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Pesquisa : B01.650.940.800.575.912.250.825 [Categoria DeCS]
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  1 / 241 MEDLINE  
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[PMID]:28178632
[Au] Autor:Neto JJL; de Almeida TS; de Medeiros JL; Vieira LR; Moreira TB; Maia AIV; Ribeiro PRV; de Brito ES; Farias DF; Carvalho AFU
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60020-181, Fortaleza, CE, Brazil.
[Ti] Título:Impact of bioaccessibility and bioavailability of phenolic compounds in biological systems upon the antioxidant activity of the ethanolic extract of Triplaris gardneriana seeds.
[So] Source:Biomed Pharmacother;88:999-1007, 2017 Apr.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The most studied bioactive potential of phenolic compounds corresponds to antioxidant activity, which in turn, is associated with a reduction in the incidence of various human diseases. However, the total quantity of these bioactive substances in foods and medicinal preparations does not reflect the amount absorbed and metabolized by the body. The present study aimed to investigate the bioaccessibility of Triplaris gardneriana seeds ethanolic extract (EETg) by determination of phenolic composition and antioxidant activities before and after in vitro digestion as well as to estimate its bioavailability by chemical analysis of plasma and urine in animal models after oral administration. The bioaccessibility indexes of phenolic compounds in EETg were 48.65 and 69.28% in the presence and absence of enzymes, respectively. Among the identified phenolics classes, flavonoids, represented by galloylated procyanidins type B, proved to be more bioaccessible, 81.48 and 96.29% in the post-intestinal phase with and without enzymes, respectively. The oral administration in Wistar rats resulted in a significant decrease in plasma of the total antioxidant capacity, TAC, by FRAP assay 4h after beginning the experiment. For urine samples, an increase in TAC by DPPH and FRAP was observed from 1 and 4h after administration, respectively. UPLC-QTOF analysis of urine detected 2 metabolites originated from the degradation of phenolic compounds, i.e. hippuric acid and phenylacetil glycine. These results suggest that phenolic compounds in T. gardneriana are unstable under gastrointestinal conditions, being flavonoids the components with higher bioaccessibility; besides that, they showed limited bioavailability due to their rapid biotransformation and urinary elimination.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Etanol/química
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Polygonaceae/química
Sementes/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Digestão/efeitos dos fármacos
Masculino
Metaboloma/efeitos dos fármacos
Compostos Fitoquímicos/análise
Extratos Vegetais/administração & dosagem
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); 0 (Phytochemicals); 0 (Plant Extracts); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE


  2 / 241 MEDLINE  
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[PMID]:28121616
[Au] Autor:Ansari P; Uddin MJ; Akther S; Azam S; Mahmud MK; Azad SB; Ullah A; Hannan JM
[Ti] Título:Investigation of antinociceptive activity of methanolic extract of Persicaria orientalis leaves in rodents.
[So] Source:J Basic Clin Physiol Pharmacol;28(2):171-179, 2017 Mar 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aims to evaluate the scientific basis of traditional application of Persicaria orientalis for reducing pain and inflammation. METHODS: An in vitro method was performed to investigate the presence of the anti-inflammatory activity of methanolic crude extract of P. orientalis. In addition, an in vivo study was conducted in which the hot-plate and tail immersion methods were applied to explore the acute effect of P. orientalis on analgesia. The potency to inhibit chronic inflammation in mice was justified by the carrageenan-induced paw edema and formalin-induced edema methods. For all in vivo testing in animal models (albino mice and rats), plant extract was given via the oral route at doses of 250 mg/kg and 500 mg/kg. RESULTS: The methanolic extract of P. orientalis produced a significant (p<0.001) inhibition of analgesia with a prolongation of pain response time by 61.80% at 500 mg/kg. The extract also exhibited a potential anti-inflammatory (56.99%) effect, which was also statistically significant (p<0.001). The present study suggests that the methanolic extract of P. orientalis has potential anti-inflammatory as well as analgesic activity and this extract is effective in the treatment of both acute and chronic pain. CONCLUSIONS: Our current study revealed pharmacological properties of the methanolic extract of P. orientalis and also gave a solid scientific platform against its traditional use. The protecting ability of P. orientalis against inflammatory stimuli may be due to phenolic or flavonoid compounds which we have found through phytochemical analysis.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Medição da Dor/efeitos dos fármacos
Extratos Vegetais/farmacologia
Folhas de Planta
Polygonaceae
[Mh] Termos MeSH secundário: Analgésicos/isolamento & purificação
Analgésicos/uso terapêutico
Animais
Relação Dose-Resposta a Droga
Edema/tratamento farmacológico
Edema/patologia
Seres Humanos
Metanol/farmacologia
Metanol/uso terapêutico
Camundongos
Dor/tratamento farmacológico
Dor/patologia
Medição da Dor/métodos
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/uso terapêutico
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Plant Extracts); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE


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[PMID]:27902928
[Au] Autor:Xu P; Su S; Tan C; Lai RS; Min ZS
[Ad] Endereço:First Clinical College, Nanjing University of Chinese Medicine, Nanjing 210029, China; Department of Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.
