Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.812.666.374 [Categoria DeCS]
Referências encontradas : 122 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 13 ir para página                         

  1 / 122 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28779899
[Au] Autor:Sak B; Jandová A; Dolezal K; Kvác M; Kvetonová D; Hlásková L; Rost M; Olsanský M; Nurcahyo W; Foitová I
[Ad] Endereço:Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceské Budejovice, Czech Republic. Electronic address: casio@paru.cas.cz.
[Ti] Título:Effects of selected Indonesian plant extracts on E. cuniculi infection in vivo.
[So] Source:Exp Parasitol;181:94-101, 2017 Oct.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study was conducted to evaluate the methanolic extracts from several plant leaves widely used in traditional medicine to cure digestive tract disorders and in the self-medication of wild animals such as non-human primates, namely Archidendron fagifolium, Diospyros sumatrana, Shorea sumatrana, and Piper betle leaves, with regard to their antimicrosporidial activity against Encephalitozoon cuniculi in immunocompetent BALB/c mice determined using molecular detection of microsporidial DNA (qPCR) in various tissues and body fluids of infected, treated mice. Of the plant extracts tested, Diospyros sumatrana provided the most promising results, reducing spore shedding by 88% compared to untreated controls. Moreover, total burden per 1 g of tissue in the D. sumatrana extract-treated group reached 87% reduction compared to untreated controls, which was comparable to the effect of the standard drug, Albendazole. This data represents the baseline necessary for further research focused on determining the structure, activity and modes of action of the active compounds, mainly of D. sumatrana, enabling subsequent development of antimicrosporidial remedies.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Diospyros/química
Encephalitozoon cuniculi/efeitos dos fármacos
Encefalitozoonose/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Albendazol/farmacologia
Albendazol/uso terapêutico
Animais
Antifúngicos/farmacologia
Cercopithecus aethiops
DNA Fúngico/isolamento & purificação
Dimetil Sulfóxido/farmacologia
Dimetil Sulfóxido/uso terapêutico
Dipterocarpaceae/química
Fabaceae/química
Fezes/parasitologia
Trato Gastrointestinal/microbiologia
Imunocompetência
Indonésia
Camundongos
Camundongos Endogâmicos BALB C
Piper betle/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Esporos Fúngicos/efeitos dos fármacos
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (DNA, Fungal); 0 (Plant Extracts); F4216019LN (Albendazole); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


  2 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28213320
[Au] Autor:Vasantha-Srinivasan P; Senthil-Nathan S; Ponsankar A; Thanigaivel A; Edwin ES; Selin-Rani S; Chellappandian M; Pradeepa V; Lija-Escaline J; Kalaivani K; Hunter WB; Duraipandiyan V; Al-Dhabi NA
[Ad] Endereço:óDivision of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, 627 412 Tirunelveli, Tamil Nadu, India.
[Ti] Título:Comparative analysis of mosquito (Diptera: Culicidae: Aedes aegypti Liston) responses to the insecticide Temephos and plant derived essential oil derived from Piper betle L.
[So] Source:Ecotoxicol Environ Saf;139:439-446, 2017 May.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Resistance to treatments with Temephos or plant derived oil, Pb-CVO, between a field collected Wild Strain (WS) and a susceptible Laboratory Strain (LS) of Ae. aegypti were measured. The Temephos (0.1mg/L) showed the greatest percentage of mosquito mortality compared to Pb-CVO (1.5mg/L) in LS Ae. aegypti. However, WS Ae. aegypti was not significantly affected by Temephos (0.1mg/L) treatment compare to the Pb-CVO (1.5mg/L). However, both strains (LS and WS) when treated with Pb-CVO (1.5mg/L) displayed steady larval mortality rate across all instars. The LC of Temephos was 0.027mg in LS, but increased in WS to 0.081mg/L. The LC of Pb-CVO treatment was observed at concentrations of 0.72 and 0.64mg/L for LS and WS strains respectively. The enzyme level of α- and ß-carboxylesterase was reduced significantly in both mosquito strains treated with Pb-CVO. Whereas, there was a prominent deviation in the enzyme ratio observed between LS and WS treated with Temephos. The GST and CYP450 levels were upregulated in the LS, but decreased in WS, after treatment with Temephos. However, treatment with Pb-CVO caused both enzyme levels to increase significantly in both the strains. Visual observations of the midgut revealed cytotoxicity from sub-lethal concentrations of Temephos (0.04mg/L) and Pb-CVO (1.0mg/L) in both strains of Ae. aegypti compared to the control. The damage caused by Temephos was slightly less in WS compared to LS mosquito strains.
