Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.791 [Categoria DeCS]
Referências encontradas : 788 [refinar]
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[PMID]:29334729
[Au] Autor:Huang R; Jiang BG; Li XN; Wang YT; Liu SS; Zheng KX; He J; Wu SH
[Ad] Endereço:School of Chemical Science and Technology, Yunnan University , Kunming 650091, China.
[Ti] Título:Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi.
[So] Source:J Agric Food Chem;66(5):1140-1146, 2018 Feb 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising α-glycosidase inhibitory activity with IC values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC = 1.22 mM).
[Mh] Termos MeSH primário: Ascomicetos/metabolismo
Cicloexanos/farmacologia
Inibidores Enzimáticos
Glicosídeo Hidrolases/antagonistas & inibidores
Paeonia/microbiologia
[Mh] Termos MeSH secundário: Antifúngicos
Antineoplásicos
Linhagem Celular Tumoral
Cicloexanos/química
Endófitos/metabolismo
Células HeLa
Seres Humanos
Células MCF-7
Oxigênio/química
Plantas Medicinais/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antineoplastic Agents); 0 (Cyclohexanes); 0 (Enzyme Inhibitors); EC 3.2.1.- (Glycoside Hydrolases); S88TT14065 (Oxygen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04998


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[PMID]:29372965
[Au] Autor:Punina EO; Machs EM; Krapivskaya EE; Rodionov AV
[Ti] Título:[Polymorphic sites in transcribed spacers of 35S rRNA genes as an indicator of origin of the Paeonia cultivars].
[So] Source:Genetika;53(2):181-91, 2017 Feb.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Region ITS1­5.8S rDNA­ITS2 is sequenced in 27 varieties of cultivated ornamental peonies, ten of which presumably originate from Paeonia lactiflora, one from P. officinalis, 13 from hybridization of P. lactiflora and P. peregrina, or P. officinalis, and three are Itoh hybrids. Comparative analysis of distribution patterns of polymorphic sites (PS) for the obtained DNA sequences and data from GenBank is carried out. Hypotheses of origin of the studied varieties, except for two, which, as previously assumed, originate from hybridization of P. lactiflora and P. peregrina, are confirmed. It is shown that the sequence ITS1­5.8S rDNA­ITS2 is a good genetic marker for cultivars of the P. lactiflora group and Itoh hybrids, and that the PS distribution patterns in these sequences can provide valuable information on the kinship and origin of individual varieties. However, insufficient knowledge of wild species from the P. officinalis kinship group limits the use of this marker in the study of varieties obtained through interspecific hybridization within the Paeonia section.
[Mh] Termos MeSH primário: Genes de Plantas
Genes de RNAr
Paeonia/genética
Polimorfismo Genético
RNA de Plantas/genética
RNA Ribossômico/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Plant); 0 (RNA, Ribosomal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE


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[PMID]:29207319
[Au] Autor:Li SS; Wu Q; Yin DD; Feng CY; Liu ZA; Wang LS
[Ad] Endereço:Key Laboratory of Plant Resources/Beijing Botanical Garden, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, China.
[Ti] Título:Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeonia suffruticosa (tree peony).
[So] Source:Phytochemistry;146:16-24, 2018 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mu Dan Pi is a traditional Chinese medicine used to treat inflammation, cancer, allergies, diabetes, angiocardiopathy, and neurodegenerative diseases. In this study, the metabolome variation within Mu Dan Pi collected from 372 tree peony cultivars was systematically investigated. In total, 42 metabolites were identified, comprising of 14 monoterpene glucosides, 11 tannins, 8 paeonols, 6 flavonoids, and 3 phenols. All cultivars revealed similar metabolite profiles, however, they were further classified into seven groups on the basis of their varying metabolite contents by hierarchical cluster analysis. Traditional cultivars for Mu Dan Pi were found to have very low metabolite contents, falling into clusters I and II. Cultivars with the highest amounts of metabolites were grouped in clusters VI and VII. Five potential cultivars, namely, 'Bai Yuan Qi Guan', 'Cao Zhou Hong', 'Da Zong Zi', 'Sheng Dan Lu', and 'Cheng Xin', with high contents of monoterpene glycosides, tannins, and paeonols, were further screened. Interestingly, the majority of investigated cultivars had relatively higher metabolite contents compared to the traditional medicinal tree peony cultivars.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Paeonia/química
Compostos Fitoquímicos/isolamento & purificação
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Medicina Tradicional Chinesa
Estrutura Molecular
Compostos Fitoquímicos/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Phytochemicals)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:27771535
[Au] Autor:Sim Y; Park G; Eo H; Huh E; Gu PS; Hong SP; Pak YK; Oh MS
[Ad] Endereço:Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
[Ti] Título:Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein.