[Ti] Título:Effects of aqueous extracts of Ecliptae herba, Polygoni multiflori radix praeparata and Rehmanniae radix praeparata on melanogenesis and the migration of human melanocytes.
[So] Source:J Ethnopharmacol;195:89-95, 2017 Jan 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Polygoni multiflori radix praeparata (PMRP), Ecliptae herba (EH) and Rehmanniae radix praeparata (RRP) are the most frequently-used herbs by Traditional Chinese Medicine practitioners for the treatment of vitiligo. Their abilities to stimulate melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression were evaluated in this study. MATERIALS AND METHODS: The effects of aqueous extracts of PMRP, EH and RRP on human melanocytes in vitro were examined by MTT assay, tyrosinase activity, melanin synthesis, migration assay and Western blot. RESULTS: Treatment with EH (at 100µg/ml and 400µg/ml) significantly increased intracellular tyrosinase activity in accordance with the elevation of melanin content at the same concentrations. Treatment with RRP (at 100µg/ml and 400µg/ml) promoted melanin production but had no stimulatory effect on tyrosinase activity. Treatment with PMRP and EH (at 100µg/ml) promoted the migration of human melanocytes in a type IV collagen-coated transwell migration assay. Western blot analysis showed MITF protein expression was elevated by PMRP, EH and RRP (at 100µg/ml). CONCLUSION: An aqueous extract of EH has a synergistic effect on melanocytes by up-regulating tyrosinase activity, enhancing melanin synthesis and promoting melanocyte migration as well as elevating MITF protein expression. RRP exhibits a significant stimulating effect on melanogenesis and MITF protein expression. These results suggest that EH and RRP contain substances with direct enhancing effects on melanogenesis and migration, possibly via their effects on MITF protein expression.
[Mh] Termos MeSH primário: Movimento Celular/efeitos dos fármacos
Eclipta/química
Melaninas/biossíntese
Melanócitos/efeitos dos fármacos
Extratos Vegetais/farmacologia
Polygonaceae/química
Rehmannia/química
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Seres Humanos
Masculino
Melanócitos/metabolismo
Fator de Transcrição Associado à Microftalmia/metabolismo
Monofenol Mono-Oxigenase/metabolismo
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MITF protein, human); 0 (Melanins); 0 (Microphthalmia-Associated Transcription Factor); 0 (Plant Extracts); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE


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[PMID]:27581792
[Au] Autor:Aly HA; Alahdal AM; Nagy AA; Abdallah HM; Abdel-Sattar EA; Azhar AS
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
[Ti] Título:Lipoic acid and Calligonum comosumon attenuate aroclor 1260-induced testicular toxicity in adult rats.
[So] Source:Environ Toxicol;32(4):1147-1157, 2017 Apr.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aroclor 1260 is one of the more representative polychlorinated biphenyls found in biota. This study was designed to delineate the testicular toxicity of Aroclor 1260 and to elucidate the potential protective role of Calligonum comosum (C. comosum) and lipoic acid in adult rats. Aroclor 1260 was dissolved in corn oil and given to rats by gavage at doses 0, 20, 40, or 60 mg/kg/day for 15 consecutive days (Groups I, II, III, and IV, respectively). Groups V and VI were pretreated with C. comosum (200 mg/kg/day) and lipoic acid (35 mg/kg/day) respectively 24 h before Aroclor 1260 (40 mg/kg/day) treatment for 15 consecutive days. Aroclor 1260 (20, 40 or 60 mg/kg/day) treatment significantly decreased testes weight, sperm count and motility and daily sperm production. Serum testosterone was significantly decreased in response to treatment with 40 and 60 mg/kg/day of Aroclor 1260. LDH-X activity was significantly decreased at the three dose levels. Hydrogen peroxide (H O ) production (in a dose-related manner) and lipid peroxidation were significantly increased in response to Aroclor 1260 (20, 40, or 60 mg/kg/day) treatment. Aroclor 1260 at the three dose levels decreased the activities of the antioxidant enzymes SOD, CAT, GPx, and GR and the non-enzymatic antioxidant GSH level. CAT, GPx and GSH showed a dose-response effect. These abnormalities were effectively attenuated by pretreatment with C. comosum (200 mg/kg/day) or lipoic acid (35 mg/kg/day). Histopathological examination showed a dose-related increase in morphological abnormalities of the testis in response to Aroclor 1260 treatment. In conclusion, Aroclor 1260 induced testicular toxicity at least, in part, by induction of oxidative stress. By reversal of biochemical and morphological changes towards normalcy, the cytoprotective role of C. comosum and lipoic acid is illuminated. In comparison, lipoic acid was more protective than C. comosum extract against testicular toxicity induced by Aroclor 1260. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1147-1157, 2017.
[Mh] Termos MeSH primário: Arocloros/toxicidade
Poluentes Ambientais/toxicidade
Depuradores de Radicais Livres/farmacologia
Extratos Vegetais/farmacologia
Testículo/efeitos dos fármacos
Ácido Tióctico/farmacologia
[Mh] Termos MeSH secundário: Animais
Citoproteção
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Estresse Oxidativo/efeitos dos fármacos
Polygonaceae/química
Ratos
Ratos Wistar
Contagem de Espermatozoides
Testículo/enzimologia
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aroclors); 0 (Environmental Pollutants); 0 (Free Radical Scavengers); 0 (Plant Extracts); 11096-82-5 (aroclor 1260); 73Y7P0K73Y (Thioctic Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22310


  5 / 241 MEDLINE  
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[PMID]:27487493
[Au] Autor:Ansari P; Uddin MJ; Rahman MM; Abdullah-Al-Mamun M; Islam MR; Ali MH; Reza AS
[Ti] Título:Anti-inflammatory, anti-diarrheal, thrombolytic and cytotoxic activities of an ornamental medicinal plant: Persicaria orientalis.
[So] Source:J Basic Clin Physiol Pharmacol;28(1):51-58, 2017 Jan 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Persicaria orientalis, an ornamental medicinal plant, has been used in traditional medicine for the treatment of various diseases. Although the plant is reported to have some important pharmacological effects, many medicinal values remain unidentified. Our objective was to evaluate the anti-inflammatory, anti-diarrheal, thrombolytic, and cytotoxic properties of the methanol extract of P. orientalis leaves (Po-MeOH). METHODS: Anti-inflammatory activity was measured by the inhibition of hypotonicity-induced human red blood cell hemolysis and albumin denaturation technique in vitro of Po-MeOH. Diarrheal episodes were examined in mice with castor oil-induced diarrhea. The clot lysis and brine shrimp lethality bioassay in vitro were used to evaluate the thrombolytic and cytotoxic activities of the plant extract, respectively. RESULTS: Using in vitro anti-inflammatory models, the results demonstrated that Po-MeOH at the five different dose ranges from 31.25 to 500 µg/mL significantly (p<0.05) protected (0.98%-50.71%) the erythrocyte membrane against lysis induced by hypotonic medium solution and protein denaturation (38.27%-79.22%) of bovine albumin, respectively. The extract exhibited a significant reduction of severity (75.17%) of castor oil-induced diarrhea in mice at the highest dose of 400 mg/kg compared to loperamide (82.06%) at 5 mg/kg. Po-MeOH also showed 33.14% clot lytic activity in the thrombolytic test and cytotoxicity with LC50 value 58.91 µg/mL in the brine shrimp bioassay. CONCLUSIONS: These findings suggest that Po-MeOH has significant anti-inflammatory and anti-diarrheal effects along with moderate thrombolytic and lower cytotoxic properties that may warrant the further exploration.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antidiarreicos/uso terapêutico
Citotoxinas/uso terapêutico
Fibrinolíticos/uso terapêutico
Extratos Vegetais/uso terapêutico
Polygonaceae
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Antidiarreicos/isolamento & purificação
Artemia
Bovinos
Citotoxinas/isolamento & purificação
Diarreia/induzido quimicamente
Diarreia/tratamento farmacológico
Diarreia/patologia
Relação Dose-Resposta a Droga
Feminino
Fibrinolíticos/isolamento & purificação
Seres Humanos
Masculino
Camundongos
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antidiarrheals); 0 (Cytotoxins); 0 (Fibrinolytic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE


  6 / 241 MEDLINE  
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[PMID]:28006914
[Au] Autor:Odonbayar B; Murata T; Batkhuu J; Yasunaga K; Goto R; Sasaki K
[Ad] Endereço:Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University , 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
[Ti] Título:Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase.
[So] Source:J Nat Prod;79(12):3065-3071, 2016 Dec 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemical investigation of the aerial parts of Atraphaxis frutescens resulted in the isolation of five 7-methoxyflavonols with pyrogallol B-ring moieties (1-5), a fisetinidol glucoside (13), and a benzyl glycoside (18), together with 26 known compounds including flavonoids, phenylpropanoid amides, anthraquinone glycosides, lignans, and a benzyl derivative. The principal chemical structural feature of the isolated compounds was either a pyrogallol or catechol B-ring moiety, and they showed potent 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. To assess the effects of these antioxidants on biological enzymes, their inhibitory effects against an insect phenoloxidase and a mushroom tyrosinase were evaluated. This study indicated that insect phenoloxidase was inhibited by phenylpropanoid amides and that mushroom tyrosinase was inhibited by the characteristic 7-methoxyflavonol 3-O-rhamnopyranosides.
[Mh] Termos MeSH primário: Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Flavonóis/isolamento & purificação
Flavonóis/farmacologia
Monofenol Mono-Oxigenase/antagonistas & inibidores
Fenóis/isolamento & purificação
Fenóis/farmacologia
Polygonaceae/química
[Mh] Termos MeSH secundário: Agaricales/enzimologia
Animais
Antioxidantes/química
Afídeos/enzimologia
Compostos de Bifenilo/farmacologia
Catecol Oxidase/antagonistas & inibidores
Flavonóis/química
Glucosídeos/química
Glucosídeos/isolamento & purificação
Glucosídeos/farmacologia
Estrutura Molecular
Mongólia
Ressonância Magnética Nuclear Biomolecular
Fenóis/química
Picratos/farmacologia
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavonols); 0 (Glucosides); 0 (Phenols); 0 (Picrates); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.10.3.1 (Catechol Oxidase); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00720


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[PMID]:27827864
[Au] Autor:Torres-Naranjo M; Suárez A; Gilardoni G; Cartuche L; Flores P; Morocho V
[Ad] Endereço:Departamento de Química, Universidad Técnica Particular de Loja, Loja 1101608, Ecuador. mbeltorres15@hotmail.com.
[Ti] Título:Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its In Vitro α-Amilase and α-Glucosidase Inhibitory Activities.
