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  1 / 991 MEDLINE  
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[PMID]:29288907
[Au] Autor:Lytou AE; Nychas GE; Panagou EZ
[Ad] Endereço:Laboratory of Microbiology and Biotechnology of Foods, Department of Food Science and Human Nutrition, Faculty of Foods, Biotechnology and Development, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece.
[Ti] Título:Effect of pomegranate based marinades on the microbiological, chemical and sensory quality of chicken meat: A metabolomics approach.
[So] Source:Int J Food Microbiol;267:42-53, 2018 Feb 21.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pomegranate juice is a product with enhanced functional properties that could be used as an alternative to traditional marination ingredients and effectively retard microbial growth along with providing an improved sensory result. In this study, two pomegranate based marinades were prepared for the marination of chicken breast fillets and the marinated samples were aerobically stored at 4 and 10°C for 9days. Raw, non-marinated chicken samples were used as control. Levels of total viable counts (TVC), Pseudomonas spp., Brochothrix thermosphacta, Enterobacteriaceae and lactic acid bacteria (LAB) were determined together with sensory assessment to evaluate the evolution of spoilage. The profile of organic acids and volatile compounds was also analyzed during storage. The shelf life of marinated samples was significantly extended compared to control samples at both storage temperatures (e.g., up to 5 and 6days for the pomegranate/lemon marinated samples stored at 4 and 10°C, respectively) as evaluated by both microbiological and sensory analyses. The profile of the organic acids and the volatilome of marinated and control samples were remarkably differentiated according to storage time, microbial load and sensory score. The findings of this study suggest that pomegranate juice could be used as a novel ingredient in marinades to improve the sensory attributes, while prolonging the shelf life of chicken meat.
[Mh] Termos MeSH primário: Conservação de Alimentos/normas
Carne/microbiologia
Metaboloma
Punicaceae/química
[Mh] Termos MeSH secundário: Animais
Bactérias/genética
Fenômenos Fisiológicos Bacterianos
Galinhas
Contagem de Colônia Microbiana
Armazenamento de Alimentos/normas
Seres Humanos
Carne/análise
Carne/normas
Metabolômica
Temperatura Ambiente
Compostos Orgânicos Voláteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Volatile Organic Compounds)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  2 / 991 MEDLINE  
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[PMID]:29351880
[Au] Autor:Nasiriboroumand M; Montazer M; Barani H
[Ad] Endereço:Department of Carpet, Faculty of Art, Shahid Bahonar University of Kerman, Kerman, Iran. Electronic address: nasiri@mail.uk.ac.ir.
[Ti] Título:Preparation and characterization of biocompatible silver nanoparticles using pomegranate peel extract.
[So] Source:J Photochem Photobiol B;179:98-104, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The potential application of any nanoparticles, including silver nanoparticles (AgNPs), strongly depends on their stability against aggregation. In the current study, an aqueous extract of pomegranate peel was used as a stabilizer during synthesis of AgNPs. Nanoparticles have been prepared by the chemical reduction method from an aqueous solution of silver nitrate in the presence of sodium borohydride as a reducing agent. The AgNPs were characterized by dynamic light scattering (DLS), zeta-potential measurements, UV-Vis spectroscopy and transmission electron microscopy (TEM). The antibacterial efficiency of AgNPs against Escherichia coli was investigated. The size, polydispersity index, FWHM, and colloidal stability of nanoparticles in dispersion depends on the extract concentrations. In the presence of pomegranate peel extract, the nanoparticles suspension shows colloidal stability at least for a week. Our studies show that synthesized AgNPs with the above described procedure were stable at pH = 3-12 and in the temperature range of 25-85 °C. Additionally, AgNPs exhibit antibacterial properties, especially at the lowest amount of extract to silver ratio (K ).