[So] Source:Neuroscience;340:166-175, 2017 Jan 06.
[Is] ISSN:1873-7544
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parkinson's disease (PD) is one of the progressive neurodegenerative diseases of whose condition is characterized by dopaminergic neuronal cell loss and dysfunction in the substantia nigra pars compacta (SNpc) and the striatum. Recent studies have demonstrated that the nuclear receptor-related 1 protein (Nurr1) is critical of dopaminergic phenotype induction in mesencephalic dopaminergic neurons. Further, Nurr1 engages in synthesizing and storing dopamine through regulating levels of tyrosine hydroxylase (TH), dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). The aim of this study was to investigate the protective effects of a herbal extract combination, consisting of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica (MABH), on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD-like symptoms and to elucidate possible mechanisms of action focusing on Nurr1. In a subacute mouse model of MPTP-induced PD, MABH treatment resulted in recovery from movement impairments. MABH prevented dopamine depletion and protected against dopaminergic neuronal degradation induced by MPTP. Additionally, MABH increased Nurr1 expression in the SNpc of mice. To evaluate the effects of MABH on Nurr1 expression, we measured the protein levels of Nurr1 and its regulating factors using Western blot analysis in PC12 cells. MABH treatment induced the phosphorylation of extracellular signal-regulated kinase protein via increasing the protein expression levels of Nurr1 and ultimately the levels of TH, VMAT2, and DAT. These results indicate that MABH has protective effects on dopaminergic neurons in a mouse model of PD by regulating Nurr1.
[Mh] Termos MeSH primário: Angelica
Bupleurum
Intoxicação por MPTP/tratamento farmacológico
Fármacos Neuroprotetores/farmacologia
Paeonia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Dopamina/metabolismo
Expressão Gênica/efeitos dos fármacos
Intoxicação por MPTP/metabolismo
Intoxicação por MPTP/patologia
Masculino
Camundongos Endogâmicos C57BL
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Neurônios/patologia
Membro 2 do Grupo A da Subfamília 4 de Receptores Nucleares/metabolismo
Células PC12
Parte Compacta da Substância Negra/efeitos dos fármacos
Parte Compacta da Substância Negra/metabolismo
Parte Compacta da Substância Negra/patologia
Fitoterapia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuroprotective Agents); 0 (Nr4a2 protein, mouse); 0 (Nr4a2 protein, rat); 0 (Nuclear Receptor Subfamily 4, Group A, Member 2); 0 (Plant Extracts); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28870900
[Au] Autor:Kim D; Radin D; Leonardi D
[Ad] Endereço:Department of Biology, College of Arts and Sciences, Washington University, St. Louis, MO, U.S.A.
[Ti] Título:Probing the Molecular Mechanisms Governing the Oncolytic Activity of on Triple-negative Breast Cancer Cells .
[So] Source:Anticancer Res;37(9):4813-4819, 2017 09.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Extracts of Paeonia suffruticosa are traditionally used in Chinese medicine to increase blood flow. Recently, this extract has been shown to possess anti-tumor and anti-inflammatory properties, though this mechanism remains unknown. In the current work, we prepared extracts of P. suffruticosa and analyzed their effects on MDA-MB-231 triple-negative breast cancer cells. MATERIALS AND METHODS: Varying concentrations of an aqueous extract of P. suffruticosa was administered to MDA-MB-231. An MTS assay was used to determine the cell viability. Cytokine production was investigated through enzyme-linked immunosorbent assay (ELISA). Caspase-Glo assays were performed to measure caspase 3/7, 8 and 9 to analyze anti-apoptotic effects. RESULTS: MTS assay for cell viability revealed that the extract increased viability at low concentrations (0.6 mg/ml) and decreased viability observed at concentrations ≥2.5 mg/ml (p<0.01). ELISA for IL-6, IL-2, and TNF-alpha revealed a biphasic dose-response inversely related to viability (p<0.05). IL-24 expression also increased at 2.5 mg/ml and 4.0 mg/ml (p<0.05). Bax levels remained relatively constant while Bcl-2 decreased significantly in all concentrations (p<0.01). Small decreases in Fas ligand levels was observed in parallel with a lack of increase in caspase-8 activity. Most notable was that while 4mg/ml of P. suffruticosa extract reduced MDA-MB-231 viability by >60% (p<0.01), the same concentration reduced the viability of non-transformed HaCat cells by ~8% (p>0.05), suggesting a selective oncolytic effect. CONCLUSION: P. suffruticosa extract has the ability to modulate the production of several tumor suppressive cytokines, induce intrinsic apoptosis and has the capability of reducing cancer burden while sparing healthy tissue.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Extratos Vegetais/uso terapêutico
Neoplasias de Mama Triplo Negativas/patologia
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Caspases/metabolismo
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Citocinas/biossíntese
Feminino
Seres Humanos
Paeonia
Extratos Vegetais/farmacologia
Neoplasias de Mama Triplo Negativas/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Cytokines); 0 (Plant Extracts); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE


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[PMID]:28783760
[Au] Autor:Zhang ZH; Xie DD; Xu S; Xia MZ; Zhang ZQ; Geng H; Chen L; Wang DM; Wei W; Yu DX; Xu DX
[Ad] Endereço:Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui Province, China.
