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[PMID]:29305891
[Au] Autor:Zanusso Junior G; Massago M; Kian D; Toledo MJO
[Ad] Endereço:Department of Basic Health Sciences at State University of Maringa, Maringa, Paraná, Brazil.
[Ti] Título:Efficacy of essential oil of Syzygium aromaticum alone and in combination with benznidazole on murine oral infection with Trypanosoma cruzi IV.
[So] Source:Exp Parasitol;185:92-97, 2018 Feb.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chagas disease (CD), caused by Trypanosoma cruzi, remains a serious public health problem. One of the causes of the high morbidity and mortality in patients is the lack of an effective drug therapy. Thus, the aim of this study was to evaluate the efficacy of the essential oil of Syzygium aromaticum alone and in combination with benznidazole (BZ) in mice orally inoculated with strain of T. cruzi IV obtained from oral CD outbreak occurred in Western Brazilian Amazonia. All the animals inoculated with metacyclic trypomastigote forms (AM14 strain, BZ resistant), derived from the insect Rhodnius robustus, became infected and there was no difference in the mortality rate between the experimental groups. When compared with untreated control animals (UTC), the treatment with essential oil of S. aromaticum (EOSA) alone promoted reduction in 1/5 parameters derived from the parasitemia curve, whereas the treatments with BZ alone or in combination (BZ + EOSA) promoted reduction in 4/5 of those parameters, presenting similar profiles of parasitemia curve. The animals treated with BZ and with the combination BZ + EOSA presented lower patency periods in comparison with the animals in EOSA group, and lower positivity of blood cultures when compared with the UTC group. The results of molecular analysis by qPCR in both blood and cardiac tissue did not show differences between the groups. The cure rates obtained with the different treatments presented the following ascending order: EOSA = 12.5% (1/8), BZ = 25.0% (2/8) and BZ + EOSA = 37.5% (3/8). Although there are no significant differences between them, these results claims that the use of this essential oil could be of interest for treatment of Chagas disease.
[Mh] Termos MeSH primário: Doença de Chagas/tratamento farmacológico
Nitroimidazóis/uso terapêutico
Óleos Voláteis/uso terapêutico
Syzygium/química
Tripanossomicidas/uso terapêutico
Trypanosoma cruzi/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Doença de Chagas/parasitologia
Ciclofosfamida
Quimioterapia Combinada
Seres Humanos
Imunossupressão
Imunossupressores
Insetos Vetores/parasitologia
Masculino
Camundongos
Nitroimidazóis/farmacologia
Óleos Voláteis/farmacologia
Parasitemia/tratamento farmacológico
Parasitemia/parasitologia
Óleos Vegetais/farmacologia
Óleos Vegetais/uso terapêutico
Rhodnius/parasitologia
Tripanossomicidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 0 (Nitroimidazoles); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Trypanocidal Agents); 8N3DW7272P (Cyclophosphamide); YC42NRJ1ZD (benzonidazole)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE


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[PMID]:28467188
[Au] Autor:Tatavarthy A; Ali L; Gill V; Hu L; Deng X; Adachi Y; Rand H; Hammack T; Zhang G
[Ad] Endereço:U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5001 Campus Drive, College Park, Maryland 20740, USA.
[Ti] Título:Evaluation of Three Real-Time PCR Methods for Detection of Salmonella from Cloves.
