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Pesquisa : B01.650.940.800.575.912.250.822.266 [Categoria DeCS]
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[PMID]:29175407
[Au] Autor:Patra DK; Pradhan C; Patra HK
[Ad] Endereço:Post-Graduate Department of Botany, Utkal University, Bhubaneswar 751004, India.
[Ti] Título:An in situ study of growth of Lemongrass Cymbopogon flexuosus (Nees ex Steud.) W. Watson on varying concentration of Chromium (Cr ) on soil and its bioaccumulation: Perspectives on phytoremediation potential and phytostabilisation of chromium toxicity.
[So] Source:Chemosphere;193:793-799, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chromium (Cr) contamination in soil is a growing concern in sustainable agricultural production and food safety. Remediation of Cr from contaminated soils is a challenging task which may not only help in sustaining agriculture but also in minimizing adverse environmental impacts. Pot culture experiments were performed with the application of varied concentration of Cr to assess the Chromium accumulation potential of Lemongrass and to study the impact of toxic concentration of Cr on morphological, physiological and biochemical parameters of the plant. The results showed an increasing accumulation trend of Chromium with increasing Chromium concentrations in both root and shoot of 60 days old Lemongrass plants, while the protein and chlorophyll contents decreased. Similarly, accumulation of Cr increased the levels of proline and antioxidant enzymes indicating the enhanced damage control activity. The potentiality of the plant with the capacity to accumulate and stabilize Cr compound in Cr contaminated soil by phytoremediation process has been explored in the present investigation.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Cromo/farmacocinética
Cromo/toxicidade
Cymbopogon/metabolismo
Solo/química
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Clorofila/metabolismo
Cromo/análise
Cymbopogon/crescimento & desenvolvimento
Proteínas de Plantas/metabolismo
Raízes de Plantas/metabolismo
Poluentes do Solo/análise
Poluentes do Solo/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Proteins); 0 (Soil); 0 (Soil Pollutants); 0R0008Q3JB (Chromium); 1406-65-1 (Chlorophyll)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28708833
[Au] Autor:Singh M; Khan MMA; Uddin M; Naeem M; Qureshi MI
[Ad] Endereço:Plant Physiology Section, Department of Botany, Aligarh Muslim University, Aligarh, India.
[Ti] Título:Proliferating effect of radiolytically depolymerized carrageenan on physiological attributes, plant water relation parameters, essential oil production and active constituents of Cymbopogon flexuosus Steud. under drought stress.
[So] Source:PLoS One;12(7):e0180129, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Carrageenan has been proved as potent growth promoting substance in its depolymerized form. However, relatively little is known about its role in counteracting the adverse effects of drought stress on plants. In a pot experiment, lemongrass (Cymbopogon flexuosus Steud.), grown under different water stress regimes [(100% field capacity (FC), 80% FC and 60% FC)], was sprayed with 40, 80 and 120 mg L-1 of gamma irradiated carrageenan (ICA). Foliar application of ICA mitigated the harmful effects of drought stress to various extents and improved the biochemical characteristics, quality attributes and active constituents (citral and geraniol) of lemongrass significantly. Among the applied treatments, ICA-80 mg L-1 proved the best in alleviating detrimental effects of drought. However, drought stress (80 and 60% FC), irrespective of the growth stages, had an adverse impact on most of the studied attributes. Generally, 60% FC proved more deleterious than 80% FC. At 80% FC, application of ICA-80 mg L-1 elevated the essential oil (EO) content by 18.9 and 25%, citral content by 7.33 and 8.19% and geraniol content by 9.2 and 8.9% at 90 and 120 days after planting (DAP), respectively, as compared to the deionized-water (DW) spray treatment (80% FC+ DW). Whereas, at 60% FC, foliar application of 80 mg L-1 ICA significantly augmented the EO content by 15.4 and 17.8% and active constituents viz. citral and geraniol, by 5.01 and 5.62% and by 6.06 and 5.61% at 90 and 120 DAP, respectively, as compared to the control (water-spray treatment).