[Ti] Título:Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells.
[So] Source:PLoS One;12(8):e0182584, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies demonstrated that inflammatory microenvironment promoted prostate cancer progression. This study investigated whether total glucosides of paeony (TGP), the active constituents extracted from the root of Paeonia Lactiflora Pall, suppressed lipopolysaccharide (LPS)-stimulated proliferation, migration and invasion in androgen insensitive prostate cancer cells. PC-3 cells were incubated with LPS (2.0 µg/mL) in the absence or presence of TGP (312.5 µg /mL). As expected, cells at S phase and nuclear CyclinD1, the markers of cell proliferation, were increased in LPS-stimulated PC-3 cells. Migration activity, as determined by wound-healing assay and transwell migration assay, and invasion activity, as determined by transwell invasion assay, were elevated in LPS-stimulated PC-3 cells. Interestingly, TGP suppressed LPS-stimulated PC-3 cells proliferation. Moreover, TGP inhibited LPS-stimulated migration and invasion of PC-3 cells. Additional experiment showed that TGP inhibited activation of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)/p38 in LPS-stimulated PC-3 cells. Correspondingly, TGP attenuated upregulation of interleukin (IL)-6 and IL-8 in LPS-stimulated PC-3 cells. In addition, TGP inhibited nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in LPS-stimulated PC-3 cells. These results suggest that TGP inhibits inflammation-associated STAT3 activation and proliferation, migration and invasion in androgen insensitive prostate cancer cells.
[Mh] Termos MeSH primário: Movimento Celular/efeitos dos fármacos
Glucosídeos/farmacologia
Lipopolissacarídeos/farmacologia
Paeonia/química
Neoplasias de Próstata Resistentes à Castração/patologia
[Mh] Termos MeSH secundário: Transporte Ativo do Núcleo Celular/efeitos dos fármacos
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Proliferação Celular/efeitos dos fármacos
Ativação Enzimática/efeitos dos fármacos
Seres Humanos
Interleucina-6/metabolismo
Interleucina-8/metabolismo
Masculino
NF-kappa B/metabolismo
Invasividade Neoplásica
Fator de Transcrição STAT3/metabolismo
Transdução de Sinais/efeitos dos fármacos
Regulação para Cima/efeitos dos fármacos
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosides); 0 (Interleukin-6); 0 (Interleukin-8); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (STAT3 Transcription Factor); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182584


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[PMID]:28730733
[Au] Autor:Xu W; Xu L; Deng B; Leng J; Tang N; Zhao LC; Zhou HH; Zhao ZZ; Yang ZJ; Xiao TT; Tian XY; Ho AHM; Chan NWK; Chow YL; Chow CY; Xu M
[Ad] Endereço:Hong Kong Baptist University, Kowloon Tong, Hong Kong.
[Ti] Título:The Potential Impact of Radix Paeoniae Alba in Embryonic Development of Mice.
