Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.822.322 [Categoria DeCS]
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  1 / 164 MEDLINE  
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[PMID]:28865293
[Au] Autor:Nguyen TT; Nguyen DH; Zhao BT; Le DD; Choi DH; Kim YH; Nguyen TH; Woo MH
[Ad] Endereço:College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea; Buon Ma Thuot University, Buon Ma Thuot City, Dak Lak Province 630000, Viet Nam.
[Ti] Título:A new lignan and a new alkaloid, and α-glucosidase inhibitory compounds from the grains of Echinochloa utilis Ohwi & Yabuno.
[So] Source:Bioorg Chem;74:221-227, 2017 Oct.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new lignan, utilisin (1), and a new alkaloid, echinoutilin (2), together with eleven known compounds 3-13 were isolated from the grains of Echinochloa utilis Ohwi & Yabuno. Their structures were identified through the analysis of spectroscopic data. The absolute configuration of 2 was determined by Mosher's method. These compounds were evaluated for α-glucosidase inhibitory activity. Among them, compounds 2, 3 and 6 exhibited considerable α-glucosidase inhibitory activity with IC values of 42.1±1.3, 58.9±3.7, and 40.9±1.1µM, respectively. The results indicate that the grains of E. utilis will be useful in the treatment of diabetes control agents.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Echinochloa/química
Inibidores de Glicosídeo Hidrolases/farmacologia
Lignanas/farmacologia
alfa-Glucosidases/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Relação Dose-Resposta a Droga
Inibidores de Glicosídeo Hidrolases/química
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Seres Humanos
Lignanas/química
Lignanas/isolamento & purificação
Simulação de Acoplamento Molecular
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Glycoside Hydrolase Inhibitors); 0 (Lignans); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE


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[PMID]:28432507
[Au] Autor:Xu J; Cai Q; Wang H; Liu X; Lv J; Yao D; Lu Y; Li W; Liu Y
[Ad] Endereço:.State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation Restoration / School of Environment, Northeast Normal University, Changchun, Jilin Province, 130117, China. xujl@foxmail.com.
[Ti] Título:Study of the potential of barnyard grass for the remediation of Cd- and Pb-contaminated soil.
[So] Source:Environ Monit Assess;189(5):224, 2017 May.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, the microwave digestion method was used to determine total cadmium (Cd) and lead (Pb) concentrations, the BCR method was used to determine different states of Cd and Pb, and atomic absorption spectroscopy (AAS) and inductively coupled plasma optical emission spectrometry (ICP-OES) were used to determine Cd and Pb concentrations in simulated soil and barnyard grass before and after planting barnyard grass to provide a theoretical basis for the remediation of Cd- and Pb-contaminated soil. The results showed that the bioconcentration factor changes with different Cd concentrations are relatively complex and that the removal rate increases regularly. The 100 mg kg Cd treatment had the highest removal rate, which reached 36.66%. For Pb, the bioconcentration factor decreased and tended to reach equilibrium as the Pb concentration increased. The highest removal rate was 41.72% and occurred in the 500 mg kg Pb treatment; however, this removal rate was generally lower than that of Cd. In addition, the reduction state had the highest change rate, followed by the residual, acid soluble and oxidation states. For Pb, the residual state has the highest change rate, followed by the acid soluble state, reduction state and oxidation state. In addition, a significant correlation was observed between the soil Pb and Cd concentrations and the concentrations of Pb and Cd that accumulated in the belowground biomass of the barnyard grass, but no significant correlation was observed between the soil Pb and Cd concentrations and the amounts of Pb and Cd that accumulated in the aboveground biomass of the barnyard grass. The highest transfer factor of Cd was 0.49, which occurred in the 5 mg kg Cd treatment. The higher transfer factor of Pb was 0.48 in the 100 mg kg Pb treatment. All of these factors indicate that the belowground biomass of barnyard grass plays a more important role in the remediation of Cd- and Pb-contaminated soils than the aboveground biomass of barnyard grass. Remediation should occur through phytostabilization. Thus, with its strong adaptability and lush growth, barnyard grass can be applied as a pioneer species for the phytoremediation of Cd- and Pb-contaminated soils.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Cádmio/análise
Echinochloa/fisiologia
Chumbo/análise
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Biomassa
Cádmio/metabolismo
Monitoramento Ambiental
Chumbo/metabolismo
Plantas
Solo
Poluentes do Solo/metabolismo
Espectrofotometria Atômica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); 2P299V784P (Lead)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-5923-5


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[PMID]:28397123
[Au] Autor:Adetunji C; Oloke J; Kumar A; Swaranjit S; Akpor B
[Ad] Endereço:Department of Biological Sciences, Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Landmark University, P.M.B. 1001, Omu Aran, Kwara State, Nigeria. charliguitar@yahoo.com.
