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Pesquisa : B01.650.940.800.575.912.250.776.500 [Categoria DeCS]
Referências encontradas : 72 [refinar]
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[PMID]:28659035
[Au] Autor:Bing SJ; Cho J; Kim A; Herath KHINM; Ahn G; Lee NH; Park JW; Jee Y
[Ad] Endereço:* Department of Veterinary Medicine and Institute for Nuclear Science & Technology, Jeju National University, Jeju 63243, South Korea.
[Ti] Título:Geraniin Promotes Recovery of Hematopoietic Cells after Radiation Injury.
[So] Source:Am J Chin Med;45(5):1003-1016, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Cells of the hematopoietic system are uniquely radiosensitive due to their rapid proliferation. Consequently, immune suppression readily and undesirably results from irradiation. Our previous studies demonstrated that geraniin isolated from Nymphaea tetragona var. angusta (water lily) had a protective effect on the splenocytes and intestinal tract of irradiated mice. This study was designed to assess the effectiveness of geraniin, an ellagitannin isolated from the water lily, in decreasing gamma ray irradiation-induced destruction of the hematopoietic system in mice. Geraniin treatment improved the survival time of bone marrow cells and maintained bone marrow integrity and also up-regulated the expression of stem cell receptors and the extent of cell mitosis. Geraniin also enhanced the proliferation and differentiation of immune cells that had been suppressed by irradiation. These results suggest geraniin is a promising agent for reconstituting hematopoietic cells after exposure to irradiation.
[Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos
Diferenciação Celular/efeitos da radiação
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/efeitos da radiação
Glucosídeos/farmacologia
Células-Tronco Hematopoéticas/citologia
Taninos Hidrolisáveis/farmacologia
Lesões Experimentais por Radiação/tratamento farmacológico
Protetores contra Radiação/farmacologia
[Mh] Termos MeSH secundário: Animais
Células da Medula Óssea
Células Cultivadas
Raios gama/efeitos adversos
Glucosídeos/administração & dosagem
Glucosídeos/isolamento & purificação
Glucosídeos/uso terapêutico
Células-Tronco Hematopoéticas/efeitos da radiação
Taninos Hidrolisáveis/administração & dosagem
Taninos Hidrolisáveis/isolamento & purificação
Taninos Hidrolisáveis/uso terapêutico
Injeções Intraperitoneais
Camundongos Endogâmicos C57BL
Nymphaea/química
Fitoterapia
Lesões Experimentais por Radiação/patologia
Protetores contra Radiação/uso terapêutico
Baço/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosides); 0 (Hydrolyzable Tannins); 0 (Radiation-Protective Agents); 0 (ellagitannin); 60976-49-0 (Geraniin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500537


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[PMID]:28282879
[Au] Autor:Zhao J; Zhang S; You S; Liu T; Xu F; Ji T; Gu Z
[Ad] Endereço:Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi 830004, China. zhaojun21cn@163.com.
[Ti] Título:Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice.
[So] Source:Int J Mol Sci;18(3), 2017 Mar 08.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Nymphaea candida was used to treat hepatitis in Ugyhur medicine, and nicotiflorin (kaempferol 3-O-ß-rutinoside) is the main characteristic component in this plant [...].
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Concanavalina A/efeitos adversos
Flavonoides/farmacologia
Galactosamina/efeitos adversos
Nymphaea/química
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Citocinas/metabolismo
Modelos Animais de Doenças
Flavonoides/química
Testes de Função Hepática
Camundongos
Estrutura Molecular
Oxirredução/efeitos dos fármacos
Estresse Oxidativo
Fenóis/química
Extratos Vegetais/química
Substâncias Protetoras/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Protective Agents); 0 (nicotiflorin); 11028-71-0 (Concanavalin A); 7535-00-4 (Galactosamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28095910
[Au] Autor:Bakr RO; El-Naa MM; Zaghloul SS; Omar MM
[Ad] Endereço:Pharmacognosy Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt. rehambkr@yahoo.com.
[Ti] Título:Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity.