[So] Source:J Food Prot;80(6):982-989, 2017 06.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of the study was to evaluate three real-time PCR platforms for rapid detection of Salmonella from cloves and to compare three different DNA extraction methods. Six trials were conducted with two clove cultivars, Ceylon and Madagascar, and three Salmonella serotypes, Montevideo, Typhimurium, and Weltevreden. Each trial consisted of 20 test portions. The preenrichment cultures were used to perform PCR for comparison of the effectiveness of U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest (FDA-PRLSW), Applied Biosystems Inc. (ABI) MicroSEQ, and GeneDisc platforms for detection of Salmonella. Three DNA extraction methods were used: standard extraction method for each PCR platform, boil preparation, and LyseNow food pathogen DNA extraction cards. The results from real-time PCR correlated well with FDA Bacteriological Analytical Manual culture assay results, with a wide range of cycle threshold (C ) values among the three PCR platforms for intended positive samples. The mean C values for MicroSEQ (16.36 ± 2.78) were significantly lower than for PRLSW (20.37 ± 3.45) and GeneDisc (23.88 ± 2.90) (P < 0.0001). Pairwise comparisons between PCR platforms using different DNA extraction methods indicate that the C values are inversely proportional to the relative DNA quantity (RDQ) yields by different platform-extraction combinations. The pairing of MicroSEQ and boil preparation generated the highest RDQ of 120 and the lowest average C value of 14.48, whereas the pairing of GeneDisc and LyseNow generated the lowest RDQ of 0.18 and the highest average C of 25.97. Boil preparation yielded higher RDQ than the other extraction methods for all three PCR platforms. Although the MicroSEQ platform generated the lowest C values, its sensitivity was compromised by narrow separations between the positive and negative samples. The PRLSW platform generated the best segregation between positive and negative groups and is less likely to produce false results. In conclusion, FDA-PRLSW was the most efficient PCR assay for Salmonella detection, and boil preparation was the best method for DNA extraction.
[Mh] Termos MeSH primário: Reação em Cadeia da Polimerase em Tempo Real
Syzygium
[Mh] Termos MeSH secundário: DNA Bacteriano
Microbiologia de Alimentos
Reação em Cadeia da Polimerase
Salmonella/genética
Sensibilidade e Especificidade
Sri Lanka
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-498


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[PMID]:27771103
[Au] Autor:Zhao M; Araújo MM; Dal S; Sigrist S; Bergaentzlé M; Ramanitrahasimbola D; Andrianjara C; Marchioni E
[Ad] Endereço:Chimie Analytique des Molécules Bioactives, Institut Pluridisciplinaire Hubert Curien (UMR 7178 CNRS/UDS), 74 route du Rhin, 67400 Illkirch, France.
[Ti] Título:Development and validation of a selective and effective pressurized liquid extraction followed by liquid chromatography-mass spectrometry method for the determination of fructosazine analogues in the ammonia treated extract of Eugenia jambolana Lamarck seeds.
[So] Source:J Chromatogr A;1473:66-75, 2016 Nov 18.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study describes a selective and effective pressurized liquid extraction (PLE) coupled with HPLC-DAD-ESI/MS method for the identification and quantification of three fructosazine analogues (FZAs), fructosazine, 2,6- and 2,5-deoxyfructosazine in Madeglucyl (MG) which is an ammonia treated extract of Eugenia jambolana Lamarck seeds, and is the world's first anti-diabetic phytodrug. FZAs were extracted from MG by PLE using methanol as extraction solvent. The PLE extract was then analyzed directly by HPLC-DAD-ESI/MS without cleanup step. Chromatographic separation of these highly related structures was achieved on a porous graphic carbon (PGC) column. The identification of the target FZAs was confirmed by the similar retention time, similar UV and MS spectra to the corresponding pure standards. The quantification was performed by using an electrospray positive ionization mass spectrometry in the selected ion monitoring (SIM) mode. The PLE procedure was optimized and overall method was validated in terms of sensitivity, linearity, selectivity and matrix effect, precision, accuracy and recovery, and stability of the target FZAs in the aqueous solution and in the PLE extracts solution of MG. The developed method was proved to be selective, sensitive, precise, accurate for the quantification of FZAs in MG.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Cromatografia Líquida
Extração Líquido-Líquido
Pirazinas/análise
Sementes/química
Espectrometria de Massas por Ionização por Electrospray
Syzygium/química
[Mh] Termos MeSH secundário: Amônia/química
Técnicas de Química Analítica/normas
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Pyrazines); 13121-64-7 (tagatosazine); 7664-41-7 (Ammonia)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28778018
[Au] Autor:Pereira NLF; Aquino PEA; Júnior JGAS; Cristo JS; Vieira Filho MA; Moura FF; Ferreira NMN; Silva MKN; Nascimento EM; Correia FMA; Cunha FAB; Boligon AA; Coutinho HDM; Ribeiro-Filho J; Matias EFF; Guedes MIF
[Ad] Endereço:Centro Universitário Dr. Leão Sampaio - UNILEÃO, Juazeiro do Norte, CE, Brazil.
