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Pesquisa : B01.650.940.800.575.912.250.774.500 [Categoria DeCS]
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[PMID]:28571916
[Au] Autor:Fang Y; Li Q; Shao Q; Wang B; Wei Y
[Ad] Endereço:State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
[Ti] Título:A general ionic liquid pH-zone-refining countercurrent chromatography method for separation of alkaloids from Nelumbo nucifera Gaertn.
[So] Source:J Chromatogr A;1507:63-71, 2017 Jul 21.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The alkaloids from lotus (Nelumbo nucifera Gaertn) are effective in lowering hyperlipemia and level of cholesterol. However, there is not a general method for their separation. In this work, a general ionic liquid pH-zone-refining countercurrent chromatography method for isolation and purification of six alkaloids from the whole lotus plant was successfully established by using ionic liquids as the modifier of the two-phase solvent system. The conditions of ionic liquid pH-zone-refining countercurrent chromatography, involving solvent systems, concentration of retainer and eluter, types of ionic liquids, the content of ionic liquids as well as ionic liquids posttreatment, were optimized to improve extraction efficiency. Finally, the separation of these six alkaloids was performed with a two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water-[C mim][PF ] at a volume ratio of 5:2:2:8:0.1, where 10mM TEA was added to the organic stationary phase as a retainer and 3mM HCl was added to the aqueous mobile phase as an eluter. As a result, six alkaloids including N-nornuciferine, liensinine, nuciferine, isoliensinine, roemerine and neferine were successfully separated with the purities of 97.0%, 90.2%, 94.7%, 92.8%, 90.4% and 95.9%, respectively. The established general method has been respectively applied to the crude samples of lotus leaves and lotus plumules. A total of 37.3mg of liensinine, 57.7mg of isoliensinine and 179.9mg of neferine were successfully purified in one run from 1.00g crude extract of lotus plumule with the purities of 93.2%, 96.5% and 98.8%, respectively. Amount of 45.6mg N-nornuciferine, 21.6mg nuciferine and 11.7mg roemerine was obtained in one step separation from 1.05g crude extract of lotus leaves with the purity of 96.9%, 95.6% and 91.33%, respectively.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Distribuição Contracorrente/métodos
Nelumbo/química
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides/química
Cromatografia Líquida de Alta Pressão
Concentração de Íons de Hidrogênio
Líquidos Iônicos/química
Extratos Vegetais/química
Folhas de Planta/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Ionic Liquids); 0 (Plant Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


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[PMID]:28320373
[Au] Autor:Yang X; Xue L; Zhao Q; Cai C; Liu QH; Shen J
[Ti] Título:Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction.
[So] Source:BMC Complement Altern Med;17(1):159, 2017 Mar 20.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Alkaloids extracted from lotus leaves (AELL) can relax vascular smooth muscle. However, whether AELL has a similar relaxant role on airway smooth muscle (ASM) remains unknown. This study aimed to explore the relaxant property of AELL on ASM and the underlying mechanism. METHODS: Alkaloids were extracted from dried lotus leaves using the high temperature rotary evaporation extraction method. The effects of AELL on mouse ASM tension were studied using force measuring and patch-clamp techniques. RESULTS: It was found that AELL inhibited the high K or acetylcholine chloride (ACh)-induced precontraction of mouse tracheal rings by 64.8 ± 2.9%, or 48.8 ± 4.7%, respectively. The inhibition was statistically significant and performed in a dose-dependent manner. Furthermore, AELL-induced smooth muscle relaxation was partially mediated by blocking voltage-dependent Ca channels (VDCC) and non-selective cation channels (NSCC). CONCLUSION: AELL, which plays a relaxant role in ASM, might be a new complementary treatment to treat abnormal contractions of the trachea and asthma.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Nelumbo/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Animais
Técnicas In Vitro
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Relaxamento Muscular/efeitos dos fármacos
Músculo Liso/fisiologia
Folhas de Planta/química
Traqueia/efeitos dos fármacos
Traqueia/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Extracts); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1674-7


