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Pesquisa : B01.650.940.800.575.912.250.822.788 [Categoria DeCS]
Referências encontradas : 297 [refinar]
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[PMID]:28457642
[Au] Autor:Wasan A; Nanda A
[Ad] Endereço:Allergy and Asthma Center, McLean, Virginia.
[Ti] Título:Systemic reaction to timothy grass pollen sublingual immunotherapy.
[So] Source:Ann Allergy Asthma Immunol;118(6):732-733, 2017 Jun.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anafilaxia/induzido quimicamente
Pólen/efeitos adversos
Rinite Alérgica Sazonal/prevenção & controle
Imunoterapia Sublingual/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Phleum
Extratos Vegetais/efeitos adversos
Extratos Vegetais/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28196255
[Au] Autor:Scadding GW; Calderon MA; Shamji MH; Eifan AO; Penagos M; Dumitru F; Sever ML; Bahnson HT; Lawson K; Harris KM; Plough AG; Panza JL; Qin T; Lim N; Tchao NK; Togias A; Durham SR; Immune Tolerance Network GRASS Study Team
[Ad] Endereço:Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom.
[Ti] Título:Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial.
[So] Source:JAMA;317(6):615-625, 2017 02 14.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at least 2 years following discontinuation of treatment. Objective: To assess whether 2 years of treatment with grass pollen sublingual immunotherapy, compared with placebo, provides improved nasal response to allergen challenge at 3-year follow-up. Design, Setting, and Participants: A randomized double-blind, placebo-controlled, 3-parallel-group study performed in a single academic center, Imperial College London, of adult patients with moderate to severe seasonal allergic rhinitis (interfering with usual daily activities or sleep). First enrollment was March 2011, last follow-up was February 2015. Interventions: Thirty-six participants received 2 years of sublingual immunotherapy (daily tablets containing 15 µg of major allergen Phleum p 5 and monthly placebo injections), 36 received subcutaneous immunotherapy (monthly injections containing 20 µg of Phleum p 5 and daily placebo tablets) and 34 received matched double-placebo. Nasal allergen challenge was performed before treatment, at 1 and 2 years of treatment, and at 3 years (1 year after treatment discontinuation). Main Outcomes and Measures: Total nasal symptom scores (TNSS; range; 0 [best] to 12 [worst]) were recorded between 0 and 10 hours after challenge. The minimum clinically important difference for change in TNSS within an individual is 1.08. The primary outcome was TNSS comparing sublingual immunotherapy vs placebo at year 3. Subcutaneous immunotherapy was included as a positive control. The study was not powered to compare sublingual immunotherapy with subcutaneous immunotherapy. Results: Among 106 randomized participants (mean age, 33.5 years; 34 women [32.1%]), 92 completed the study at 3 years. In the intent-to-treat population, mean TNSS score for the sublingual immunotherapy group was 6.36 (95% CI, 5.76 to 6.96) at pretreatment and 4.73 (95% CI, 3.97 to 5.48) at 3 years, and for the placebo group, the score was 6.06 (95% CI, 5.23 to 6.88) at pretreatment and 4.81 (95% CI, 3.97 to 5.65) at 3 years. The between-group difference (adjusted for baseline) was -0.18 (95% CI, -1.25 to 0.90; [P = .75]). Conclusions and Relevance: Among patients with moderate to severe seasonal allergic rhinitis, 2 years of sublingual grass pollen immunotherapy was not significantly different from placebo in improving the nasal response to allergen challenge at 3-year follow-up. Trial Registration: clinicaltrials.gov Identifier: NCT01335139; EudraCT Number: 2010-023536-16.
[Mh] Termos MeSH primário: Alérgenos/uso terapêutico
Phleum/imunologia
Pólen/imunologia
Rinite Alérgica Sazonal/terapia
Imunoterapia Sublingual/métodos
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Feminino
Seres Humanos
Análise de Intenção de Tratamento
Masculino
Phleum/efeitos adversos
Pólen/efeitos adversos
Rinite Alérgica Sazonal/etnologia
Imunoterapia Sublingual/efeitos adversos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2016.21040


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[PMID]:28120604
[Au] Autor:Perales Chordá C; Sáez González E; Martí Garrido J; López Salgueiro R; Hernández Fernández de Rojas D
[Ad] Endereço:Department of Allergy, Hospital La Fe, Valencia, Spain. Phone: +34 679 633 188 E-mail: perales_carcho@gva.es.