[Ti] Título:Antibacterial activity and antibiotic modulating potential of the essential oil obtained from Eugenia jambolana in association with led lights.
[So] Source:J Photochem Photobiol B;174:144-149, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bacterial resistance has risen as an important health problem with impact on the pharmaceutical industry because many antibiotics have become ineffective, which has affected their commercialization. The Brazilian biodiversity is marked by a vast variety of natural products with significant therapeutic potential, which could bring new perspectives in the treatment of infections caused by resistant microorganisms. The present study aimed to evaluate the antibacterial effect of the essential oil obtained from Eugenia jambolana (EjEO) using the method of microdilution method to determine the Minimum Inhibitory Concentration (MIC). The modulatory effect of this oil on antibiotic activity was determined using both the broth microdilution and gaseous contact methods. The antibacterial effect of the association of the gaseous contact and the use of a LED unit with red and blue lights was also determined. The chemical components of the EjEO were characterized by HPLC, which revealed the presence of α-pinene as a major constituent. The EjEO presented a MIC≥128µg/mL against S. aureus and ≥1024µg/mL against E. coli. The combination of the EjEO with antibiotics presented synergism against E. coli and antagonism against S. aureus. An antagonistic effect was obtained from the association of EjEO with amikacin and erythromycin by the method of gaseous contact. On the other hand, the association of EjEO with ciprofloxacin presented a synergistic effect against S. aureus and E. coli exposed to LED lights. A similar effect was observed in the association of the EjEO with norfloxacin presented synergism against S. aureus in the same conditions. In conclusion, our results demonstrated that the essential oil obtained from Eugenia jambolana interfere with the action of antibiotics against bacteria exposed to LED lights. Thus, further researches are required to elucidate the mechanisms underlying these effects, which could open new perspectives in the development of new antibacterial therapies.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Luz
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
Syzygium/química
[Mh] Termos MeSH secundário: Escherichia coli/efeitos dos fármacos
Escherichia coli/efeitos da radiação
Testes de Sensibilidade Microbiana
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


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[PMID]:28764054
[Au] Autor:VenuGopal KS; Anu-Appaiah KA
[Ad] Endereço:Microbiology and Fermentation Technology, CSIR-Central Food Technological Research Institute, Mysuru 570020, Karnataka, India.
[Ti] Título:Seed incorporation during vinification and its impact on chemical and organoleptic properties in Syzygium cumini wine.
[So] Source:Food Chem;237:693-700, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Syzgium cumini (Jamun) is an evergreen tropical tree, its various parts are known for many therapeutic properties. The present work represents the production of wines from jamun fruits using two different native isolates (Saccharomyces cerevisiae - KF551990 and Pichia gummiguttae - MCC 1273) and influence of jamun seeds on the physico-chemical parameters, chromatic properties, phenolic components and sensory attributes of wine. Wine produced was bottle aged for one year. On aging there was a reduction in bitterness and astringency. Aging lead to reduction in monomeric anthocyanin with an increase in co-pigmented and polymeric anthocynins thus affecting the wine color. Anthocyanin analysis in jamun wine indicated petunidin 3,5-diglucoside as the principal anthocyanin. PCA analysis of wine revealed association of young jamun wine with anthocyanin components. PLS analysis exhibited both positive and negative correlation between various attributes indicating sensory perception of jamun wine is affected by overall composition of the wine.