[So] Source:Molecules;21(11), 2016 Nov 02.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The phytochemical investigation of , collected in Loja-Ecuador, led to the isolation of nine known compounds identified as: lupeol acetate ( ); - -coumaric acid ( ); lupeol ( ); ß-sitosterol ( ) - -coumaric acid ( ); linoleic acid ( ) (+)-catechin ( ); afzelin ( ) and quercitrin ( ). The structures of the isolated compounds were determined based on analysis of NMR and MS data, as well as comparison with the literature. The hypoglycemic activity of crude extracts and isolated compounds was assessed by the ability to inhibit α-amylase and α-glucosidase enzymes. The hexane extract showed weak inhibitory activity on α-amylase, with an IC value of 625 µg·mL , while the other extracts and isolated compounds were inactive at the maximum dose tested. The results on α-glucosidase showed more favorable effects; the hexanic and methanolic extracts exhibited a strong inhibitory activity with IC values of 48.22 µg·mL and 19.22 µg·mL , respectively. Four of the nine isolated compounds exhibited strong inhibitory activity with IC values below 8 µM, much higher than acarbose (377 uM). Linoleic acid was the most potent compound (IC = 0.42 µM) followed by afzelin, (+)-catechin and quercitrin.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Polygonaceae/química
alfa-Amilases/antagonistas & inibidores
alfa-Glucosidases
[Mh] Termos MeSH secundário: Ativação Enzimática/efeitos dos fármacos
Inibidores de Glicosídeo Hidrolases/química
Inibidores de Glicosídeo Hidrolases/farmacologia
Concentração Inibidora 50
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Compostos Fitoquímicos/química
Compostos Fitoquímicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Glycoside Hydrolase Inhibitors); 0 (Phytochemicals); 0 (Plant Extracts); EC 3.2.1.1 (alpha-Amylases); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27649564
[Au] Autor:Conlisk E; Swab R; Martínez-Berdeja A; Daugherty MP
[Ad] Endereço:San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, United States of America.
[Ti] Título:Post-Fire Recovery in Coastal Sage Scrub: Seed Rain and Community Trajectory.
[So] Source:PLoS One;11(9):e0162777, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Disturbance is a primary mechanism structuring ecological communities. However, human activity has the potential to alter the frequency and intensity of natural disturbance regimes, with subsequent effects on ecosystem processes. In Southern California, human development has led to increased fire frequency close to urban areas that can form a positive feedback with invasive plant spread. Understanding how abiotic and biotic factors structure post-fire plant communities is a critical component of post-fire management and restoration. In this study we considered a variety of mechanisms affecting post-fire vegetation recovery in Riversidean sage scrub. Comparing recently burned plots to unburned plots, we found that burning significantly reduced species richness and percent cover of exotic vegetation the first two years following a 100-hectare wildfire. Seed rain was higher in burned plots, with more native forb seeds, while unburned plots had more exotic grass seeds. Moreover, there were significant correlations between seed rain composition and plant cover composition the year prior and the year after. Collectively, this case study suggests that fire can alter community composition, but there was not compelling evidence of a vegetation-type conversion. Instead, the changes in the community composition were temporary and convergence in community composition was apparent within two years post-fire.
[Mh] Termos MeSH primário: Asteraceae/crescimento & desenvolvimento
Conservação dos Recursos Naturais/métodos
Ecossistema
Fogo
Polygonaceae/crescimento & desenvolvimento
Salvia/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: California
Geografia
Atividades Humanas
Seres Humanos
Espécies Introduzidas
Desenvolvimento Vegetal
Poaceae/crescimento & desenvolvimento
Sementes/crescimento & desenvolvimento
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0162777


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[PMID]:27510839
[Au] Autor:Kim CY; Chung KS; Cheon SY; Lee K; Ham I; Choi HY; Cho YB; Cho BH; Mok SY; An HJ
[Ad] Endereço:Department of Pharmacology, College of Oriental Medicine, Sangji University, Wonju, Gangwon­do 220702, Republic of Korea.
[Ti] Título:Hypolipidemic effects of HVC1 in a high cholesterol diet­induced rat model of hyperlipidemia.
