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Romero, Gustavo Adolfo Sierra
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[PMID]:28415906
[Au] Autor:Araújo-Vilges KM; Oliveira SV; Couto SCP; Fokoue HH; Romero GAS; Kato MJ; Romeiro LAS; Leite JRSA; Kuckelhaus SAS
[Ad] Endereço:a Laboratory of Cell Immunology, Faculty of Medicine , University of Brasilia Campus Darcy Ribeiro , Brasilia - DF , Brazil.
[Ti] Título:Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice.
[So] Source:Pharm Biol;55(1):1601-1607, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Plants of the Piperaceae family produce piplartine that was used to synthesize the cinnamides. OBJECTIVE: To assess the effects of piplartine (1) and cinnamides (2-5) against the protozoa responsible for malaria and leishmaniasis, and peritoneal cells of Swiss mice. MATERIALS AND METHODS: Cultures of Leishmania amazonensis, Plasmodium falciparum-infected erythrocytes, and peritoneal cells were incubated, in triplicate, with different concentrations of the compounds (0 to 256 µg/mL). The inhibitory concentration (IC ) in L. amazonensis and cytotoxic concentration (CC ) in peritoneal cell were assessed by the MTT method after 6 h of incubation, while the IC for P. falciparum-infected erythrocytes was determined by optical microscopy after 48 or 72 h of incubation; the Selectivity Index (SI) was calculated by CC /IC . RESULTS: All compounds inhibited the growth of microorganisms, being more effective against P. falciparum after 72 h of incubation, especially for the compounds 1 (IC = 3.2 µg/mL) and 5 (IC = 6.6 µg/mL), than to L. amazonensis (compound 1 = 179.0 µg/mL; compound 5 = 106.0 µg/mL). Despite all compounds reducing the viability of peritoneal cells, the SI were <10 to L. amazonensis, whereas in the cultures of P. falciparum the SI >10 for the piplartine (>37.4) and cinnamides 4 (>10.7) and 5 (= 38.4). DISCUSSION AND CONCLUSION: The potential of piplartine and cinnamides 4 and 5 in the treatment of malaria suggest further pre-clinical studies to evaluate their effects in murine malaria and to determine their mechanisms in cells of the immune system.
[Mh] Termos MeSH primário: Cinamatos/farmacologia
Leishmania/efeitos dos fármacos
Piperidonas/farmacologia
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Cinamatos/administração & dosagem
Cinamatos/química
Relação Dose-Resposta a Droga
Eritrócitos/parasitologia
Feminino
Seres Humanos
Concentração Inibidora 50
Masculino
Camundongos
Peritônio/citologia
Peritônio/efeitos dos fármacos
Piperaceae/química
Piperidonas/administração & dosagem
Piperidonas/isolamento & purificação
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Piperidones); 0 (piplartine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1313870


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[PMID]:27213575
[Au] Autor:Leesombun A; Boonmasawai S; Shimoda N; Nishikawa Y
[Ad] Endereço:National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
[Ti] Título:Effects of Extracts from Thai Piperaceae Plants against Infection with Toxoplasma gondii.
[So] Source:PLoS One;11(5):e0156116, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Herbal medicines and natural herb extracts are widely used as alternative treatments for various parasitic diseases, and such extracts may also have potential to decrease the side effects of the standard regimen drugs used to treat toxoplasmosis (sulfadiazine-pyrimethamine combination). We evaluated how effective the Thai piperaceae plants Piper betle, P. nigrum and P. sarmentosum are against Toxoplasma gondii infection in vitro and in vivo. Individually, we extracted the piperaceae plants with ethanol, passed them through a rotary evaporator and then lyophilized them to obtain crude extracts for each one. The in vitro study indicated that the P. betle extract was the most effective extract at inhibiting parasite growth in HFF cells (IC50 on RH-GFP: 23.2 µg/mL, IC50 on PLK-GFP: 21.4 µg/mL). Furthermore, treatment of experimental mice with the P. betle extract for 7 days after infection with 1,000 tachyzoites of the T. gondii PLK strain increased their survival (survival rates: 100% in 400 mg/kg-treated, 83.3% in 100 mg/kg-treated, 33.3% in 25 mg/kg-treated, 33.3% in untreated mice). Furthermore, treatment with 400 mg/kg of the P. betle extract resulted in 100% mouse survival following infection with 100,000 tachyzoites. The present study shows that P. betle extract has the potential to act as a medical plant for the treatment of toxoplasmosis.
