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Pesquisa : B01.650.940.800.575.912.250.789.500 [Categoria DeCS]
Referências encontradas : 30 [refinar]
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[PMID]:27773258
[Au] Autor:Barman N; Badwaik LS
[Ad] Endereço:Department of Food Engineering and Technology, School of Engineering, Tezpur University, Napaam, Assam, India.
[Ti] Título:Effect of ultrasound and centrifugal force on carambola (Averrhoa carambola L.) slices during osmotic dehydration.
[So] Source:Ultrason Sonochem;34:37-44, 2017 01.
[Is] ISSN:1873-2828
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Osmotic dehydration (OD) of carambola slices were carried out using glucose, sucrose, fructose and glycerol as osmotic agents with 70°Bx solute concentration, 50°C of temperature and for time of 180min. Glycerol and sucrose were selected on the basis of their higher water loss, weight reduction and lowers solid gain. Further the optimization of OD of carambola slices (5mm thick) were carried out under different process conditions of temperature (40-60°C), concentration of sucrose and glycerol (50-70°Bx), time (180min) and fruit to solution ratio (1:10) against various responses viz. water loss, solid gain, texture, rehydration ratio and sensory score according to a composite design. The optimized value for temperature, concentration of sucrose and glycerol has been found to be 50°C, 66°Bx and 66°Bx respectively. Under optimized conditions the effect of ultrasound for 10, 20, 30min and centrifugal force (2800rpm) for 15, 30, 45 and 60min on OD of carambola slices were checked. The controlled samples showed 68.14% water loss and 13.05% solid gain in carambola slices. While, the sample having 30min ultrasonic treatment showed 73.76% water loss and 9.79% solid gain; and the sample treated with centrifugal force for 60min showed 75.65% water loss and 6.76% solid gain. The results showed that with increasing in treatment time the water loss, rehydration ratio were increased and solid gain, texture were decreased.
[Mh] Termos MeSH primário: Averrhoa/química
Centrifugação
Osmose
Ondas Ultrassônicas
Água/química
[Mh] Termos MeSH secundário: Paladar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28443386
[Au] Autor:Chua CB; Sun CK; Tsui HW; Yang PJ; Lee KH; Hsu CW; Tsai IT
[Ad] Endereço:a Department of Emergency Medicine , E-Da Hospital, I-Shou University , Kaohsiung City , Taiwan.
[Ti] Título:Association of renal function and symptoms with mortality in star fruit (Averrhoa carambola) intoxication.
[So] Source:Clin Toxicol (Phila);55(7):624-628, 2017 Aug.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Star fruit (SF) is a commonly available fruit produced and eaten in tropical and subtropical countries. Since 1993, various reports have described neurotoxicity after eating SF, but this clinical condition remains unfamiliar. We aimed to describe this clinical entity, the role of renal dysfunction in this disorder, treatment strategies, and prognosis of patients with SF intoxication. METHODS: We conducted a search of PubMed and Google Scholar databases from 1993 to 2016. We included reports describing patients with a clear history of SF ingestion with acute symptoms. We described the demographic characteristics, reported SF intake, treatments used, and outcomes. RESULTS: We reviewed totally 126 patients (male:female = 1.5:1) from 33 articles with mean age 54.4 ± 11 (range: 30-84). The most common symptom was hiccups (65%), whereas confusion and seizure were the most common symptoms associated with mortality (42% and 61%, respectively). Pre-intoxication renal function also affected mortality. While there was no mortality in patients with normal renal function (NRF), the mortality of patients among reported cases with chronic renal insufficiency and end-stage renal disease undergoing dialysis were 36% and 27%, respectively. With the inclusion of patients reported to have NRF, the overall mortality was 24%. Consistently, the number of SF consumed was substantially higher in the patients with NRF than those with renal functional impairment. The most common treatment strategy was hemodialysis (59%). CONCLUSIONS: Patients with impaired renal function were at higher risks of SF intoxication. Severe neurologic symptoms mandate immediate medical intervention because of the association between their occurrence and high mortalities. Toxin removal through dialysis, rather than symptomatic relief, seems to be beneficial to patient survival. Early and continuous dialysis appears to alleviate severe symptoms and prevent symptom rebounds.