[Mh] Termos MeSH primário: Carragenina/farmacologia
Cymbopogon/efeitos dos fármacos
Óleos Voláteis/análise
Água/metabolismo
[Mh] Termos MeSH secundário: Anidrases Carbônicas/metabolismo
Carragenina/química
Carragenina/efeitos da radiação
Cromatografia Gasosa
Cymbopogon/crescimento & desenvolvimento
Cymbopogon/fisiologia
Secas
Raios gama
Nitrato Redutase/metabolismo
Óleos Voláteis/química
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/crescimento & desenvolvimento
Folhas de Planta/fisiologia
Proteínas de Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Proteins); 059QF0KO0R (Water); 9000-07-1 (Carrageenan); EC 1.7.99.4 (Nitrate Reductase); EC 4.2.1.1 (Carbonic Anhydrases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180129


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[PMID]:28699786
[Au] Autor:Kim YW; You HJ; Lee S; Kim B; Kim DK; Choi JB; Kim JA; Lee HJ; Joo IS; Lee JS; Kang DH; Lee G; Ko GP; Lee SJ
[Ad] Endereço:1 Department of Biotechnology, School of Life Sciences and Biotechnology for BK21 PLUS, Korea University, Seoul 02841, Republic of Korea.
[Ti] Título:Inactivation of Norovirus by Lemongrass Essential Oil Using a Norovirus Surrogate System.
[So] Source:J Food Prot;80(8):1293-1302, 2017 Aug.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay. It was revealed that citral, a single compound in LGEO, showed dramatic reduction in MNV-1 infectivity (-73.09% when using a treatment of 0.02%, v/v). The inhibitory activity of LGEO on viral replication was further investigated in HG23 cells that harbored a human norovirus replicon. LGEO treatment significantly reduced viral replication in HG23 cells, which suggests that LGEO may have dual inhibitory activities that inactivate viral coat proteins required for viral infection and suppress norovirus genome replication in host cells. In animal experiments, oral administration of murine norovirus preincubated with LGEO significantly suppressed virus infectivity in vivo. Collectively, these results suggest that LGEO, in particular the LGEO component citral, inactivates the norovirus and its subsequent replication in host cells. Thus, LGEO shows promise as a method of inhibiting norovirus within the food industry.
[Mh] Termos MeSH primário: Cymbopogon/química
Norovirus/efeitos dos fármacos
Óleos Voláteis/farmacologia
Inativação de Vírus
[Mh] Termos MeSH secundário: Animais
Infecções por Caliciviridae
Seres Humanos
Camundongos
Norovirus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-162


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[PMID]:28577541
[Au] Autor:Omoruyi BE; Muchenje V
[Ad] Endereço:Department of Biochemistry and Microbiology, University of Fort Hare, Private Bag X1314, Alice, 5700, South Africa.
[Ti] Título:Phytomedical assessment of two Cymbopogon species found in Nkonkobe Municipality: toxicological effect on human Chang liver cell line.
[So] Source:BMC Complement Altern Med;17(1):287, 2017 Jun 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cymbopogon species are widely used as herbal remedies by the traditional healers living in Nkonkobe Municipality for the treatment and management of skin and respiratory infections. According to our survey, the plants seem to be very important because of the higher demands. METHODS: The leaves of C. validis and C. plurinodis were hydro-distilled and the resulted extracted oils were analyzed by GC/MS. Minimum inhibitory concentrations (MICs) ranging from 7.8 to 500.0 µg/ml of the extracted oils were tested against eight bacterial strains, using micro-well dilution method. The human Chang liver cell viability was determined using the CellTiter-Blue cell assay. RESULTS: GC-MS analysis of the C. validis essential oil amounted to 87.03%, major components identified were Linalyl alcohol (18.9%), 2-Nephthalenemethanol (6.67%), Longifolene (6.53%), Cubedol (6.08%). Total oil percentage of C. plurinodis was 81.47% and the main components were characterized as 3-Cyclohexane-1-ol (13.58%), Nerolidol (13.6%) and 2-Carene (12.6%). The essential oils from both plants were found to be active against the growth of Gram positive than the Gram negative bacterial tested. Lethal dose at 50 (LD ) of both plants showed 74.87 ± 1.41 and 81.66 ± 1.40 degree of toxicity at 24 h. CONCLUSION: Both plants extracts were toxic to human Chang liver cell lines.