[So] Source:Phytother Res;31(9):1376-1383, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although Radix Paeoniae Alba (RPA) has been ranked as one of the top 6 herbs used frequently to prevent and treat miscarriages clinically, there is no clear evidence regarding its safety in embryonic development. This study aims to evaluate the potential impacts of RPA on embryonic stem cells (ESCs) and pregnant mice. Cytotoxicity assays of the extract were performed in ESCs and 3T3 cells. Pregnant ICR mice were orally treated with RPA extracts at dosages of 0 (G1 group as negative controls), 2, 8 and 32 g/kg/day (G2, G3 and G4 groups) respectively from the gestation day (Gd) 6-15. On Gd 18, there was no significant difference in the IC values between ESCs and 3T3 cells (p > 0.05). There was no significant difference in the maternal and fetal evaluations among four groups (p > 0.05). Fetal IL-2, IL-2r, TNF-α, TNF-αr, IL-4, IL-4r, IL-10r, IL-17 and IL-17r of G4 group were significantly lower than G1 group (p < 0.05). In conclusion, RPA at dosage of 32 g/kg/day (16-folds of human daily dosage) did not cause adverse impact in cultured ESCs and pregnant mice. RPA might down-regulate fetal Th1/Th2/Th17 cytokines and receptors maybe beneficial to embryonic survival and development. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Desenvolvimento Embrionário/efeitos dos fármacos
Células-Tronco Embrionárias/efeitos dos fármacos
Paeonia/química
[Mh] Termos MeSH secundário: Células 3T3
Animais
Citocinas/metabolismo
Feminino
Feto/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos ICR
Gravidez
Receptores de Citocinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Drugs, Chinese Herbal); 0 (Receptors, Cytokine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5864


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[PMID]:28494313
[Au] Autor:Shen ZJ; Xu C; Chen YS; Zhang Z
[Ad] Endereço:School of Life Science, Hefei Normal University, Lianhua Road 1688, Hefei, Anhui, China; School of Resources and Environment Engineering, Anhui University, Jiulong Road 111, Hefei, Anhui, China.
[Ti] Título:Heavy metals translocation and accumulation from the rhizosphere soils to the edible parts of the medicinal plant Fengdan (Paeonia ostii) grown on a metal mining area, China.
[So] Source:Ecotoxicol Environ Saf;143:19-27, 2017 Sep.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fengdan (Paeonia ostii) is one of Chinese 34 famous medicinal materials. This study investigated the concentrations of Arsenic (As), Chromium (Cr), Cadmium (Cd), Copper (Cu), Lead (Pb), Iron (Fe), Manganese (Mn), and Zinc (Zn) in rhizosphere soils, cortex mouton and seeds of Fengdan planted in a metal mining area, China. The mean concentrations of As, Cd, Cu, and Zn in the rhizosphere soils were above the limits set by the Chinese Soil Environmental Quality Standard (GB 15618-1995). The contamination factor (CF) of Cd was >5, while it was >2for As, Cu, Pb, and Zn in all the soils. The integrated pollution index for all the soils was >3 and Ë‚ 5. Metal concentrations in the edible parts of Fengdan were in the following decreasing order: Mn>Fe>Zn>Cu>Pb>As>Cr≥Cd. The transfer factor mean values for As, Cu, Cd and Fe in the cortex moutan of old Fengdan (over 6 years) were significantly higher than in young Fengdan. Available metal concentrations, pH and soil organic matter content influenced the metal concentrations of the cortex moutan. The results indicated that mining and smelting operations have led to heavy metals contamination of soils and medicinal parts of Fengdan. The major metal pollutants were elemental Cd, Cu, Pb, and Zn. Heavy metals mainly accumulated in the cortex moutan of Fengdan. The mean concentrations of Cd, Cu, and Pb in the old cortex moutan (over 6 years) were above those of the Chinese Green Trade Standards for Medicinal Plants and Preparations in Foreign Trade (WM/T2-2004).
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Metais Pesados/metabolismo
Mineração
Paeonia/efeitos dos fármacos
Rizosfera
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Disponibilidade Biológica
China
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/metabolismo
Metais Pesados/análise
Paeonia/química
Paeonia/crescimento & desenvolvimento
Paeonia/metabolismo
Raízes de Plantas/química
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/metabolismo
Plantas Medicinais
Sementes/química
Sementes/efeitos dos fármacos
Sementes/crescimento & desenvolvimento
Sementes/metabolismo
Solo/química
Poluentes do Solo/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Metals, Heavy); 0 (Soil); 0 (Soil Pollutants); 0 (moutan cortex)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


  9 / 788 MEDLINE  
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[PMID]:28411689
[Au] Autor:Zhong LJ; Xie ZS; Yang H; Li P; Xu XJ
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Moutan Cortex and Paeoniae Radix Rubra reverse high-fat-diet-induced metabolic disorder and restore gut microbiota homeostasis.
