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Pesquisa : B01.650.940.800.575.912.250.779 [Categoria DeCS]
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[PMID]:28806951
[Au] Autor:Kalmobé J; Ndjonka D; Boursou D; Vildina JD; Liebau E
[Ad] Endereço:Department of Biological Sciences, Faculty of Science, University of Ngaoundéré, PO, Box 454, Ngaoundéré, Cameroon.
[Ti] Título:Phytochemical analysis and in vitro anthelmintic activity of Lophira lanceolata (Ochnaceae) on the bovine parasite Onchocerca ochengi and on drug resistant strains of the free-living nematode Caenorhabditis elegans.
[So] Source:BMC Complement Altern Med;17(1):404, 2017 Aug 14.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Onchocerciasis is one of the tropical neglected diseases (NTDs) caused by the nematode Onchocerca volvulus. Control strategies currently in use rely on mass administration of ivermectin, which has marked activity against microfilariae. Furthermore, the development of resistance to ivermectin was observed. Since vaccine and safe macrofilaricidal treatment against onchocerciasis are still lacking, there is an urgent need to discover novel drugs. This study was undertaken to investigate the anthelmintic activity of Lophira lanceolata on the cattle parasite Onchocerca ochengi and the anthelmintic drug resistant strains of the free living nematode Caenorhabditis elegans and to determine the phytochemical profiles of the extracts and fractions of the plants. METHODS: Plant was extracted in ethanol or methanol-methylene chloride. O. ochengi, C. elegans wild-type and C. elegans drug resistant strains were cultured in RPMI-1640 and NGM-agar respectively. Drugs diluted in dimethylsulphoxide/RPMI or M9-Buffer were added in assays and monitored at 48 h and 72 h. Worm viability was determined by using the MTT/formazan colorimetric method. Polyphenol, tannin and flavonoid contents were determined by dosage of gallic acid and rutin. Acute oral toxicity was evaluated using Swiss albino mice. RESULTS: Ethanolic and methanolic-methylene chloride extracts killed O. ochengi with LC values of 9.76, 8.05, 6.39 µg/mL and 9.45, 7.95, 6.39 µg/mL respectively for leaves, trunk bark and root bark after 72 h. The lowest concentrations required to kill 50% of the wild-type of C. elegans were 1200 and 1890 µg/mL with ethanolic crude extract, 1000 and 2030 µg/mL with MeOH-CH Cl for root bark and trunk bark of L. lanceolata, respectively after 72 h. Leave extracts of L. lanceolata are lethal to albendazole and ivermectin resistant strains of C. elegans after 72 h. Methanol/methylene chloride extracted more metabolites. Additionally, extracts could be considered relatively safe. CONCLUSION: Ethanolic and methanolic-methylene chloride crude extracts and fractions of L. lanceolata showed in vitro anthelmintic activity. The extracts and fractions contained polyphenols, tannins, flavonoids and saponins. The mechanism of action of this plant could be different from that of albendazole and ivermectin. These results confirm the use of L. lanceolata by traditional healers for the treatment of worm infections.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Caenorhabditis elegans
Infecções por Nematoides/parasitologia
Ochnaceae/química
Onchocerca
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Albendazol/farmacologia
Animais
Bovinos
Resistência a Medicamentos
Flavonoides/análise
Flavonoides/farmacologia
Ivermectina/farmacologia
Camundongos
Infecções por Nematoides/veterinária
Oncocercose/parasitologia
Oncocercose/veterinária
Fitoterapia
Casca de Planta
Extratos Vegetais/química
Raízes de Plantas
Caules de Planta
Polifenóis/análise
Polifenóis/farmacologia
Saponinas/análise
Saponinas/farmacologia
Taninos/análise
Taninos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Saponins); 0 (Tannins); 70288-86-7 (Ivermectin); F4216019LN (Albendazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1904-z


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[PMID]:28032512
[Au] Autor:Ismail AM; Musa AM; Nasir T; Magaji MG; Jega YA; Ibrahim I
[Ad] Endereço:a Department of Pharmaceutical and Medicinal Chemistry , Usmanu Danfodiyo University , Sokoto , Nigeria.