  3 / 269 MEDLINE  
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[PMID]:28314100
[Au] Autor:Li X; Sui Y; Wu Q; Xie B; Sun Z
[Ad] Endereço:College of Food Science and Technology, Huazhong Agricultural University , Wuhan 430070, China.
[Ti] Título:Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice.
[So] Source:J Agric Food Chem;65(19):3801-3810, 2017 May 17.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the protective role of lotus seedpod oligomeric procyanidins (LSOPC) and synbiotics (Bifidobacterium Bb-12 and xylo-oligosaccharide) against high fat and streptozotocin (STZ)-induced diabetes. Administration of LSOPC or synbiotics had no effect on blood glucose in normal mice. Treatments with LSOPC for 12 weeks markedly reduced blood glucose, FFA, endotoxin, and GHbA1c and improved glucose homeostasis, lipid metabolism, and insulin levels. In addition, administration of LSOPC significantly reversed the increase of mTOR and p66 in liver, skeletal muscle, and white adipose tissue (WAT). LSOPC significantly increased glucose uptake and glycolysis in liver, skeletal muscle, and WAT while improving heat generation in brown adipose tissue (BAT) and inhibiting gluconeogenesis and lipogenesis in liver. Furthermore, synbiotics strengthened the improving effect of LSOPC. These findings demonstrated that LSOPC and synbiotics may regulate glucose disposal in peripheral target tissues through the p66 -mTOR signaling pathway.
[Mh] Termos MeSH primário: Biflavonoides/administração & dosagem
Glicemia/metabolismo
Catequina/administração & dosagem
Diabetes Mellitus Experimental/tratamento farmacológico
Nelumbo/química
Extratos Vegetais/administração & dosagem
Proantocianidinas/administração & dosagem
Transdução de Sinais/efeitos dos fármacos
Serina-Treonina Quinases TOR/metabolismo
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/metabolismo
Suplementos Nutricionais/análise
Homeostase/efeitos dos fármacos
Seres Humanos
Insulina/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos ICR
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Blood Glucose); 0 (Insulin); 0 (Plant Extracts); 0 (Proanthocyanidins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.1 (mTOR protein, mouse)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00233


  4 / 269 MEDLINE  
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[PMID]:28273649
[Au] Autor:Sang M; Du G; Hao J; Wang L; Liu E; Zhang Y; Wang T; Gao X; Han L
[Ad] Endereço:Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
[Ti] Título:Modeling and optimizing inhibitory activities of Nelumbinis folium extract on xanthine oxidase using response surface methodology.
[So] Source:J Pharm Biomed Anal;139:37-43, 2017 May 30.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Xanthine oxidase (XOD), which could oxidize hypoxanthine to xanthine and then to uric acid, is a key enzyme in the pathogenesis of hyperuricemia and also a well-known target for the drug development to treat gout. In our study, the total alkaloids of Nelumbinis folium markedly inhibited XOD activity, with IC value being 3.313µg/mL. UHPLC-Q-TOF-MS and 3D docking analysis indicated that roemerine was a potential active ingredient. A response surface methodology combined with central composite design experiment was further developed and validated for the optimization of the reaction conditions between the total alkaloids of Nelumbinis folium and XOD, which could be considered as a meaningful research for the development of XOD inhibitor rapidly and sensitively.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Inibidores Enzimáticos/química
Modelos Moleculares
Nelumbo
Extratos Vegetais/química
Xantina Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/farmacologia
Inibidores Enzimáticos/farmacologia
Inibidores Enzimáticos/uso terapêutico
Supressores da Gota/química
Supressores da Gota/farmacologia
Supressores da Gota/uso terapêutico
Hiperuricemia/tratamento farmacológico
Hiperuricemia/enzimologia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Folhas de Planta
Xantina Oxidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Enzyme Inhibitors); 0 (Gout Suppressants); 0 (Plant Extracts); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