[Ti] Título:Synergetic effect of rhamnolipid from Pseudomonas aeruginosa C1501 and phytotoxic metabolite from Lasiodiplodia pseudotheobromae C1136 on Amaranthus hybridus L. and Echinochloa crus-galli weeds.
[So] Source:Environ Sci Pollut Res Int;24(15):13700-13709, 2017 May.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Rhamnolipid (Rh) is a biosurfactant produced by the bacterial Pseudomonas aeruginosa. This present study investigates rhizospheric strain C1501 of P. aeruginosa with an accession number KF976394 with the best production of rhamnolipid: a biosurfactant. The partially purified rhamnolipid from strain C1501 and Tween 80 was tested on mycelial growth of wild strain C1136. The enzyme activities involved in biodegradation, as well as necrosis induction on the tested weeds, were performed using scanning electron microscopy. It was observed that the different concentrations of rhamnolipid tested enhanced the dry mycelia weight yield of Lasiodiplodia pseudotheobromae which has been established to be producing a phytotoxic metabolite for killing weeds. It was observed that strain C1136 had a high level of cellulase and xylanase enzyme activities during this study. The scanning electron microscopy showed that the mutant strain of C1136 combined with 0.003% v/v of rhamnolipid enhances biodegradability and a high level of necrosis on the tested weeds compared with that on the untreated weeds. The highest CMCase activities and xylanase activities were obtained on the fourth day from the phytotoxic metabolite produced from the mutant strain of L. pseudotheobromae when combined with 0.003% v/v of rhamnolipid. This study has shown that rhamnolipid can serve as an adjuvant in order to enhance the penetrability of bioherbicide active ingredient for controlling weeds.
[Mh] Termos MeSH primário: Echinochloa
Pseudomonas aeruginosa/metabolismo
[Mh] Termos MeSH secundário: Amaranthus/metabolismo
Glicolipídeos/metabolismo
Tensoativos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycolipids); 0 (Surface-Active Agents); 0 (rhamnolipid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8983-8


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[PMID]:27990574
[Au] Autor:Romanowska E; Buczynska A; Wasilewska W; Krupnik T; Drozak A; Rogowski P; Parys E; Zienkiewicz M
[Ad] Endereço:Department of Molecular Plant Physiology, Faculty of BiologyUniversity of Warsaw, Miecznikowa 1, 02-096, Warsaw, Poland. romanela@biol.uw.edu.pl.
[Ti] Título:Differences in photosynthetic responses of NADP-ME type C4 species to high light.
[So] Source:Planta;245(3):641-657, 2017 Mar.