[So] Source:Mol Med Rep;14(4):3152-8, 2016 Oct.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:HVC1, a novel formation containing four herbs, was developed and its hypolipidemic effects in rats with high cholesterol diet (HCD)­induced hyperlipidemia were investigated. The rats were given a HCD for 8 weeks. The HVC1­treated groups were orally administered HVC1 at doses of 10, 50 or 250 mg/kg, respectively, and the simvastatin group was treated at a dose of 10 mg/kg. The normal diet and HCD control groups were administered with physiological saline. Oral administration of HVC1 (10, 50 or 250 mg/kg) significantly reduced the body weight of rats with hyperlipidemia and regulated the total cholesterol, low­density lipoprotein cholesterol and high­density lipoprotein cholesterol levels in the serum. In addition, tissue analysis revealed that lipid accumulation in the liver and aorta was reduced by HVC1 administration. Furthermore, HVC1 significantly reduced the mRNA expression of peroxisome proliferator­activated receptor­Î³, 3­hydroxy­3­methylglutaryl­CoA reductase and low­density lipoprotein receptor, as well as the protein level of 5' adenosine monophosphate­activated protein kinase in the liver. The results clearly demonstrate that HVC1 has a potent hypolipidemic effect, and suggest that HVC1 should be evaluated as a potential treatment for hyperlipidemia.
[Mh] Termos MeSH primário: Hiperlipidemias/tratamento farmacológico
Hipolipemiantes/uso terapêutico
Metabolismo dos Lipídeos/efeitos dos fármacos
Medicina Tradicional Coreana
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Aorta/metabolismo
Colesterol/sangue
Colesterol/metabolismo
Dieta Hiperlipídica/efeitos adversos
Regulação da Expressão Gênica/efeitos dos fármacos
Hiperlipidemias/sangue
Hiperlipidemias/etiologia
Hiperlipidemias/metabolismo
Hipolipemiantes/química
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
PPAR gama/genética
Extratos Vegetais/química
Plantas Medicinais/química
Polygonaceae/química
RNA Mensageiro/genética
Ranunculaceae/química
Ratos
Ratos Sprague-Dawley
Receptores de LDL/genética
Rosaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypolipidemic Agents); 0 (PPAR gamma); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (Receptors, LDL); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2016.5615


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[PMID]:27504055
[Au] Autor:Chin YT; Hsieh MT; Lin CY; Kuo PJ; Yang YC; Shih YJ; Lai HY; Cheng GY; Tang HY; Lee CC; Lee SY; Wang CC; Lin HY; Fu E; Whang-Peng J; Liu LF
[Ad] Endereço:Taipei Cancer Center, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan; Department of Dentistry, Wan-Fang Medical Center, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan.
[Ti] Título:2,3,5,4'-Tetrahydroxystilbene-2-O-ß-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis.
[So] Source:Mediators Inflamm;2016:6953459, 2016.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. Human gingival fibroblast cells were treated with lipopolysaccharide (LPS) extracted from P. gingivalis in the presence of resveratrol or THSG to analyze the expression of TNF-α, IL-1ß, and IL-6 genes. Increased AMP-activated protein kinase (AMPK) activation and SirT1 expression were induced by THSG. Treatment of THSG decreased the expression of LPS-induced inflammatory cytokines, enhanced AMPK activation, and increased the expression of SirT1. In addition, it suppressed the activation of NF-κB when cells were stimulated with P. gingivalis LPS. The anti-inflammatory effect of THSG and P. Multiflori crude extracts was reproduced in ligature-induced periodontitis animal modeling. In conclusion, THSG inhibited the inflammatory responses of P. gingivalis-stimulated human gingival fibroblasts and ameliorated ligature-induced periodontitis in animal model.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Medicamentos de Ervas Chinesas/uso terapêutico
Gengiva/citologia
Glucosídeos/farmacologia
Glucosídeos/uso terapêutico
Periodontite/tratamento farmacológico
Polygonaceae/química
Estilbenos/farmacologia
Estilbenos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Animais
Células Cultivadas
Medicamentos de Ervas Chinesas/química
Feminino
Fibroblastos/efeitos dos fármacos
Gengiva/efeitos dos fármacos
Gengiva/patologia
Glucosídeos/química
Seres Humanos
Masculino
Ratos
Ratos Sprague-Dawley
Estilbenos/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside); 0 (Drugs, Chinese Herbal); 0 (Glucosides); 0 (Stilbenes)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE
[do] DOI:10.1155/2016/6953459



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