[Ti] Título:Anti-proliferative study and isolation of Ochnaflavone from the ethyl acetate-soluble fraction of Ochna kibbiensis Hutch & Dalziel.
[So] Source:Nat Prod Res;31(18):2149-2152, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anti-proliferative activity of the ethyl acetate fractions of Ochna schweinfurthiana F. Hoffm. and Ochna kibbiensis Hutch. and Dalziel methanol leaf extracts were investigated against glioblastoma multiforme (GBM U-1242 MG) cell line. O. kibbiensis significantly (p < 0.001) and dose dependently (IC = 25.74 µg/mL) reduced cell count. At 125 µg/mL, O. kibbiensis extract reduced cell count by about 92% compared to the untreated control. On the other hand, at 125 µg/mL, O. schweinfurthiana extract reduced cell count only by 20%, indicating a much weaker activity (IC = 823.51 µg/mL). Following from the result obtained, ethyl acetate fraction of O. kibbiensis was subjected to chromatographic purification. This led to the isolation of ochnaflavone; the structure of the isolated compound was identified by analysis of its nuclear magnetic resonance (NMR) spectral data and comparison with data in the literature. Although the isolated ochnaflavone could not be tested for anti-proliferative activity due to insufficient quantity, the obtained results indicate the presence of bioactive anti-GBM principles in O. kibbiensis.
[Mh] Termos MeSH primário: Flavonoides/química
Flavonoides/farmacologia
Ochnaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetatos/química
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais/métodos
Flavonoides/isolamento & purificação
Seres Humanos
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids); 0 (Plant Extracts); 50276-96-5 (ochnaflavone); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1274892


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[PMID]:27295334
[Au] Autor:Elo-Manga SS; Tih AE; Ghogomu RT; Blond A; Bodo B
[Ti] Título:Chemical constituents of the leaves of Campylospermum elongatum.
[So] Source:Z Naturforsch C;72(1-2):71-75, 2017 Jan 01.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The leaves of Campylospermum elongatum have furnished the cyano-glycoside (lithospermoside), nine isomeric biflavonoid derivatives among which five are I3-II6 linked (robustaflavone; 4'-O-methyl robustaflavone; 4',4″'-di-O-methyl robustaflavone; 7,4',4″-tri-O-methyl robustaflavone; 4',7″-di-O-methyl robustaflavone) and four I3-II8 linked (amentoflavone; 7-O-methyl amentoflavone; 7,7″-di-O-methyl amentoflavone; 7, 4',7″-tri-O-methyl amentoflavone) and a flavone glycoside, 4″-O-methyl-7-O-ß-d-galactosylapigenin. All structures were established from a complete spectroscopic analysis (MS, IR, 1D, and 2D NMR, including HSQC, HMBC, and NOESY) as well as by comparing the obtained spectroscopic data with literature. This is the first report on the characterization of 4'-O-methyl-7-O-ß-d-galactosylapigenin from the genus campylospermum and thus has important chemotaxonomic implications.
[Mh] Termos MeSH primário: Flavonoides/isolamento & purificação
Ochnaceae/química
[Mh] Termos MeSH secundário: Etanol
Flavonas/química
Flavonas/isolamento & purificação
Flavonoides/química
Hidrólise
Metanol
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Folhas de Planta/química
Solventes
Espectrometria de Fluorescência
Espectrofotometria Infravermelho
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavones); 0 (Flavonoids); 0 (Solvents); 3K9958V90M (Ethanol); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160614
[St] Status:MEDLINE


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[PMID]:26094613
[Au] Autor:Campana PR; Mansur DS; Gusman GS; Ferreira D; Teixeira MM; Braga FC
[Ad] Endereço:Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, campus Pampulha, Belo Horizonte, CEP 31.270-901, Brazil.
[Ti] Título:Anti-TNF-α Activity of Brazilian Medicinal Plants and Compounds from Ouratea semiserrata.