[Mh] Termos MeSH primário: Averrhoa/envenenamento
Doenças Transmitidas por Alimentos/etiologia
Frutas/envenenamento
Falência Renal Crônica/complicações
Rim/fisiopatologia
Síndromes Neurotóxicas/etiologia
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Doenças Transmitidas por Alimentos/mortalidade
Doenças Transmitidas por Alimentos/fisiopatologia
Doenças Transmitidas por Alimentos/terapia
Seres Humanos
Falência Renal Crônica/mortalidade
Falência Renal Crônica/fisiopatologia
Falência Renal Crônica/terapia
Masculino
Meia-Idade
Síndromes Neurotóxicas/mortalidade
Síndromes Neurotóxicas/fisiopatologia
Síndromes Neurotóxicas/terapia
Diálise Renal
Insuficiência Renal Crônica/mortalidade
Insuficiência Renal Crônica/fisiopatologia
Insuficiência Renal Crônica/terapia
Medição de Risco
Fatores de Risco
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1314490


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[PMID]:27916421
[Au] Autor:Kurup SB; S M
[Ad] Endereço:Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India.
[Ti] Título:Protective potential of Averrhoa bilimbi fruits in ameliorating the hepatic key enzymes in streptozotocin-induced diabetic rats.
[So] Source:Biomed Pharmacother;85:725-732, 2017 Jan.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:BACK GROUND: Diabetes is a mutifactorial disease which leads to several complications. Currently available drug regimens for management of diabetes have certain drawbacks. Need for safer and effective medicines from natural sources having potent antidiabetic activity. Averrhoa bilimbi Linn. (Oxalidaceae) is a medicinal plant and is reported to possess hypoglycemic activity. OBJECTIVE: To investigate the antidiabetic potential of Averrhoa bilimbi fruit extract in streptozotocin-induced diabetic rats. METHODS: Diabetes was induced in male Sprague Dawley rats by single intraperitoneal injection of streptozotocin (STZ) (40mg/kg body weight). The diabetic rats were treated orally with ethyl acetate fraction of A. bilimbi fruits (ABE) (25mg/kg body weight) and metformin (100mg/kg body weight) by intragastric intubation for 60days. After 60days, the rats were sacrificed; blood, liver and pancreas were collected. Several indices such as blood glucose, plasma insulin, toxicity markers and the activities of carbohydrate-metabolizing enzymes were assayed. The phytochemicals present in the ABE was identified by gas chromatography-mass spectrometry analysis. RESULTS: ABE significantly (p<0.05) reduced the level of blood glucose and hepatic toxicity markers and increased plasma insulin in diabetic rats. ABE modulated the activities of carbohydrate-metabolizing enzymes, significantly increased the activities of hexokinase (59%) and pyruvate kinase (68%) and reduced the activities of glucose-6-phosphatase (32%) and fructose-1, 6-bisphosphatase (20%). The histological studies of the pancreas also supported our findings. The results were compared with metformin, a standard oral hypoglycemic drug. GC-MS analysis of ABE revealed the presence of 11 chemical constituents in the extract. CONCLUSIONS: ABE exerts its antidiabetic effect by promoting glucose metabolism via glycolysis and inhibiting hepatic endogenous glucose production via gluconeogenesis.
[Mh] Termos MeSH primário: Averrhoa/química
Diabetes Mellitus Experimental/terapia
Frutas/química
Hipoglicemiantes/farmacologia
Fígado/enzimologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Glicemia/efeitos dos fármacos
Hipoglicemiantes/química
Insulina/sangue
Fígado/patologia
Masculino
Tamanho do Órgão
Pâncreas/efeitos dos fármacos
Pâncreas/patologia
Fitoterapia
Extratos Vegetais/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27845599
[Au] Autor:Shimizu MH; Gois PH; Volpini RA; Canale D; Luchi WM; Froeder L; Heilberg IP; Seguro AC
[Ad] Endereço:a Department of Nephrology, School of Medicine , University of São Paulo , São Paulo , Brazil.