[Is] ISSN:1432-2048
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:MAIN CONCLUSION: Three species chosen as representatives of NADP-ME C4 subtype exhibit different sensitivity toward photoinhibition, and great photochemical differences were found to exist between the species. These characteristics might be due to the imbalance in the excitation energy between the photosystems present in M and BS cells, and also due to that between species caused by the penetration of light inside the leaves. Such regulation in the distribution of light intensity between M and BS cells shows that co-operation between both the metabolic systems determines effective photosynthesis and reduces the harmful effects of high light on the degradation of PSII through the production of reactive oxygen species (ROS). We have investigated several physiological parameters of NADP-ME-type C4 species (e.g., Zea mays, Echinochloa crus-galli, and Digitaria sanguinalis) grown under moderate light intensity (200 µmol photons m s ) and, subsequently, exposed to excess light intensity (HL, 1600 µmol photons m s ). Our main interest was to understand why these species, grown under identical conditions, differ in their responses toward high light, and what is the physiological significance of these differences. Among the investigated species, Echinochloa crus-galli is best adapted to HL treatment. High resistance of the photosynthetic apparatus of E. crus-galli to HL was accompanied by an elevated level of phosphorylation of PSII proteins, and higher values of photochemical quenching, ATP/ADP ratio, activity of PSI and PSII complexes, as well as integrity of the thylakoid membranes. It was also shown that the non-radiative dissipation of energy in the studied plants was not dependent on carotenoid contents and, thus, other photoprotective mechanisms might have been engaged under HL stress conditions. The activity of the enzymes superoxide dismutase and ascorbate peroxidase as well as the content of malondialdehyde and H O suggests that antioxidant defense is not responsible for the differences observed in the tolerance of NADP-ME species toward HL stress. We concluded that the chloroplasts of the examined NADP-ME species showed different sensitivity to short-term high light irradiance, suggesting a role of other factors excluding light factors, thus influencing the response of thylakoid proteins. We also observed that HL affects the mesophyll chloroplasts first hand and, subsequently, the bundle sheath chloroplasts.
[Mh] Termos MeSH primário: Digitaria/fisiologia
Echinochloa/fisiologia
Luz
Malato Desidrogenase/metabolismo
Fotossíntese/efeitos da radiação
Zea mays/fisiologia
[Mh] Termos MeSH secundário: Difosfato de Adenosina/metabolismo
Trifosfato de Adenosina/metabolismo
Transporte Biológico/efeitos da radiação
Carotenoides/metabolismo
Respiração Celular/efeitos da radiação
Clorofila/metabolismo
Digitaria/enzimologia
Digitaria/efeitos da radiação
Echinochloa/enzimologia
Echinochloa/efeitos da radiação
Transporte de Elétrons/efeitos da radiação
Eletroforese em Gel de Poliacrilamida
Fluorescência
Peróxido de Hidrogênio/metabolismo
Malondialdeído/metabolismo
Células do Mesofilo/metabolismo
Células do Mesofilo/efeitos da radiação
Metaboloma
Fosforilação/efeitos da radiação
Complexo de Proteína do Fotossistema I/metabolismo
Complexo de Proteína do Fotossistema II/metabolismo
Folhas de Planta/efeitos da radiação
Tilacoides/metabolismo
Tilacoides/efeitos da radiação
Zea mays/enzimologia
Zea mays/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Photosystem I Protein Complex); 0 (Photosystem II Protein Complex); 1406-65-1 (Chlorophyll); 36-88-4 (Carotenoids); 4Y8F71G49Q (Malondialdehyde); 61D2G4IYVH (Adenosine Diphosphate); 8L70Q75FXE (Adenosine Triphosphate); BBX060AN9V (Hydrogen Peroxide); EC 1.1.1.37 (Malate Dehydrogenase); EC 1.1.1.40 (malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1007/s00425-016-2632-1


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[PMID]:27825481
[Au] Autor:Radhakrishnan R; Park JM; Lee IJ
[Ad] Endereço:School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Republic of Korea.
[Ti] Título:Enterobacter sp. I-3, a bio-herbicide inhibits gibberellins biosynthetic pathway and regulates abscisic acid and amino acids synthesis to control plant growth.
[So] Source:Microbiol Res;193:132-139, 2016 Dec.