[Mh] Termos MeSH primário: Piperaceae/química
Extratos Vegetais/farmacologia
Toxoplasma/efeitos dos fármacos
Toxoplasmose Animal/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/farmacologia
Antiprotozoários/uso terapêutico
Células Cultivadas
Cercopithecus aethiops
Feminino
Camundongos
Camundongos Endogâmicos C57BL
Piper betle/química
Piper nigrum/química
Extratos Vegetais/uso terapêutico
Plantas Medicinais
Sulfadiazina/farmacologia
Tailândia
Toxoplasma/crescimento & desenvolvimento
Toxoplasmose Animal/patologia
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Plant Extracts); 0N7609K889 (Sulfadiazine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0156116


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[PMID]:26821820
[Au] Autor:Varela MT; Dias RZ; Martins LF; Ferreira DD; Tempone AG; Ueno AK; Lago JH; Fernandes JP
[Ad] Endereço:Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau 210, Diadema, SP 09913-030, Brazil.
[Ti] Título:Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
[So] Source:Bioorg Med Chem Lett;26(4):1180-3, 2016 Feb 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The essential oils from leaves of Piper malacophyllum (Piperaceae) showed to be mainly composed by two alkenylphenol derivatives: gibbilimbols A and B. After isolation and structural characterization by NMR and MS data analysis, both compounds were evaluated against promastigote/amastigote forms of Leishmania (L.) infantum as well as trypomastigote/amastigote forms of Trypanosoma cruzi. The obtained results indicated that gibbilimbol B displayed potential against the tested parasites and low toxicity to mammalian cells, stimulating the preparation of several quite simple synthetic analogues in order to improve its activity and to explore the preliminary structure-activity relationships (SAR) data. Among the prepared derivatives, compound LINS03003 (n-octyl-4-hydroxybenzylamine) displayed the most potent IC50 values of 5.5 and 1.8 µM against amastigotes of T. cruzi and L. (L.) infantum, respectively, indicating higher activity than the natural prototype. In addition, this compound showed remarkable selectivity index (SI) towards the intracellular forms of Leishmania (SI=13.1) and T. cruzi (SI=4.3). Therefore, this work indicated that preparation of synthetic compounds structurally based in the bioactive natural products could be an interesting source of novel and selective compounds against these protozoan parasites.
[Mh] Termos MeSH primário: Antiprotozoários/síntese química
Fenóis/química
[Mh] Termos MeSH secundário: Antiprotozoários/química
Antiprotozoários/farmacologia
Leishmania infantum/efeitos dos fármacos
Óleos Voláteis/química
Fenóis/isolamento & purificação
Fenóis/farmacologia
Piperaceae/química
Piperaceae/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Relação Estrutura-Atividade
Trypanosoma cruzi/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Oils, Volatile); 0 (Phenols); 0 (gibbilimbol A); 0 (gibbilimbol B)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE


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[PMID]:26739167
[Au] Autor:Naumann J; Der JP; Wafula EK; Jones SS; Wagner ST; Honaas LA; Ralph PE; Bolin JF; Maass E; Neinhuis C; Wanke S; dePamphilis CW
[Ad] Endereço:Institut für Botanik, Technische Universität Dresden, Germany Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University jxn25@psu.edu.
[Ti] Título:Detecting and Characterizing the Highly Divergent Plastid Genome of the Nonphotosynthetic Parasitic Plant Hydnora visseri (Hydnoraceae).
[So] Source:Genome Biol Evol;8(2):345-63, 2016 Jan 06.