[Ti] Título:N-acetylcysteine protects against star fruit-induced acute kidney injury.
[So] Source:Ren Fail;39(1):193-202, 2017 11.
[Is] ISSN:1525-6049
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Star fruit (SF) is a popular fruit, commonly cultivated in many tropical countries, that contains large amount of oxalate. Acute oxalate nephropathy and direct renal tubular damage through release of free radicals are the main mechanisms involved in SF-induced acute kidney injury (AKI). The aim of this study was to evaluate the protective effect of N-acetylcysteine (NAC) on SF-induced nephrotoxicity due to its potent antioxidant effect. MATERIALS AND METHODS: Male Wistar rats received SF juice (4 mL/100 g body weight) by gavage after a 12 h fasting and water deprivation. Fasting and water deprivation continued for 6 h thereafter to warrant juice absorption. Thereafter, animals were allocated to three experimental groups: SF (n = 6): received tap water; SF + NAC (n = 6): received NAC (4.8 g/L) in drinking water for 48 h after gavage; and Sham (n = 6): no interventions. After 48 h, inulin clearance studies were performed to determine glomerular filtration rate. In a second series of experiment, rats were housed in metabolic cages for additional assessments. RESULTS: SF rats showed markedly reduced inulin clearance associated with hyperoxaluria, renal tubular damage, increased oxidative stress and inflammation. NAC treatment ameliorated all these alterations. Under polarized light microscopy, SF rats exhibited intense calcium oxalate birefringence crystals deposition, dilation of renal tubules and tubular epithelial degeneration, which were attenuate by NAC therapy. CONCLUSIONS: Our data show that therapeutic NAC attenuates renal dysfunction in a model of acute oxalate nephropathy following SF ingestion by reducing oxidative stress, oxaluria, and inflammation. This might represent a novel indication of NAC for the treatment of SF-induced AKI.
[Mh] Termos MeSH primário: Acetilcisteína/farmacologia
Lesão Renal Aguda/tratamento farmacológico
Antioxidantes/farmacologia
Averrhoa/efeitos adversos
Estresse Oxidativo/efeitos dos fármacos
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Lesão Renal Aguda/induzido quimicamente
Animais
Creatinina/metabolismo
Frutas/efeitos adversos
Taxa de Filtração Glomerular
Hiperoxalúria/tratamento farmacológico
Rim/fisiopatologia
Masculino
Oxalatos/efeitos adversos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oxalates); 0 (Protective Agents); AYI8EX34EU (Creatinine); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE
[do] DOI:10.1080/0886022X.2016.1256315


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[PMID]:27941348
[Au] Autor:Li J; Wei X; Xie Q; Hoa Pham TT; Wei J; He P; Jiao Y; Xu X; Giang Nguyen TH; Wen Q; Huang R
[Ad] Endereço:Department of Pharmacology, Guangxi Medical University, Nanning, PR China.
[Ti] Título:Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on High-Fat Diet-Induced Obesity and Insulin Resistance in Mice.
[So] Source:Cell Physiol Biochem;40(5):993-1004, 2016.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: The roots of Averrhoa carambola L. (Oxalidaceae) have long been used as a traditional Chinese medicine for the treatment of diabetes and diabetes-related diseases. 2-dodecyl-6-methoxycycyclohexa-2,5-1,4-dione (DMDD) has been isolated from A. carambola L. roots, and this study was carried out to investigate the potential beneficial effects of DMDD on obesity and insulin resistance induced by a high-fat diet (HFD) in mice. METHODS: C57BL/6J mice were fed a HFD for 16 weeks and orally administered DMDD (12.5, 25, or 50 mg/kg of body weight per day) and metformin (280 mg/kg of body weight per day) for the last 4 weeks. RESULTS: The body weights and adipose tissue weights as well as the serum levels of blood glucose, total cholesterol, triglycerides, free fatty acids, insulin, interleukin-6, and tumor necrosis factor-α were significantly decreased by DMDD, and the expression of Toll-like receptor 4 (TLR4) and myeloid differentiation factor (Myd88) in the epididymal adipose tissue was downregulated by DMDD. In contrast, insulin sensitivity was enhanced. The results of the glucose tolerance tests, insulin tolerance tests, and insulin release tests indicated that there was a marked improvement in insulin secretion, and the areas under the curve corresponding to the three tests were also significantly decreased by DMDD. The activities of superoxide dismutase and glutathione peroxidase were simultaneously enhanced, whereas the content of malondialdehyde was decreased by DMDD in the liver homogenates of the C57BL/6J mice. In addition, hepatic steatosis and adipocyte hypertrophy, as assessed by H&E staining of liver and adipose tissues, were significantly improved by DMDD. CONCLUSION: These data suggest that MDD has potential benefits for the treatment of HFD-induced obesity and insulin resistance, and its effects may be associated with improvements in lipid metabolism and inhibition of the expression of TLR4 in adipose tissues.