[Mh] Termos MeSH primário: Syzygium
[Mh] Termos MeSH secundário: Antocianinas
Cor
Sementes
Vitis
Vinho
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


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[PMID]:28763204
[Au] Autor:Woo JH; Ahn JH; Jang DS; Lee KT; Choi JH
[Ad] Endereço:College of Pharmacy, Kyung Hee University , Seoul 02447, South Korea.
[Ti] Título:Effect of Kumatakenin Isolated From Cloves on the Apoptosis of Cancer Cells and the Alternative Activation of Tumor-Associated Macrophages.
[So] Source:J Agric Food Chem;65(36):7893-7899, 2017 Sep 13.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The flower bud of Syzygium aromaticum (clove) has been used for centuries as a spice and herbal medicine. The biological activities of kumatakenin, a flavonoid that has recently been isolated from cloves, are poorly characterized. In the present study, the anticancer effects of kumatakenin in human ovarian cancer cells and tumor-associated macrophages (TAMs) were investigated. We found that kumatakenin exhibited significant cytotoxic activity in human ovarian cancer cells, SKOV3 and A2780. A propidium iodide and Annexin V-FITC staining assay showed that kumatakenin induces apoptosis in ovarian cancer cells. Kumatakenin treatment increased the activity of caspase-3, -8, and -9, and caspase inhibitors attenuated kumatakenin-induced SKOV3 cell death. In addition, kumatakenin was found to reduce the expressions of MCP-1 and RANTES, which are major determinants of macrophage recruitment at tumor sites in ovarian cancer cells. Moreover, kumatakenin inhibited the expression of M2 markers and cancer-promoting factors, including IL-10, MMP-2/-9, and VEGF, in macrophages stimulated by the ovarian cancer cells. In conclusion, these results suggest that kumatakenin shows anticancer activities by inducing apoptosis of ovarian cancer cells and inhibiting the alternative activation of TAM.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Macrófagos/efeitos dos fármacos
Neoplasias Ovarianas/fisiopatologia
Syzygium/química
[Mh] Termos MeSH secundário: Caspase 3/genética
Caspase 3/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Quimiocina CCL2/genética
Quimiocina CCL2/metabolismo
Feminino
Seres Humanos
Interleucina-10/genética
Interleucina-10/metabolismo
Macrófagos/imunologia
Neoplasias Ovarianas/genética
Neoplasias Ovarianas/imunologia
Neoplasias Ovarianas/metabolismo
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCL2 protein, human); 0 (Chemokine CCL2); 0 (Drugs, Chinese Herbal); 0 (Vascular Endothelial Growth Factor A); 130068-27-8 (Interleukin-10); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01543


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[PMID]:28711658
[Au] Autor:Sutariya B; Taneja N; Saraf M
[Ad] Endereço:Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai, 400068, Maharashtra, India.
[Ti] Título:Betulinic acid, isolated from the leaves of Syzygium cumini (L.) Skeels, ameliorates the proteinuria in experimental membranous nephropathy through regulating Nrf2/NF-κB pathways.
[So] Source:Chem Biol Interact;274:124-137, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Membranous nephropathy (MN) is associated with increased oxidative stress and inflammatory markers in the kidney. Betulinic acid (BA) is a potent antioxidant and anti-inflammatory compound isolated from the leaves of Syzygium cumini (L.) Skeels. In the present study, we investigated the effects of BA on experimental MN in rats and explored the mechanisms by which it enhances antioxidant activities and resolves inflammatory condition in experimental MN. Passive Heymann nephritis (PHN) was induced in Sprague-Dawley rats by a single tail vein injection of anti- Fx1A antiserum. The rats were orally administered BA (25 and 50 mg kg  d ) or dexamethasone (DEX; 0.07 mg kg-1, reference compound) for 4 weeks after the induction of PHN. Blood, urine, and kidney tissue were collected for analysis at the end of the study. Treatment of PHN rats with BA or DEX significantly attenuated renal dysfunction, histopathological alterations and reduced immune complex deposition in the kidneys. Furthermore, BA ameliorated mRNA and protein expression of NF-κB, iNOS, TNF-α, Nrf2, HO-1 and NQO1 in the kidney. BA also restored malondialdehyde level and antioxidant enzyme activities in the kidney. In a nutshell, the protective effect of BA can be explained by its anti-inflammatory and anti-oxidant activities, which in turn is due to downregulation of NF-κB pathway and activation of Nrf2. The results indicated that BA can effectively suppress experimental PHN in rats by regulating Nrf2/NF-κB pathways.