[Mh] Termos MeSH primário: Inseticidas
Óleos Voláteis
Temefós
[Mh] Termos MeSH secundário: Aedes/efeitos dos fármacos
Aedes/enzimologia
Aedes/crescimento & desenvolvimento
Animais
Resistência a Inseticidas
Larva/efeitos dos fármacos
Piper betle/efeitos dos fármacos
Óleos Vegetais
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Oils); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


  3 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28137670
[Au] Autor:Leesombun A; Boonmasawai S; Nishikawa Y
[Ad] Endereço:National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address: arpron.lee@mahidol.ac.th.
[Ti] Título:Effects of Thai piperaceae plant extracts on Neospora caninum infection.
[So] Source:Parasitol Int;66(3):219-226, 2017 Jun.
[Is] ISSN:1873-0329
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. This study investigated the effects of Thai piperaceae (Piper betle, P. nigrum, and P. sarmentosum) extracts on Neospora caninum infections in vitro and in vivo. In an in vitro parasite growth assay based on the green fluorescent protein (GFP) signal, P. betle was the most effective extract at inhibiting parasite growth in human foreskin fibroblast cells (IC of GFP-expressing N. caninum parasites, 22.1µg/ml). The P. betle extract, at 25µg per ml, inhibited parasite invasion into host cells. Furthermore, in two independent experiments, treating N. caninum-infected mice with the P. betle extract for 7days post-infection increased their survival. In trial one, the anti-N. caninum effects of the P. betle extract reduced the mouse clinical scores for 30days post-infection (dpi). The survival rate of the mice treated with 400mg/kg was 100% compared with 66.6% for those treated with 100mg/kg and the non-treated controls. In trial two, treating the infected mice with the P. betle extract increased their survival at 50dpi. All mice in the non-treatment group died; however, the survival rates of the 400mg/kg-treated and 100mg/kg-treated mice were 83.3% and 33.3%, respectively. Also, a trend towards a reduced parasite burden was noted in the brains of the P. betle extract-treated mice, compared with the control mice. Therefore P. betle extract has potential as a medicinal plant for treating neosporosis.
[Mh] Termos MeSH primário: Coccidiose/tratamento farmacológico
Neospora/efeitos dos fármacos
Piper betle/química
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antiprotozoários
Encéfalo/parasitologia
Coccidiose/epidemiologia
Coccidiose/parasitologia
Feminino
Fibroblastos/parasitologia
Proteínas de Fluorescência Verde
Seres Humanos
Camundongos
Neospora/crescimento & desenvolvimento
Carga Parasitária
Fitoterapia
Extratos Vegetais/química
Folhas de Planta/química
Plantas Medicinais/química
Tailândia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (Plant Extracts); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


  4 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27506505
[Au] Autor:Mitra S; Pati AK; Manna A; Ghosh A; Sen S; Chatterjee S; Chatterjee M
[Ad] Endereço:Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.
[Ti] Título:A study of the free radical scavenging effects of Piper betle leaf extract in patients with vitiligo.
[So] Source:Indian J Dermatol Venereol Leprol;83(1):40-46, 2017 Jan-Feb.
[Is] ISSN:0973-3922
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vitiligo is an idiopathic skin disease manifested by depigmented macules. It is characterised by melanocyte destruction, and redox imbalance is proposed to play a contributory role. AIM: The aim of this study was to analyze the effects of an ethanolic extract of Piper betle leaves on the generation of reactive oxygen species in erythrocytes sourced from vitiligo patients. METHODS: The effect of Piper betle on the generation of reactive oxygen species in erythrocytes was measured by flow cytometry in patients with active and stable vitiligo versus healthy controls, using 5-(and-6)-chloromethyl-2'-7'-dichlorodihydrofluorescein diacetate. RESULTS: The generation of reactive oxygen species in erythrocytes was higher in patients with vitiligo (n = 23) compared to healthy controls (n = 18). The geometrical mean fluorescence channel was 23.05 ± 2.11 in patients versus 17.77 ± 1.79 in controls, P = 0.039. The levels of reactive oxygen species were higher in patients with active vitiligo. Treatment of erythrocytes with Piper betle in concentrations of 0.5 and 1.0 µg/ml significantly decreased the baseline levels of reactive oxygen species by 31.7% in healthy controls, and 47.6% and 44.3% in patients with active vitiligo, respectively. Piper betle effectively scavenged hydrogen peroxide, which was evident by a decrease in the geometrical mean fluorescence channel by 52.4% and 62.9% in healthy controls, and 45.0% and 57.0% in patients with active vitiligo. LIMITATIONS: The study had a small sample size. Future studies should focus on evaluation of the antioxidant role of Piper betle at the lesional site. CONCLUSION: This pilot study indicates that patients with active vitiligo demonstrate enhanced generation of reactive oxygen species in erythrocytes, which was significantly reduced following ex vivo treatment with Piper betle.
