anti-inflammatory activity on monosodium urate crystal-induced paw edema model at all evaluated times. CONCLUSIONS: The specie P. pseudocaryophyllus showed remarkable anti-hyperuricemic effects through uricosuric effects and inhibition of xanthine oxidase and therefore can be considered as a promise in the treatment of diseases related to hyperuricemia. Moreover, ethyl acetate extracts had significant anti-inflammatory activity.
[Mh] Termos MeSH primário: Anti-Inflamatórios
Supressores da Gota
Pimenta
Extratos Vegetais
Xantina Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Gota/sangue
Gota/tratamento farmacológico
Gota/urina
Supressores da Gota/farmacologia
Supressores da Gota/uso terapêutico
Hiperuricemia/sangue
Hiperuricemia/tratamento farmacológico
Hiperuricemia/urina
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Folhas de Planta
Ratos Wistar
Ácido Úrico/sangue
Ácido Úrico/urina
Xantina Oxidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Gout Suppressants); 0 (Plant Extracts); 268B43MJ25 (Uric Acid); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE


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[PMID]:26632088
[Au] Autor:Bajer T; Ligor M; Ligor T; Buszewski B
[Ad] Endereço:Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Torun, Poland.
[Ti] Título:Design of the extraction process for terpenes and other volatiles from allspice by solid-phase microextraction and hydrodistillation.
[So] Source:J Sep Sci;39(4):769-75, 2016 Feb.
[Is] ISSN:1615-9314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Methods for the separation and determination of terpenes (mono- and sesqui-) and phenylpropanoids such as eugenol and methyleugenol from samples of allspice berries have been developed. Chromatographic analyses of isolated groups of compounds were carried out by means of gas chromatography coupled with mass spectrometry. A comparison of various types of solid-phase microextraction fibers was performed. The highest yields of terpenes were extracted by polydimethylsiloxane and divinylbenzene/Carboxen/polydimethylsiloxane fibers (almost the same for these two fibers), approximately twice as much as by Carbowax/divinylbenzene fiber. The highest amounts of monoterpenes were extracted by divinylbenzene/Carboxen/polydimethylsiloxane fiber, and the highest amounts of sesquiterpenes were extracted by polydimethylsiloxane fiber. Moreover, the effect of water addition on extraction yields as well as time and temperature of extraction were tested. Aroma profiles of extracts obtained by solid-phase microextraction and essential oil obtained by hydrodistillation of allspice berries were compared. The aroma profile of the divinylbenzene/Carboxen/polydimethylsiloxane fiber extract was similar to the aroma profile of essential oil. Particular characteristics of volatile allspice matters were presented. The linear retention indices for each compound were calculated.
[Mh] Termos MeSH primário: Pimenta/química
Microextração em Fase Sólida/métodos
Terpenos/análise
Água/química
[Mh] Termos MeSH secundário: Dimetilpolisiloxanos/química
Destilação
Cromatografia Gasosa-Espectrometria de Massas/métodos
Monoterpenos/química
Óleos Voláteis
Polietilenoglicóis/química
Sesquiterpenos/química
Temperatura Ambiente
Terpenos/química
Compostos de Vinila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dimethylpolysiloxanes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (Terpenes); 0 (Vinyl Compounds); 0 (carbowax 600); 059QF0KO0R (Water); 30IQX730WE (Polyethylene Glycols); 63148-62-9 (baysilon); IZ715T4SBU (divinyl benzene)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151204
[St] Status:MEDLINE
[do] DOI:10.1002/jssc.201500605


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[PMID]:26299134
[Au] Autor:Chaverri C; Cicció JF
[Ti] Título:Leaf and fruit essential oil compositions of Pimenta guatemalensis (Myrtaceae) from Costa Rica.
[So] Source:Rev Biol Trop;63(1):303-11, 2015 Mar.
[Is] ISSN:0034-7744
[Cp] País de publicação:Costa Rica
[La] Idioma:eng
[Ab] Resumo:Pitnenta is a genus of flowering plants in the Myrtaceae family, which has about 15 species, mostly found in the Caribbean region of the Americas. Commonly used for culinary and medicinal purposes, the best known commercial species are allspice, P. dioica (P. officinalis) and bay rum, P. racemosa, but there is little information concerning P. guatemalensis. The aim of the present study was to identify the chemical composition of the leaf and fruit essential oils ofP. guatemalensis. The extraction of essential oils of P. guatemalensis growing wild in Costa Rica was carried out by the hydrodistillation method at atmospheric pressure, using a modified Clevenger type apparatus. The chemical composition of the oils was analyzed by capillary gas chromatographyflame ionization detector (GC/FID) and gas chromatography-mass spectrometry (GC/MS) using the retention indices on DB-5 type capillary column. A total of 103 and 63 compounds were identified in the leaf and fruit oils, respectively, corresponding to 96.8% and 86.1% of the total amount of the oils. The leaf oil consisted mainly of eugenol (72.8%), and mono- and sesquiterpene hydrocarbons (18.2%). Among terpenes the major components were beta-caryophyllene (8.2%) and terpinolene (3.0%). The fruit oil also consisted mainly of eugenol (74.7%) and minor amounts of oxygenated mono- and sesquiterpenes (7.3%), mainly caryophyllene oxide (3.3%). This is the first report of the chemical composition of the essential oils obtained from this plant species.
[Mh] Termos MeSH primário: Frutas/química
Óleos Voláteis/química
Pimenta/química
Folhas de Planta/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Costa Rica
Cromatografia Gasosa-Espectrometria de Massas
Pimenta/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150824
[Lr] Data última revisão:
150824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150825
[St] Status:MEDLINE