[So] Source:Phytother Res;29(10):1509-15, 2015 Oct.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Several plant species are used in Brazil to treat inflammatory diseases and associated conditions. TNF-α plays a pivotal role on inflammation, and several plant extracts have been assayed against this target, both in vitro and in vivo. The effect of 11 Brazilian medicinal plants on TNF-α release by LPS-activated THP-1 cells was evaluated. The plant materials were percolated with different solvents to afford 15 crude extracts, whose effect on TNF-α release was determined by ELISA. Among the evaluated extracts, only Jacaranda caroba (Bignoniaceae) presented strong toxicity to THP-1 cells. Considering the 14 non-toxic extracts, TNF-α release was significantly reduced by seven of them (inhibition > 80%), originating from six plants, namely Cuphea carthagenensis (Lythraceae), Echinodorus grandiflorus (Alismataceae), Mansoa hirsuta (Bignoniaceae), Ouratea semiserrata (Ochnaceae), Ouratea spectabilis and Remijia ferruginea (Rubiaceae). The ethanol extract from O. semiserrata leaves was fractionated over Sephadex LH-20 and RP-HPLC to give three compounds previously reported for the species, along with agathisflavone and epicatechin, here described for the first time in the plant. Epicatechin and lanceoloside A elicited significant inhibition of TNF-α release, indicating that they may account for the effect produced by O. semiserrata crude extract.
[Mh] Termos MeSH primário: Extratos Vegetais
Plantas Medicinais
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Bignoniaceae
Brasil
Cromatografia Líquida de Alta Pressão
Dextranos
Ochnaceae
Extratos Vegetais/farmacologia
Folhas de Planta
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dextrans); 0 (Plant Extracts); 0 (Solvents); 0 (Tumor Necrosis Factor-alpha); 9014-76-0 (sephadex)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150623
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5401


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[PMID]:25781676
[Au] Autor:Iniaghe LO; Ighodaro I; Magaji MG; Tabot TP; Maduka IT
[Ti] Título:Neurobehavioural evaluation of Lophira alata (Ochnaceae) stem bark extract in mice.
[So] Source:J Basic Clin Physiol Pharmacol;26(6):523-9, 2015 Nov.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stem bark and leaves of Lophira alata (Family: Ochnaceae) have been used traditionally for their anti-psychotic, anti-convulsant and anxiolytic properties. Since no existing data was found on the neurobehavioural properties, this study was carried out to evaluate some neurobehavioural properties of the aqueous extract of the stem bark of L. alata in animal models. METHODS: The oral mean lethal dose (LD50) of the extract was estimated, and preliminary phytochemical screening was conducted. Lophira alata extract (200, 400 and 800 mg/kg, p.o.) was investigated for antidepressant effect using the forced swim and tail suspension tests, and the anxiolytic potential was assessed using the stair case and hole board tests. Pentylenetetrazole-induced convulsion test was used to investigate the anticonvulsant potential of the extract. RESULTS: The LD50 was estimated to be >5000 mg/kg. Oral administration of L. alata extract produced a significant (p<0.05) non-dose-dependent decrease in the period of immobility in both the forced swim and tail suspension tests. While a significant decrease (p<0.05) in episodes of grooming was recorded in the staircase test, the number of head dips was not significantly reduced (p>0.05) in the hole board test. In the pentylenetetrazole-induced convulsion, a non-dose-dependent increase in onset of tonic-clonic seizures and protection from death was recorded. CONCLUSIONS: The results obtained suggest that the aqueous stem bark extract of L. alata possesses neurobehavioural properties which may account for its use in ethnomedicine.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Ochnaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Ansiolíticos/administração & dosagem
Ansiolíticos/isolamento & purificação
Ansiolíticos/farmacologia
Anticonvulsivantes/administração & dosagem
Anticonvulsivantes/isolamento & purificação
Anticonvulsivantes/farmacologia
Antidepressivos/administração & dosagem
Antidepressivos/isolamento & purificação
Antidepressivos/farmacologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Dose Letal Mediana
Masculino
Camundongos
Casca de Planta
Extratos Vegetais/administração & dosagem
Folhas de Planta
Caules de Planta
Convulsões/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Anticonvulsants); 0 (Antidepressive Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151103
[Lr] Data última revisão:
151103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150318
[St] Status:MEDLINE


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[PMID]:25553908
[Au] Autor:Ndongo JT; Issa ME; Messi AN; Mbing JN; Cuendet M; Pegnyemb DE; Bochet CG
[Ad] Endereço:a Department of Chemistry , Higher Teacher Training College, University of Yaoundé 1 , P.O. Box 47, Yaoundé , Cameroon.