[Mh] Termos MeSH primário: Depuradores de Radicais Livres/uso terapêutico
Piper betle
Extratos Vegetais/uso terapêutico
Folhas de Planta
Vitiligo/tratamento farmacológico
Vitiligo/metabolismo
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Eritrócitos/efeitos dos fármacos
Eritrócitos/metabolismo
Feminino
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Masculino
Meia-Idade
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Resultado do Tratamento
Vitiligo/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0 (Plant Extracts); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160811
[St] Status:MEDLINE
[do] DOI:10.4103/0378-6323.187688


  5 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27780233
[Au] Autor:Wu YH; Yen CJ; Hsiao JR; Ou CY; Huang JS; Wong TY; Tsai ST; Huang CC; Lee WT; Chen KC; Fang SY; Wu JL; Hsueh WT; Lin FC; Yang MW; Chang JY; Liao HC; Wu SY; Lin CL; Wang YH; Weng YL; Yang HC; Chen YS; Chang JS
[Ad] Endereço:Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
[Ti] Título:A Comprehensive Analysis on the Association between Tobacco-Free Betel Quid and Risk of Head and Neck Cancer in Taiwanese Men.
[So] Source:PLoS One;11(10):e0164937, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Although betel quid (BQ) is an established risk factor of head and neck cancer (HNC), insufficiencies exist in the literature regarding the dose-response, BQ types, HNC sites, and BQ cessation. The current study was conducted to fill these insufficiencies. MATERIALS AND METHODS: A hospital-based case-control study was conducted to evaluate the association between BQ and HNC. In-person interview was conducted to collect data on BQ chewing. The current analysis included 487 men newly diagnosed with HNC and 617 male controls who were frequency-matched to the cases by age. The association between BQ and HNC was assessed using multivariable unconditional logistic regression. RESULTS: Ever BQ chewing was associated with an increased HNC risk regardless of the BQ types. A non-linear positive association between BQ and HNC was observed, with a steep rise in HNC risk for the first 5 pack-years or 200,000 minutes of BQ consumption. Every year of BQ cessation was associated with a 2.9% reduction in HNC risk; however, the risk did not reduce to the level of non-BQ chewers even after 20 years of BQ cessation. Eliminating BQ chewing may prevent 51.6% of HNCs, 62.6% of oral cancers, and 41.3% of pharyngeal cancers in Taiwan. CONCLUSION: Our results supported the positive association between BQ and HNC. BQ cessation is effective in reducing HNC risk and should be encouraged. Because BQ cessation may not reduce the HNC risk to the level of non-BQ chewers, it is important to prevent the initiation of BQ chewing.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/epidemiologia
Neoplasias de Cabeça e Pescoço/epidemiologia
Piper betle/efeitos adversos
Fumar/epidemiologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Seres Humanos
Modelos Logísticos
Masculino
Mastigação
Meia-Idade
Fatores de Risco
Fumar/efeitos adversos
Taiwan/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0164937


  6 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27725236
[Au] Autor:Abdul Ghani ZD; Husin JM; Rashid AH; Shaari K; Chik Z
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur; Industrial Biotechnology Research Centre, Sirim Berhad, 40700 Shah Alam, Malaysia. Electronic address: zuleen@sirim.my.
[Ti] Título:Biochemical studies of Piper betle L leaf extract on obese treated animal using 1H-NMR-based metabolomic approach of blood serum samples.