[Mh] Termos MeSH primário: Nanopartículas Metálicas/química
Prata/química
[Mh] Termos MeSH secundário: Difusão Dinâmica da Luz
Frutas/química
Frutas/metabolismo
Química Verde
Concentração de Íons de Hidrogênio
Microscopia Eletrônica de Transmissão
Extratos Vegetais/química
Punicaceae/química
Punicaceae/metabolismo
Espectrofotometria Ultravioleta
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE


  3 / 991 MEDLINE  
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[PMID]:29278908
[Au] Autor:Pérez-Ramírez IF; Reynoso-Camacho R; Saura-Calixto F; Pérez-Jiménez J
[Ad] Endereço:Research and Graduate Studies in Food Science, Facultad de Química, Universidad Autónoma de Querétaro , Cerro de las Campanas s/n, 76010 Santiago de Querétaro, Querétaro, México.
[Ti] Título:Comprehensive Characterization of Extractable and Nonextractable Phenolic Compounds by High-Performance Liquid Chromatography-Electrospray Ionization-Quadrupole Time-of-Flight of a Grape/Pomegranate Pomace Dietary Supplement.
[So] Source:J Agric Food Chem;66(3):661-673, 2018 Jan 24.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Grape and pomegranate are rich sources of phenolic compounds, and their derived products could be used as ingredients for the development of functional foods and dietary supplements. However, the profile of nonextractable or macromolecular phenolic compounds in these samples has not been evaluated. Here, we show a comprehensive characterization of extractable and nonextractable phenolic compounds of a grape/pomegranate pomace dietary supplement using high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight (HPLC-ESI-QTOF) and matrix-assisted laser desorption/ionization (MALDI)-TOF techniques. The main extractable phenolic compounds were several anthocyanins (principally malvidin 3-O-glucoside) as well as gallotannins and gallagyl derivatives; some phenolic compounds were reported in grape or pomegranate for the first time. Additionally, there was a high proportion of nonextractable phenolic compounds, including vanillic acid, and dihydroxybenzoic acid. Unidentified polymeric structures were detected by MALDI-TOF MS analysis. This study shows that mixed grape and pomegranate pomaces are a source of different classes of phenolic compounds including a high proportion of nonextractable phenolic compounds.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Suplementos Nutricionais/análise
Fenóis/química
Extratos Vegetais/química
Punicaceae/química
Espectrometria de Massas por Ionização por Electrospray/métodos
Vitis/química
[Mh] Termos MeSH secundário: Fenóis/isolamento & purificação
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05901


  4 / 991 MEDLINE  
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[PMID]:28987497
[Au] Autor:Yari A; Rashnoo S
[Ad] Endereço:Department of Chemistry, Faculty of Science, Lorestan University, 6817817133, Khorramabad, Iran. Electronic address: a.yari@ymail.com.
[Ti] Título:Optimization of a new method for extraction of cyanidin chloride and pelargonidin chloride anthocyanins with magnetic solid phase extraction and determination in fruit samples by HPLC with central composite design.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1067:38-44, 2017 Nov 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Here, we are reporting a sensitive, simple and rapid method for the analysis of cyanidin chloride and pelargonidin chloride anthocyanins in cherry, sour cherry, pomegranate and barberry produced in Iran. The analytes were extracted with acetonitrile-hydrochloric acid (1% v/v) mixture under optimized pretreatment conditions. Clean-up of the extract from fruits was conducted by magnetic solid phase extraction using salicylic acid functionalized silica-coated magnetite nanoparticles (SCMNPs) as the adsorbent. The optimized conditions searched with central composite design. Working under optimum conditions specified as: SCMNPs modified with salicylic acid, sorbent contact time and sample 10min, mechanical stirring time 57.3min. HPLC with UV-detection was used for determination of the analytes. The limit of detection, LOD, obtained for the two anthocyanins were 0.02 and 0.03µgg , respectively. The ranges of the spiked recoveries were 80.0-97.6 and 72.9-97.2%, with the relative standard deviations (RSD) of 2.1 and 2.5%, respectively.