[Mh] Termos MeSH primário: Cymbopogon/química
Fígado/efeitos dos fármacos
Óleos Voláteis/toxicidade
Extratos Vegetais/toxicidade
Óleos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Bactérias/efeitos dos fármacos
Bactérias/crescimento & desenvolvimento
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cymbopogon/toxicidade
Seres Humanos
Fígado/citologia
Testes de Sensibilidade Microbiana
Óleos Voláteis/química
Óleos Voláteis/isolamento & purificação
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Óleos Vegetais/química
Óleos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1682-7


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[PMID]:28389086
[Au] Autor:Naveenkumar R; Muthukumar A; Sangeetha G; Mohanapriya R
[Ad] Endereço:Department of Mycology and Plant Pathology, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India; Annamalai University, Annamalainagar, Chidambaram 608002, Tamil Nadu, India. Electronic address: pathonaveen92@yahoo.com.
[Ti] Título:Developing eco-friendly biofungicide for the management of major seed borne diseases of rice and assessing their physical stability and storage life.
[So] Source:C R Biol;340(4):214-225, 2017 Apr.
[Is] ISSN:1768-3238
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Three plant oils (Cymbopogon citratus, Cymbopogon martini, and Pelargonium graveolens) were developed as EC formulations and tested for their physical stabilities. EC formulations (10EC, 20EC and 30EC) of C. citratus, C. martini and P. graveolens had emulsion stability, spontaneity property, heat and cold stability. EC formulated plant oils were screened against the major seed borne fungi of rice such as Curvularia lunata, Fusarium moniliforme, Bipolaris oryzae, and Sarocladium oryzae. The level of inhibition varied among the concentrations of EC formulations. Among the three EC formulations, that of C. citratus oil 30EC recorded 100% inhibition on the mycelial growth of test pathogens. In the blotter paper method, rice seeds treated with a formulation of C. citratus oil 30EC controlled the infection of C. lunata, F. moniliforme, B. oryzae and S. oryzae in rice seed to the tune of 66.0%, 60.4%, 66.0% and 69.1%, respectively. Seed soaking with formulation of C. citratus oil 30EC showed the highest percentage of normal seedlings, the lowest number of abnormal seedling and fresh ungerminated seeds when tested with the roll-towel method. Seed soaking with 30EC formulation of C. citratus oil increased seed germination, shoot length, root length and vigour of rice seedlings when tested with the plastic tray method. Transmission of pathogens from seed to seedling was reduced significantly by the 30EC formulation of C. citratus oil when tested with the plastic pot method. The effect of the storage life of the 30EC formulation of C. citratus oil showed that it had retained their antifungal effect till the end of the incubation period (120 days), and is able to inhibit the mycelial growth of all test pathogens to the 100% level.
[Mh] Termos MeSH primário: Antifúngicos/química
Oryza
Doenças das Plantas/microbiologia
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
Ascomicetos/efeitos dos fármacos
Cymbopogon/química
Estabilidade de Medicamentos
Fusarium/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Pelargonium/química
Óleos Vegetais/farmacologia
Sementes/efeitos dos fármacos
Sementes/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Oils)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170409
[St] Status:MEDLINE


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[PMID]:28359199
[Au] Autor:Uchida NS; Silva-Filho SE; Aguiar RP; Wiirzler LAM; Cardia GFE; Cavalcante HAO; Silva-Comar FMS; Becker TCA; Silva EL; Bersani-Amado CA; Cuman RKN
[Ad] Endereço:* Department of Pharmacology and Therapeutics, State University of Maringá, 87020-900 Maringá, PR, Brazil.