[Is] ISSN:1759-6653
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plastid genomes of photosynthetic flowering plants are usually highly conserved in both structure and gene content. However, the plastomes of parasitic and mycoheterotrophic plants may be released from selective constraint due to the reduction or loss of photosynthetic ability. Here we present the greatly reduced and highly divergent, yet functional, plastome of the nonphotosynthetic holoparasite Hydnora visseri (Hydnoraceae, Piperales). The plastome is 27 kb in length, with 24 genes encoding ribosomal proteins, ribosomal RNAs, tRNAs, and a few nonbioenergetic genes, but no genes related to photosynthesis. The inverted repeat and the small single copy region are only approximately 1.5 kb, and intergenic regions have been drastically reduced. Despite extreme reduction, gene order and orientation are highly similar to the plastome of Piper cenocladum, a related photosynthetic plant in Piperales. Gene sequences in Hydnora are highly divergent and several complementary approaches using the highest possible sensitivity were required for identification and annotation of this plastome. Active transcription is detected for all of the protein-coding genes in the plastid genome, and one of two introns is appropriately spliced out of rps12 transcripts. The whole-genome shotgun read depth is 1,400× coverage for the plastome, whereas the mitochondrial genome is covered at 40× and the nuclear genome at 2×. Despite the extreme reduction of the genome and high sequence divergence, the presence of syntenic, long transcriptionally active open-reading frames with distant similarity to other plastid genomes and a high plastome stoichiometry relative to the mitochondrial and nuclear genomes suggests that the plastome remains functional in H. visseri. A four-stage model of gene reduction, including the potential for complete plastome loss, is proposed to account for the range of plastid genomes in nonphotosynthetic plants.
[Mh] Termos MeSH primário: Variação Genética
Genoma de Planta
Genomas de Plastídeos
Piperaceae/genética
[Mh] Termos MeSH secundário: Sequência de Bases
DNA Intergênico/genética
Evolução Molecular
Íntrons
Dados de Sequência Molecular
Fases de Leitura Aberta
RNA Ribossômico/genética
RNA de Transferência/genética
Proteínas Ribossômicas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Intergenic); 0 (RNA, Ribosomal); 0 (Ribosomal Proteins); 9014-25-9 (RNA, Transfer)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE
[do] DOI:10.1093/gbe/evv256


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Texto completo SciELO Brasil
[PMID]:26628019
[Au] Autor:Cunico MM; Trebien HA; Galetti FC; Miguel OG; Miguel MD; Auer CG; Silva CL; de Souza AO
[Ad] Endereço:Laboratório de Inventário Florestal, Departamento de Ciências Florestais, Universidade Federal do Paraná, Curitiba, PR, Brazil.
[Ti] Título:Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae).
[So] Source:An Acad Bras Cienc;87(4):1991-2000, 2015 Oct-Dec.
[Is] ISSN:1678-2690
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924. EE, HF, DF, and piperovatine showed a potential antimycobacterial effect with MICs of 16.0, 62.0, 62.0 and 8.0 µg/mL, respectively. Piperovatine was more effective than the EE or the other fractions. The selectivity index (SI=IC50/MIC) values calculated for EE, HF, DF and piperovatine based on the MICs and the cytotoxicity against J774 macrophages (IC50 by MTT assay) revealed values of 6.43, 2.34, 1.5 and 9.66, respectively.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Antibacterianos/farmacologia
Cloreto de Metileno/farmacologia
Piperaceae/química
Extratos Vegetais/farmacologia
Ácido Sórbico/análogos & derivados
[Mh] Termos MeSH secundário: Analgésicos/toxicidade
Animais
Antibacterianos/toxicidade
Cobaias
Dose Letal Mediana
Cloreto de Metileno/toxicidade
Camundongos
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Coelhos
Ácido Sórbico/farmacologia
Ácido Sórbico/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Bacterial Agents); 0 (Plant Extracts); 25090-18-0 (piperovatine); 588X2YUY0A (Methylene Chloride); X045WJ989B (Sorbic Acid)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:151218
[Lr] Data última revisão:
151218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151203
[St] Status:MEDLINE


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[PMID]:26039266
[Au] Autor:Lei J; Burgess EJ; Richardson AT; Hawkins BC; Baird SK; Smallfield BM; van Klink JW; Perry NB
[Ad] Endereço:Department of Chemistry, University of Otago, Dunedin, New Zealand.
[Ti] Título:Cytotoxic Amides from Fruits of Kawakawa, Macropiper excelsum.