[Mh] Termos MeSH primário: Antocianinas/isolamento & purificação
Cromatografia Líquida de Alta Pressão/métodos
Frutas/química
Nanopartículas de Magnetita/química
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Antocianinas/análise
Antocianinas/química
Prunus avium/química
Punicaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Magnetite Nanoparticles); 7690-51-9 (pelargonidin); 7732ZHU564 (cyanidin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  5 / 991 MEDLINE  
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[PMID]:28903731
[Au] Autor:Noritake SM; Liu J; Kanetake S; Levin CE; Tam C; Cheng LW; Land KM; Friedman M
[Ad] Endereço:Department of Biological Sciences, University of the Pacific, Stockton, CA, 95211, USA.
[Ti] Título:Phytochemical-rich foods inhibit the growth of pathogenic trichomonads.
[So] Source:BMC Complement Altern Med;17(1):461, 2017 Sep 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Trichomonads are increasingly becoming resistant to conventional modes of treatment. It is of interest to test bioactive, natural compounds for efficacy against these pathogens. METHODS: Using a cell assay, black tea, green tea, grape, pomegranate, and jujube extracts, as well as whole dried jujube were tested against three trichomonads: Trichomonas vaginalis strain G3 (found in humans), Tritrichomonas foetus strain D1 (found in cattle), and Tritrichomonas foetus-like organism strain C1 (found in cats). The most effective of the test substances was subsequently tested against two metronidazole-resistant Trichomonas vaginalis strains, and on normal mucosal flora. RESULTS: Black tea extract inhibited all the tested trichomonads, but was most effective against the T. vaginalis organisms. Inhibition by black tea was correlated with the total and individual theaflavin content of the two tea extracts determined by HPLC. Metronidazole-resistant Trichomonas vaginalis strains were also inhibited by the black tea extract. The response of the organisms to the remaining preparations was variable and unique. We observed no effect of the black tea extract on common normal flora bacteria. CONCLUSIONS: The results suggest that the black tea, and to a lesser degree green tea, grape seed, and pomegranate extracts might present possible natural alternative therapeutic agents to treat Trichomonas vaginalis infections in humans and the related trichomonad infections in animals, without negatively affecting the normal flora.
[Mh] Termos MeSH primário: Doenças do Gato/microbiologia
Doenças dos Bovinos/microbiologia
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Tricomoníase/microbiologia
Tricomoníase/veterinária
Trichomonas vaginalis/efeitos dos fármacos
Tritrichomonas foetus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Camellia sinensis/química
Gatos
Bovinos
Seres Humanos
Viabilidade Microbiana/efeitos dos fármacos
Punicaceae/química
Trichomonas vaginalis/genética
Trichomonas vaginalis/crescimento & desenvolvimento
Trichomonas vaginalis/isolamento & purificação
Tritrichomonas foetus/genética
Tritrichomonas foetus/crescimento & desenvolvimento
Tritrichomonas foetus/isolamento & purificação
Vitis/química
Ziziphus/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1967-x


  6 / 991 MEDLINE  
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[PMID]:28709945
[Au] Autor:Adaramoye O; Erguen B; Nitzsche B; Höpfner M; Jung K; Rabien A
[Ad] Endereço:Department of Urology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Drug Metabolism and Toxicology Section, Department of Biochemistry, University of Ibadan, Nigeria. Electronic address: aoadaramoye@yahoo.com.
[Ti] Título:Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells.