[Is] ISSN:1618-0623
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Very few bacterial species were identified as bio-herbicides for weed control. The present research was focused to elucidate the plant growth retardant properties of Enterobacter sp. I-3 during their interaction by determining the changes in endogenous photosynthetic pigments, plant hormones and amino acids. The two bacterial isolates I-4-5 and I-3 were used to select the superior bacterium for controlling weed seeds (Echinochloa crus-galli L. and Portulaca oleracea L.) germination. The post-inoculation of I-3 (Enterobacter sp. I-3) significantly inhibited the weeds seed germination than their controls. The mechanism of bacterium induced plant growth reduction was identified in lettuce treated with I-3 bacterium and compared their effects with known chemical herbicide, trinexapac-ethyl (TE). The treatment of I-3 and TE showed a significant inhibitory effect on shoot length, leaf number, leaf length, leaf width, shoot weight, root weight and chlorophyll content in lettuce seedlings. The endogenous gibberellins (GAs) and abscisic acid (ABA) analysis showed that Enterobacter sp. I-3 treated plants had lower levels of GAs (GA , GA , GA and GA ) and GAs/ABA ratio and then, the higher level of ABA when compared to their controls. Indeed, the individual amino acids ie., aspartic acid, glutamic acid, glycine, threonine, alanine, serine, leucine, isoleucine and tyrosine were declined in TE and I-3 exposed plants. Our results suggest that the utilization of Enterobacter sp. I-3 inhibits the GAs pathway and amino acids synthesis in weeds to control their growth can be an alternative to chemical herbicides.
[Mh] Termos MeSH primário: Ácido Abscísico/metabolismo
Aminoácidos/metabolismo
Echinochloa/crescimento & desenvolvimento
Enterobacter/metabolismo
Giberelinas/antagonistas & inibidores
Desenvolvimento Vegetal
Portulaca/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Echinochloa/microbiologia
Herbicidas/metabolismo
Reguladores de Crescimento de Planta/metabolismo
Portulaca/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Gibberellins); 0 (Herbicides); 0 (Plant Growth Regulators); 72S9A8J5GW (Abscisic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27296446
[Au] Autor:Kumar PA; Pushpadass HA; Franklin ME; Simha HV; Nath BS
[Ad] Endereço:ICAR-National Dairy Research Institute, Southern Regional Station, Bengaluru-560030, India.
[Ti] Título:Effect of enzymatic hydrolysis of starch on pasting, rheological and viscoelastic properties of milk-barnyard millet (Echinochloa frumentacea) blends meant for spray drying.
[So] Source:Int J Biol Macromol;91:838-45, 2016 Oct.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The influence of enzymatic hydrolysis of starch on the pasting properties of barnyard millet was studied using a rheometer. The effects of blending hydrolyzed barnyard millet wort with milk at different ratios (0:1, 1:1, 1:1.5 and 1:2) on flow and viscoelastic behavior were investigated. From the pasting curves, it was evident that enzymatically-hydrolyzed starch did not exhibit typical pasting characteristics expected of normal starch. The Herschel-Bulkley model fitted well to the flow behaviour data, with coefficient of determination (R(2)) ranging from 0.942 to 0.988. All milk-wort blends demonstrated varying degree of shear thinning with flow behavior index (n) ranging from 0.252 to 0.647. Stress-strain data revealed that 1:1 blend of milk to wort had the highest storage modulus (7.09-20.06Pa) and an elastically-dominant behavior (phase angle <45°) over the tested frequency range. The crossover point of G' and G" shifted to higher frequencies with increasing wort content. From the flow and viscoelastic behavior, it was concluded that the 1:1 blend of milk to wort would have least phase separation and better flowability during spray drying.
[Mh] Termos MeSH primário: Aspergillus oryzae/química
Echinochloa/química
Proteínas Fúngicas/química
Amido/química
Viscosidade
alfa-Amilases/química
[Mh] Termos MeSH secundário: Hidrólise
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungal Proteins); 9005-25-8 (Starch); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE


  7 / 164 MEDLINE  
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[PMID]:27245684
[Au] Autor:Sharma S; Saxena DC; Riar CS
[Ad] Endereço:Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal, Punjab, 148106, India.
[Ti] Título:Isolation of Functional Components ß-Glucan and γ-Amino Butyric Acid from Raw and Germinated Barnyard Millet (Echinochloa frumentaceae) and their Characterization.