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[PMID]:26285912
[Au] Autor:Ribeiro LP; Ansante TF; Niculau ES; Pavarini R; Silva MF; Seffrin RC; Vendramim JD
[Ad] Endereço:Centro de Pesquisa para Agricultura Familiar, Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina (CEPAF/EPAGRI), Av. Servidão Ferdinando Tusset S/N, São Cristóvão, CEP 89801-970, Chapecó, SC, Brasil. leandro_universidade@hotmail.com.
[Ti] Título:Pimenta pseudocaryophyllus Derivatives: Extraction Methods and Bioactivity Against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae).
[So] Source:Neotrop Entomol;44(6):634-42, 2015 Dec.
[Is] ISSN:1678-8052
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Plant-based insecticides can play an important role in integrated insect pest management (IPM), especially in protecting stored grains. The aim of this study was to evaluate the bioactivity of derivatives (powder, ethanolic extract, and essential oil (EO)) from the leaves of Pimenta pseudocaryophyllus (Myrtaceae), a Brazilian native species, against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae), the main insect pest of stored corn. The powder and essential oil prepared from leaves showed a repellent effect. Moreover, the EO exhibited promising insecticidal activity through residual contact (LC50 = 1522 mg kg(-1)) and significantly decreased the F 1 progeny and the percentage of damaged grains. However, the essential oil obtained from P. pseudocaryophyllus leaves did not result in significant mortality of S. zeamais adults after 72 h of exposure by fumigation in concentrations up to 400 µL L(-1) of air. Based on GC-MS analysis, 20 compounds were identified in the essential oil of P. pseudocaryophyllus leaves, being chavibetol (38.14%), methyl eugenol (11.35%), and terpinolene (9.17%) as the major constituents. Essential oil from P. pseudocaryophyllus leaves is an interesting source of compounds with grain-protectant properties and should be analyzed in future studies aiming to develop new bioinsecticides to use in the IPM of stored grains.
[Mh] Termos MeSH primário: Controle de Insetos
Inseticidas/química
Óleos Voláteis/química
Pimenta/química
Gorgulhos
[Mh] Termos MeSH secundário: Animais
Brasil
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171112
[Lr] Data última revisão:
171112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150820
[St] Status:MEDLINE
[do] DOI:10.1007/s13744-015-0321-6