[So] Source:Chem Biol Interact;274:100-106, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Prostate cancer (PCa) is an international health problem and search for its effective treatment is in progress. Punicalagin (PN), polyphenol from pomegranate fruit, is known to exhibit potent anticancer activity in lung, breast and cervical cells. However, there is paucity of information on its effect in PCa. This study evaluated anti-proliferative effects of PN and its effects on extrinsic pathway of apoptosis in PCa cells, and angiogenesis in chicken chorioallantoic membrane (CAM). Antioxidant activities of PN were determined by 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging and inhibition of lipid peroxidation (LPO) methods. PCa (PC-3 and LNCaP) and normal prostate (BPH-1) cells were cultured and treated with PN (10, 50 and 100 µM). Cytotoxicity and viability effects of PN were determined by lactate dehydrogenase (LDH) and XTT assays, respectively. Antiangiogenic effects were measured using CAM assay, while apoptosis was assessed by DNA fragmentation, enrichment factor by Cell Death Detection ELISA kit and expressions of caspases-3 and -8. Results showed that PN (10-200 µM) significantly scavenged DPPH and inhibited LPO in a concentration-dependent manner. Furthermore, PN (10-100 µM) concentration-dependently inhibited viability in PC-3 and LNCaP, while viability in BPH-1 was insignificantly affected. PN had low toxicity on cells in vitro at concentrations tested. Also, PN (100 µM) increased enrichment factor in PC-3 (2.34 ± 0.05) and LNCaP (2.31 ± 0.26) relative to control (1.00 ± 0.00). In addition, PN (50 µM) decreased the network of vessels in CAM, suggesting its anti-angiogenic effect. Moreso, PN increased the expressions of caspases-3 and -8 in PC-3. Overall, PN exerts anti-proliferative activity in PCa cells via induction of apoptosis and anti-angiogenic effect.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Taninos Hidrolisáveis/farmacologia
Extratos Vegetais/química
Punicaceae/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Caspase 3/análise
Caspase 8/análise
Linhagem Celular Tumoral
Fragmentação do DNA/efeitos dos fármacos
Frutas/química
Frutas/metabolismo
Seres Humanos
Taninos Hidrolisáveis/química
Taninos Hidrolisáveis/isolamento & purificação
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Neovascularização Fisiológica/efeitos dos fármacos
Polifenóis/química
Punicaceae/metabolismo
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (Polyphenols); 65995-63-3 (punicalagin); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 8)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


  7 / 991 MEDLINE  
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[PMID]:28665969
[Au] Autor:Houston DMJ; Bugert JJ; Denyer SP; Heard CM
[Ad] Endereço:School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff Wales, United Kingdom.
[Ti] Título:Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV.
[So] Source:PLoS One;12(6):e0179291, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is a clinical need for new therapeutic products against Herpes simplex virus (HSV). The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of pomegranate rind extract (PRE) and co-administered zinc (II) ions. MATERIALS AND METHODS: PRE was used in conjunction with zinc (II) salts to challenge HSV-1 and aciclovir-resistant HSV in terms of virucidal plaque assay reduction and antiviral activities in epithelial Vero host cells. Cytotoxicity was determined by the MTS assay using a commercial kit. RESULTS: Zinc sulphate, zinc citrate, zinc stearate and zinc gluconate demonstrated similar potentiated virucidal activity with PRE against HSV-1 by up to 4-fold. A generally parabolic relationship was observed when HSV-1 was challenged with PRE and varying concentrations of ZnSO4, with a maximum potentiation factor of 5.5. Punicalagin had 8-fold greater virucidal activity than an equivalent mass of PRE. However, antiviral data showed that punicalagin had significantly lower antiviral activity compared to the activity of PRE (EC50 = 0.56 µg mL-1) a value comparable to aciclovir (EC50 = 0.18 µg mL-1); however, PRE also demonstrated potency against aciclovir-resistant HSV (EC50 = 0.02 µg mL-1), whereas aciclovir showed no activity. Antiviral action of PRE was not influenced by ZnSO4. No cytotoxicity was detected with any test solution. CONCLUSIONS: The potentiated virucidal activity of PRE by coadministered zinc (II) has potential as a multi-action novel topical therapeutic agent against HSV infections, such as coldsores.
[Mh] Termos MeSH primário: Aciclovir/farmacologia
Antivirais/farmacologia
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 2/efeitos dos fármacos
Extratos Vegetais/farmacologia
Punicaceae/química
Compostos de Zinco/farmacologia
[Mh] Termos MeSH secundário: Animais
Antivirais/administração & dosagem
Cercopithecus aethiops
Citotoxicidade Imunológica/efeitos dos fármacos
Farmacorresistência Viral
Sinergismo Farmacológico
Ácido Elágico/farmacologia
Herpesvirus Humano 1/crescimento & desenvolvimento
Herpesvirus Humano 2/crescimento & desenvolvimento
Extratos Vegetais/administração & dosagem
Células Vero
Ensaio de Placa Viral
Compostos de Zinco/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts); 0 (Zinc Compounds); 19YRN3ZS9P (Ellagic Acid); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179291


  8 / 991 MEDLINE  
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[PMID]:28655305
[Au] Autor:Amri Z; Ghorbel A; Turki M; Akrout FM; Ayadi F; Elfeki A; Hammami M
[Ad] Endereço:Biochemistry Laboratory, LR12ES05 "Nutrition- Functional Foods and vascular Health", Faculty of Medicine, University of Monastir, 5019, Monastir, Tunisia. zahraamri23@yahoo.fr.