[Mh] Termos MeSH primário: Averrhoa/química
Cicloexenos/uso terapêutico
Dieta Hiperlipídica/efeitos adversos
Resistência à Insulina
Obesidade/tratamento farmacológico
Raízes de Plantas/química
Substâncias Protetoras/uso terapêutico
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/metabolismo
Animais
Antioxidantes/metabolismo
Glicemia/efeitos dos fármacos
Glicemia/metabolismo
Peso Corporal/efeitos dos fármacos
Cicloexenos/química
Cicloexenos/farmacologia
Citocinas/sangue
Jejum
Fígado Gorduroso/sangue
Fígado Gorduroso/tratamento farmacológico
Fígado Gorduroso/patologia
Comportamento Alimentar/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Teste de Tolerância a Glucose
Insulina/sangue
Lipídeos/sangue
Fígado/efeitos dos fármacos
Fígado/enzimologia
Masculino
Camundongos Endogâmicos C57BL
Fator 88 de Diferenciação Mieloide/genética
Fator 88 de Diferenciação Mieloide/metabolismo
Obesidade/sangue
Obesidade/genética
Tamanho do Órgão/efeitos dos fármacos
Fitoterapia
Substâncias Protetoras/química
Substâncias Protetoras/farmacologia
Receptor 4 Toll-Like/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione); 0 (Antioxidants); 0 (Blood Glucose); 0 (Cyclohexenes); 0 (Cytokines); 0 (Insulin); 0 (Lipids); 0 (Myeloid Differentiation Factor 88); 0 (Protective Agents); 0 (Toll-Like Receptor 4)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27643515
[Au] Autor:Xie Q; Zhang S; Chen C; Li J; Wei X; Xu X; Xuan F; Chen N; Pham T; Qin N; He J; Ye F; Huang W; Huang R; Wen Q
[Ad] Endereço:Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China.
[Ti] Título:Protective Effect of 2-Dodecyl-6-Methoxycyclohexa-2, 5-Diene-1, 4-Dione, Isolated from Averrhoa Carambola L., Against Palmitic Acid-Induced Inflammation and Apoptosis in Min6 Cells by Inhibiting the TLR4-MyD88-NF-κB Signaling Pathway.
