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[PMID]:28905696
[Au] Autor:Hirota K; Nishita M; Matsuyama H; Yumoto I
[Ad] Endereço:1​Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8571, Japan.
[Ti] Título:Paralkalibacillus indicireducens gen., nov., sp. nov., an indigo-reducing obligate alkaliphile isolated from indigo fermentation liquor used for dyeing.
[So] Source:Int J Syst Evol Microbiol;67(10):4050-4056, 2017 Oct.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Obligately alkaliphilic, indigo-reducing strains, designated Bps-1 , Bps-2 and Bps-3, were isolated from an indigo fermentation liquor used for dyeing, which was produced from sukumo (composted Polygonum indigo leaves) obtained from a craft centre in Data City, Hokkaido, Japan, by using medium containing cellulase-treated sukumo. The 16S rRNA gene sequence phylogeny suggested that Bps-1 has a distinctive position among the alkaliphilic species of the genus Bacillus, with its closest neighbours being Bacillus pseudofirmus DSM 8715 , Bacillus lindianensis DSM 26864 and Bacillus alcalophilus DSM 485 (96.1, 95.8 and 95.5 % 16S rRNA gene sequence similarities, respectively). The 16S rRNA sequence of strain Bps-1 was identical to those of strains Bps-2 and Bps-3. Cells of the novel isolate were Gram-stain-positive and were facultatively anaerobic straight rods that were motile by means of a pair of flagella (subpolar and centre sides). Spherical endospores were formed in the terminal position. Strain Bps-1 grew between 18 and 40 °C with optimum growth at 33 °C. The isolate grew in the pH range 8‒11, with optimum growth at pH 9‒10. The isoprenoid quinone detected was menaquinone-7 (MK-7), and the DNA G+C content was 40.3 %. The whole-cell fatty acid profile (>10 %) mainly consisted of anteiso-C15 : 0, iso-C15 : 0 and C16 : 0. On the basis of the phenotypic, chemotaxonomic and phylogenetic data, the isolates represent a novel species of a novel genus, for which the name Paralkalibacillus indicireducens gen. nov., sp. nov. is proposed. The type strain of this species is Bps-1 (JCM 31808 =NCIMB 15080 ), with strains Bps-2 and Bps-3 representing additional strains of the species.
[Mh] Termos MeSH primário: Bacillaceae/classificação
Fermentação
Índigo Carmim
Filogenia
[Mh] Termos MeSH secundário: Bacillaceae/genética
Bacillaceae/isolamento & purificação
Técnicas de Tipagem Bacteriana
Composição de Bases
Corantes
DNA Bacteriano/genética
Ácidos Graxos/química
Japão
Hibridização de Ácido Nucleico
Polygonum
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 8427BML8NY (vitamin MK 7); D3741U8K7L (Indigo Carmine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002248


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[PMID]:28429937
[Au] Autor:Kumar S; Lee HY; Liou JP
[Ad] Endereço:School of Pharmacy, College of Pharmacy, Taipei Medical University , Taipei 11031, Taiwan.
[Ti] Título:Total Synthesis of Two Glycosylated Stilbenes, Oxyresveratrol 2-O-ß-d-Glucopyranoside and 2,3,5,4'-Tetrahydroxystilbene 2-O-ß-d-Glucopyranoside.
[So] Source:J Nat Prod;80(5):1294-1301, 2017 May 26.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glycosylated stilbenes are biologically active secondary metabolites of plants and have the potential to alleviate a broad range of human diseases. However, some of these compounds are not naturally abundant, and thus the synthesis of such molecules is desirable. This paper reports the first synthesis of oxyresveratrol 2-O-ß-d-glucopyranoside (1) and 2,3,5,4'-tetrahydroxystilbene 2-O-ß-d-glucopyranoside (1'), which are stilbene glycosides obtained from the rhizomes of Schoenocaulon officinale and Polygonum multiflorum, respectively. A facile four-step synthesis of 1 involved selective protection of the hydroxy groups and Wittig olefination to generate the compound in 8% overall yield. For compound 1', a 10-step synthesis utilized selective protection of the hydroxy groups, Baeyer-Villiger oxidation, modified Duff formylation, and Wittig olefination to generate the compound in 6.9% overall yield.
[Mh] Termos MeSH primário: Glucosídeos/isolamento & purificação
Glucosídeos/farmacologia
Polygonum/química
Rizoma/química
Estilbenos/síntese química
Estilbenos/isolamento & purificação
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Glucosídeos/química
Glicosilação
Seres Humanos
Estilbenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2,3,5,4'-tetrahydroxystilbene 2-O-beta-D-glucopyranoside); 0 (Glucosides); 0 (Stilbenes); 0 (oxyresveratrol 2-O-beta-D-glucopyranoside)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00861