[So] Source:Planta Med;81(12-13):1163-8, 2015 Aug.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cytotoxic amides have been isolated from the fruits of the endemic New Zealand medicinal plant kawakawa, Macropiper excelsum (Piperaceae). The main amide was piperchabamide A and this is the first report of this rare compound outside the genus Piper. Eleven other amides were purified including two new compounds with the unusual 3,4-dihydro-1(2H)-pyridinyl group. The new compounds were fully characterized by 2D NMR spectroscopy, which showed a slow exchange between two rotamers about the amide bond, and they were chemically synthesized. In view of the antitumor activity of the related piperlongumine, all of these amides plus four synthetic analogs were tested for cytotoxicity. The most active was the piperine homolog piperdardine, with an IC50 of 14 µM against HT 29 colon cancer cells.
[Mh] Termos MeSH primário: Alcaloides/química
Amidas/química
Benzodioxóis/química
Piperaceae/química
Piperidinas/química
Extratos Vegetais/química
Alcamidas Poli-Insaturadas/química
[Mh] Termos MeSH secundário: Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Amidas/isolamento & purificação
Amidas/farmacologia
Benzodioxóis/isolamento & purificação
Benzodioxóis/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Frutas/química
Células HT29
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Piperidinas/isolamento & purificação
Piperidinas/farmacologia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Plantas Medicinais
Alcamidas Poli-Insaturadas/isolamento & purificação
Alcamidas Poli-Insaturadas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Amides); 0 (Benzodioxoles); 0 (Piperidines); 0 (Plant Extracts); 0 (Polyunsaturated Alkamides); U71XL721QK (piperine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150820
[Lr] Data última revisão:
150820
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150604
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1546106


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[PMID]:25771354
[Au] Autor:Oyemitan IA; Olayera OA; Alabi A; Abass LA; Elusiyan CA; Oyedeji AO; Akanmu MA
[Ad] Endereço:Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State 220005, Nigeria; Department of Chemistry and Chemical Technology, Walter Sisulu University, Nelson Mandela Drive Campus, 5117 Mthatha, South Africa. Electronic address: oyemitan@oauife.edu.ng.
[Ti] Título:Psychoneuropharmacological activities and chemical composition of essential oil of fresh fruits of Piper guineense (Piperaceae) in mice.
[So] Source:J Ethnopharmacol;166:240-9, 2015 May 26.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Piper guineense Schum & Thonn (Piperaceae) is a medicinal plant used in the Southern States of Nigeria to treat fever, mental disorders and febrile convulsions. AIMS OF THE STUDY: This study aims at determining the chemical composition and the central nervous system (CNS) activities of the essential oil obtained from the plant׳s fresh fruits in order to rationalize its folkloric use. MATERIALS AND METHODS: Essential oil of P. guineense (EOPG) obtained by hydrodistillation was analysed by GC/MS. EOPG (50-200mg/kg, i.p.) was evaluated for behavioural, hypothermic, sedative, muscle relaxant, anti-psychotic and anticonvulsant activities using standard procedures. RESULTS AND DISCUSSION: Analysis of the oil reveals 44 compounds of which 30 compounds constituting 84.7% were identified. The oil was characterized by sesquiterpenoids (64.4%) while only four monoterpeneoids (21.3%) were found present in the oil. Major compounds identified were ß-sesquiphellandrene (20.9%), linalool (6.1%), limonene (5.8%), Z-ß-bisabolene (5.4%) and α-pinene (5.3%). The EOPG (50-200mg/kg, i.p.) caused significant (p<0.01) inhibition on rearing {F(4,20)=43}, locomotor {F(4,20)=22} activity and decreased head dips in hole board {F(4,20)=7} indicating CNS depressant effect; decreased rectal temperature {F(4,20)=7-16}, signifying hypothermic activity; decreased ketamine-induced sleep latency {F(4,20)=7.8} and prolonged total sleeping time {F(4,20)=8.8}, indicating sedative effect; reduced muscular tone on the hind-limb grip test {F(4,20)=22}, inclined board {F(4,20)=4-49} and rota rod {F(4,20)=13-106}, implying muscle relaxant activity; induced catalepsy {F(4,20)=47-136}, inhibited apomorphine-induced climbing behaviour {F(4,20)=9} and inhibited apomorphine-induced locomotor {F(4,20)=16}, suggesting anti-psychotic effect; and protected mice against pentylenetetrazole-induced convulsions, indicating anticonvulsant potential. CONCLUSION: The most abundant component of the fresh fruits essential oil of P. guineense was ß-sesquiphellandrene (20.9%); and the oil possesses CNS depressant, hypothermic, sedative, muscle relaxant, antipsychotic and anticonvulsant activities, thus providing scientific basis for its ethnomedicinal applications.