[So] Source:J Ethnopharmacol;194:690-697, 2016 Dec 24.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Piper betle L. (PB) belongs to the Piperaceae family. The presence of a fairly large quantity of diastase in the betel leaf is deemed to play an important role in starch digestion and calls for the study of weight loss activities and metabolite profile from PB leaf extracts using metabolomics approach to be performed. PB dried leaves were extracted with 70% ethanol and the extracts were subjected to five groups of rats fed with high fat (HF) and standard diet (SD). They were then fed with the extracts in two doses and compared with a negative control group given water only according to the study protocol. The body weights and food intakes were monitored every week. At the end of the study, blood serum of the experimental animal was analysed to determine the biochemical and metabolite changes. PB treated group demonstrated inhibition of body weight gain without showing an effect on the food intake. In serum bioassay, the PB treated group (HF/PB (100mg/kg and 500mg/kg) showed an increased in glucose and cholesterol levels compared to the Standard Diet (SD/WTR) group, a decrease in LDL level and increase in HDL level when compared with High Fat Diet (HF/WTR) group. For metabolite analysis, two separation models were made to determine the metabolite changes via group activities. The best separation of PCA serum in Model 1 and 2 was achieved in principle component 1 and principle component 2. SUS-Plot model showed that HF group was characterized by high-level of glucose, glycine and alanine. Increase in the ß-hydroxybutyrate level similar with SD group animals was evident in the HF/PB(500mg/kg) group. This finding suggested that the administration of 500mg/kg PB extracts leads to increase in oxidation process in the body thus maintaining the body weight and without giving an effect on the appetite even though HF was continuously consumed by the animals until the end of the studies and also a reduction in food intake, thus maintaining their body weight although they were continuously consumed HF.
[Mh] Termos MeSH primário: Metabolômica
Obesidade/tratamento farmacológico
Piper betle/química
Extratos Vegetais/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Masculino
Obesidade/sangue
Obesidade/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


  7 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27721053
[Au] Autor:Srinivasan R; Devi KR; Kannappan A; Pandian SK; Ravi AV
[Ad] Endereço:Department of Biotechnology, Science Campus, Alagappa University, Karaikudi 630004, Tamil Nadu, India.
[Ti] Título:Piper betle and its bioactive metabolite phytol mitigates quorum sensing mediated virulence factors and biofilm of nosocomial pathogen Serratia marcescens in vitro.
[So] Source:J Ethnopharmacol;193:592-603, 2016 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Piper betle, a tropical creeper plant belongs to the family Piperaceae. The leaves of this plant have been well known for their therapeutic, religious and ceremonial value in South and Southeast Asia. It has also been reported to possess several biological activities including antimicrobial, antioxidant, antinociceptive, antidiabetic, insecticidal and gastroprotective activities and used as a common ingredient in indigenous medicines. In Indian system of ayurvedic medicine, P. betle has been well recognized for its antiseptic properties and is commonly applied on wounds and lesions for its healing effects. AIM OF THE STUDY: To evaluate the anti-quorum sensing (anti-QS) and antibiofilm efficacy of P. betle and its bioactive metabolite phytol against Serratia marcescens. MATERIALS AND METHODS: The P. betle ethyl acetate extract (PBE) was evaluated for its anti-QS efficacy against S. marcescens by assessing the prodigiosin and lipase production at 400 and 500µgml concentrations. In addition, the biofilm biomass quantification assay was performed to evaluate the antibiofilm activity of PBE against S. marcescens. Besides, the influence of PBE on bacterial biofilm formation was assessed through microscopic techniques. The biofilm related phenomenons like exopolysaccharides (EPS) production, hydrophobicity and swarming motility were also examined to support the antibiofilm activity of PBE. Transcriptional analysis of QS regulated genes in S. marcescens was also done. Characterization of PBE was done by separation through column chromatography and identification of active metabolites by gas chromatography -mass spectrometry. The major compounds of active fractions such as hexadecanoic acid, eugenol and phytol were assessed for their anti-QS activity against S. marcescens. Further, the in vitro bioassays such as protease, biofilm and HI quantification were also carried out to confirm the anti-QS and antibiofilm potential of phytol in PBE. RESULTS: PBE inhibits QS mediated prodigiosin pigment production in S. marcescens, which confirmed its anti-QS potential against S. marcescens. At 500µgml concentration, PBE significantly inhibited the production of protease, lipase, biofilm and EPS to the level of 71%, 68%, 65% and 43% in S. marcescens, respectively. Further, their antibiofilm efficacy was confirmed through microscopic techniques. In addition, PBE effectively inhibited the hydrophobicity and swarming motility. Additionally, the results of qPCR analysis validated the downregulation of QS genes. Chromatographic techniques the presence of hexadecanoic acid, eugenol and phytol in PBE and the potential bioactive compound with anti-QS activity was identified as phytol. In vitro assays with phytol evidenced the potent inhibition of QS-controlled prodigiosin, protease, biofilm and hydrophobicity in S. marcescens, without exerting any deleterious effect on its growth. CONCLUSION: This study demonstrates the promising anti-QS and antibiofilm activities of PBE and its active metabolite phytol, and confirms the ethnopharmacological applications of these leaves against S. marcescens infections.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Fitol/farmacologia
Piper betle/química
Percepção de Quorum/efeitos dos fármacos
Serratia marcescens/efeitos dos fármacos
[Mh] Termos MeSH secundário: Biofilmes/crescimento & desenvolvimento
Biomassa
Infecção Hospitalar/microbiologia
Infecção Hospitalar/urina
Relação Dose-Resposta a Droga
Seres Humanos
Microscopia Confocal
Microscopia Eletrônica de Varredura
Fitol/isolamento & purificação
Piper betle/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Prodigiosina/antagonistas & inibidores
Serratia marcescens/crescimento & desenvolvimento
Serratia marcescens/metabolismo
Serratia marcescens/patogenicidade
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
150-86-7 (Phytol); OL369FU7CJ (Prodigiosin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  8 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27213575
[Au] Autor:Leesombun A; Boonmasawai S; Shimoda N; Nishikawa Y
[Ad] Endereço:National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
[Ti] Título:Effects of Extracts from Thai Piperaceae Plants against Infection with Toxoplasma gondii.