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[PMID]:28407912
[Au] Autor:Klimczak U; Wozniak M; Tomczyk M; Granica S
[Ad] Endereço:Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland; Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
[Ti] Título:Chemical composition of edible aerial parts of meadow bistort (Persicaria bistorta (L.) Samp.).
[So] Source:Food Chem;230:281-290, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Persicaria bistorta (syn. Polygonum bistorta) is a herbaceous plant native to Europe and Asia. The leaves, young shoots or aerial parts of bistort are one of the main ingredients in a savoury pudding common to parts of the North of England. The aim of the present study was to investigate the chemical composition of extracts from aerial parts of common bistort. The UHPLC method allowed the detection of thirty-five major and minor compounds in the analysed plant material. Major constituents were isolated and identified. Two new natural products were obtained namely quercetin and kaempferol 3-O-(5″-O-malonyl)-α-l-arabinofuranosides. The bioactivity assays showed that isolated malonylated flavonoids inhibit the production of reactive oxygen species (IC in the range 22.4-40.6µM) and myeloperoxidase release (IC in the range 22.2-32.2µM) from stimulated human neutrophils. Aerial parts of P. bistorta are a rich source of polyphenols and some of them have anti-inflammatory potential.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Flavonoides/química
Componentes Aéreos da Planta/química
Folhas de Planta/química
Polygonum/química
[Mh] Termos MeSH secundário: Flavonoides/análise
Seres Humanos
Polifenóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Polyphenols)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28327126
[Au] Autor:Tran TT; Kim M; Jang Y; Lee HW; Nguyen HT; Nguyen TN; Park HW; Le Dang Q; Kim JC
[Ad] Endereço:R&D Center of Bioactive Compounds, Vietnam Institute of Industrial Chemistry, 2nd Pham Ngu Lao, Hoan Kiem, Hanoi, 10 000, Vietnam.
[Ti] Título:Characterization and mechanisms of anti-influenza virus metabolites isolated from the Vietnamese medicinal plant Polygonum chinense.
[So] Source:BMC Complement Altern Med;17(1):162, 2017 Mar 21.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Polygonum chinense Linn. is a common medicinal plant in Southeast Asia and has been used in traditional medicine in Vietnam. The plant contains phytochemicals with various biological properties; however, its antiviral effect has not yet been demonstrated. This study was aimed to evaluate the anti-influenza virus activity of crude extracts of P. chinense, to characterize antiviral metabolites therefrom and to investigate their mechanisms of antiviral action. METHODS: The methanol (MeOH) extract and organic solvent layers of P. chinense were prepared by extraction and partition with relevant solvents. The ethyl acetate (EtOAc) layer showing antiviral activity was chromatographed repeatedly on SiO and Sephadex LH-20 columns to give eight pure metabolites. Their chemical structures were determined by NMR and MS spectral data. Anti-influenza virus activity of the eight metabolites against virus strains A/Puerto Rico/8/34 (H1N1, PR8), A/Hong Kong/8/68 (H3N2, HK) and B/Lee/40 (Lee) was evaluated on the basis of cytopathic effect (CPE) and plaque inhibition assays. Time-of-addition, confocal microscopy and neuraminidase inhibition assay were performed for mode-of-action studies of active ingredients. RESULTS: The MeOH extract of P. chinense showed anti-influenza virus activity with EC values ranging from 38.4 to 55.5 µg/mL in a CPE inhibition assay. Among the eight pure metabolites isolated from P. chinense, ellagic acid (PC5), methyl gallate (PC7) and caffeic acid (PC8) significantly inhibited viral replication in a dose-dependent manner in both plaque inhibition and CPE inhibition assays with EC values ranging from 14.7 to 81.1 µg/mL and CC values higher than 300 µg/mL. Mode-of-action studies suggested that PC5 and PC7 suppress virus entry into or replication in cells, while PC8 targets influenza viral neuraminidase, even oseltamivir-resistant one. CONCLUSION: These results demonstrated that P. chinense and its metabolites possess effective anti-influenza virus activities. The botanical materials of P. chinense could be a promising multitargeted inhibitor of influenza A and B viruses and applied to development of a novel herbal medicine.
[Mh] Termos MeSH primário: Antivirais/química
Antivirais/farmacologia
Influenza Humana/virologia
Orthomyxoviridae/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Polygonum/química
[Mh] Termos MeSH secundário: Antivirais/isolamento & purificação
Linhagem Celular
Seres Humanos
Orthomyxoviridae/genética
Orthomyxoviridae/fisiologia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais/química
Internalização do Vírus/efeitos dos fármacos
Replicação Viral/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1675-6