[Ti] Título:Protective Effect of Cymbopogon citratus Essential Oil in Experimental Model of Acetaminophen-Induced Liver Injury.
[So] Source:Am J Chin Med;45(3):515-532, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:To investigate the hepatoprotective effect of Cymbopogon citratus or lemongrass essential oil (LGO), it was used in an animal model of acute liver injury induced by acetaminophen (APAP). Swiss mice were pretreated with LGO (125, 250 and 500[Formula: see text]mg/kg) and SLM (standard drug, 200[Formula: see text]mg/kg) for a duration of seven days, followed by the induction of hepatotoxicity of APAP (single dose, 250[Formula: see text]mg/kg). The liver function markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase were determined to evaluate the hepatoprotective effects of the LGO. The livers were used to determine myeloperoxidase (MPO) activity, nitric oxide (NO) production and histological analysis. The effect of LGO on leukocyte migration was evaluated in vitro. Anti-oxidant activity was performed by assessing the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro. LGO pretreatment decreased significantly the levels of ALT, AST and ALP compared with APAP group. MPO activity and NO production were decreased. The histopathological analysis showed an improved of hepatic lesions in mice after LGO pretreatment. LGO inhibited neutrophil migration and exhibited anti-oxidant activity. Our results suggest that LGO has protective activity against liver toxicity induced by paracetamol.
[Mh] Termos MeSH primário: Acetaminofen/efeitos adversos
Analgésicos não Entorpecentes/efeitos adversos
Antipiréticos/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Cymbopogon/química
Óleos Voláteis/uso terapêutico
Fitoterapia
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Modelos Animais de Doenças
Masculino
Camundongos
Óleos Voláteis/administração & dosagem
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Antipyretics); 0 (Oils, Volatile); 362O9ITL9D (Acetaminophen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500318


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[PMID]:28235740
[Au] Autor:Gautam M; Agrawal M
[Ad] Endereço:Laboratory of Air Pollution and Global Climate Change, Department of Botany, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: meenu400@gmail.com.
[Ti] Título:Influence of metals on essential oil content and composition of lemongrass (Cymbopogon citratus (D.C.) Stapf.) grown under different levels of red mud in sewage sludge amended soil.
[So] Source:Chemosphere;175:315-322, 2017 May.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lemongrass is a commercially important perennial herb with medicinal value and ability to tolerate high alkaline and saline conditions. Essential oil bearing plants can grow safely in soil contaminated with heavy metals without severe effects on morphology and oil yield. The present study was aimed to assess the essential oil content and composition in lemongrass in response to elevated metals in above-ground plant parts. Pot experiment was conducted for six months using sewage sludge as soil amendment (soil: sludge: 2:1 w/w) followed by red mud treatments (0, 5, 10 and 15% w/w). Garden soil without sludge and red mud was control and there were ten replicates of each treatment. Oil content in leaves was differently affected due to presence of metals in soil under different treatments. Oil content under S (5% red mud) treatment was raised by 42.9 and 11.5% compared to the control and S treatment, respectively. Among identified compounds in oil under red mud treatments, 17 compounds contributed more than 90% of total volatiles (citral contributing approximately 70%). Under S treatment, essential oil showed maximum citral content (75.3%). Contents of Fe, Zn, Cu, Cd, Ni and Pb in above-ground plant parts exceeded, whereas Mn was detected within WHO permissible limits for medicinal plants. However, metal contents in essential oil were well within FSSAI limits for food. The study suggests utilization of 5 and 10% red mud in sludge amended soil for lemongrass cultivation to have better oil yield and quality, without metal contamination.