[So] Source:PLoS One;11(5):e0156116, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Herbal medicines and natural herb extracts are widely used as alternative treatments for various parasitic diseases, and such extracts may also have potential to decrease the side effects of the standard regimen drugs used to treat toxoplasmosis (sulfadiazine-pyrimethamine combination). We evaluated how effective the Thai piperaceae plants Piper betle, P. nigrum and P. sarmentosum are against Toxoplasma gondii infection in vitro and in vivo. Individually, we extracted the piperaceae plants with ethanol, passed them through a rotary evaporator and then lyophilized them to obtain crude extracts for each one. The in vitro study indicated that the P. betle extract was the most effective extract at inhibiting parasite growth in HFF cells (IC50 on RH-GFP: 23.2 µg/mL, IC50 on PLK-GFP: 21.4 µg/mL). Furthermore, treatment of experimental mice with the P. betle extract for 7 days after infection with 1,000 tachyzoites of the T. gondii PLK strain increased their survival (survival rates: 100% in 400 mg/kg-treated, 83.3% in 100 mg/kg-treated, 33.3% in 25 mg/kg-treated, 33.3% in untreated mice). Furthermore, treatment with 400 mg/kg of the P. betle extract resulted in 100% mouse survival following infection with 100,000 tachyzoites. The present study shows that P. betle extract has the potential to act as a medical plant for the treatment of toxoplasmosis.
[Mh] Termos MeSH primário: Piperaceae/química
Extratos Vegetais/farmacologia
Toxoplasma/efeitos dos fármacos
Toxoplasmose Animal/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/farmacologia
Antiprotozoários/uso terapêutico
Células Cultivadas
Cercopithecus aethiops
Feminino
Camundongos
Camundongos Endogâmicos C57BL
Piper betle/química
Piper nigrum/química
Extratos Vegetais/uso terapêutico
Plantas Medicinais
Sulfadiazina/farmacologia
Tailândia
Toxoplasma/crescimento & desenvolvimento
Toxoplasmose Animal/patologia
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Plant Extracts); 0N7609K889 (Sulfadiazine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0156116


  9 / 122 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27135695
[Au] Autor:Vasantha-Srinivasan P; Senthil-Nathan S; Thanigaivel A; Edwin ES; Ponsankar A; Selin-Rani S; Pradeepa V; Sakthi-Bhagavathy M; Kalaivani K; Hunter WB; Duraipandiyan V; Al-Dhabi NA
[Ad] Endereço:Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tirunelveli 627 412, Tamil Nadu, India.
[Ti] Título:Developmental response of Spodoptera litura Fab. to treatments of crude volatile oil from Piper betle L. and evaluation of toxicity to earthworm, Eudrilus eugeniae Kinb.