[So] Source:BMC Complement Altern Med;17(1):52, 2017 Jan 17.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nymphaea alba L. represents an interesting field of study. Flowers have antioxidant and hepatoprotective effects, rhizomes constituents showed cytotoxic activity against liver cell carcinoma, while several Nymphaea species have been reported for their hepatoprotective effects. Leaves of N. alba have not been studied before. Therefore, in this study, in-depth characterization of the leaf phytoconstituents as well as its antioxidant and hepatoprotective activities have been performed where N. alba leaf extract was evaluated as a possible therapeutic alternative in hepatic disorders. METHODS: The aqueous ethanolic extract (AEE, 70%) was investigated for its polyphenolic content identified by high-resolution electrospray ionisation mass spectrometry (HRESI-MS/MS), while the petroleum ether fraction was saponified, and the lipid profile was analysed using gas liquid chromatography (GLC) analysis and compared with reference standards. The hepatoprotective activity of two doses of the extract (100 and 200 mg/kg; P.O.) for 5 days was evaluated against CCl -induced hepatotoxicity in male Wistar albino rats, in comparison with silymarin. Liver function tests; aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transpeptidase (GGT) and total bilirubin were performed. Oxidative stress parameters; malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC) as well as inflammatory mediator; tumour necrosis factor (TNF)-α were detected in the liver homogenate. Histopathological examination of the liver and immunohistochemical staining of caspase-3 were performed RESULTS: Fifty-three compounds were tentatively identified for the first time in N.alba leaf extract, where ellagitannins represent the main identified constituents. Nine hydrocarbons, two sterols and eleven fatty acids were identified in the petroleum ether extract where, palmitic acid and linolenic acids represented the major saturated and unsaturated fatty acid respectively. N.alba AEE significantly improved the liver function, oxidative stress parameters as well as TNF-α in addition to the amelioration of histopathological features of the liver and a profound decrease in caspase-3 expression. CONCLUSION: These results shed light on the hepatoprotective effect of N. alba that is comparable with that of silymarin. The antioxidant activities of N. alba extract in addition to the inhibition of crucial inflammatory mediator, as TNF-α, might be the possible hepatoprotective mechanisms.
[Mh] Termos MeSH primário: Anti-Inflamatórios/química
Antioxidantes/química
Nymphaea/química
Extratos Vegetais/química
Substâncias Protetoras/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Egito
Seres Humanos
Fígado/efeitos dos fármacos
Fígado/imunologia
Masculino
Nymphaea/crescimento & desenvolvimento
Extratos Vegetais/farmacologia
Folhas de Planta/química
Substâncias Protetoras/farmacologia
Ratos
Ratos Wistar
Silimarina/farmacologia
Espectrometria de Massas em Tandem
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); 0 (Silymarin); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1561-2


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[PMID]:27824613
[Au] Autor:Oyeyemi IT; Akanni OO; Adaramoye OA; Bakare AA
[Ti] Título:Methanol extract of Nymphaea lotus ameliorates carbon tetrachloride-induced chronic liver injury in rats via inhibition of oxidative stress.
[So] Source:J Basic Clin Physiol Pharmacol;28(1):43-50, 2017 Jan 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nymphaea lotus (NL) is an aquatic perennial plant used traditionally in the management of various liver diseases. In this study, the protective effect of methanol extract of NL against carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats was investigated. METHODS: Male Wistar rats were assigned into six groups of five rats each. Group I received corn oil (0.5 mL p.o.) and served as control, group II received CCl4 (1 mL/kg i.p., 1:3 in corn oil), group III received NL (200 mg/kg), and groups IV, V, and VI received CCl4+NL (50, 100, and 200 mg/kg, respectively) for 6 weeks. Twenty-four hours after the last exposure, rats were bled and killed. RESULTS: The activities of alanine aminotransaminase (ALT), aspartate aminotransferase (AST), and levels of total bilirubin (TB) in the serum, thiobarbituric acid reactive substances (TBARS), superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione (GSH) in the liver, and histopathology of the liver were determined using standard procedures. NL significantly (p<0.05) lowered the levels of ALT, AST, and TB and exhibited antioxidant potentials in rats exposed to CCl4 relative to the control values. Specifically, NL at 100 and 200 mg/kg significantly (p<0.05) increased CCl4-induced decrease in hepatic GSH and GPx and also decreased the level of hepatic TBARS in CCl4-intoxicated rats. Histopathological findings revealed cellular infiltration and fibrosis in rats that received CCl4 only, which were ameliorated in rats that received NL+CCl4. CONCLUSIONS: The data suggest that NL exhibited hepatoprotective effects in CCl4-intoxicated rats via antioxidative mechanism.
[Mh] Termos MeSH primário: Tetracloreto de Carbono/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Metanol/uso terapêutico
Nymphaea
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Masculino
Metanol/farmacologia
Estresse Oxidativo/fisiologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); CL2T97X0V0 (Carbon Tetrachloride); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


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[PMID]:27829354
[Au] Autor:Wu Q; Wu J; Li SS; Zhang HJ; Feng CY; Yin DD; Wu RY; Wang LS
[Ad] Endereço:Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
[Ti] Título:Transcriptome sequencing and metabolite analysis for revealing the blue flower formation in waterlily.
[So] Source:BMC Genomics;17(1):897, 2016 11 09.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Waterlily (Nymphaea spp.), a perennial herbaceous aquatic plant, is divided into two ecological groups: hardy waterlily and tropical waterlily. Although the hardy waterlily has no attractive blue flower cultivar, its adaptability is stronger than tropical waterlily because it can survive a cold winter. Thus, breeding hardy waterlily with real blue flowers has become an important target for breeders. Molecular breeding may be a useful way. However, molecular studies on waterlily are limited due to the lack of sequence data. RESULTS: In this study, six cDNA libraries generated from the petals of two different coloring stages of blue tropical waterlily cultivar Nymphaea 'King of Siam' were sequenced using the Illumina HiSeq™ 2500 platform. Each library produced no less than 5.65 Gb clean reads. Subsequently, de novo assembly generated 112,485 unigenes, including 26,206 unigenes annotated to seven public protein databases. Then, 127 unigenes could be identified as putative homologues of color-related genes in other species, including 28 up-regulated and 5 down-regulated unigenes. In petals, 16 flavonoids (4 anthocyanins and 12 flavonols) were detected in different contents during the color development due to the different expression levels of color-related genes, and four flavonols were detected in waterlily for the first time. Furthermore, UA3GTs were selected as the most important candidates involved in the flavonoid metabolic pathway, UA3GTs induced blue petal color formation in Nymphaea 'King of Siam'. CONCLUSIONS: This study will improve our understanding of the molecular mechanism of blue flowers in waterlily and provide the basis for molecular breeding of blue hardy waterlily cultivars.
[Mh] Termos MeSH primário: Flores/genética
Flores/metabolismo
Metaboloma
Nymphaea/genética
Nymphaea/metabolismo
Transcriptoma
[Mh] Termos MeSH secundário: Biologia Computacional/métodos
Perfilação da Expressão Gênica
Metabolômica
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE


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[PMID]:27215682
[Au] Autor:Bello FH; Maiha BB; Anuka JA
[Ad] Endereço:Department of Pharmacology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. Electronic address: tbells116@gmail.com.
[Ti] Título:The effect of methanol rhizome extract of Nymphaea lotus Linn. (Nymphaeaceae) in animal models of diarrhoea.
[So] Source:J Ethnopharmacol;190:13-21, 2016 Aug 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Nymphaea lotus, which is widely distributed throughout tropical Africa, enjoys a number of ethnomedical uses in Nigeria. Traditionally, the rhizomes of N. lotus are used to cure diarrhoea. AIM OF STUDY: This study aims to evaluate the antidiarrhoeal activity of the methanol rhizome extract of N. lotus plant in laboratory animals. MATERIALS AND METHODS: The extract was screened for activity against castor oil-induced diarrhoea and magnesium sulphate-induced diarrhoea as well as effect on gastric transit time in mice. The effect of methanol rhizome extract of Nymphaea lotus on the perfused isolated tissue preparation was also determined. RESULTS: For castor oil-induced diarrhoea, the extract at doses of 200, 400 and 800mg/kg produced significant reduction in the frequency of diarrhoea (at p<0.001, p<0.001 and p<0.01 respectively). The extract at 800mg/kg produced a significant delay in onset of diarrhoea (p<0.05) comparable to loperamide (3mg/kg). The frequency of magnesium sulphate-induced diarrhoea was also significantly reduced in the groups treated with 200, 400 and 800mg/kg of the extract at p<0.001, p<0.001 and p<0.01 respectively. At doses of 200mg/kg and 400mg/kg, the protection produced was comparable to loperamide, 3mg/kg. All treated groups produced significant reduction in the transit of charcoal meal along the intestinal tract at p<0.001. The extract at low concentration (4×10(-4)-6.4×10(-2)mg/ml) had contractile effect on the tone of contraction of the rabbit jejunum while at higher concentrations (8×10(-2)-512×10(-2)mg/ml) produced significant reduction in the tone and rate of spontaneous contraction of rabbit jejunum. The extract at lower concentrations (4×10(-4)-2×10(-2)mg/ml) has no effect on contraction of the guinea pig ileum while higher concentrations (4×10(-2)-512×10(-2)mg/ml) produced significant relaxant activity on guinea pig ileum. CONCLUSION: This study has shown that the methanol rhizome extract of N. lotus has antidiarrhoeal properties thus justifying its use by the local population for this purpose.
[Mh] Termos MeSH primário: Antidiarreicos/farmacologia
Defecação/efeitos dos fármacos
Diarreia/prevenção & controle
Íleo/efeitos dos fármacos
Jejuno/efeitos dos fármacos
Metanol/química
Nymphaea/química
Peristaltismo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Rizoma/química
Solventes/química
[Mh] Termos MeSH secundário: Animais
Antidiarreicos/isolamento & purificação
Antidiarreicos/toxicidade
Óleo de Rícino
Diarreia/induzido quimicamente
Diarreia/fisiopatologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Feminino
Cobaias
Íleo/fisiopatologia
Técnicas In Vitro
Jejuno/fisiopatologia
Dose Letal Mediana
Loperamida/farmacologia
Sulfato de Magnésio
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Coelhos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidiarrheals); 0 (Plant Extracts); 0 (Solvents); 6X9OC3H4II (Loperamide); 7487-88-9 (Magnesium Sulfate); 8001-79-4 (Castor Oil); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE


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[PMID]:26915077
[Au] Autor:Park G; Sim Y; Lee W; Sung SH; Oh MS
[Ad] Endereço:Department of Life and Nanopharmaceutical Science, Graduates School and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, Seoul, Republic of Korea.
[Ti] Título:Protection on Skin Aging Mediated by Antiapoptosis Effects of the Water Lily (Nymphaea Tetragona Georgi) via Reactive Oxygen Species Scavenging in Human Epidermal Keratinocytes.
[So] Source:Pharmacology;97(5-6):282-93, 2016.
[Is] ISSN:1423-0313
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:AIMS: The water lily (WL) is found in Europe, Asia, and North America. WL reportedly has various pharmacological activities that improve the activities of daily life in humans. To our knowledge, no previous study has investigated about the aspect of protection on skin aging due to the mitochondria-mediated antiapoptosis effects of WL rhizome extract (WLRE) on human epidermal keratinocytes. METHODS: Human epidermal keratinocytes cells were treated with WLRE (100, 200, and 400 µg/ml) for 1 h and then with ultraviolet radiation B (UVB) (50 mJ/cm2) for another 23 h. The levels of lactate dehydrogenase, reactive oxygen species (ROS), MitoTracker, caspase-3, and glutathione were analyzed spectrophotometrically. Also, the levels of B-cell lymphoma 2 (Bcl-2) family proteins were determined with immunohistochemistry or western blotting. RESULTS: We investigated the protective effects of WLRE against UVB-induced mitochondria-mediated apoptosis. WLRE significantly and concentrations-dependently reduced UVB-induced apoptotic cytotoxicity. Furthermore, WLRE decreased ROS generation, mitochondrial dysfunction, Bcl-2-associated X protein levels, and cytochrome c release from mitochondria while increasing Bcl-2 protein levels as assessed. Moreover, WLRE inhibited caspase-3 activity and expression, indicating the inhibition of the apoptotic cascade, and induced increased levels of total glutathione, heme oxygenase 1, and radical-scavenging activity. CONCLUSION: Together, these results demonstrate that WLRE can protect human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis by regulating ROS-eliminating pathways.
[Mh] Termos MeSH primário: Queratinócitos/efeitos dos fármacos
Nymphaea
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Envelhecimento da Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Citocromos c/metabolismo
Glutationa/metabolismo
Seres Humanos
Queratinócitos/metabolismo
Mitocôndrias/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Rizoma
Envelhecimento da Pele/fisiologia
Raios Ultravioleta/efeitos adversos
Proteína X Associada a bcl-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (BAX protein, human); 0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Reactive Oxygen Species); 0 (bcl-2-Associated X Protein); 9007-43-6 (Cytochromes c); EC 3.4.22.- (Caspase 3); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160226
[St] Status:MEDLINE
[do] DOI:10.1159/000444022


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[PMID]:26419810
[Au] Autor:Taylor ML; Cooper RL; Schneider EL; Osborn JM
[Ad] Endereço:Department of Biology, Creighton University, 2500 California Plaza, Omaha, Nebraska 68178-0324 USA MackenzieTaylor@creighton.edu.
[Ti] Título:Pollen structure and development in Nymphaeales: insights into character evolution in an ancient angiosperm lineage.
[So] Source:Am J Bot;102(10):1685-702, 2015 Oct.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: A knowledge of pollen characters in early-diverging angiosperm lineages is essential for understanding pollen evolution and the role of pollen in angiosperm diversification. In this paper, we report and synthesize data on mature pollen and pollen ontogeny from all genera of Nymphaeales within a comparative, phylogenetic context and consider pollen evolution in this early-diverging angiosperm lineage. We describe mature pollen characters for Euryale, Barclaya, and Nymphaea ondinea, taxa for which little to no structural data exist. METHODS: We studied mature pollen for all nymphaealean genera using light, scanning electron, and transmission electron microscopy. We reviewed published reports of nymphaealean pollen to provide a comprehensive discussion of pollen characters in water lilies. KEY RESULTS: Nymphaeales exhibit diversity in key pollen characters, including dispersal unit size, ornamentation, aperture morphology, and tapetum type. All Nymphaeales pollen are tectate-columellate, exhibiting one of two distinct patterns of infratectal ultrastructure-a thick infratectal space with robust columellae or a thin infratectal space with thin columellae. All genera have pollen with a lamellate endexine that becomes compressed in the proximal, but not distal wall. This endexine ultrastructure supports the operculate hypothesis for aperture origin. Nymphaeaceae pollen exhibit a membranous granular layer, which is a synapomorphy of the family. CONCLUSIONS: Variation in pollen characters indicates that significant potential for lability in pollen development was present in Nymphaeales at the time of its divergence from the rest of angiosperms. Structural and ontogenetic data are essential for interpreting pollen characters, such as infratectum and endexine ultrastructure in Nymphaeales.
[Mh] Termos MeSH primário: Nymphaeaceae/anatomia & histologia
Nymphaeaceae/crescimento & desenvolvimento
Pólen/anatomia & histologia
Pólen/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Evolução Biológica
Malásia
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Nymphaea/anatomia & histologia
Nymphaea/classificação
Nymphaea/crescimento & desenvolvimento
Nymphaea/ultraestrutura
Nymphaeaceae/classificação
Nymphaeaceae/ultraestrutura
Filogenia
Pólen/ultraestrutura
Polinização
Estados Unidos
Austrália Ocidental
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151015
[Lr] Data última revisão:
151015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151001
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1500249


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[PMID]:26325430
[Au] Autor:Hossain MA; Lee SJ; Park JY; Reza MA; Kim TH; Lee KJ; Suh JW; Park SC
[Ad] Endereço:College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, South Korea. Electronic address: mdakil_hossain@yahoo.com.
[Ti] Título:Modulation of quorum sensing-controlled virulence factors by Nymphaea tetragona (water lily) extract.
[So] Source:J Ethnopharmacol;174:482-91, 2015 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Nymphaea tetragona is a widely distributed ornamental species with ethnomedicinal uses in the treatment of diarrhea, dysentery, eruptive fevers, and infections. The anti-infectious activities of this herb have already been assessed to clarify its traditional use as a medicine. AIM OF STUDY: In this study, we aimed to verify the inhibitory effects of N. tetragona 50% methanol extract (NTME) on quorum sensing (QS)-controlled virulence factors of bacteria since QS and its virulence factors are novel targets for antimicrobial therapy. MATERIALS AND METHODS: The antibacterial activity of this extract was evaluated against Chromobacterium violaceum and Pseudomonas aeruginosa. The inhibition of the violacein pigment of C. violaceum by NTME was determined qualitative and quantitative using standard methods. The effects of NTME on swarming motility, biofilm viability, pyocyanin production, and LasA protease activity were evaluated using P. aeruginosa. Finally, the in vitro and in vivo cytotoxicity of NTME were verified by MTT assay and oral administration to rats, respectively. RESULTS: The extract had concentration-dependent antibacterial activity against gram-negative bacteria. NTME at 1/2× minimum inhibitory concentration (MIC), 1× MIC and 2× MIC significantly lowered the levels of violacein of C. violaceum compared to that of the control. The swarming motility of P. aeruginosa was inhibited by ≥70% by treatment with 1/2× MIC of NTME. There were remarkable reductions in pyocyanin production and LasA protease activity in the overnight culture supernatant of P. aeruginosa supplemented with NTME when compared with that of the untreated control. The confocal micrographs of 24h biofilms of P. aeruginosa exposed to NTME exhibited a lower number of live cells than the control. No toxic effect was observed in in vitro and in vivo cytotoxicity assays of NTME. CONCLUSIONS: NTME was demonstrated to have significant concentration-dependent inhibitory effects on quorum sensing-mediated virulence factors of bacteria with non-toxic properties, and could thus be a prospective quorum sensing inhibitor.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Bactérias/patogenicidade
Nymphaea/química
Extratos Vegetais/farmacologia
Percepção de Quorum/efeitos dos fármacos
Fatores de Virulência
[Mh] Termos MeSH secundário: Animais
Biofilmes/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Chromobacterium/efeitos dos fármacos
Relação Dose-Resposta a Droga
Camundongos
Testes de Sensibilidade Microbiana
Pseudomonas aeruginosa/efeitos dos fármacos
Piocianina/biossíntese
Ratos
Staphylococcus aureus/efeitos dos fármacos
Sais de Tetrazólio
Tiazóis
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Tetrazolium Salts); 0 (Thiazoles); 0 (Virulence Factors); 9OQM399341 (Pyocyanine); EUY85H477I (thiazolyl blue)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150902
[St] Status:MEDLINE


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[PMID]:25976993
[Au] Autor:Yin DD; Yuan RY; Wu Q; Li SS; Shao S; Xu YJ; Hao XH; Wang LS
[Ad] Endereço:Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Assessment of flavonoids and volatile compounds in tea infusions of water lily flowers and their antioxidant activities.
[So] Source:Food Chem;187:20-8, 2015 Nov 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Water lily, a member of the Nymphaeaceae family, can be made into tea on the basis of outstanding fragrance characteristics and health care functions. In this study, 16 flavonoids were identified and quantified in tea infusions prepared from the petals of 33 water lily cultivars using HPLC-DAD and HPLC-ESI-MS/MS. The infusions were analyzed with HS-SPME coupled with GC-MS; 29 volatile compounds were detected, of which nine were found to be scent components. The cultivars were clustered into three clusters characterized according to scent components. The 'Conqueror' and 'Virginia' cultivars had the highest antioxidant activities. The concentrations of polyphenols and flavonoids showed significant positive correlations with antioxidant activity as measured by DPPH, ABTS(+), and FRAP assays. This study is valuable for a fuller understanding of this important tea and can also be used for the development of water lily.
[Mh] Termos MeSH primário: Antioxidantes/análise
Flavonoides/análise
Nymphaea/química
Chás de Ervas/análise
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Flores/química
Cromatografia Gasosa-Espectrometria de Massas
Polifenóis/análise
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Polyphenols); 0 (Teas, Herbal); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150515
[Lr] Data última revisão:
150515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150516
[St] Status:MEDLINE



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