[Mh] Termos MeSH primário: Sistema Nervoso Central/efeitos dos fármacos
Frutas/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
Piper/química
Piperaceae/química
[Mh] Termos MeSH secundário: Animais
Ansiolíticos/química
Ansiolíticos/farmacologia
Anticonvulsivantes/química
Anticonvulsivantes/farmacologia
Temperatura Corporal/efeitos dos fármacos
Cicloexenos/química
Cicloexenos/farmacologia
Etnofarmacologia/métodos
Feminino
Hipnóticos e Sedativos/química
Hipnóticos e Sedativos/farmacologia
Masculino
Camundongos
Monoterpenos/química
Monoterpenos/farmacologia
Atividade Motora/efeitos dos fármacos
Fitoterapia/métodos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Sesquiterpenos/química
Sesquiterpenos/farmacologia
Sono/efeitos dos fármacos
Terpenos/química
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Anticonvulsants); 0 (Cyclohexenes); 0 (Hypnotics and Sedatives); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Terpenes); 0 (beta-bisabolene); 9MC3I34447 (limonene); D81QY6I88E (linalool); JPF3YI7O34 (alpha-pinene)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150420
[Lr] Data última revisão:
150420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150316
[St] Status:MEDLINE


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[PMID]:25439875
[Au] Autor:Ramos-Aguilar OP; Ornelas-Paz Jde J; Ruiz-Cruz S; Zamudio-Flores PB; Cervantes-Paz B; Gardea-Béjar AA; Pérez-Martínez JD; Ibarra-Junquera V; Reyes-Hernández J
[Ad] Endereço:Centro de Investigación en Alimentación y Desarrollo A.C.-Unidad Cuauhtémoc, Av. Río Conchos s/n, Parque Industrial, CP 31570 Cd. Cuauhtémoc, Chihuahua, Mexico; Instituto Tecnológico de Sonora, Departamento de Biotecnología y Ciencias Alimentarias, 5 de Febrero No. 818 Sur, CP 85000 Cd. Obregón, Son
[Ti] Título:Effect of ripening and heat processing on the physicochemical and rheological properties of pepper pectins.
[So] Source:Carbohydr Polym;115:112-21, 2015 Jan 22.
[Is] ISSN:1879-1344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Water-, chelator-, and alkali-soluble pectins were isolated from raw and heat-processed Jalapeño peppers (green and red) and their physiochemical and rheological properties were determined. The yield, tristimulus color, degree of methyl esterification, monosaccharide composition, molecular weights distribution, and protein content depended on ripening and heat processing. The viscosity properties of pectins were independent of ripening. The water-soluble pectin was the most abundant pectin. Pectins from grilled peppers showed the lowest L* values. The alkali-soluble pectin showed the highest protein content. The content of xylose, rhamnose, and mannose in pectins was highly altered by tested factors. The degree of methyl esterification of pectins ranged from 26.8 to 91.6%. The peak Mw of the main fraction of tested pectins was sequentially reduced by ripening and heat processing. Pectins from raw peppers showed the best viscosity properties.
[Mh] Termos MeSH primário: Temperatura Alta
Pectinas/química
Piperaceae/química
Reologia
[Mh] Termos MeSH secundário: Química Física
Pectinas/isolamento & purificação
Solubilidade
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pectins)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


  9 / 98 MEDLINE  
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[PMID]:25263165
[Au] Autor:Zhang Y; Wang X; Ma L; Dong L; Zhang X; Chen J; Fu X
[Ad] Endereço:School of Pharmacy, Ningxia Medical University.
[Ti] Título:Anti-inflammatory, antinociceptive activity of an essential oil recipe consisting of the supercritical fluid CO2 extract of white pepper, long pepper, cinnamon, saffron and myrrh in vivo.