[So] Source:Cell Physiol Biochem;39(5):1705-1715, 2016.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Studies have demonstrated that 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione (DMDD), isolated from the roots of Averrhoa carambola L., has significant therapeutic potential for the treatment of diabetes. However, the protective effect of DMDD against pancreatic beta cell dysfunction has never been reported. We investigated whether DMDD protected against palmitic acid-induced dysfunction in pancreatic ß-cell line Min6 cells by attenuating the inflammatory response and apoptosis and to shed light on its possible mechanism. METHODS: Cell viability was assessed by CCK-8. Glucose-stimulated insulin secretion levels and inflammatory cytokines levels were examined by ELISA. Apoptosis was assessed by Annexin V-FITC/PI Flow cytometry assay, Hoechst 33342/PI double-staining assay, and Transmission electron microscopy assay. Relative quantitative real-time PCR and western blot were used to determine the expressions of genes and proteins. RESULTS: Cell viability and glucose-stimulated insulin secretion levels were increased in DMDD-pretreated Min6 cells. DMDD inhibited inflammatory cytokines IL-6, TNF-α and MCP-1 generations in palmitic acid (PA)-induced Min6 cells. Moreover, DMDD protected against PA-induced Min6 cells apoptosis and the expression of Cleaved-Caspase-3, -8 and -9 were down-regulated and the Bcl-2/Bax ratio was increased in DMDD-pretreated Min6 cells. In addition, the expression of TLR4, MyD88 and NF-κB were down-regulated in DMDD-pretreated Min6 cells and TAK-242-pretreated group cells. CONCLUSIONS: DMDD protected Min6 cells against PA-induced dysfunction by attenuating the inflammatory response and apoptosis, and its mechanism of this protection was associated with inhibiting the TLR4-MyD88-NF-κB signaling pathway.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Averrhoa/química
Cicloexenos/farmacologia
Células Secretoras de Insulina/efeitos dos fármacos
Ácido Palmítico/antagonistas & inibidores
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/isolamento & purificação
Apoptose/efeitos dos fármacos
Caspases/genética
Caspases/metabolismo
Linhagem Celular Transformada
Sobrevivência Celular/efeitos dos fármacos
Quimiocina CCL2/genética
Quimiocina CCL2/metabolismo
Cicloexenos/isolamento & purificação
Regulação da Expressão Gênica
Inflamação
Células Secretoras de Insulina/metabolismo
Células Secretoras de Insulina/patologia
Interleucina-6/genética
Interleucina-6/metabolismo
Camundongos
Fator 88 de Diferenciação Mieloide/genética
Fator 88 de Diferenciação Mieloide/metabolismo
NF-kappa B/genética
NF-kappa B/metabolismo
Ácido Palmítico/farmacologia
Raízes de Plantas/química
Proteínas Proto-Oncogênicas c-bcl-2/genética
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Transdução de Sinais/genética
Receptor 4 Toll-Like/genética
Receptor 4 Toll-Like/metabolismo
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
Proteína X Associada a bcl-2/genética
Proteína X Associada a bcl-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Bax protein, mouse); 0 (Ccl2 protein, mouse); 0 (Chemokine CCL2); 0 (Cyclohexenes); 0 (Interleukin-6); 0 (Myd88 protein, mouse); 0 (Myeloid Differentiation Factor 88); 0 (NF-kappa B); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 0 (Tumor Necrosis Factor-alpha); 0 (bcl-2-Associated X Protein); 0 (interleukin-6, mouse); 114100-40-2 (Bcl2 protein, mouse); 2V16EO95H1 (Palmitic Acid); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160920
[St] Status:MEDLINE


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[PMID]:27455199
[Au] Autor:Marín-Guirao JI; Rodríguez-Romera P; Lupión-Rodríguez B; Camacho-Ferre F; Tello-Marquina JC
[Ad] Endereço:Plant Production in Mediterranean Crop Systems Research Group, Department of Agronomy, University of Almeria, Almeria, Spain. jignaciomarin@gmail.com.
[Ti] Título:Effect of Trichoderma on horticultural seedlings' growth promotion depending on inoculum and substrate type.
[So] Source:J Appl Microbiol;121(4):1095-102, 2016 Oct.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The biostimulant effect of Trichoderma spp. on horticultural crops are highly variable. Thus, practical use of Trichoderma sp. requires feasible formulated products and suitable substrates. METHODS AND RESULTS: This study evaluates the survival and the growth-promotion effect of a Trichoderma saturnisporum rice formulation compared with a nonformulated conidia suspension (seven treatments in total), on tomato, pepper and cucumber seedlings grown in two substrates: (i) rich in organic matter (OM) and (ii) mineral substrate without OM. The results showed beneficial effects on seedling growth in the OM-rich substrate when T. saturnisporum rice formulation (mainly at maximum concentration) was applied, but the effects were opposite when the mineral substrate without OM was used. The effects were closely linked to the level of inoculum in the substrate, which was greater upon application of the formulated inoculum as opposed to the nonformulated one. CONCLUSIONS: The use of rice to prepare the inoculum of T. saturnisporum seems to be promising for seedling growth in the nursery when it is applied in a substrate that is rich in organic matter, but it must be considered that under certain conditions of food shortage, Trichoderma sp. could show pathogenicity to seedlings. SIGNIFICANCE AND IMPACT OF THE STUDY: This study provides evidence of the complexity inherent in the use of micro-organisms in agriculture, while also confirming that the activity of the biofertilizers based on Trichoderma depends on the type of inoculum and its concentration, as well as the properties of the medium in which the fungi develop. Further studies assessing the effectiveness or possible pathogenicity of Trichoderma in different soils under greenhouse conditions must be addressed.