[Ti] Título:Esophageal dysfunction and immunological changes induced by grass sublingual immunotherapy.
[So] Source:Eur Ann Allergy Clin Immunol;49(1):28-30, 2017 Jan.
[Is] ISSN:1764-1489
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Sublingual immunotherapy frequently causes local oropharyngeal adverse events which are usually of mild severity, and tend to be self-limited and disappear within the first weeks of therapy. The mechanism of action involves changes in the specific humoral response to allergens, with increases in allergen-specific immunoglobulin G4 (IgG4) and blunting of the seasonal increase in allergen-specific IgE. We describe the case of a 25-year-old man diagnosed with grass pollen induced allergic rhinoconjunctivitis, who was treated with a lyophilisate of Phleum pratense by sublingual route. After 5 weeks of therapy he developed repeatedly intense symptoms of esophageal dysfunction immediately after the administration. Symptoms recurred every day, subsided in some hours without treatment and disappeared with the termination of therapy. The episode coincided with a marked elevation of total and specific IgE. The immunological changes gradually declined during the three years of follow up. The reported case suggests the need to evaluate the role of the immunological changes detected after the first weeks of sublingual therapy with Phleum pratense, in the induction of esophageal disorders.
[Mh] Termos MeSH primário: Doenças do Esôfago/etiologia
Imunoglobulina E/sangue
Phleum/imunologia
Imunoterapia Sublingual/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Inibidores da Bomba de Prótons/farmacologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton Pump Inhibitors); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


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[PMID]:28103254
[Au] Autor:Mardo K; Visnapuu T; Vija H; Aasamets A; Viigand K; Alamäe T
[Ad] Endereço:Department of Genetics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
[Ti] Título:A Highly Active Endo-Levanase BT1760 of a Dominant Mammalian Gut Commensal Bacteroides thetaiotaomicron Cleaves Not Only Various Bacterial Levans, but Also Levan of Timothy Grass.
[So] Source:PLoS One;12(1):e0169989, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bacteroides thetaiotaomicron, an abundant commensal of the human gut, degrades numerous complex carbohydrates. Recently, it was reported to grow on a ß-2,6-linked polyfructan levan produced by Zymomonas mobilis degrading the polymer into fructooligosaccharides (FOS) with a cell surface bound endo-levanase BT1760. The FOS are consumed by B. thetaiotaomicron, but also by other gut bacteria, including health-promoting bifidobacteria and lactobacilli. Here we characterize biochemical properties of BT1760, including the activity of BT1760 on six bacterial levans synthesized by the levansucrase Lsc3 of Pseudomonas syringae pv. tomato, its mutant Asp300Asn, levansucrases of Zymomonas mobilis, Erwinia herbicola, Halomonas smyrnensis as well as on levan isolated from timothy grass. For the first time a plant levan is shown as a perfect substrate for an endo-fructanase of a human gut bacterium. BT1760 degraded levans to FOS with degree of polymerization from 2 to 13. At optimal reaction conditions up to 1 g of FOS were produced per 1 mg of BT1760 protein. Low molecular weight (<60 kDa) levans, including timothy grass levan and levan synthesized from sucrose by the Lsc3Asp300Asn, were degraded most rapidly whilst levan produced by Lsc3 from raffinose least rapidly. BT1760 catalyzed finely at human body temperature (37°C) and in moderately acidic environment (pH 5-6) that is typical for the gut lumen. According to differential scanning fluorimetry, the Tm of the endo-levanase was 51.5°C. All tested levans were sufficiently stable in acidic conditions (pH 2.0) simulating the gastric environment. Therefore, levans of both bacterial and plant origin may serve as a prebiotic fiber for B. thetaiotaomicron and contribute to short-chain fatty acids synthesis by gut microbiota. In the genome of Bacteroides xylanisolvens of human origin a putative levan degradation locus was disclosed.
[Mh] Termos MeSH primário: Bacteroides thetaiotaomicron/enzimologia
Frutanos/metabolismo
Glicosídeo Hidrolases/metabolismo
Phleum/metabolismo
[Mh] Termos MeSH secundário: Erwinia/enzimologia
Frutanos/genética
Frutanos/isolamento & purificação
Halomonas/enzimologia
Hexosiltransferases/metabolismo
Seres Humanos
Hidrólise
Intestinos/microbiologia
Peso Molecular
Oligossacarídeos/metabolismo
Pseudomonas syringae/enzimologia
Homologia de Sequência
Especificidade por Substrato
Zymomonas/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fructans); 0 (Oligosaccharides); 0 (fructooligosaccharide); EC 2.4.1.- (Hexosyltransferases); EC 2.4.1.10 (levansucrase); EC 3.2.1.- (Glycoside Hydrolases); EC 3.2.1.65 (levanase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169989


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[PMID]:28103252
[Au] Autor:Sharma A; Sharma N; Bhalla P; Singh M
[Ad] Endereço:Plant Molecular Biology and Biotechnology Laboratory, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Melbourne, VIC, Australia.
[Ti] Título:Comparative and Evolutionary Analysis of Grass Pollen Allergens Using Brachypodium distachyon as a Model System.
[So] Source:PLoS One;12(1):e0169686, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Comparative genomics have facilitated the mining of biological information from a genome sequence, through the detection of similarities and differences with genomes of closely or more distantly related species. By using such comparative approaches, knowledge can be transferred from the model to non-model organisms and insights can be gained in the structural and evolutionary patterns of specific genes. In the absence of sequenced genomes for allergenic grasses, this study was aimed at understanding the structure, organisation and expression profiles of grass pollen allergens using the genomic data from Brachypodium distachyon as it is phylogenetically related to the allergenic grasses. Combining genomic data with the anther RNA-Seq dataset revealed 24 pollen allergen genes belonging to eight allergen groups mapping on the five chromosomes in B. distachyon. High levels of anther-specific expression profiles were observed for the 24 identified putative allergen-encoding genes in Brachypodium. The genomic evidence suggests that gene encoding the group 5 allergen, the most potent trigger of hay fever and allergic asthma originated as a pollen specific orphan gene in a common grass ancestor of Brachypodium and Triticiae clades. Gene structure analysis showed that the putative allergen-encoding genes in Brachypodium either lack or contain reduced number of introns. Promoter analysis of the identified Brachypodium genes revealed the presence of specific cis-regulatory sequences likely responsible for high anther/pollen-specific expression. With the identification of putative allergen-encoding genes in Brachypodium, this study has also described some important plant gene families (e.g. expansin superfamily, EF-Hand family, profilins etc) for the first time in the model plant Brachypodium. Altogether, the present study provides new insights into structural characterization and evolution of pollen allergens and will further serve as a base for their functional characterization in related grass species.
[Mh] Termos MeSH primário: Alérgenos/genética
Brachypodium/genética
Brachypodium/imunologia
Poaceae/genética
Poaceae/imunologia
Pólen/genética
Pólen/imunologia
[Mh] Termos MeSH secundário: Alérgenos/química
Alérgenos/classificação
Cromossomos de Plantas/genética
Sequência Conservada
Evolução Molecular
Genoma de Planta
Seres Humanos
Lolium/genética
Lolium/imunologia
Modelos Genéticos
Modelos Imunológicos
Modelos Moleculares
Phleum/genética
Phleum/imunologia
Filogenia
Proteínas de Plantas/química
Proteínas de Plantas/genética
Proteínas de Plantas/imunologia
Pólen/química
Domínios Proteicos
Rinite Alérgica Sazonal/etiologia
Rinite Alérgica Sazonal/imunologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Plant Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169686


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[PMID]:27838323
[Au] Autor:Nolte H; Casale TB; Lockey RF; Fogh BS; Kaur A; Lu S; Nelson HS
[Ad] Endereço:Research and Development, Merck & Co., Inc., Kenilworth, NJ. Electronic address: hendrik.nolte@merck.com.
[Ti] Título:Epinephrine Use in Clinical Trials of Sublingual Immunotherapy Tablets.
[So] Source:J Allergy Clin Immunol Pract;5(1):84-89.e3, 2017 Jan - Feb.
[Is] ISSN:2213-2201
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allergy immunotherapy can result in systemic allergic reactions and even life-threatening anaphylaxis requiring epinephrine administration. OBJECTIVE: The objective of this study was to describe epinephrine use in the clinical trial development programs of 3 rapidly dissolving sublingual immunotherapy tablets (SLIT-tablets; Merck & Co., Inc., Kenilworth, NJ/ALK, Hørsholm, Denmark/Torii Pharmaceutical Co., Ltd., Tokyo, Japan). METHODS: Data on epinephrine use were collected from 13 timothy grass SLIT-tablet trials (MK-7243; ≤2800 bioequivalent allergen units/75,000 SQ-T dose, n = 2497; placebo, n = 2139), 5 short ragweed SLIT-tablet trials (MK-3641; ≤12 Amb a 1-U, n = 1725; placebo, n = 770), and 11 house dust mite (HDM) SLIT-tablet trials (MK-8237; ≤12 SQ-HDM; n = 3930; placebo, n = 2246). RESULTS: In grass SLIT-tablet trials, epinephrine was used 13 times (grass SLIT-tablet, n = 10; placebo, n = 3). Eight administrations were for grass SLIT-tablet-related adverse events (AEs): 4 for systemic allergic reactions and 4 for local mouth and/or throat swelling. In ragweed SLIT-tablet trials, epinephrine was used 9 times in 8 subjects (ragweed SLIT-tablet, n = 7; placebo, n = 1 [2 administrations for protracted anaphylaxis]). Four administrations were for ragweed SLIT-tablet-related AEs: 1 for systemic allergic reaction and 3 for local mouth and/or pharynx/throat swelling. In HDM SLIT-tablet trials, epinephrine was administered 13 times (HDM SLIT-tablet, n = 8; placebo, n = 5). Four administrations were for HDM SLIT-tablet-related AEs: 1 for systemic allergic reaction and 3 for local events. Of the 16 epinephrine administrations for events related to SLIT-tablet treatment, 11 occurred within the first week of treatment (7 administrations on day 1) and 5 were subject self-administered. CONCLUSIONS: Epinephrine administrations in response to SLIT-tablet-related reactions in clinical trials are uncommon, typically occur within the first week of treatment, and are rarely self-administered. All SLIT-tablet-related events treated with epinephrine were nonserious.
[Mh] Termos MeSH primário: Anafilaxia/prevenção & controle
Antígenos de Dermatophagoides/uso terapêutico
Antígenos de Plantas/uso terapêutico
Asma/terapia
Epinefrina/administração & dosagem
Rinite Alérgica/terapia
Imunoterapia Sublingual/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Ambrosia
Anafilaxia/etiologia
Animais
Asma/complicações
Asma/imunologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Phleum
Pyroglyphidae
Rinite Alérgica/complicações
Rinite Alérgica/imunologia
Imunoterapia Sublingual/efeitos adversos
Comprimidos
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; CLINICAL TRIAL, PHASE II; CLINICAL TRIAL, PHASE III; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antigens, Dermatophagoides); 0 (Antigens, Plant); 0 (Tablets); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161114
[St] Status:MEDLINE


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[PMID]:27321436
[Au] Autor:Clifford RL; Jones MJ; MacIsaac JL; McEwen LM; Goodman SJ; Mostafavi S; Kobor MS; Carlsten C
[Ad] Endereço:Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
[Ti] Título:Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.
[So] Source:J Allergy Clin Immunol;139(1):112-121, 2017 Jan.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allergic disease affects 30% to 40% of the world's population, and its development is determined by the interplay between environmental and inherited factors. Air pollution, primarily consisting of diesel exhaust emissions, has increased at a similar rate to allergic disease. Exposure to diesel exhaust may play a role in the development and progression of allergic disease, in particular allergic respiratory disease. One potential mechanism underlying the connection between air pollution and increased allergic disease incidence is DNA methylation, an epigenetic process with the capacity to integrate gene-environment interactions. OBJECTIVE: We sought to investigate the effect of allergen and diesel exhaust exposure on bronchial epithelial DNA methylation. METHODS: We performed a randomized crossover-controlled exposure study to allergen and diesel exhaust in humans, and measured single-site (CpG) resolution global DNA methylation in bronchial epithelial cells. RESULTS: Exposure to allergen alone, diesel exhaust alone, or allergen and diesel exhaust together (coexposure) led to significant changes in 7 CpG sites at 48 hours. However, when the same lung was exposed to allergen and diesel exhaust but separated by approximately 4 weeks, significant changes in more than 500 sites were observed. Furthermore, sites of differential methylation differed depending on which exposure was experienced first. Functional analysis of differentially methylated CpG sites found genes involved in transcription factor activity, protein metabolism, cell adhesion, and vascular development, among others. CONCLUSIONS: These findings suggest that specific exposures can prime the lung for changes in DNA methylation induced by a subsequent insult.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Alérgenos/toxicidade
Brônquios/efeitos dos fármacos
Metilação de DNA/efeitos dos fármacos
Mucosa Respiratória/efeitos dos fármacos
Emissões de Veículos/toxicidade
[Mh] Termos MeSH secundário: Adulto
Antígenos de Dermatophagoides/toxicidade
Asma/genética
Asma/metabolismo
Betula/imunologia
Brônquios/metabolismo
Ilhas de CpG
Feminino
Seres Humanos
Exposição por Inalação/efeitos adversos
Masculino
Meia-Idade
Phleum/imunologia
Proteínas de Plantas/toxicidade
Mucosa Respiratória/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Allergens); 0 (Antigens, Dermatophagoides); 0 (Plant Proteins); 0 (Vehicle Emissions)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:27072297
[Au] Autor:Uyeno Y; Akiyama K; Hasunuma T; Yamamoto H; Yokokawa H; Yamaguchi T; Kawashima K; Itoh M; Kushibiki S; Hirako M
[Ad] Endereço:Faculty of Agriculture, Shinshu University, Minamiminowa, Nagano, Japan.
[Ti] Título:Effects of supplementing an active dry yeast product on rumen microbial community composition and on subsequent rumen fermentation of lactating cows in the mid-to-late lactation period.
[So] Source:Anim Sci J;88(1):119-124, 2017 Jan.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:The effects of supplementing feed of cows in mid-to-late lactation with an active yeast product (Actisaf Sc 47) were evaluated using 15 Holstein cows in a replicated 3 × 3 Latin square design. The animals were fed a mixed ration with 33% neutral detergent fiber, consisting of timothy hay (29.8%), a commercial concentrate (70.0%) and commercial calcium triphosphate (0.2%), twice daily to meet 105% of their energy requirement. Yeast supplement was set at 0, 5 and 10 g per day over 21-day periods, each of which consisted of 14 days for adaptation followed by 7 days of data collection. Milking performance, plasma metabolite parameters, rumen volatile fatty acids, lipopolysaccharide and microbial properties were measured. Although there were no significant differences in feeding and milking performance or blood parameters associated with supplementation, the acetate to propionate ratio in the rumen fluid tended to decrease (P = 0.08). The population of Bacteroidetes tended to be less prominent (P = 0.07) and the fibrolytic bacterium Fibrobacter significantly increased (P < 0.05) in the rumen fluid of the yeast 10 g group compared with that of the control. These data suggest that effects of supplementing live yeast to cows in mid-to-late lactation may be limited to microbial composition and fermentation characteristics in the rumen.
[Mh] Termos MeSH primário: Ração Animal
Fenômenos Fisiológicos da Nutrição Animal/fisiologia
Bovinos/metabolismo
Bovinos/fisiologia
Dieta/veterinária
Suplementos Nutricionais
Fermentação
Lactação/fisiologia
Probióticos
Rúmen/metabolismo
Rúmen/microbiologia
Saccharomyces cerevisiae
[Mh] Termos MeSH secundário: Animais
Fibras na Dieta
Ácidos Graxos Voláteis/metabolismo
Feminino
Fibrobacter
Lipopolissacarídeos/metabolismo
Phleum
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fiber); 0 (Fatty Acids, Volatile); 0 (Lipopolysaccharides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160414
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12612


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[PMID]:26589301
[Au] Autor:Rosenkranz E; Hilgers RD; Uciechowski P; Petersen A; Plümäkers B; Rink L
[Ad] Endereço:Institute of Immunology, Faculty of Medicine, University Hospital, RWTH Aachen University, Pauwelstr. 30, 52074, Aachen, Germany.
[Ti] Título:Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.
[So] Source:Eur J Nutr;56(2):557-567, 2017 Mar.
[Is] ISSN:1436-6215
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The trace element zinc is essential for immune function and its regulation. Since zinc deficiency and allergic hyperresponsive reactions are often accompanied, the influence of zinc on allergen-induced cell growth, CD4+ regulatory T (Treg) cell numbers and cytokine expression during allergic immune reactions was investigated. METHODS: Peripheral blood mononuclear cells (PBMCs) from non-atopic and atopic subjects were treated with timothy grass allergen pre-incubated with or without zinc. Proliferation was determined by analyzing the incorporation of H-thymidine. Intracellular zinc and Foxp3 levels and cell surface antigens were measured by FACS, cytokine expression by ELISA and real-time PCR. RESULTS: Incubation with 50 µM zinc sulfate (Zn50) enhances cytosolic zinc concentrations in CD3+ T cells. The data also reveal that the combination of Zn50 plus allergen significantly reduces PBMC proliferation of atopic subjects. Additionally, Zn50 plus allergen enhances Th1 cytokine responses shown by increased interferon (IFN)-γ/interleukin (IL)-10 ratios as well as enhanced tumor necrosis factor-α release. In response to allergen, zinc increases Treg cells and upregulates the mRNA expression of cytotoxic T-lymphocyte antigen-4 in atopic subjects. Interestingly, Zn50 alone leads to an increase of CD4+CD25high(hi)+ cells in atopic and non-atopic subjects. CONCLUSIONS: Zinc may regulate unwanted hyperresponsive immune reactions by suppressing proliferation through a significant shift from IL-10 to the Th1 cytokine IFN-γ, and enhanced regulatory T cell numbers. Therefore, zinc supplementation may be a promising tool for the therapy of allergies, without negatively affecting the immune system.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Hipersensibilidade Imediata/imunologia
Linfócitos T Reguladores/efeitos dos fármacos
Linfócitos T Reguladores/imunologia
Zinco/farmacologia
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Seres Humanos
Interferon gama/análise
Interferon gama/genética
Interleucina-10/análise
Interleucina-10/genética
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/imunologia
Contagem de Linfócitos
Phleum/imunologia
RNA Mensageiro/análise
Linfócitos T Reguladores/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (IL10 protein, human); 0 (RNA, Messenger); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151122
[St] Status:MEDLINE
[do] DOI:10.1007/s00394-015-1100-1


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[PMID]:28124640
[Au] Autor:Krajewska-Wojtys A; Jarzab J; Gawlik R; Bozek A
[Ad] Endereço:Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, Poland.
[Ti] Título:Local allergic rhinitis to pollens is underdiagnosed in young patients.
[So] Source:Am J Rhinol Allergy;30(6):198-201, 2016 Nov 01.
[Is] ISSN:1945-8932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Local allergic rhinitis (LAR) has been observed in patients without atopy. However, LAR is still underdiagnosed in patients with perennial or seasonal nasal symptoms. OBJECTIVE: The aim of this study was to determine the prevalence of LAR in young patients with a previous diagnosis of nonallergic rhinitis or suspicion of allergy. METHODS: A total of 121 patients, ages 12-18 years old, with confirmed nonallergic rhinitis and typical seasonal nasal symptoms were examined. Skin-prick tests; serum and nasal specific immunoglobulin E (IgE) measurements; and nasal provocation tests by using grass (Phleum partense), Artemisia, and birch pollens were performed. A control group of age-matched patients with a diagnosis of seasonal allergic rhinitis underwent the same procedures as the test group. RESULTS: LAR to grass pollen (P. partense), Artemisia, and birch was confirmed in 17 (16.6%), 6 (5.9%), and 9 (8.9%) of patients, respectively. Polyvalent allergy was established in 21 subjects (20.8%): grass and Artemisia, 11 patients (10.9%); and grass and birch, 10 patients (9.9%). The remaining 48 patients (47.5%) were diagnosed with nonallergic rhinitis. The results of the nasal provocation tests and the concentrations of nasal IgE were similar among the analyzed groups. Furthermore, the concentration of nasal IgE increased faster in patients with LAR than in patients with allergic rhinitis; however, this difference was not statistically significant. CONCLUSION: LAR is a serious problem in young patients; however, its significance is still unappreciated.
[Mh] Termos MeSH primário: Erros de Diagnóstico/estatística & dados numéricos
Rinite Alérgica/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Alérgenos/imunologia
Antígenos de Plantas/imunologia
Artemisia/imunologia
Betula/imunologia
Erros de Diagnóstico/prevenção & controle
Feminino
Seres Humanos
Masculino
Phleum/imunologia
Polônia/epidemiologia
Pólen/imunologia
Prevalência
Rinite Alérgica/diagnóstico
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.2500/ajra.2016.30.4369



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