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[PMID]:28236459
[Au] Autor:Wang Y; Zhang L; Zhou H; Guo X; Wu S
[Ad] Endereço:Research Center of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.
[Ti] Título:K-targeted strategy for isolation of phenolic alkaloids of Nelumbo nucifera Gaertn by counter-current chromatography using lysine as a pH regulator.
[So] Source:J Chromatogr A;1490:115-125, 2017 Mar 24.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Counter-current chromatography (CCC) is an efficient liquid-liquid partition chromatography technique without support matrix. Despite there are many significant advancements in the CCC separation of natural products especially for non-ionic neutral compounds, CCC isolation of ionic compounds including alkaloids is still a challenging process guide by classical partition coefficients (K) or distribution ratio (K ) because their partition coefficient could not be equal to distribution ratio in common ionic conditions. Here, taking the extract of embryo of the seed of Nelumbo nucifera Gaertn as sample, we introduced a modified K-targeted strategy for isolation of phenolic alkaloids by use of lysine as a pH regulator. The results indicated that if the mass of basic regulators such as aqueous ammonia and lysine added into the solvent system were high enough to inhibit the ionization of the targeted alkaloids, the distribution ratio of targets with ionic and non-ionic molecular forms got stable and might not been changed as the concentration of the pH regulator. In this case, the distribution ratio of target was almost equal to the partition coefficient. Thus, the targets could be isolated by K-targeted CCC separation through adding a certain amount pH regulators into the solvent system. Further experiments also showed that the sample concentration was an important factor on the distribution ratio of targets. Meanwhile, CCC experiments indicated that lysine was more suitable than aqueous ammonia for the separation of phenolic alkaloids because the chemical property of lysine-target complex in the CCC fractions was more stable. Therefore, the preparative CCC separation was performed using 20mM lysine as a pH regulator with more than 800mg injection mass. After simple back-extraction with dichloromethane, the lysine in the CCC fraction was removed completely and pure isoliensinine and neferine were obtained. In summary, the whole results indicated that the modified K-targeted CCC strategy using lysine as the pH regulator was efficient for isolation of phenolic alkaloids from crude plant extracts. It not only provided a practical strategy for the isolation of neferine and its analogues, but also introduced a powerful method to resolve the peak skewing (leading or tailing) in CCC separation of ionic compounds.
[Mh] Termos MeSH primário: Alcaloides
Distribuição Contracorrente/métodos
Lisina/química
Nelumbo/química
Fenóis
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Alcaloides/análise
Alcaloides/química
Alcaloides/isolamento & purificação
Fenóis/análise
Fenóis/química
Fenóis/isolamento & purificação
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Phenols); 0 (Plant Extracts); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


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[PMID]:27987489
[Au] Autor:Li F; Sun XY; Li XW; Yang T; Qi LW
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
[Ti] Título:Enrichment and separation of quercetin-3-O-ß-d-glucuronide from lotus leaves (nelumbo nucifera gaertn.) and evaluation of its anti-inflammatory effect.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1040:186-191, 2017 Jan 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This work aimed to establish a systematic strategy to enrich and separate quercetin-3-O-ß-d-glucuronide (Q3GA) from lotus leaves with macroporous resin and semi-preparative HPLC. Six resins were tested, and LX-5 was chosen as the appropriate resin for Q3GA based on the adsorption and desorption performances. After one-step enrichment, the content of Q3GA increased from 2.15% in crude extract to 52.25% in 30% ethanol fraction with yield of 11.97%. The Q3GA was then isolated from the 30% ethanol fraction by semi-preparative HPLC, and the purity of Q3GA was above 98.00% with yield of 19.76%. These results suggested that the aforementioned strategy was a useful and economic method to enrich and separate Q3GA from lotus leaves. Additionally, the anti-inflammatory effect of Q3GA was evaluated in lipopolysaccharide-treated RAW264.7 macrophages, and the result demonstrated that Q3GA could significantly inhibit LPS-induced NO release in vitro in a dose-dependent manner compared with control group.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Nelumbo/química
Folhas de Planta/química
Quercetina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/métodos
Lipopolissacarídeos/imunologia
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Camundongos
Óxido Nítrico/imunologia
Quercetina/isolamento & purificação
Quercetina/farmacologia
Células RAW 264.7
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (quercetin 3-O-glucuronide); 31C4KY9ESH (Nitric Oxide); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE


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[PMID]:27831927
[Au] Autor:Libao C; Runzhi J; Mengli Y; Liangjun L; Shuyan L
[Ad] Endereço:School of Horticulture and Plant Protection, Yangzhou University, Jiangsu, P. R.
[Ti] Título:A comparative proteomic analysis for adventitious root formation in lotus root (Nelumbo nucifera Gaertn).
[So] Source:Z Naturforsch C;72(5-6):181-196, 2017 May 01.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Adventitious roots (ARs) directly affect lotus seedling growth and product quality because principal root is not well developed. However, the details of AR formation at the molecular level have not been determined in lotus. Therefore, three stages were chosen to identify the change of proteins abundant during rhizome formation, using isobaric tags for relative and absolute quantization coupled with liquid chromatography-tandem mass spectrometry to gain insight into the molecular mechanisms involved in AR formation. We totally obtained 323,375 spectra during AR formation. After filtering to eliminate low-scoring spectra, 66,943 spectra, including 53,106 unique spectra, were identified. These unique spectra matched 28,905 peptides, including 24,992 unique peptides, which were assembled into 6686 proteins. In the C0/C1 and C1/C2 stages, 66 and 32 proteins showed enhanced abundance, and 173 and 73 proteins showed decreased abundance, respectively. Seventeen important AR formation-related proteins from the three stages were identified, and the expressions of nine genes from the above-identified proteins were assessed by qRT-PCR. This article provides a comprehensive understanding of the changes in metabolism during AR formation, and is helpful to accelerate the progress of breeding in fulture in lotus root.
[Mh] Termos MeSH primário: Nelumbo/metabolismo
Proteínas de Plantas/metabolismo
Proteômica/métodos
Rizoma/metabolismo
[Mh] Termos MeSH secundário: Cromatografia Líquida
Regulação da Expressão Gênica de Plantas
Nelumbo/genética
Nelumbo/crescimento & desenvolvimento
Proteínas de Plantas/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Rizoma/crescimento & desenvolvimento
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


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[PMID]:27667670
[Au] Autor:Sharma BR; Gautam LN; Adhikari D; Karki R
[Ad] Endereço:Department of Oriental Medicine Resources, College of Natural Sciences, Mokpo National University, 61, Muan-gun, Jeonnam, 534-729, Korea.
[Ti] Título:A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development.
[So] Source:Phytother Res;31(1):3-26, 2017 Jan.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nelumbo nucifera, also known as sacred lotus, has primarily been used as food throughout the Asian continent, and its medicinal values have been described in Ayurvedic and Traditional Chinese Medicine. The purpose of this study is to systematically characterize the chemical profiling and pharmacological activities of N. nucifera. Herein, we critically reviewed and analysed the phytochemical and pharmacological reports of N. nucifera. Our search for the keyword 'Nelumbo nucifera pharmacology' in all databases reported in Web of Science yielded 373 results excluding reviews and abstracts in document types. Two hundred and forty-three spectrum natural compounds from different parts of N. nucifera belonging to diverse chemical groups, including alkaloids, flavonoids, glycosides, terpenoids, steroids, fatty acids, proteins, minerals, and vitamins have been reported. In addition, distinct pharmacological activities, mainly against cancer, microbial infection, diabetes, inflammation, atherosclerosis, and obesity, have been associated with crude extracts, fractions, and isolated compounds. This review highlights potential use of neferine, liensinine, isoliensinine, and nuciferine in clinical trials. In depth, mechanism of the potential chemical entities from N. nucifera via structure activity relationship needs to be explored to guarantee the stability and safety for the clinical use. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Medicina Tradicional Chinesa/métodos
Nelumbo/química
Fitoterapia/métodos
Extratos Vegetais/química
Sementes/química
[Mh] Termos MeSH secundário: Desenho de Drogas
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5732