[Mh] Termos MeSH primário: Glomerulonefrite Membranosa/prevenção & controle
Proteinúria/prevenção & controle
Transdução de Sinais/efeitos dos fármacos
Syzygium/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticorpos/administração & dosagem
Anticorpos/imunologia
Antioxidantes/metabolismo
Dexametasona/farmacologia
Feminino
Glomerulonefrite Membranosa/patologia
Complexo Antigênico da Nefrite de Heymann/imunologia
Rim/efeitos dos fármacos
Rim/metabolismo
Rim/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Malondialdeído/sangue
Fator 2 Relacionado a NF-E2/genética
Fator 2 Relacionado a NF-E2/metabolismo
NF-kappa B/genética
NF-kappa B/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Coelhos
Ratos
Ratos Sprague-Dawley
Syzygium/metabolismo
Triterpenos/química
Triterpenos/isolamento & purificação
Triterpenos/uso terapêutico
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Antioxidants); 0 (Heymann Nephritis Antigenic Complex); 0 (NF-E2-Related Factor 2); 0 (NF-kappa B); 0 (Triterpenes); 0 (Tumor Necrosis Factor-alpha); 4G6A18707N (betulinic acid); 4Y8F71G49Q (Malondialdehyde); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


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[PMID]:28578702
[Au] Autor:Ulla A; Alam MA; Sikder B; Sumi FA; Rahman MM; Habib ZF; Mohammed MK; Subhan N; Hossain H; Reza HM
[Ad] Endereço:Department of Pharmaceutical Sciences, North South University, Dhaka, -1229, Bangladesh.
[Ti] Título:Supplementation of Syzygium cumini seed powder prevented obesity, glucose intolerance, hyperlipidemia and oxidative stress in high carbohydrate high fat diet induced obese rats.
[So] Source:BMC Complement Altern Med;17(1):289, 2017 Jun 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Obesity and related complications have now became epidemic both in developed and developing countries. Cafeteria type diet mainly composed of high fat high carbohydrate components which plays a significant role in the development of obesity and metabolic syndrome. This study investigated the effect of Syzygium cumini seed powder on fat accumulation and dyslipidemia in high carbohydrate high fat diet (HCHF) induced obese rats. METHOD: Male Wistar rats were fed with HCHF diet ad libitum, and the rats on HCHF diet were supplemented with Syzygium cumini seed powder for 56 days (2.5% w/w of diet). Oral glucose tolerance test, lipid parameters, liver marker enzymes (AST, ALT and ALP) and lipid peroxidation products were analyzed at the end of 56 days. Moreover, antioxidant enzyme activities were also measured in all groups of rats. RESULTS: Supplementation with Syzygium cumini seed powder significantly reduced body weight gain, white adipose tissue (WAT) weights, blood glucose, serum insulin, and plasma lipids such as total cholesterol, triglyceride, LDL and HDL concentration. Syzygium cumini seed powder supplementation in HCHF rats improved serum aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP) activities. Syzygium cumini seed powder supplementation also reduced the hepatic thiobarbituric acid reactive substances (TBARS) and elevated the antioxidant enzyme superoxide dismutase (SOD) and catalase (CAT) activities as well as increased glutathione (GSH) concentration. In addition, histological assessment showed that Syzygium cumini seed powder supplementation prevented inflammatory cell infiltration; fatty droplet deposition and fibrosis in liver of HCHFD fed rats. CONCLUSION: Our investigation suggests that Syzygium cumini seed powder supplementation prevents oxidative stress and showed anti-inflammatory and antifibrotic activity in liver of HCHF diet fed rats. In addition, Syzygium cumini seed powder may be beneficial in ameliorating insulin resistance and dyslipidemia probably by increasing lipid metabolism in liver of HCHF diet fed rats.