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[PMID]:28301958
[Au] Autor:Rodrigues MJ; Custódio L; Lopes A; Oliveira M; Neng NR; Nogueira JM; Martins A; Rauter AP; Varela J; Barreira L
[Ad] Endereço:a CCMAR, Centro de Ciências do Mar , Universidade do Algarve , Faro , Portugal.
[Ti] Título:Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum.
[So] Source:Pharm Biol;55(1):1348-1357, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Several Polygonum species (Polygonaceae) are used in traditional medicine in Asia, Europe and Africa to treat inflammation and diabetes. OBJECTIVE: Evaluate the in vitro antioxidant, anti-inflammatory and antidiabetic potential of methanol and dichloromethane extracts of leaves and roots of the halophyte Polygonum maritimum L. MATERIAL AND METHODS: Antioxidant activity was determined (up to 1 mg/mL) as radical-scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), copper (CCA) and iron (ICA) chelating activities and iron reducing power (FRAP). NO production was measured in lipopolysaccharide (LPS)-stimulated macrophages for 24 h at concentrations up to 100 µg/mL and antidiabetic potential was assessed by α-amylase and α-glucosidase inhibition (up to 10 mg/mL) assays. The phytochemical composition of the extracts was determined by gas chromatography-mass spectrometry (GC-MS). RESULTS: The methanol leaf extract had the highest activity against DPPH• (IC = 26 µg/mL) and ABTS • (IC = 140 µg/mL), FRAP (IC = 48 µg/mL) and CCA (IC = 770 µg/mL). Only the dichloromethane leaf extract (LDCM) showed anti-inflammatory activity (IC = 48 µg/mL). The methanol root (IC = 19 µg/mL) and leaf (IC = 29 µg/mL) extracts strongly inhibited baker's yeast α-glucosidase, but LDCM had higher rat's α-glucosidase inhibition (IC = 2527 µg/mL) than acarbose (IC = 4638 µg/mL). GC-MS analysis identified ß-sitosterol, stigmasterol, 1-octacosanol and linolenic acid as possible molecules responsible for the observed bioactivities. CONCLUSIONS: Our findings suggest P. maritimum as a source of high-value health promoting commodities for alleviating symptoms associated with oxidative and inflammatory diseases, including diabetes.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
Polygonum
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Cromatografia Gasosa-Espectrometria de Massas
Camundongos
Compostos Fitoquímicos/análise
Polygonum/química
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Hypoglycemic Agents); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1301493


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[PMID]:28245598
[Au] Autor:Huang Y; Sun HY; Qin XL; Li YJ; Liao SG; Gong ZP; Lu Y; Wang YL; Wang AM; Lan YY; Zheng L
[Ad] Endereço:Provincial Key Laboratory of Pharmaceutics in Guizhou Province, Guizhou Medical University, 4 Beijing Road, Guiyang 550004, China. mailofhy@126.com.
[Ti] Título:A UPLC-MS/MS Method for Simultaneous Determination of Free and Total Forms of a Phenolic Acid and Two Flavonoids in Rat Plasma and Its Application to Comparative Pharmacokinetic Studies of Polygonum capitatum Extract in Rats.
[So] Source:Molecules;22(3), 2017 Feb 25.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The principal active constituents of are phenolic acids and flavonoids, such as gallic acid, quercitrin, and quercetin. The aim of this study was to develop and validate a method to determine the three constituents and the corresponding conjugated metabolites of in vivo and to conduct pharmacokinetic studies on the herb, a well-known Miao medicinal plant in China. Gallic acid, quercitrin, and quercetin were analysed by ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS). Protein precipitation in plasma samples was performed using methanol. For the determination of total forms of analytes, an additional process of hydrolysis was conducted using ß-glucuronidase and sulphatase. The analytes were separated on a BEH C column (50 mm × 2.1 mm; i.d., 1.7 µm) and quantified by multiple reaction monitoring (MRM) mode. The linear regression showed high linearity over a 729-fold dynamic range for the three analytes. The relative standard deviations of intra- and inter-day measurements were less than 9.5%, and the method was accurate to within -11.1% to 12.5%. The extraction recoveries for gallic acid, quercitrin, and quercetin were 94.3%-98.8%, 88.9%-98.8%, and 95.7%-98.5%, respectively. All samples were stable under short- and long-term storage conditions. The validated method was successfully applied to a comparative pharmacokinetic study of gallic acid, quercitrin, and quercetin in their free and total forms in rat plasma. The study revealed significantly higher exposure of the constituents in total forms for gallic acid and quercetin, while quercitrin was detected mainly in its corresponding free form in vivo. The established method was rapid and sensitive for the simultaneous quantification of free and total forms of multiple constituents of extract in plasma.
[Mh] Termos MeSH primário: Ácido Gálico/sangue
Polygonum/química
Quercetina/análogos & derivados
Quercetina/sangue
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Ácido Gálico/química
Ácido Gálico/farmacocinética
Masculino
Extratos Vegetais/química
Plantas Medicinais/química
Plasma/química
Quercetina/química
Quercetina/farmacocinética
Ratos
Ratos Sprague-Dawley
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 2Y8906LC5P (quercitrin); 632XD903SP (Gallic Acid); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