[So] Source:J Oleo Sci;63(12):1251-60, 2014.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study was designed to investigate the anti-inflammatory and antinociceptive activities of essential oil recipe (OR) in rodents. The anti-inflammatory activity was evaluated by inflammatory models of dimethylbenzene (DMB)-induced ear vasodilatation and acetic acid-induced capillary permeability enhancement in mice whereas the antinociceptive activity was evaluated using acetic acid-induced writhes and hot plate test methods in mice. Additionally, the chemical composition of OR has been also analyzed by gas chromatography and mass spectrometry (GC/MS). 37 compounds, representing 74.42% of the total oil content, were identified. ß-Selinene (7.38%), aromadendrene (5.30%), ß-elemene (5.22%), cis-piperitol (5.21%), cis-ß-guaiene (4.67%), ylangene (3.70%), 3-heptadecene (3.55%), δ-cadinene (3%) and ß-cadinene (2.87%) were found to be the major constituents of the oil. Oral pretreatment with OR (62.5-1000 mg/kg) not only decreased the DMB-induced ear vasodilatation but also attenuated capillary permeability under acetic acid challenge in mice. OR significantly reduced the writhing number evoked by acetic acid injection. All test samples showed no significant analgesic activity on the hot plate pain threshold in mice. These data demonstrated that the OR inhibits inflammatory and peripheral inflammatory pain. These results may support the fact that the essential oil of traditional Hui prescription played a role in the inflammation of stroke.
[Mh] Termos MeSH primário: Analgésicos
Anti-Inflamatórios
Dióxido de Carbono
Cinnamomum zeylanicum/química
Crocus/química
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/farmacologia
Piper nigrum/química
Piperaceae/química
Óleos Vegetais/isolamento & purificação
Óleos Vegetais/farmacologia
Terpenos/química
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Masculino
Camundongos Endogâmicos ICR
Óleos Voláteis/química
Óleos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Terpenes); 142M471B3J (Carbon Dioxide); H74221J5J4 (myrrh oil)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140930
[St] Status:MEDLINE


  10 / 98 MEDLINE  
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[PMID]:25230516
[Au] Autor:Li R; Yang JJ; Wang YF; Sun Q; Hu HB
[Ti] Título:Chemical composition, antioxidant, antimicrobial and anti-inflammatory activities of the stem and leaf essential oils from Piper flaviflorum from Xishuangbanna, SW China.
[So] Source:Nat Prod Commun;9(7):1011-4, 2014 Jul.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study is the first investigation of the chemical composition, antioxidant, antimicrobial and anti-inflammatory activities of the stem and leaf essential oils from Piper flaviflorum C.DC (SEOP and LEOP), a plant that has been consumed as a wild vegetable, and used as medicine, and spice by the ethnic groups in Xishuangbanna, SW China. Analyzed by GC-MS, 42 and 30 components were identified representing 90.1% and 95.3% of the SEOP and LEOP, with (E)-nerolidol (16.7% and 40.5%), beta-caryophyllene (26.6% and 14.6%) and elixene (5.3% and 12.3%) as their main constituents, respectively. Our results indicate that SEOP and LEOP have good anti-inflammatory activity by significantly inhibiting NO production induced by LPS in RAW 264.7 cells at 0.04 per thousand without effect on cell viability, and negligible antioxidant activity in both ABTS and FRAP assays. Moreover, the LEOP showed comparable activity with the positive control (tigecycline) against Aspergillus fumigatus, with MIC and MBC values ranging from 256 to 1024 microg/mL. The anti-inflammatory activity in LPS-induced RAW 264.7 cells is worthy of further investigation to discover the possible mechanisms of the NO production inhibition effect of these essential oils.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Óleos Voláteis/farmacologia
Piperaceae/química
Folhas de Planta/química
Óleos Vegetais/farmacologia
Caules de Planta/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Antioxidantes/química
Linhagem Celular
Sobrevivência Celular
Radicais Livres
Macrófagos/efeitos dos fármacos
Camundongos
Testes de Sensibilidade Microbiana
Óxido Nítrico/metabolismo
Óleos Voláteis/química
Óleos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Free Radicals); 0 (Oils, Volatile); 0 (Plant Oils); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140918
[Lr] Data última revisão:
140918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140919
[St] Status:MEDLINE



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