  9 / 269 MEDLINE  
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[PMID]:27596426
[Au] Autor:Li S; Li X; Lamikanra O; Luo Q; Liu Z; Yang J
[Ad] Endereço:College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
[Ti] Título:Effect of cooking on physicochemical properties and volatile compounds in lotus root (Nelumbo nucifera Gaertn).
[So] Source:Food Chem;216:316-23, 2017 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of boiling and steaming on lotus root volatile compounds and some of its physicochemical properties were determined. A total of 52 compounds identified in the raw tuber by GC-MS were a combination of the rhizome's native compounds and those from the soil and water environment, and are predominantly a mixture of straight chain and cyclic alkanes, and aromatic hydrocarbons. Boiling increased concentrations of most of these compounds, unlike steaming that lowered total volatile components of the tuber. Cooking increased complexity of volatile compounds with the production of new compounds such as methylated derivatives, particularly in steam cooked lotus. Other heat-induced compounds include antioxidants such as butylated hydroxyl compounds and antifungal organic compounds such as dimethyl disulfide. Instrumental texture measurements indicate that the characteristic post-cooked retention of crunchiness in lotus root is likely to be related to retention of its springiness index through the cooking process.
[Mh] Termos MeSH primário: Culinária
Nelumbo/química
Raízes de Plantas/química
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Antifúngicos/análise
Antioxidantes/análise
Dissulfetos/análise
Temperatura Alta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antioxidants); 0 (Disulfides); 0 (Volatile Organic Compounds); 3P8D642K5E (dimethyl disulfide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


  10 / 269 MEDLINE  
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[PMID]:27827862
[Au] Autor:Zheng Y; Wang Q; Zhuang W; Lu X; Miron A; Chai TT; Zheng B; Xiao J
[Ad] Endereço:College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China. zyffst@163.com.
[Ti] Título:Cytotoxic, Antitumor and Immunomodulatory Effects of the Water-Soluble Polysaccharides from Lotus (Nelumbo nucifera Gaertn.) Seeds.
[So] Source:Molecules;21(11), 2016 Nov 02.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Lotus is an edible and medicinal plant, and the extracts from its different parts exhibit various bioactivities. In the present study, the hot water-soluble polysaccharides from lotus seeds (LSPS) were evaluated for their cancer cell cytotoxicity, immunomodulatory and antitumor activities. LSPS showed significant inhibitory effects on the mouse gastric cancer MFC cells, human liver cancer HuH-7 cells and mouse hepatocarcinoma H22 cells. The animal studies showed that LSPS inhibited tumor growth in H22 tumor-bearing mice with the highest inhibition rate of 45.36%, which is comparable to that induced by cyclophosphamide (30 mg/kg) treatment (50.79%). The concentrations of white blood cells were significantly reduced in cyclophosphamide-treated groups ( < 0.01), while LSPS showed much fewer side effects according to the hematology analysis. LSPS improved the immune response in H22 tumor-bearing mice by enhancing the spleen and thymus indexes, and increasing the levels of serum cytokines including tumor necrosis factor-α and interleukin-2. Moreover, LSPS also showed in vivo antioxidant activity by increasing superoxide dismutase activity, thus reducing the malondialdehyde level in the liver tissue. These results suggested that LSPS can be used as an antitumor and immunomodulatory agent.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Fatores Imunológicos/farmacologia
Nelumbo/química
Extratos Vegetais/farmacologia
Polissacarídeos/farmacologia
Sementes/química
[Mh] Termos MeSH secundário: Animais
Biomarcadores
Linhagem Celular Tumoral
Citocinas/sangue
Citocinas/metabolismo
Seres Humanos
Imunomodulação/efeitos dos fármacos
Camundongos
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Biomarkers); 0 (Cytokines); 0 (Immunologic Factors); 0 (Plant Extracts); 0 (Polysaccharides)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE



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