[Mh] Termos MeSH primário: Inoculantes Agrícolas/fisiologia
Capsicum/microbiologia
Cucumis sativus/microbiologia
Lycopersicon esculentum/microbiologia
Plântulas/crescimento & desenvolvimento
Trichoderma/fisiologia
[Mh] Termos MeSH secundário: Inoculantes Agrícolas/crescimento & desenvolvimento
Agricultura
Averrhoa/crescimento & desenvolvimento
Averrhoa/microbiologia
Capsicum/crescimento & desenvolvimento
Cucumis sativus/crescimento & desenvolvimento
Lycopersicon esculentum/crescimento & desenvolvimento
Oryza/crescimento & desenvolvimento
Oryza/microbiologia
Plântulas/microbiologia
Esporos Fúngicos/crescimento & desenvolvimento
Esporos Fúngicos/imunologia
Esporos Fúngicos/fisiologia
Trichoderma/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE
[do] DOI:10.1111/jam.13245


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[PMID]:27262321
[Au] Autor:Saghir SA; Sadikun A; Al-Suede FS; Majid AM; Murugaiyah V
[Ti] Título:Antihyperlipidemic, Antioxidant and Cytotoxic Activities of Methanolic and Aqueous Extracts of Different Parts of Star Fruit.
[So] Source:Curr Pharm Biotechnol;17(10):915-25, 2016.
[Is] ISSN:1873-4316
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Star fruit (Averrhoa carambola) is a well-known plant in Malaysia which bears a great significance in traditional medicine. OBJECTIVES: This study aimed to evaluate the antihyperlipidemic effect, antioxidant potential and cytotoxicity of aqueous and methanolic extracts of ripe and unripe fruits, leaves and stem of A. carambola. METHODS: Antihyperlipidemic activity was assessed in poloxamer-407 (P-407) induced acute hyperlipidemic rat's model. The antioxidant activity was assessed in vitro using 2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging, 1-diphenyl-2-dipicrylhydrazyl radical scavenging (DPPH) and ferric reducing antioxidant power (FRAP) assays. In addition, cytotoxicity of A. carambola extracts was assessed using MTS assay on four leukemic cell lines (human colon cancer, human promyeloid leukemia, erythroid leukemia, acute myeloid leukemia) and one normal cell (human umbilical vein endothelial cells). RESULTS: Methanolic extract of leaves had the most potent antihyperlipidemic activity in P-407 model, whereby it significantly reduced serum levels of total cholesterol (P<0.01), triglycerides (P<0.01), low-density lipoprotein (P<0.05), verylow- density lipoprotein (P<0.01) and atherogenic index (P<0.01). On the other hand, methanolic extracts of A. carambola stem and leaves showed the strongest antioxidant activity. Total phenolic and flavonoid contents of the extracts exhibited significant correlations with antioxidant but not with antihyperlipidemic activities. All plant parts showed no cytotoxic effect on the selected cancer or normal cell lines. CONCLUSION: Antihyperlipidemic activity of different parts of A. carambola is greatly affected by extraction solvents used. Methanolic extract of A. carambola leaves exhibited higher antihyperlipidemic and antioxidant potentials compared to other parts of the plant.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Averrhoa
Hipolipemiantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Flavonoides/farmacologia
Frutas
Lipoproteínas LDL
Masculino
Medicina Tradicional
Fenóis/farmacologia
Folhas de Planta
Poloxâmero/química
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Hypolipidemic Agents); 0 (Lipoproteins, LDL); 0 (Phenols); 0 (Plant Extracts); 106392-12-5 (Poloxamer)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160606
[St] Status:MEDLINE


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[PMID]:27080855
[Au] Autor:Soumya SL; Nair BR
[Ad] Endereço:Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581, Kerala, India. sl.soumya@yahoo.com.