[So] Source:Chin J Nat Med;15(3):210-219, 2017 Mar.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate the therapeutic effcts of Moutan Cortex (CM, root bark of Paeonia suffruticosa Andr) and Paeoniae Radix Rubra (PR, root of Paeonia veitchii Lynch) on metabolic disorders, focusing on the infuence of CM and PR on the obesity-related gut microbiota homeostasis. The diet-induced obese (DIO) mouse model was used to test the therapeutic effects of CM and PR. The mice were orally administered with CM and PR for 6 weeks, and oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed to evaluate the insulin sensitivity of the mice. Sterol-regulatory element binding proteins (SREBPs) and their target genes were measured by quantitative RT-PCR. High-throughput 16S ribosomal RNA (16S rRNA) gene sequencing technology was used to determine the composition of gut microbiota, and the metabolites in serum were analyzed by GC-MS. Our results indicated that CM and PR combination alleviated obese and insulin resistance in the DIO mice, leading to increased glucose uptake and gene expression in muscle and liver, and down-regulated SREBPs and their target genes in liver. Interesting, neither the CM-PR extracts, nor the major components of CM and PR did not affect SREBPs activity in cultured cells. Meanwhile, CM and PR significantly modulated the gut microbiota of the high-fat diet (HFD) treated mice, similar to metformin, and CM-PR reversed the overall microbiota composition similar to the normal chow diet (NCD) treated mice. In conclusion, our results provide novel mechanisms of action for the effects of CM and PR in treating DIO-induced dysregulation of sugar and lipid metabolism.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/administração & dosagem
Microbioma Gastrointestinal/efeitos dos fármacos
Doenças Metabólicas/tratamento farmacológico
Doenças Metabólicas/microbiologia
Paeonia/química
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Dieta Hiperlipídica/efeitos adversos
Homeostase/efeitos dos fármacos
Seres Humanos
Insulina/metabolismo
Masculino
Doenças Metabólicas/genética
Doenças Metabólicas/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Proteínas de Ligação a Elemento Regulador de Esterol/genética
Proteínas de Ligação a Elemento Regulador de Esterol/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Drugs, Chinese Herbal); 0 (Insulin); 0 (Sterol Regulatory Element Binding Proteins); 0 (moutan cortex)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


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[PMID]:28400341
[Au] Autor:Yu C; Fan X; Li Z; Liu X; Wang G
[Ad] Endereço:Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
[Ti] Título:Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a double-blind, randomised, placebo-controlled trial.
[So] Source:Eur J Dermatol;27(2):150-154, 2017 Apr 01.
[Is] ISSN:1952-4013
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Although acitretin has been widely used for the treatment of psoriasis, additional safer and more effective approaches, including traditional Chinese medicine, are needed. To investigate the efficacy and safety of total glucosides of paeony (TGP) combined with acitretin in the treatment of moderate-to-severe plaque psoriasis. A randomised, double-blind, placebo-controlled, multi-centre clinical study was conducted. In total, 108 patients with moderate-to-severe plaque psoriasis were randomly assigned to treatment with "TGP plus acitretin" (group A) or "placebo plus acitretin" (group B) for 12 weeks. After 12 weeks of therapy, the percentage of patients achieving a 50% reduction in Psoriasis Area and Severity Index was 90% in group A and 70.5% in group B (p<0.05). The rate of serum alanine aminotransferase elevation was 6.25% in group A and 20.4% in group B (p<0.05). TGP is conducive to enhancing anti-psoriatic efficacy and reducing liver damage due to acitretin. TGP combined with acitretin is a safe and effective treatment approach for moderate-to-severe plaque psoriasis.
[Mh] Termos MeSH primário: Acitretina/uso terapêutico
Glucosídeos/uso terapêutico
Ceratolíticos/uso terapêutico
Paeonia/química
Fitoterapia
Extratos Vegetais/uso terapêutico
Psoríase/tratamento farmacológico
[Mh] Termos MeSH secundário: Acitretina/efeitos adversos
Adulto
Alanina Transaminase/sangue
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Glucosídeos/efeitos adversos
Seres Humanos
Ceratolíticos/efeitos adversos
Masculino
Meia-Idade
Extratos Vegetais/efeitos adversos
Raízes de Plantas
Fatores de Proteção
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Glucosides); 0 (Keratolytic Agents); 0 (Plant Extracts); EC 2.6.1.2 (Alanine Transaminase); LCH760E9T7 (Acitretin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1684/ejd.2016.2946



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