[Ti] Título:Effect of pomegranate extracts on brain antioxidant markers and cholinesterase activity in high fat-high fructose diet induced obesity in rat model.
[So] Source:BMC Complement Altern Med;17(1):339, 2017 Jun 27.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To investigate beneficial effects of Pomegranate seeds oil (PSO), leaves (PL), juice (PJ) and (PP) on brain cholinesterase activity, brain oxidative stress and lipid profile in high-fat-high fructose diet (HFD) induced-obese rat. METHODS: In vitro and in vivo cholinesterase activity, brain oxidative status, body and brain weight and plasma lipid profile were measured in control rats, HFD-fed rats and HFD-fed rats treated by PSO, PL, PJ and PP. RESULTS: In vitro study showed that PSO, PL, PP, PJ inhibited cholinesterase activity in dose dependant manner. PL extract displayed the highest inhibitory activity by IC50 of 151.85 mg/ml. For in vivo study, HFD regime induced a significant increase of cholinesterase activity in brain by 17.4% as compared to normal rats. However, the administration of PSO, PL, PJ and PP to HDF-rats decreased cholinesterase activity in brain respectively by 15.48%, 6.4%, 20% and 18.7% as compared to untreated HFD-rats. Moreover, HFD regime caused significant increase in brain stress, brain and body weight, and lipid profile disorders in blood. Furthermore, PSO, PL, PJ and PP modulated lipid profile in blood and prevented accumulation of lipid in brain and body evidenced by the decrease of their weights as compared to untreated HFD-rats. In addition administration of these extract protected brain from stress oxidant, evidenced by the decrease of malondialdehyde (MDA) and Protein carbonylation (PC) levels and the increase in superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. CONCLUSION: These findings highlight the neuroprotective effects of pomegranate extracts and one of mechanisms is the inhibition of cholinesterase and the stimulation of antioxidant capacity.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Encéfalo/efeitos dos fármacos
Colinesterases/metabolismo
Dieta Hiperlipídica/efeitos adversos
Frutose/efeitos adversos
Obesidade/tratamento farmacológico
Extratos Vegetais/administração & dosagem
Punicaceae/química
[Mh] Termos MeSH secundário: Animais
Encéfalo/enzimologia
Encéfalo/metabolismo
Modelos Animais de Doenças
Glutationa Peroxidase/metabolismo
Seres Humanos
Masculino
Malondialdeído/metabolismo
Obesidade/enzimologia
Obesidade/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 30237-26-4 (Fructose); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 3.1.1.8 (Cholinesterases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1842-9


  9 / 991 MEDLINE  
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[PMID]:28616977
[Au] Autor:García-Villalba R; Vissenaekens H; Pitart J; Romo-Vaquero M; Espín JC; Grootaert C; Selma MV; Raes K; Smagghe G; Possemiers S; Van Camp J; Tomas-Barberan FA
[Ad] Endereço:Research Group on Quality, Safety, and Bioactivity of Plant Foods, Laboratory of Food & Health, Department of Food Science and Technology, CEBAS-CSIC , 30100 Campus de Espinardo, Murcia Spain.
[Ti] Título:Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.