[Mh] Termos MeSH primário: Dieta Hiperlipídica/efeitos adversos
Carboidratos da Dieta/efeitos adversos
Intolerância à Glucose/prevenção & controle
Hiperlipidemias/prevenção & controle
Obesidade/prevenção & controle
Syzygium/metabolismo
[Mh] Termos MeSH secundário: Animais
Intolerância à Glucose/dietoterapia
Intolerância à Glucose/metabolismo
Seres Humanos
Hiperlipidemias/dietoterapia
Hiperlipidemias/metabolismo
Masculino
Obesidade/dietoterapia
Obesidade/metabolismo
Estresse Oxidativo
Ratos
Ratos Wistar
Sementes/química
Sementes/metabolismo
Syzygium/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Carbohydrates)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1799-8


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[PMID]:28407719
[Au] Autor:Han X; Parker TL
[Ad] Endereço:a doTERRA International, LLC , Pleasant Grove , UT , USA.
[Ti] Título:Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts.
[So] Source:Pharm Biol;55(1):1619-1622, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Clove (Eugenia caryophyllata Thunb. [Myrtaceae]) essential oil (CEO) has been shown to possess antimicrobial, antifungal, antiviral, antioxidant, anti-inflammatory and anticancer properties. However, few studies have focused on its topical use. OBJECTIVE: We investigated the biological activity of a commercially available CEO in a human skin disease model. MATERIALS AND METHODS: We evaluated the effect of CEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodelling in a validated human dermal fibroblast system, which was designed to model chronic inflammation and fibrosis. Four concentrations of CEO (0.011, 0.0037, 0.0012, and 0.00041%, v/v) were studied. The effect of 0.011% CEO on genome-wide gene expression was also evaluated. RESULTS AND DISCUSSION: CEO at a concentration of 0.011% showed robust antiproliferative effects on human dermal fibroblasts. It significantly inhibited the increased production of several proinflammatory biomarkers such as vascular cell adhesion molecule-1 (VCAM-1), interferon γ-induced protein 10 (IP-10), interferon-inducible T-cell α chemoattractant (I-TAC), and monokine induced by γ interferon (MIG). CEO also significantly inhibited tissue remodelling protein molecules, namely, collagen-I, collagen-III, macrophage colony-stimulating factor (M-CSF), and tissue inhibitor of metalloproteinase 2 (TIMP-2). Furthermore, it significantly modulated global gene expression and altered signalling pathways critical for inflammation, tissue remodelling, and cancer signalling processes. CEO significantly inhibited VCAM-1 and collagen III at both protein and gene expression levels. CONCLUSIONS: This study provides important evidence of CEO-induced anti-inflammatory and tissue remodelling activity in human dermal fibroblasts. This study also supports the anticancer properties of CEO and its major active component eugenol.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Inflamação/tratamento farmacológico
Óleos Voláteis/farmacologia
Syzygium/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Células Cultivadas
Relação Dose-Resposta a Droga
Eugenol/isolamento & purificação
Eugenol/farmacologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/patologia
Fibrose/tratamento farmacológico
Fibrose/patologia
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Inflamação/patologia
Neoplasias/tratamento farmacológico
Neoplasias/patologia
Óleos Voláteis/administração & dosagem
Óleos Voláteis/isolamento & purificação
Transdução de Sinais/efeitos dos fármacos
Pele/efeitos dos fármacos
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Oils, Volatile); 3T8H1794QW (Eugenol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1314513


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[PMID]:28367666
[Au] Autor:M HR; Ghosh D; Banerjee R; Salimath BP
[Ad] Endereço:a Department of Studies in Biotechnology , Molecular Oncology Lab, University of Mysore , Mysore , India.
