|
[PMID]: | 28568647 |
[Au] Autor: | Schunck RVA; Macedo IC; Laste G; de Souza A; Valle MTC; Salomón JLO; Nunes EA; Campos ACW; Gnoatto SCB; Bergold AM; Konrath EL; Dallegrave E; Arbo MD; Torres ILS; Leal MB |
[Ad] Endereço: | Programa de Pós-Graduação em Ciências Biológicas - Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500/107, 90050-170, Porto Alegre, RS, Brazil. |
[Ti] Título: | Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats. |
[So] Source: | Phytother Res;31(8):1199-1208, 2017 Aug. | [Is] ISSN: | 1099-1573 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain-derived neurotrophic factor and interleukin-10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P. incarnata group) water for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days); (3: alcohol withdrawal group) alcohol for 19 days, 1 day interval and water (8 days); and (4: P. incarnata in alcohol withdrawal) alcohol for 19 days, 1 day interval and P. incarnata 200 mg/kg (8 days). The tail-flick and hot plate tests were used as nociceptive response measures. Confirming previous study of our group, it was showed that alcohol-treated groups presented an increase in the nociceptive thresholds after alcohol withdrawal, which was reverted by P. incarnata, measured by the hot plate test. Besides, alcohol treatment increased brain-derived neurotrophic factor and interleukin-10 levels in prefrontal cortex, which was not reverted by P. incarnata. Considering these results, the P. incarnata treatment might be a potential therapy in the alcohol withdrawal syndrome. Copyright © 2017 John Wiley & Sons, Ltd. |
[Mh] Termos MeSH primário: |
Nociceptividade/efeitos dos fármacos Passiflora/química Extratos Vegetais/farmacologia Síndrome de Abstinência a Substâncias/tratamento farmacológico
|
[Mh] Termos MeSH secundário: |
Animais Fator Neurotrófico Derivado do Encéfalo/metabolismo Interleucina-10/metabolismo Masculino Medição da Dor Ratos Ratos Wistar
|
[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Brain-Derived Neurotrophic Factor); 0 (Plant Extracts); 130068-27-8 (Interleukin-10) |
[Em] Mês de entrada: | 1710 |
[Cu] Atualização por classe: | 171003 |
[Lr] Data última revisão:
| 171003 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170602 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1002/ptr.5839 |
|
|
|