[So] Source:J Agric Food Chem;65(27):5480-5493, 2017 Jul 12.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A TWIN-SHIME system was used to compare the metabolism of pomegranate polyphenols by the gut microbiota from two individuals with different urolithin metabotypes. Gut microbiota, ellagitannin metabolism, short-chain fatty acids (SCFA), transport of metabolites, and phase II metabolism using Caco-2 cells were explored. The simulation reproduced the in vivo metabolic profiles for each metabotype. The study shows for the first time that microbial composition, metabolism of ellagitannins, and SCFA differ between metabotypes and along the large intestine. The assay also showed that pomegranate phenolics preserved intestinal cell integrity. Pomegranate polyphenols enhanced urolithin and propionate production, as well as Akkermansia and Gordonibacter prevalence with the highest effect in the descending colon. The system provides an insight into the mechanisms of pomegranate polyphenol gut microbiota metabolism and absorption through intestinal cells. The results obtained by the combined SHIME/Caco-2 cell system are consistent with previous human and animal studies and show that although urolithin metabolites are present along the gastrointestinal tract due to enterohepatic circulation, they are predominantly produced in the distal colon region.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Cumarínicos/metabolismo
Microbioma Gastrointestinal
Trato Gastrointestinal/metabolismo
Extratos Vegetais/metabolismo
Polifenóis/metabolismo
Punicaceae/metabolismo
[Mh] Termos MeSH secundário: Animais
Bactérias/metabolismo
Ácidos Graxos Voláteis/metabolismo
Trato Gastrointestinal/microbiologia
Seres Humanos
Taninos Hidrolisáveis/metabolismo
Intestinos/metabolismo
Intestinos/microbiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Fatty Acids, Volatile); 0 (Hydrolyzable Tannins); 0 (Plant Extracts); 0 (Polyphenols); 0 (ellagitannin); 0 (urolithin B); 1143-70-0 (3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02049


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[PMID]:28603126
[Au] Autor:Riaz A; Khan RA; Afroz S; Mallick N
[Ad] Endereço:Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
[Ti] Título:Prophylactic and therapeutic effect of Punica granatum in trinitrobenzene sulfonic acid induced inflammation in rats.
[So] Source:Pak J Pharm Sci;30(1):155-162, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Pomegranate (Punica granatum L., Punicaceae) contains varieties of antioxidants and phytochemicals; there are evidences that phytochemicals and antioxidants play a vital role in reducing inflammation. Hence this investigation was planned to assess the outcome of Punica granatum on trinitrobenzene sulfonic acid provoked colitis in rats at 2, 5 and 8ml/kg of the body weight. The effect of P. granatum was assessed in two group i.e. prophylaxis as pre-colitis and therapeutic as post-colitis. After completion of dosing in both the groups, macroscopic and histological examination of colon was carried out along with estimation of serum myeloperoxidase, glutathione, alkaline phosphate, fibrinogen and C-reactive protein. In prophylactic procedure P. granatum revealed significant (P<0.05) changes in biochemical markers of inflammation at 5 and 8ml/kg doses. However in therapeutic procedure significant change was observed only at 8ml/kg. Thus results of the present study suggest that P. granatum have a role in prevention as well as treatment of inflammation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Colite/prevenção & controle
Colo/efeitos dos fármacos
Fármacos Gastrointestinais/farmacologia
Extratos Vegetais/farmacologia
Punicaceae/química
Ácido Trinitrobenzenossulfônico
[Mh] Termos MeSH secundário: Fosfatase Alcalina/sangue
Animais
Anti-Inflamatórios/isolamento & purificação
Biomarcadores/sangue
Proteínas de Transporte/sangue
Colite/sangue
Colite/induzido quimicamente
Colite/patologia
Colo/metabolismo
Colo/patologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Fibrinogênio/metabolismo
Fármacos Gastrointestinais/isolamento & purificação
Glutationa/sangue
Mediadores da Inflamação/sangue
Masculino
Peroxidase/sangue
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Carrier Proteins); 0 (Crp protein, rat); 0 (Gastrointestinal Agents); 0 (Inflammation Mediators); 0 (Plant Extracts); 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid); 9001-32-5 (Fibrinogen); EC 1.11.1.7 (Peroxidase); EC 3.1.3.1 (Alkaline Phosphatase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE



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