[Ti] Título:Suppression of VEGF-induced angiogenesis and tumor growth by Eugenia jambolana, Musa paradisiaca, and Coccinia indica extracts.
[So] Source:Pharm Biol;55(1):1489-1499, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Abnormal angiogenesis and evasion of apoptosis are hallmarks of cancer. Accordingly, anti-angiogenic and pro-apoptotic therapies are effective strategies for cancer treatment. Medicinal plants, namely, Eugenia jambolana Lam. (Myrtaceae), Musa paradisiaca L. (Musaceae), and Coccinia indica Wight & Arn. (Cucurbitaceae), have not been greatly investigated for their anticancer potential. OBJECTIVE: We investigated the anti-angiogenic and pro-apoptotic efficacy of ethyl acetate (EA) and n-butanol (NB) extracts of E. jambolana (seeds), EA extracts of M. paradisiaca (roots) and C. indica (leaves) with respect to mammary neoplasia. MATERIALS AND METHODS: Effect of extracts (2-200 µg/mL) on cytotoxicity and MCF-7, MDA-MB-231 and endothelial cell (EC) proliferation and in vitro angiogenesis were evaluated by MTT, [H]thymidine uptake and EC tube formation assays, respectively. In vivo tumour proliferation, VEGF secretion and angiogenesis were assessed using the Ehrlich ascites tumour (EAT) model followed by rat corneal micro-pocket and chicken chorioallantoic membrane (CAM) assays. Apoptosis induction was assessed by morphological and cell cycle analysis. RESULTS: EA extracts of E. jambolana and M. paradisiaca exhibited the highest cytotoxicity (IC 25 and 60 µg/mL), inhibited cell proliferation (up to 81%), and tube formation (83% and 76%). In vivo treatment reduced body weight (50%); cell number (16.5- and 14.7-fold), secreted VEGF (∼90%), neoangiogenesis in rat cornea (2.5- and 1.5-fold) and CAM (3- and 1.6-fold) besides EAT cells accumulation in sub-G1 phase (20% and 18.38%), respectively. DISCUSSION AND CONCLUSION: Considering the potent anti-angiogenic and pro-apoptotic properties, lead molecules from EA extracts of E. jambolana and M. paradisiaca can be developed into anticancer drugs.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Carcinoma de Ehrlich/prevenção & controle
Membrana Corioalantoide/irrigação sanguínea
Cucurbitaceae/química
Musa/química
Neovascularização Patológica
Neovascularização Fisiológica/efeitos dos fármacos
Extratos Vegetais/farmacologia
Syzygium/química
Fator A de Crescimento do Endotélio Vascular/farmacologia
[Mh] Termos MeSH secundário: 1-Butanol/química
Acetatos/química
Inibidores da Angiogênese/isolamento & purificação
Animais
Antineoplásicos Fitogênicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Carcinoma de Ehrlich/sangue
Carcinoma de Ehrlich/patologia
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Embrião de Galinha
Neovascularização da Córnea/patologia
Neovascularização da Córnea/fisiopatologia
Neovascularização da Córnea/prevenção & controle
Relação Dose-Resposta a Droga
Feminino
Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Seres Humanos
Células MCF-7
Camundongos
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Raízes de Plantas/química
Plantas Medicinais
Ratos Wistar
Sementes/química
Fatores de Tempo
Carga Tumoral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Angiogenesis Inhibitors); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); 76845O8NMZ (ethyl acetate); 8PJ61P6TS3 (1-Butanol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1307422



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