[So] Source:Plant Foods Hum Nutr;71(3):231-8, 2016 Sep.
[Is] ISSN:1573-9104
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The study was carried out to analyze the characteristics of two functional constituents' viz. γ-amino butyric acid (GABA) and ß-glucan extracted from raw and germination barnyard millet (var. PRJ-1). A significant (P ≤ 0.05) effect of germination (sprouting) was observed in yield, chemical composition, functional, rheological and antioxidant properties of ß-glucan and GABA. The yield of GABA extract was 12.34 % and the content increased from 6.37 mg/100 g in raw to 35.70 mg/100 g in germinated sample. The DPPH, total antioxidant and hydrogen peroxide scavenging activities of GABA extract increased after germination from 45.34 to 65.34 %, 15.3 to 33.3 millimole/g and 38.4 to 64.7 millimole/g, respectively. The yield of ß-glucan extract of raw and germinated flour was 6.05 and 5.01 % whereas the ß-glucan contents were 83.30 and 79.64 %, respectively. The functional properties of ß-glucan i.e., swelling power, water binding capacity and DPPH scavenging activity increased from 1.45 to 1.76 g/g, 2.13 to 2.32 g/g and 44.39 to 57.42 %, respectively, after germination. Similarly there was an increase in the storage modulus after germination process which attributes a better viscoelastic capacity of ß-glucan at low frequencies. The results exploit that the ß-glucan and GABA might promise a polymeric incipient to be implemented as food additives with variable functional and structural characteristics.
[Mh] Termos MeSH primário: Echinochloa/química
Germinação
beta-Glucanas/análise
Ácido gama-Aminobutírico/análise
[Mh] Termos MeSH secundário: Antioxidantes/análise
Gorduras na Dieta/análise
Proteínas na Dieta/análise
Farinha/análise
Análise de Alimentos
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Dietary Fats); 0 (Dietary Proteins); 0 (beta-Glucans); 56-12-2 (gamma-Aminobutyric Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE
[do] DOI:10.1007/s11130-016-0545-6


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[PMID]:27088639
[Au] Autor:Kato-Noguchi H; Suzuki M; Noguchi K; Ohno O; Suenaga K; Laosinwattana C
[Ad] Endereço:Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki, Kagawa, 761-0795, Japan. hisashi@ag.kagawa-u.ac.jp.
[Ti] Título:A Potent Phytotoxic Substance in Aglaia odorata Lour.
[So] Source:Chem Biodivers;13(5):549-54, 2016 May.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Aglaia odorata Lour. (Meliaceae) was found to have very strong allelopathic activity and a bioherbicide PORGANIC(™) was developed from its leaf extracts. However, the phytotoxic substances causing the strong allelopathic activity of the plants have not yet been determined. Therefore, we investigated allelopathic properties and phytotoxic substances in A. odorata. Aqueous EtOH extracts of A. odorata leaves inhibited root and shoot growth of garden cress (Lepidum sativum), lettuce (Lactuca sativa), alfalfa (Medicago sativa), timothy (Phleum pratense), ryegrass (Lolium multiflorum), and Echinochloa crus-galli with the extract concentration-dependent manner. The extracts were then purified and a major phytotoxic substance with allelopathic activity was isolated and identified by spectral data as rocaglaol. Rocaglaol inhibited the growth of garden cress and E. crus-galli at concentrations > 0.3 and 0.03 µm, respectively. The concentrations required for 50% inhibition ranged from 0.09 to 2.5 µm. The inhibitory activity of rocaglaol on the weed species, E. crus-galli, was much greater than that of abscisic acid. These results suggest that rocaglaol may be a major contributor to the allelopathic effect of A. odorata and bioherbicide PORGANIC(™) .