[Mh] Termos MeSH primário: Cymbopogon/metabolismo
Metais Pesados/metabolismo
Óleos Voláteis/metabolismo
Esgotos
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Fertilizantes
Componentes Aéreos da Planta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertilizers); 0 (Metals, Heavy); 0 (Oils, Volatile); 0 (Sewage); 0 (Soil Pollutants)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


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[PMID]:28202077
[Au] Autor:Kimutai A; Ngeiywa M; Mulaa M; Njagi PG; Ingonga J; Nyamwamu LB; Ombati C; Ngumbi P
[Ad] Endereço:Department of Biological Sciences, University of Kabianga, P.O. Box 2030-20200, Kericho, Kenya. kimutaialbert@yahoo.com.
[Ti] Título:Repellent effects of the essential oils of Cymbopogon citratus and Tagetes minuta on the sandfly, Phlebotomus duboscqi.
[So] Source:BMC Res Notes;10(1):98, 2017 Feb 15.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The sandfly, Phlebotomus duboscqi is a vector of zoonotic cutaneous leishmaniasis (ZCL) that is an important public health problem in Eastern Africa. Repellents have been used for protection of humans against vectors of ZCL and other vectors that transmit killer diseases including malaria, Rift Valley fever, dengue, and yellow fever. The repellent effects of different doses of the essential oils from the lemon grass, Cymbopogon citratus and Mexican marigold, Tagetes minuta were evaluated in a two-chamber bioassay against 3- to 7-day-old unfed females of P. duboscqi in the laboratory. The results were compared with those that were obtained when test animals were treated with an equivalent dose of diethyl-3-methylbenzamide, which is a repellent that is commonly used as a positive control. RESULTS: Overall, percentage repellency increased with increasing doses of the essential oils while biting rates decreased with increasing concentrations of the oils. Further, the oil of C. citratus was more potent than that of T. minuta with regard to protection time and biting deterrence. The effective doses at 50% (ED ) and at 90% (ED ) for the oil of C. citratus, were 0.04 and 0.79 mg/ml, respectively. Those of the oil of T. minuta were 0.10 and 12.58 mg/ml. In addition, the percentage repellency of 1 mg/ml of the essential oils of C. citratus and T. minuta against sandflies was 100% and 88.89%, respectively. A lower dose of 0.5 mg/ml of the oils, elicited 89.13% repellency for C. citratus and 52.22% for T. minuta. CONCLUSION: The laboratory tests showed that the essential oils of the two plants were highly repellent to adult sand flies, P. duboscqi. Thus, the two essential oils are candidate natural repellents that can be used against P. duboscqi due to their high efficacy at very low doses, hence, the envisaged safety in their use over chemical repellents. It remains to carry out clinical studies on human subjects with appropriate formulations of the oils prior to recommending their adoption for use against the sandflies.
[Mh] Termos MeSH primário: Cymbopogon/química
Repelentes de Insetos/farmacologia
Óleos Voláteis/farmacologia
Phlebotomus/fisiologia
Óleos Vegetais/farmacologia
Tagetes/química
[Mh] Termos MeSH secundário: Animais
Bioensaio/métodos
Cricetinae
DEET/farmacologia
Relação Dose-Resposta a Droga
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Controle de Insetos/métodos
Insetos Vetores/efeitos dos fármacos
Insetos Vetores/fisiologia
Óleos Voláteis/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Oils, Volatile); 0 (Plant Oils); 134-62-3 (DEET)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2396-0


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[PMID]:28152462
[Au] Autor:Bonferoni MC; Sandri G; Rossi S; Usai D; Liakos I; Garzoni A; Fiamma M; Zanetti S; Athanassiou A; Caramella C; Ferrari F
[Ad] Endereço:Department of Drug Sciences, University of Pavia, Vle Taramelli 12, 27100 Pavia, Italy; Center for Health Technology (CHT), University of Pavia, Via A. Ferrata 1, 27100 Pavia, Italy. Electronic address: cbonferoni@unipv.it.