[Ti] Título:Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana.
[So] Source:Nat Prod Res;29(17):1684-7, 2015.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), ß-D-fructofuranosyl-α-D-glucopyranoside (5) and 3ß-O-D-glucopyranosyl-ß-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm. All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay. Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 µM, respectively.
[Mh] Termos MeSH primário: Flavonoides/química
Ochnaceae/química
Casca de Planta/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Biflavonoides/química
Células HeLa
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Flavonoids); 0 (Plant Extracts); 28441-98-7 (agathisflavone); 9I1VC79L77 (amentoflavone)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150803
[Lr] Data última revisão:
150803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150103
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2014.991321


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[PMID]:25366720
[Au] Autor:Chai SF; Jiang YS; Zhuang XY; Shi YC; Wei X; Luo WH; Chen ZY
[Ad] Endereço:College of Forestry, South China Agricultural University, Guangzhou, China.
[Ti] Título:Genetic diversity and differentiation of the endangered and endemic species Sauvagesia rhodoleuca in China as detected by ISSR analysis.
[So] Source:Genet Mol Res;13(4):8258-67, 2014 Oct 20.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Sauvagesia rhodoleuca (Ochnaceae) is an endangered plant that is endemic to southern China. The levels of genetic variation and patterns of population structure in S. rhodoleuca were investigated using inter-simple sequence repeat markers. Eleven primers were used to amplify DNA samples from 117 individuals, and a total of 92 loci were detected. Our results indicated that genetic diversity was quite low both at the species level (percentage of polymorphic bands (PPB) = 41.30%, Nei's gene diversity (h) = 0.1331, and Shannon information index (I) = 0.2028) and the population level (PPB = 16.30-28.26%, h = 0.0496-0.1012, and I = 0.0756-0.1508). A high level of genetic differentiation among populations was detected based on Nei's genetic diversity analysis (0.4344) and analysis of molecular variance (47.03%). The low genetic diversity within population and high population differentiation of S. rhodoleuca were assumed to result largely from limited gene flow, genetic drift, inbreeding, and clonal growth. Conservation strategies for this endangered species are proposed based on the genetic data.
[Mh] Termos MeSH primário: Variação Genética
Genética Populacional
Repetições de Microssatélites
Ochnaceae/genética
[Mh] Termos MeSH secundário: China
Espécies em Perigo de Extinção
Evolução Molecular
Geografia
Espécies Introduzidas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141104
[Lr] Data última revisão:
141104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141105
[St] Status:MEDLINE
[do] DOI:10.4238/2014.October.20.2


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[PMID]:25263311
[Au] Autor:Aba PE; Ozioko IE; Udem ND; Udem SC
[Ti] Título:Some biochemical and haematological changes in rats pretreated with aqueous stem bark extract of Lophira lanceolata and intoxicated with paracetamol (acetaminophen).
[So] Source:J Complement Integr Med;11(4):273-7, 2014 Dec.