[Mh] Termos MeSH primário: Aglaia/química
Benzofuranos/farmacologia
Echinochloa/efeitos dos fármacos
Lepidium sativum/efeitos dos fármacos
Extratos Vegetais/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Benzofuranos/química
Benzofuranos/isolamento & purificação
Relação Dose-Resposta a Droga
Echinochloa/crescimento & desenvolvimento
Lepidium sativum/crescimento & desenvolvimento
Conformação Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0 (Plant Extracts); 0 (rocaglaol)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500175


  9 / 164 MEDLINE  
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[PMID]:26905829
[Au] Autor:Huang T; Sun J; An L; Zhang L; Han C
[Ad] Endereço:Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, Jiangsu 221004, PR China; Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, PR China. Electronic address: ton
[Ti] Título:Synthesis and herbicidal evaluation of novel benzothiazole derivatives as potential inhibitors of D1 protease.
[So] Source:Bioorg Med Chem Lett;26(7):1854-9, 2016 Apr 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:D1 protease is a C-terminal processing protease that has been predicted to be an ideal herbicidal target. Three novel series of benzothiazole derivatives were synthesized and evaluated for their herbicidal activities against Brassica napus (rape) and Echinochloa crusgalli (barnyard grass). The preliminary bioassay indicated that most of the synthesized compounds possess promising D1 protease inhibitory activities and considerable herbicidal activities. Molecular docking was performed to position representative compounds into the active site of D1 protease to determine a probable binding model.
[Mh] Termos MeSH primário: Benzotiazóis/química
Benzotiazóis/farmacologia
Brassica napus/efeitos dos fármacos
Echinochloa/efeitos dos fármacos
Herbicidas/química
Herbicidas/farmacologia
[Mh] Termos MeSH secundário: Brassica napus/enzimologia
Brassica napus/fisiologia
Echinochloa/enzimologia
Echinochloa/fisiologia
Endopeptidases/metabolismo
Simulação de Acoplamento Molecular
Inibidores de Proteases/química
Inibidores de Proteases/farmacologia
Controle de Plantas Daninhas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzothiazoles); 0 (Herbicides); 0 (Protease Inhibitors); EC 3.4.- (Endopeptidases)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE


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[PMID]:26725284
[Au] Autor:Nguyen DH; Zhao BT; Le DD; Yoon YH; Ko JY; Woo KS; Jun do Y; Kim YH; Woo MH
[Ad] Endereço:College of Pharmacy, Catholic University of Daegu , Gyeongsan 38430, Republic of Korea.
[Ti] Título:Isolation of Lignan and Fatty Acid Derivatives from the Grains of Echinochloa utilis and Their Inhibition of Lipopolysaccharide-Induced Nitric Oxide Production in RAW 264.7 Cells.
[So] Source:J Agric Food Chem;64(2):425-32, 2016 Jan 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two new fatty acid derivatives, echinochlorins A (8) and B (9) and a racemic lignan, (±)-anti-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-acetoxypropen-1-yl]-2-methoxyphenoxy}propan-1,3-diol 3-acetate (1), were isolated from Echinochloa utilis grains, along with six known lignans (2-7) and two fatty acid derivatives (10, 11). Their structures were established by spectroscopic data analyses (IR, UV, HR-FABMS, GC-MS, and 1D and 2D NMR). The configuration of 1 was determined by Mosher's method. Compound 5 displayed potential inhibitory activity on lipopolysaccharide-induced NO production in macrophage RAW 264.7 cells with an IC50 value of 4.8 ± 0.5 µM. These isolated compounds in crude EtOH extract were also quantitated by HPLC.
[Mh] Termos MeSH primário: Echinochloa/química
Ácidos Graxos/farmacologia
Lignanas/farmacologia
Macrófagos/efeitos dos fármacos
Óxido Nítrico/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Ácidos Graxos/química
Ácidos Graxos/isolamento & purificação
Lignanas/química
Lignanas/isolamento & purificação
Lipopolissacarídeos/farmacologia
Macrófagos/metabolismo
Camundongos
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Células RAW 264.7
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Lignans); 0 (Lipopolysaccharides); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160120
[Lr] Data última revisão:
160120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160105
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b05638



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