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[PMID]:28000515
[Au] Autor:Xiao H; Rao Ravu R; Tekwani BL; Li W; Liu WB; Jacob MR; Khan SI; Cai X; Peng CY; Khan IA; Li XC; Wang W
[Ad] Endereço:a TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy , Hunan University of Chinese Medicine , Changsha , P.R. China.
[Ti] Título:Biological evaluation of phytoconstituents from Polygonum hydropiper.
[So] Source:Nat Prod Res;31(17):2053-2057, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fourteen compounds including vanicoside B (1), vanicoside F (2), vanicoside E (3) and 5,6-dehydrokawain (4), aniba-dimer-A (5), 6,6'-((1α,2α,3ß,4ß)-2,4-diphenylcyclobutane-1,3-diyl)bis(4-methoxy-2H-pyran-2-one) (6), (+)-ketopinoresinol (7), isorhamnetin (8), 3,7-dihydroxy-5,6-dimethoxy-flavone (9), isalpinin (10), cardamomin (11), pinosylvin (12), 2-desoxy-4-epi-pulchellin (13) and ß-sitosterol (14) were isolated from dichloromethane-soluble portion of Polygonum hydropiper. By using Alamar blue assay, compounds 2, 7, 8, 11 and 12 were found to be active against Trypanosoma brucei with IC values in the range of 0.49-7.77 µg/mL. Cardamomin (11) had most significant activity against T. brucei with IC /IC values of 0.49/0.81 µg/mL compared to the positive control DFMO (IC /IC : 3.02/8.05 µg/mL). Furthermore, in antimalarial, antimicrobial, anti-inflammatory, PPAR and cytotoxic assays, some compounds have demonstrated moderate inhibitory potentials.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Antimaláricos/farmacologia
Polygonum/química
Tripanossomicidas/farmacologia
Trypanosoma brucei brucei/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/farmacologia
Antimaláricos/química
Chalconas/farmacologia
Cinamatos/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Testes de Sensibilidade Microbiana
Estrutura Molecular
PPAR gama/genética
Compostos Fitoquímicos/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Sitosteroides/farmacologia
Tripanossomicidas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antimalarials); 0 (Chalcones); 0 (Cinnamates); 0 (PPAR gamma); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Sitosterols); 0 (Trypanocidal Agents); 155179-21-8 (vanicoside B); 5LI01C78DD (gamma-sitosterol); H8KP1OJ8JX (cardamonin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1269094


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[PMID]:27442262
[Au] Autor:Rodrigues DF; Maniscalco DA; Silva FA; Chiari BG; Castelli MV; Isaac VL; Cicarelli RM; López SN
[Ad] Endereço:Department of Biological Sciences, School of Pharmaceutical Sciences of Araraquara, São Paulo State University, Araraquara, Brazil.
[Ti] Título:Trypanocidal Activity of Flavokawin B, a Component of Polygonum ferrugineum Wedd.
[So] Source:Planta Med;83(3-04):239-244, 2017 Feb.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The trypanocidal potential of the natural chalcone flavokawin B, which was isolated from the hexanic extract of Wedd., is reported here. Although flavokawin B is widespread, this is the first report about its trypanocidal properties on both (IC = 9.5 µM, IC = 34.7 µM benznidazol, Y strain) epimastigotes and (IC = 4.8 µM, IC = 6.4 µM pentamidine, 29-13 strain) procyclic forms, which was also corroborated on strain 427 (IC = 6.2 µM). In order to learn more about its properties, unspecific cytotoxicity on Hep G2 cells was investigated as well as the -splicing inhibitory potential on cells. The results shown here point to flavokawin B as a candidate in the search for new agents. It is also cheaper and less toxic than the available drugs to treat trypanosomiasis with a special focus on sleeping sickness disease.
[Mh] Termos MeSH primário: Flavonoides/farmacologia
Tripanossomicidas/farmacologia
Trypanosoma brucei brucei/efeitos dos fármacos
Trypanosoma cruzi/efeitos dos fármacos
Tripanossomíase/tratamento farmacológico
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Chalcona/farmacologia
Relação Dose-Resposta a Droga
Flavonoides/química
Flavonoides/isolamento & purificação
Células Hep G2
Seres Humanos
Concentração Inibidora 50
Polygonum/química
Tripanossomicidas/química
Tripanossomicidas/isolamento & purificação
Trypanosoma brucei brucei/genética
Tripanossomíase Africana/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Trypanocidal Agents); 0 (flavokawain B); 5S5A2Q39HX (Chalcone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-112031