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[PMID]:25945840
[Au] Autor:Zhang L; Shamaladevi N; Jayaprakasha GK; Patil BS; Lokeshwar BL
[Ad] Endereço:Sheila and David Fuente Graduate Program in Cancer Biology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida, USA.
[Ti] Título:Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills breast cancer cells by autophagy and delays growth of triple negative breast cancer in athymic mice.
[So] Source:Oncotarget;6(18):16379-95, 2015 Jun 30.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bioactive compounds from edible plants have limited efficacy in treating advanced cancers, but they have potential to increase the efficacy of chemotherapy drugs in a combined treatment. An aqueous extract of berries of Pimenta dioica (Allspice) shows promise as one such candidate for combination therapy or chemoprevention. An aqueous extract of Allspice (AAE) was tested against human breast cancer (BrCa) cells in vitro and in vivo. AAE reduced the viability and clonogenic growth of several types of BrCa cells (IC50 ≤ 100 µg/ml) with limited toxicity in non-tumorigenic, quiescent cells (IC50 >200 µg/ml). AAE induced cytotoxicity in BrCa was inconsistent with apoptosis, but was associated with increased levels of autophagy markers LC3B and LC3B-positive puncta. Silencing the expression of autophagy related genes (ATGs) prevented AAE-induced cell death. Further, AAE caused inhibition of Akt/mTOR signaling, and showed enhanced cytotoxicity when combined with rapamycin, a chemotherapy drug and an inhibitor of mTOR signaling. Oral administration (gavage) of AAE into athymic mice implanted with MDA-MB231 tumors inhibited tumor growth slightly but not significantly (mean decrease ~ 14%, p ≥ 0.20) if mice were gavaged post-tumor implant. Tumor growth showed a significant delay (38%) in tumor palpability and growth rate (time to reach tumor volume ≥ 1,000 mm3) when mice were pre-dosed with AAE for two weeks. Analysis of tumor tissues showed increased levels of LC3B in AAE treated tumors, indicating elevated autophagic tumor cell death in vivo in treated mice. These results demonstrate antitumor and chemo-preventive activity of AAE against BrCa and potential for adjuvant to mTOR inhibition.
[Mh] Termos MeSH primário: Autofagia/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Pimenta/metabolismo
Extratos Vegetais/farmacologia
Neoplasias de Mama Triplo Negativas/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Proteína 5 Relacionada à Autofagia
Proteína 7 Relacionada à Autofagia
Linhagem Celular Tumoral
Feminino
Xenoenxertos
Seres Humanos
Células MCF-7
Camundongos
Camundongos Nus
Proteínas Associadas aos Microtúbulos/genética
Proteínas Associadas aos Microtúbulos/metabolismo
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Interferência de RNA
RNA Interferente Pequeno
Distribuição Aleatória
Transdução de Sinais/efeitos dos fármacos
Serina-Treonina Quinases TOR/antagonistas & inibidores
Enzimas Ativadoras de Ubiquitina/genética
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (ATG5 protein, human); 0 (Autophagy-Related Protein 5); 0 (MAP1LC3B protein, human); 0 (Microtubule-Associated Proteins); 0 (Plant Extracts); 0 (RNA, Small Interfering); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 6.2.1.45 (Autophagy-Related Protein 7); EC 6.2.1.45 (Ubiquitin-Activating Enzymes); EC 6.3.2.19 (Atg7 protein, human)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150507
[St] Status:MEDLINE


  9 / 44 MEDLINE  
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[PMID]:25842910
[Au] Autor:Misharina TA; Alinkina ES; Medvedeva IB
[Ti] Título:[Antiradical properties of essential oils and extracts from clove bud and pimento].
[So] Source:Prikl Biokhim Mikrobiol;51(1):99-104, 2015 Jan-Feb.
[Is] ISSN:0555-1099
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The antiradical properties of essential oils and extracts from the clove bud (Eugenia caryophyllata Thumb.) and berries of tree (Pimenta dioica (L.) Meriff) were studied and compared with the properties of synthetic antioxidant ionol (2,6-ditret-butyl-4-hydroxytoluene, BHT) in model reactions with the stable free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. The essential oils of clove bud and pimento had qualitatively close composition of the main components but differed by their quantitative content. In the studied samples, eugenol was the main compound with high antiradical activity. The reaction rates of essential oils and extracts with the DPPH radical were practically the same for essential oils and twice the reaction rate of BHT. The values of antiradical efficiency (AE) were also close for essential oils and were twice that for extracts and ionol. A synergetic action of components in the essential oil and extract of pimento on antiradical efficiency values was found.
[Mh] Termos MeSH primário: Antioxidantes/química
Óleos Voláteis/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Compostos de Bifenilo/química
Hidroxitolueno Butilado/química
Depuradores de Radicais Livres/química
Óleos Voláteis/química
Picratos/química
Pimenta/química
Extratos Vegetais/química
Syzygium/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Oils, Volatile); 0 (Picrates); 0 (Plant Extracts); 1P9D0Z171K (Butylated Hydroxytoluene); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150407
[St] Status:MEDLINE


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[PMID]:25660768
[Au] Autor:Mercês Ede A; Camurugi F; Barreto GS; Solé M; Juncá FA
[Ad] Endereço:Programa de Pós-graduação em Zoologia, Departamento de Ciências Biológicas, Universidade Estadual de Feira de Santana, Av. Transnordestina, 44036-900, Feira de Santana, Bahia, Brasil.; Email: crillbio@yahoo.com.br.
[Ti] Título:The tadpole of Bokermannohyla lucianae (Napoli & Pimenta 2003) (Amphibia, Anura, Hylidae).
[So] Source:Zootaxa;3904(2):298-300, 2014 Jan 06.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Mh] Termos MeSH primário: Anuros/crescimento & desenvolvimento
Larva/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Estruturas Animais/anatomia & histologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Anuros/classificação
Anuros/genética
Tamanho Corporal
Feminino
Larva/classificação
Larva/genética
Masculino
Tamanho do Órgão
Pimenta
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150210
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.3904.2.9



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