[Ti] Título:Assessment of heavy metals in Averrhoa bilimbi and A. carambola fruit samples at two developmental stages.
[So] Source:Environ Monit Assess;188(5):291, 2016 May.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Though the fruits of Averrhoa bilimbi and A. carambola are economically and medicinally important, they remain underutilized. The present study reports heavy metal quantitation in the fruit samples of A. bilimbi and A. carambola (Oxalidaceae), collected at two stages of maturity. Heavy metals are known to interfere with the functioning of vital cellular components. Although toxic, some elements are considered essential for human health, in trace quantities. Heavy metals such as Cr, Mn, Co, Cu, Zn, As, Se, Pb, and Cd were analyzed by atomic absorption spectroscopy (AAS). The samples under investigation included, A. bilimbi unripe (BU) and ripe (BR), A. carambola sour unripe (CSU) and ripe (CSR), and A. carambola sweet unripe (CTU) and ripe (CTR). Heavy metal analysis showed that relatively higher level of heavy metals was present in BR samples compared to the rest of the samples. The highest amount of As and Se were recorded in BU samples while Mn content was highest in CSU samples and Co in CSR. Least amounts of Cr, Zn, Se, Cd, and Pb were noted in CTU while, Mn, Cu, and As were least in CTR. Thus, the sweet types of A. carambola (CTU, CTR) had comparatively lower heavy metal content. There appears to be no reason for concern since different fruit samples of Averrhoa studied presently showed the presence of various heavy metals in trace quantities.
[Mh] Termos MeSH primário: Averrhoa/química
Monitoramento Ambiental
Poluentes Ambientais/análise
Metais Pesados/análise
[Mh] Termos MeSH secundário: Frutas/química
Espectrofotometria Atômica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Metals, Heavy)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-016-5298-z


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[PMID]:26775968
[Au] Autor:Leivas CL; Iacomini M; Cordeiro LM
[Ad] Endereço:Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CP 19.046, CEP 81.531-980, Curitiba, PR, Brazil.
[Ti] Título:Pectic type II arabinogalactans from starfruit (Averrhoa carambola L.).
[So] Source:Food Chem;199:252-7, 2016 May 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A structural characterization of polysaccharides from edible tropical fruit named starfruit (Averrhoa carambola L.) was carried out. After the purification steps, two homogeneous fractions were obtained. Fraction 50R was composed of rhamnose, arabinose, galactose and uronic acid in 4.3:56.2:37.4:2M ratio, respectively and fraction 10R was composed of rhamnose, arabinose, galactose and uronic acid in 2.8:65.8:28.5:3M ratio, respectively. Methylation and NMR spectroscopy analyses showed that these fractions are formed by pectic arabinogalactans, which contain (1→3), (1→6) and (1→3,6)-linked Galp units. The side chains have 3-O-, 5-O- and 3,5-di-O-linked α-Araf and nonreducing end-units of α-Araf, Arap, ß-Galp and α-GlcpA. These arabinogalactans were linked to type I rhamnogalacturonans.
[Mh] Termos MeSH primário: Averrhoa/química
Frutas/química
Galactanos/química
Pectinas/química
Polissacarídeos/química
[Mh] Termos MeSH secundário: Arabinose/análise
Galactose/análise
Ramnose/análise
Ácidos Urônicos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Galactans); 0 (Pectins); 0 (Polysaccharides); 0 (Uronic Acids); 89NA02M4RX (pectin); B40ROO395Z (Arabinose); QN34XC755A (Rhamnose); X2RN3Q8DNE (Galactose)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE



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