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[PMID]:27309618
[Au] Autor:Yang YX; An MM; Jin YS; Chen HS
[Ad] Endereço:a School of Pharmacy , Second Military Medical University , Shanghai 200433 , China.
[Ti] Título:Chemical constituents from the rhizome of Polygonum paleaceum and their antifungal activity.
[So] Source:J Asian Nat Prod Res;19(1):47-52, 2017 Jan.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new compounds neopaleaceolactoside (1), along with nine known compounds phyllocoumarin (2), quercetin (3), quercitrin (4), quercetin-3-methyl ether (5), vincetoxicoside B (6), isoquercitrin (7), kaempferol (8), (-)-epicatechin (9), and chlorogenic acid (10), was isolated from Polygonum paleaceum Wall. Their chemical structures were established based on one-dimensional and two-dimensional nuclear magnetic resonance techniques, mass spectrometry and by comparison with spectroscopic data reported. Some selected compounds were screened for their antifungal activity. Quercetin (3), vincetoxicoside B (6), kaempferol (8), and (-)-epicatechin (9) showed synergistic antifungal activities with the FICI values <0.5. A preliminary structure-activity relationship could be observed that free 3-OH in the structure of flavonoids was important for synergistic antifungal activity.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Antioxidantes/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Polygonum/química
Rizoma/química
[Mh] Termos MeSH secundário: Antifúngicos/química
Antioxidantes/química
Antioxidantes/farmacologia
Medicamentos de Ervas Chinesas/química
Flavonoides/química
Quempferóis/farmacologia
Estrutura Molecular
Quercetina/análogos & derivados
Quercetina/farmacologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antioxidants); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Kaempferols); 0 (neopaleaceolactoside); 0 (quercetin 3-O-methyl ether); 0YX10VRV6J (isoquercitrin); 2Y8906LC5P (quercitrin); 731P2LE49E (kaempferol); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1196672


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[PMID]:26749490
[Au] Autor:Song ZT; Zhu MJ
[Ad] Endereço:School of Bioscience and Bioengineering, South China University of Technology, Guangzhou Higher Education Mega Center, Panyu, Guangzhou, People's Republic of China.
[Ti] Título:Feed additive production by fermentation of herb Polygonum hydropiper L. and cassava pulp with simultaneous flavonoid dissolution.
[So] Source:Biotechnol Appl Biochem;64(2):290-300, 2017 Mar.
[Is] ISSN:1470-8744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fermentation of herb Polygonum hydropiper L. (PHL) and cassava pulp (CP) for feed additive production with simultaneous flavonoid dissolution was investigated, and a two-stage response surface methodology (RSM) based on Plackett-Burman factorial design (PB design) was used to optimize the flavonoid dissolution and protein content. Using the screening function of PB design, four different significant factors for the two response variables were acquired: factors A (CP) and B (PHL) for the flavonoid dissolution versus factors G (inoculum size) and H (fermentation time) for protein content. Then, two RSMs were used sequentially to improve the values of the two response variables separately. The mutual corroboration of the experimental results in the present study confirmed the validity of the associated experimental design. The validation experiment showed a flavonoid dissolution rate of 94.00%, and a protein content of 18.20%, gaining an increase in 21.20% and 199.10% over the control, respectively. The present study confirms the feasibility of feed additive production by Saccharomyces cerevisiae with CP and PHL and simultaneous optimization of flavonoid dissolution and protein content using a two-stage RSM.
[Mh] Termos MeSH primário: Fermentação
Flavonoides/química
Aditivos Alimentares/síntese química
[Mh] Termos MeSH secundário: Meios de Cultura/química
Etanol/química
Aditivos Alimentares/química
Manihot/química
Manihot/metabolismo
Polygonum/química
Polygonum/metabolismo
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 0 (Flavonoids); 0 (Food Additives); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160111
[St] Status:MEDLINE
[do] DOI:10.1002/bab.1473



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