[Ti] Título:A novel ionic amphiphilic chitosan derivative as a stabilizer of nanoemulsions: Improvement of antimicrobial activity of Cymbopogon citratus essential oil.
[So] Source:Colloids Surf B Biointerfaces;152:385-392, 2017 Apr 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Amphiphilic chitosans have been recently proposed to improve delivery of poorly soluble drugs. In the present paper a derivative obtained by ionic interaction between chitosan and oleic acid was for the first time studied to physically stabilize o/w nanoemulsions of an antimicrobial essential oil, Cymbopogon citratus (Lemongrass), in a low energy and mild conditions emulsification process. The novel combination of spontaneous emulsification process with chitosan oleate amphiphilic properties resulted in a stable dispersion of a few hundred nanometer droplets. Positive zeta potential confirmed the presence of a chitosan shell around the oil droplets, which is responsible for the nanoemulsion physical stabilization and for the maintenance of chitosan bioactive properties, such as mucoadhesion. Cytotoxicity test was performed on four different cell lines (HEp-2, Caco-2, WKD and McCoy cells) showing biocompatibility of the system. The maintenance and in some cases even a clear improvement in the essential oil antimicrobial activity towards nine bacterial and ten fungal strains, all of clinical relevance was verified for Lemongrass nanoemulsion.
[Mh] Termos MeSH primário: Quitosana/química
Cymbopogon/química
Nanopartículas/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Bactérias/efeitos dos fármacos
Células CACO-2
Emulsões/química
Emulsões/farmacologia
Fungos/efeitos dos fármacos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Emulsions); 0 (Oils, Volatile); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE


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[PMID]:28110431
[Au] Autor:Bishoyi AK; Kavane A; Sharma A; Geetha KA
[Ad] Endereço:PDPIAS, Charotar University of Science and Technology, Changa, Anand, Gujarat, India.
[Ti] Título:A report on identification of sequence polymorphism in barcode region of six commercially important Cymbopogon species.
[So] Source:Mol Biol Rep;44(1):19-24, 2017 Feb.
[Is] ISSN:1573-4978
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:CYMBOPOGON: is an important member of grass family Poaceae, cultivated for essential oils which have greater medicinal and industrial value. Taxonomic identification of Cymbopogon species is determined mainly by morphological markers, odour of essential oils and concentration of bioactive compounds present in the oil matrices which are highly influenced by environment. Authenticated molecular marker based taxonomical identification is also lacking in the genus; hence effort was made to evaluate potential DNA barcode loci in six commercially important Cymbopogon species for their individual discrimination and authentication at the species level. Four widely used DNA barcoding regions viz., ITS 1 & ITS 2 spacers, matK, psbA-trnH and rbcL were taken for the study. Gene sequences of the same or related genera of the concerned loci were mined from NCBI domain and primers were designed and validated for barcode loci amplification. Out of the four loci studied, sequences from matK and ITS spacer loci revealed 0.46% and 5.64% nucleotide sequence diversity, respectively whereas the other two loci i.e., psbA-trnH and rbcL showed 100% sequence homology. The newly developed primers can be used for barcode loci amplification in the genus Cymbopogon. The identified Single Nucleotide Polymorphisms from the studied sequences may be used as barcodes for the six Cymbopogon species. The information generated can also be utilized for barcode development of the genus by including more number of Cymbopgon species in future.
[Mh] Termos MeSH primário: Cymbopogon/classificação
Código de Barras de DNA Taxonômico/métodos
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Sequência de Bases
Cymbopogon/genética
DNA de Plantas/genética
DNA Espaçador Ribossômico/genética
Filogenia
Análise de Sequência de DNA/métodos
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (DNA, Ribosomal Spacer)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE
[do] DOI:10.1007/s11033-017-4097-0



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