[Is] ISSN:1553-3840
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study investigated the acute toxicity effect of aqueous stem bark extract of Lophira lanceolata and the activities of liver enzymes and other markers of organ damage in rats pretreated with aqueous stem bark extract of L. lanceolata extract and subsequently intoxicated with paracetamol (PCM). METHODS: A total of 30 rats were used to determine the acute toxicity of aqueous extract of L. lanceolata stem. They were divided into six groups consisting of five rats each. The groups (A-F) were administered the increasing doses of the extract (500 mg/kg, 1,000 mg/kg, 2,000 mg/kg, 3,200 mg/kg, 4,000 mg/kg and 5,000 mg/kg) orally. The rats were observed over a period of 24 h for acute toxicity signs such as dullness, anorexia, morbidity and death. Thirty rats of mixed sexes randomly assigned to six groups (A-F) of five rats each were used for the study on the effects of L. lanceolata extract on the haematology, liver enzymes and markers of organ damage of extract-pretreated PCM-intoxicated rats. The rats in groups A-D were pretreated with 100 mg/kg, 200 mg/kg, 300 mg/kg of L. lanceolata extract and 100 mg/kg Silymarin, respectively, twice a day for 7 days. On the seventh day, all the rats in groups A-E received 1,000 mg/kg PCM (per os). Group E rats served as negative control while group F rats were neither intoxicated nor treated with the extract and served as positive control. Eighteen hours after PCM intoxication, blood samples were collected for biochemical analyses. The serum activities of these enzymes (aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [ALP]) and other markers of organ damages (bilirubin and total protein) were investigated. Haematologic parameters such as packed cell volume, red blood cell count, white blood cell count and haemoglobin concentration were also determined. RESULTS: The extract did not cause any death in all the groups even at the highest dose (5,000 mg/kg body weight). The results also showed varying degrees in the activity of the enzymes in the serum in comparison with the negative control. The mean serum ALP, ALT and AST activity of group C (rats pretreated with 300 mg/kg of the extract and 1,000 mg/kg PCM) were significantly (p<0.05) lower than that of the group E (rats intoxicated with 1,000 mg/kg PCM only). The AST and ALP activities of groups C-E rats) were statistically comparable. The serum ALT activities of group C rats were significantly (p<0.05) lower than that of group E rats but were statistically comparable (p>0.05) with the group F counterpart. The bilirubin levels were significantly (p<0.05) lower in the groups pretreated with the extract and Silymarin in comparison with the D group. The total protein and the haematologic indices were not significantly different (p>0.05) across the groups. CONCLUSIONS: This study therefore showed that the aqueous stem bark extract of L. lanceolata possesses some active constituents that have antihepatotoxic potentials.
[Mh] Termos MeSH primário: Acetaminofen/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Fígado/efeitos dos fármacos
Ochnaceae
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Fosfatase Alcalina/sangue
Animais
Aspartato Aminotransferases/sangue
Bilirrubina/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/sangue
Feminino
Fígado/fisiopatologia
Masculino
Casca de Planta
Extratos Vegetais/toxicidade
Caules de Planta
Ratos
Ratos Wistar
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 059QF0KO0R (Water); 362O9ITL9D (Acetaminophen); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); EC 3.1.3.1 (Alkaline Phosphatase); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140930
[St] Status:MEDLINE


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[PMID]:24862223
[Au] Autor:Schneider JV; Bissiengou P; Amaral Mdo C; Tahir A; Fay MF; Thines M; Sosef MS; Zizka G; Chatrou LW
[Ad] Endereço:Senckenberg Research Institute and Natural History Museum Frankfurt, Department of Botany and Molecular Evolution, Senckenberganlage 25, D-60325 Frankfurt am Main, Germany; Goethe-University, Department of Ecology, Evolution and Diversity, Max-von-Laue-Str. 13, D-60439 Frankfurt am Main, Germany; Bi
[Ti] Título:Phylogenetics, ancestral state reconstruction, and a new infrafamilial classification of the pantropical Ochnaceae (Medusagynaceae, Ochnaceae s.str., Quiinaceae) based on five DNA regions.
[So] Source:Mol Phylogenet Evol;78:199-214, 2014 Sep.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ochnaceae s.str. (Malpighiales) are a pantropical family of about 500 species and 27 genera of almost exclusively woody plants. Infrafamilial classification and relationships have been controversial partially due to the lack of a robust phylogenetic framework. Including all genera except Indosinia and Perissocarpa and DNA sequence data for five DNA regions (ITS, matK, ndhF, rbcL, trnL-F), we provide for the first time a nearly complete molecular phylogenetic analysis of Ochnaceae s.l. resolving most of the phylogenetic backbone of the family. Based on this, we present a new classification of Ochnaceae s.l., with Medusagynoideae and Quiinoideae included as subfamilies and the former subfamilies Ochnoideae and Sauvagesioideae recognized at the rank of tribe. Our data support a monophyletic Ochneae, but Sauvagesieae in the traditional circumscription is paraphyletic because Testulea emerges as sister to the rest of Ochnoideae, and the next clade shows Luxemburgia+Philacra as sister group to the remaining Ochnoideae. To avoid paraphyly, we classify Luxemburgieae and Testuleeae as new tribes. The African genus Lophira, which has switched between subfamilies (here tribes) in past classifications, emerges as sister to all other Ochneae. Thus, endosperm-free seeds and ovules with partly to completely united integuments (resulting in an apparently single integument) are characters that unite all members of that tribe. The relationships within its largest clade, Ochnineae (former Ochneae), are poorly resolved, but former Ochninae (Brackenridgea, Ochna) are polyphyletic. Within Sauvagesieae, the genus Sauvagesia in its broad circumscription is polyphyletic as Sauvagesia serrata is sister to a clade of Adenarake, Sauvagesia spp., and three other genera. Within Quiinoideae, in contrast to former phylogenetic hypotheses, Lacunaria and Touroulia form a clade that is sister to Quiina. Bayesian ancestral state reconstructions showed that zygomorphic flowers with adaptations to buzz-pollination (poricidal anthers), a syncarpous gynoecium (a near-apocarpous gynoecium evolved independently in Quiinoideae and Ochninae), numerous ovules, septicidal capsules, and winged seeds with endosperm are the ancestral condition in Ochnoideae. Although in some lineages poricidal anthers were lost secondarily, the evolution of poricidal superstructures secured the maintenance of buzz-pollination in some of these genera, indicating a strong selective pressure on keeping that specialized pollination system.
[Mh] Termos MeSH primário: Ochnaceae/classificação
Filogenia
[Mh] Termos MeSH secundário: Teorema de Bayes
DNA de Plantas/química
Ochnaceae/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140922
[Lr] Data última revisão:
140922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140528
[St] Status:MEDLINE


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[PMID]:24830509
[Au] Autor:Kongstad KT; Wubshet SG; Johannesen A; Kjellerup L; Winther AM; Jäger AK; Staerk D
[Ad] Endereço:Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.
[Ti] Título:High-resolution screening combined with HPLC-HRMS-SPE-NMR for identification of fungal plasma membrane H(+)-ATPase inhibitors from plants.
[So] Source:J Agric Food Chem;62(24):5595-602, 2014 Jun 18.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Crude extracts of 33 plant species were assessed for fungal plasma membrane (PM) H(+)-ATPase inhibition. This led to identification of 18 extracts showing more than 95% inhibition at a concentration of 7.5 mg/mL and/or a concentration-dependent activity profile. These extracts were selected for semi-high-resolution fungal PM H(+)-ATPase inhibition screening, and, on the basis of these results, Haplocoelum foliolosum (Hiern) Bullock and Sauvagesia erecta L. were selected for investigation by high-resolution fungal PM H(+)-ATPase inhibition screening. Structural analysis performed by high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy (HPLC-HRMS-SPE-NMR) led to identification of chebulagic acid (1) and tellimagrandin II (2) from H. foliolosum. Preparative-scale isolation of the two metabolites allowed determination of IC50 values for PM H(+)-ATPase, and growth inhibition of Saccharomyces cerevisiae and Candida albicans. Chebulagic acid and tellimagrandin II are both potent inhibitors of the PM H(+)-ATPase with inhibitory effect on the growth of S. cerevisiae.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão
Inibidores Enzimáticos/análise
Espectroscopia de Ressonância Magnética
Extratos Vegetais/química
ATPases Translocadoras de Prótons/antagonistas & inibidores
[Mh] Termos MeSH secundário: Benzopiranos/análise
Benzopiranos/farmacologia
Candida albicans/efeitos dos fármacos
Candida albicans/crescimento & desenvolvimento
Inibidores Enzimáticos/farmacologia
Fungos/metabolismo
Ácido Gálico/análogos & derivados
Ácido Gálico/análise
Ácido Gálico/farmacologia
Glucosídeos/análise
Glucosídeos/farmacologia
Ochnaceae/química
ATPases Translocadoras de Prótons/metabolismo
Saccharomyces cerevisiae/efeitos dos fármacos
Saccharomyces cerevisiae/crescimento & desenvolvimento
Sapindaceae/química
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Enzyme Inhibitors); 0 (Glucosides); 0 (Plant Extracts); 0 (tellimagrandin II); 23094-71-5 (chebulagic acid); 632XD903SP (Gallic Acid); EC 3.6.3.14 (Proton-Translocating ATPases)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:140904
[Lr] Data última revisão:
140904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140517
[St] Status:MEDLINE
[do] DOI:10.1021/jf501605z



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