[So] Source:Chemosphere;155:336-347, 2016 Jul.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Evaluations of biological effects of (Pb-CVO) the crude volatile oil of Piper betle leaves on the tobacco cutworm Spodoptera litura were conducted. Pb-CVO was subjected to GC-MS analysis and twenty vital compounds were isolated from the betel leaf oil. Pb-CVO was tested at four different concentrations (0.25, 0.5, 1.0 and 1.5%) against S. litura. The treated insects exhibited dose depended mortality. The mortality rate was significantly higher at the 1.0 and 1.5% Pb-CVO. The LC50 (Lethal concentration) were observed at 0.48% Pb-CVO. Larval and pupal durations increased in all treatment concentrations (0.25, 0.3, 0.4 and 0.5%) whereas, pupal weight decreased compared to control. Adult longevity of S. litura was reduced in all treatments but predominantly in the 0.4 and 0.5% Pb-CVO. Correspondingly, mean fecundity rate was reduced at all concentrations compared to control. Histological studies of larvae mid-gut profiles of S. litura were severely damaged in 1.0 and 1.5% and showed abnormalities in mid-gut cells with 0.25 and 0.5% Pb-CVO treatments. Earthworm toxicity illustrated that 0.1% of chemical insecticides (monocrotophos and cypermethrin) varied widely in their contact toxicities compared to 0.5 and 1.0% Pb-CVO and control in both contact filter paper and artificial soil test. These findings suggest that twenty essential compounds of betel leaf oil were significant inhibitors of the development and caused behavioral changes of S. litura. Treatment with betel leaf oil at these concentrations had no adverse effect on earthworm populations.
[Mh] Termos MeSH primário: Óleos Voláteis/toxicidade
Oligoquetos/fisiologia
Piper betle
Spodoptera/fisiologia
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa-Espectrometria de Massas
Hemípteros/efeitos dos fármacos
Inseticidas/farmacologia
Larva/efeitos dos fármacos
Longevidade/efeitos dos fármacos
Oligoquetos/efeitos dos fármacos
Petróleo
Pupa/efeitos dos fármacos
Piretrinas
Spodoptera/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile); 0 (Petroleum); 0 (Pyrethrins); 1TR49121NP (cypermethrin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE


  10 / 122 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27133067
[Au] Autor:Venkadeswaran K; Thomas PA; Geraldine P
[Ad] Endereço:Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620024 Tamil Nadu, India.
[Ti] Título:An experimental evaluation of the anti-atherogenic potential of the plant, Piper betle, and its active constitutent, eugenol, in rats fed an atherogenic diet.
[So] Source:Biomed Pharmacother;80:276-88, 2016 May.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Hypercholesterolemia is a major risk factor for systemic atherosclerosis and subsequent cardiovascular disease. Lipoperoxidation-mediated oxidative damage is believed to contribute strongly to the progression of atherogenesis. In the current investigation, putative anti-atherogenic and antioxidative properties of an ethanolic extract of Piper betle and of its active constituent, eugenol, were sought in an experimental animal model of chronic hypercholesterolemia. Atherogenic diet-fed rats that received either Piper betle extract orally (500mg/kg b.wt) or eugenol orally (5mg/kg b.wt) for 15days (commencing 30days after the atherogenic diet had been started) exhibited the following variations in different parameters, when compared to atherogenic diet-fed rats that received only saline: (1) significantly lower mean levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol and very low density lipoprotein cholesterol in both serum and hepatic tissue samples; (2) lower mean serum levels of aspartate amino-transferase, alanine amino-transferase, alkaline phosphatase, lactate dehydrogenase and lipid-metabolizing enzymes (lipoprotein lipase, 3-hydroxy-3-methyl-glutaryl-CoA reductase; (3) significantly lower mean levels of enzymatic antioxidants (catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase) and non-enzymatic antioxidants (reduced glutathione, vitamin C and vitamin E) and significantly higher mean levels of malondialdehyde in haemolysate and hepatic tissue samples. Histopathological findings suggested a protective effect of the Piper betle extract and a more pronounced protective effect of eugenol on the hepatic and aortic tissues of atherogenic diet-fed (presumed atherosclerotic) rats. These results strongly suggest that the Piper betle extract and its active constituent, eugenol, exhibit anti-atherogenic effects which may be due to their anti-oxidative properties.
[Mh] Termos MeSH primário: Aterosclerose/tratamento farmacológico
Dieta Aterogênica
Comportamento Alimentar
Piper betle/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Aorta Torácica/efeitos dos fármacos
Aorta Torácica/patologia
Aterosclerose/sangue
Biomarcadores/sangue
Colesterol/metabolismo
Eugenol/farmacologia
Eugenol/uso terapêutico
Fígado/efeitos dos fármacos
Fígado/enzimologia
Fígado/metabolismo
Fígado/patologia
Masculino
Malondialdeído/metabolismo
Fitoterapia
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biomarkers); 3T8H1794QW (Eugenol); 4Y8F71G49Q (Malondialdehyde); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE



página 1 de 13 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde