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Pesquisa : B01.650.940.800.575.912.250.839 [Categoria DeCS]
Referências encontradas : 21 [refinar]
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  1 / 21 MEDLINE  
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[PMID]:28573232
[Au] Autor:Shahat AA; Mahmoud EA; Al-Mishari AA; Alsaid MS
[Ad] Endereço:Pharmacognosy Department, College of Pharmacy, King Saud University P.O. Box 2457, Riyadh 11451.
[Ti] Título:ANTIMICROBIAL ACTIVITIES OF SOME SAUDI ARABIAN HERBAL PLANTS.
[So] Source:Afr J Tradit Complement Altern Med;14(2):161-165, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several edible plants are used in Kingdom of Saudi Arabia since early time to control microbial infections. In the present study, twenty-four Saudi Arabian medicinal plants d according to traditionally used were select and investigated for the antimicrobial activities. MATERIALS AND METHODS: This study was designed at evaluating the antimicrobial activities of the methanol extracts of twenty-four species of sixteen plant families used in the traditional medicine by Saudi Arabian people for the treatment of numerous ailments of the microbial and non-microbial origin against four Gram-positive, four Gram-negative bacteria and four fungi and yeast using the agar well diffusion method. RESULTS: Of most of the plants tested were found to be active against two to eight organisms. Five plants were active against eight organisms. The data appeared that extracts of (SY-176), (SY- (SY-181), (SY-188), (SY-197) and (SY-198) have anti-microbial activity against the most of tested bacteria, fungi and yeast. Whereas (SY-, the extracts of (SY-175), (SY-187), and (SY-195) have poor action against the tested bacteria, fungi and yeast. CONCLUSION: The antimicrobial activity of plant extracts against bacteria was more effective than against fungi.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Bactérias/efeitos dos fármacos
Fungos/efeitos dos fármacos
Magnoliopsida
Extratos Vegetais/farmacologia
Plantas Medicinais
[Mh] Termos MeSH secundário: Artemisia
Bactérias/crescimento & desenvolvimento
Echium
Fungos/crescimento & desenvolvimento
Testes de Sensibilidade Microbiana
Resedaceae
Rumex
Arábia Saudita
Ziziphus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.17


  2 / 21 MEDLINE  
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[PMID]:25947421
[Au] Autor:Müller A
[Ad] Endereço:ETH Zurich, Institute of Agricultural Sciences, Biocommunication and Entomology, Schmelzbergstrasse 9/LFO, 8092 Zurich, Switzerland.; Email: andreas.mueller@usys.ethz.ch.
[Ti] Título:Palaearctic Hoplitis bees of the subgenus Platosmia (Megachilidae, Osmiini): biology, taxonomy and key to species.
[So] Source:Zootaxa;3936(1):71-81, 2015 Mar 18.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Platosmia, a subgenus of the osmiine bee genus Hoplitis (Megachilidae), contains ten species, which are confined to desertic and semidesertic areas of the Palaearctic region. Analysis of female pollen loads and field observations indicate that several H. (Platosmia) species are strictly oligolectic on Reseda (Resedaceae) and possibly Hedysareae (Fabaceae), while others are mesolectic on both Reseda and Fabaceae. The few data available so far suggest that preexisting cavities in stones and rocks serve as nesting sites of H. (Platosmia). The taxonomic revision of H. (Platosmia) revealed the existence of an undescribed species from the Arabian peninsula, H. arabiae spec. nov.. Hoplitis incognita Zanden, 1996 and H. quarzazati (Zanden, 1998) are newly synonymized with H. maghrebensis (Zanden, 1992) and H. platalea (Warncke, 1990), respectively. Identification keys for all H. (Platosmia) species are given including the hitherto unknown male or female sex of three species.
[Mh] Termos MeSH primário: Abelhas/classificação
[Mh] Termos MeSH secundário: Animais
Abelhas/anatomia & histologia
Abelhas/fisiologia
Fabaceae
Feminino
Masculino
Comportamento de Nidação
Pólen
Resedaceae
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150508
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.3936.1.3


  3 / 21 MEDLINE  
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[PMID]:25858449
[Au] Autor:Edilu A; Adane L; Woyessa D
[Ti] Título:In vitro antibacterial activities of compounds isolated from roots of Caylusea abyssinica.
[So] Source:Ann Clin Microbiol Antimicrob;14:15, 2015 Mar 21.
[Is] ISSN:1476-0711
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Caylusea absyssinica, a plant used as vegetable and for medicinal purposes was selected for in vitro antibacterial evaluation in this study. The main aim of this study was to isolate compounds from the plant roots and evaluate their antibacterial activities on clinical bacterial test strains. METHODS: Compounds from roots of Caylusea absyssinica (fresen) were identified based on observed spectral (1H-NMR, 13C-NMR and IR) data and physical properties (melting point) as well as reported literature. Disk diffusion method was employed to evaluate the antibacterial activities of the isolated compounds on four test bacterial strains namely, Staphylococcus aureus (ATCC25903), Escherichia coli (ATCC25722), Pseudomonas aeruginosa (DSMZ1117) and Salmonella thyphimurium (ATCC13311). RESULTS: Two compounds, CA1 and CA2 were isolated from the methanol crude extract of the roots of Caylusea absyssinica (fresen). The compounds were identified as ß-sitosterol and stigmasterol, respectively. Evaluation of antibacterial activities revealed that the compounds are active against all the bacterial strains in the experiment, showing inhibition zones ranging from 12 mm-15 mm by CA1 and 11 mm-18 mm by CA2 against the different test strains. However, the compounds were less active than the reference drug (Gentamycine), which showed minimum inhibition zone of 21 mm (Pseudomonas aeruginosa) and maximum of 28 mm (Escherichia coli) inhibition zone. DISCUSSION AND CONCLUSION: The isolation of the compounds is the first report from roots of Caylusea abyssinica and could be potential candidates for future antibacterial drug development programs.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Extratos Vegetais/farmacologia
Resedaceae/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Bactérias/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150411
[St] Status:MEDLINE
[do] DOI:10.1186/s12941-015-0072-6


  4 / 21 MEDLINE  
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[PMID]:25383693
[Au] Autor:Samuni-Blank M; Izhaki I; Gerchman Y; Dearing MD; Karasov WH; Trabelcy B; Edwards TM; Arad Z
[Ad] Endereço:Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, Haifa 3498838, Israel.
[Ti] Título:Taste and physiological responses to glucosinolates: seed predator versus seed disperser.
[So] Source:PLoS One;9(11):e112505, 2014.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In contrast to most other plant tissues, fleshy fruits are meant to be eaten in order to facilitate seed dispersal. Although fleshy fruits attract consumers, they may also contain toxic secondary metabolites. However, studies that link the effect of fruit toxins with seed dispersal and predation are scarce. Glucosinolates (GLSs) are a family of bitter-tasting compounds. The fleshy fruit pulp of Ochradenus baccatus was previously found to harbor high concentrations of GLSs, whereas the myrosinase enzyme, which breaks down GLSs to produce foul tasting chemicals, was found only in the seeds. Here we show the differential behavioral and physiological responses of three rodent species to high dose (80%) Ochradenus' fruits diets. Acomys russatus, a predator of Ochradenus' seeds, was the least sensitive to the taste of the fruit and the only rodent to exhibit taste-related physiological adaptations to deal with the fruits' toxins. In contrast, Acomys cahirinus, an Ochradenus seed disperser, was more sensitive to a diet containing the hydrolyzed products of the GLSs. A third rodent (Mus musculus) was deterred from Ochradenus fruits consumption by the GLSs and their hydrolyzed products. We were able to alter M. musculus avoidance of whole fruit consumption by soaking Ochradenus fruits in a water solution containing 1% adenosine monophosphate, which blocks the bitter taste receptor in mice. The observed differential responses of these three rodent species may be due to evolutionary pressures that have enhanced or reduced their sensitivity to the taste of GLSs.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Glucosinolatos/metabolismo
Roedores/fisiologia
Paladar/fisiologia
[Mh] Termos MeSH secundário: Animais
Frutas/metabolismo
Glucosinolatos/química
Camundongos
Comportamento Predatório/fisiologia
Resedaceae/metabolismo
Dispersão de Sementes/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Glucosinolates)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0112505


  5 / 21 MEDLINE  
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[PMID]:24509155
[Au] Autor:Radulovic NS; Zlatkovic DB; Ilic-Tomic T; Senerovic L; Nikodinovic-Runic J
[Ad] Endereço:Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS-18000 Nis, Serbia. Electronic address: nikoradulovic@yahoo.com.
[Ti] Título:Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy.
[So] Source:J Ethnopharmacol;153(1):125-32, 2014 Apr 11.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Reseda lutea L. (Resedaceae) or Wild Mignonette is a widely distributed plant species. Pliny the Elder (AD 23-AD 79), a Roman scholar and naturalist, reported the use of R. lutea for reducing tumors in his Historia naturalis. Accounts of the beneficial effects of R. lutea in tumor treatment could also be found in the works of later authors, such as Étienne François Geoffroy (1672-1731) and Samuel Frederick Gray (1766-1828). However, to date no in vivo or in vitro evidence exists in support of the alleged tumor healing properties of R. lutea. MATERIALS AND METHODS: The composition of autolysates obtained from different organs (root, flower and fruit) of R. lutea was investigated by GC and GC-MS analyses and IR, 1D and 2D NMR spectroscopy. These analyses led to the discovery of a new compound isolated in pure form from the flower autolysate. Autolysates and their major constituents were submitted to MTT-dye reduction cytotoxic assay on human A375 (melanoma) and MRC5 (fibroblast) cell lines. Mechanism of the cytotoxic effects was studied by cell cycle analysis and Annexin V assay. RESULTS: Benzyl isothiocyanate and 2-(α-l-rhamnopyranosyloxy)benzyl isothiocyanate were identified as the major constituents of the root and flower autolysates, respectively (the later represents a new natural product). These compounds showed significant antiproliferative effects against both cell lines, which could also explain the observed high cytotoxic activity of the tested autolysates. Cell cycle analysis revealed apoptosis as the probable mechanism of cell death. CONCLUSIONS: Tumor healing properties attributed to R. lutea in the pre-modern texts were substantiated by the herein obtained results. Two isothiocyanates were found to be the major carriers of the observed activity. Although there was a relatively low differential effect of the plant metabolites on transformed and non-transformed cell lines, one can argue that the noted strong cytotoxicity provides first evidence that could explain the long forgotten use of this particular species.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Melanoma/tratamento farmacológico
Extratos Vegetais/farmacologia
Resedaceae/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular
Linhagem Celular Tumoral
Etnofarmacologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Isotiocianatos/isolamento & purificação
Isotiocianatos/farmacologia
Espectroscopia de Ressonância Magnética
Melanoma/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Isothiocyanates); 0 (Plant Extracts)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:140328
[Lr] Data última revisão:
140328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140211
[St] Status:MEDLINE


  6 / 21 MEDLINE  
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[PMID]:23839819
[Au] Autor:Wölfle U; Haarhaus B; Schempp CM
[Ad] Endereço:Section skintegral, Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany. ute.woelfle@uniklinik-freiburg.de
[Ti] Título:The photoprotective and antioxidative properties of luteolin are synergistically augmented by tocopherol and ubiquinone.
[So] Source:Planta Med;79(11):963-5, 2013 Jul.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Ultraviolet radiation induces DNA damage and oxidative stress which can result in skin inflammation, photoaging, and photocarcinogenesis. The flavonoid luteolin that is present in high amounts in the dyers weld, Reseda luteola, is one of the most potent antioxidative plant metabolites and also has ultraviolet-absorbing properties.The aim of this study was to determine whether tocopherol and ubiquinone add synergistic antioxidative values to luteolin. None of the substances showed cytotoxic effects in concentrations from 0.25 to 4 µg/mL. The photoprotective and antioxidant effect of equivalent concentrations of luteolin, tocopherol, and ubiquinone and their combination in a ratio of 4 : 4 : 1 were studied in solar simulator irradiated human skin fibroblasts. Luteolin had a half-maximal radical scavenging concentration of 2 µg/mL, whereas tocopherol and ubiquinone were only effective at higher concentrations. None of the substances showed a phototoxic effect, and only luteolin had a moderate photoprotective effect at 2 µg/mL. The combination of luteolin, tocopherol, and ubiquinone exerted a synergistic radical scavenging effect already at a concentration of 0.25 µg/mL and a complete photoprotection at 2 µg/mL.In summary, our findings suggest that the potent antioxidant and photoprotective effect of flavonoids like luteolin may be further increased by the addition of low concentrations of other antioxidants such as tocopherol and ubiquinone.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Luteolina/farmacologia
Resedaceae/química
Tocoferóis/farmacologia
Ubiquinona/farmacologia
[Mh] Termos MeSH secundário: Dano ao DNA
Sinergismo Farmacológico
Fibroblastos/efeitos dos fármacos
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Luteolina/isolamento & purificação
Estresse Oxidativo
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Pele
Raios Ultravioleta/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 1339-63-5 (Ubiquinone); KUX1ZNC9J2 (Luteolin); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130711
[St] Status:MEDLINE
[do] DOI:10.1055/s-0032-1328716


  7 / 21 MEDLINE  
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[PMID]:23788702
[Au] Autor:Samuni-Blank M; Izhaki I; Dearing MD; Karasov WH; Gerchman Y; Kohl KD; Lymberakis P; Kurnath P; Arad Z
[Ad] Endereço:Department of Biology, Technion-Israel Institute of Technology, 32000 Haifa, Israel. michal.samuni@gmail.com
[Ti] Título:Physiological and behavioural effects of fruit toxins on seed-predating versus seed-dispersing congeneric rodents.
[So] Source:J Exp Biol;216(Pt 19):3667-73, 2013 Oct 01.
[Is] ISSN:1477-9145
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fleshy, ripe fruits attract seed dispersers but also seed predators. Although many fruit consumers (legitimate seed dispersers as well as seed predators) are clearly exposed to plant secondary compounds (PSCs), their impact on the consumers' physiology and foraging behaviour has been largely overlooked. Here, we document the divergent behavioural and physiological responses to fruit consumption of three congeneric rodent species in the Middle East, representing both seed dispersers and seed predators. The fruit pulp of the desert plant Ochradenus baccatus contains high concentrations of glucosinolates (GLSs). These GLSs are hydrolyzed into active toxic compounds upon contact with the myrosinase enzyme released from seeds crushed during fruit consumption. Acomys russatus and A. cahirinus share a desert habitat. Acomys russatus acts as an O. baccatus seed predator, and A. cahirinus circumvents the activation of the GLSs by orally expelling vital seeds. We found that between the three species examined, A. russatus was physiologically most tolerant to whole fruit consumption and even A. minous, which is evolutionarily naïve to O. baccatus, exhibits greater tolerance to whole fruit consumption than A. cahirinus. However, like A. cahirinus, A. minous may also behaviourally avoid the activation of the GLSs by making a hole in the pulp and consuming only the seeds. Our findings demonstrate that seed predators have a higher physiological tolerance than seed dispersers when consuming fruits containing toxic PSCs. The findings also demonstrate the extreme ecological/evolutionary lability of this plant-animal symbiosis to shift from predation to mutualism and vice versa.
[Mh] Termos MeSH primário: Comportamento Alimentar
Frutas/metabolismo
Glucosinolatos/metabolismo
Murinae/fisiologia
Resedaceae/metabolismo
Dispersão de Sementes
Toxinas Biológicas/metabolismo
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Tamanho Corporal
Ingestão de Alimentos
Ecossistema
Frutas/química
Glucosinolatos/química
Hidrólise
Murinae/sangue
Resedaceae/química
Resedaceae/enzimologia
Sementes/química
Sementes/enzimologia
Sementes/metabolismo
Toxinas Biológicas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Glucosinolates); 0 (Toxins, Biological); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:130905
[Lr] Data última revisão:
130905
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130622
[St] Status:MEDLINE
[do] DOI:10.1242/jeb.089664


  8 / 21 MEDLINE  
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[PMID]:22967092
[Au] Autor:Tamiru W; Engidawork E; Asres K
[Ad] Endereço:Department of Pharmacology and Therapeutics, School of Pharmacy, Addis Ababa University, P,O, Box 1176, Addis Ababa, Ethiopia.
[Ti] Título:Evaluation of the effects of 80% methanolic leaf extract of Caylusea abyssinica (fresen.) fisch. & Mey. on glucose handling in normal, glucose loaded and diabetic rodents.
[So] Source:BMC Complement Altern Med;12:151, 2012 Sep 11.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The leaves of Caylusea abyssinica (fresen.) Fisch. & Mey. (Resedaceae), a plant widely distributed in East African countries, have been used for management of diabetes mellitus in Ethiopian folklore medicine. However, its use has not been scientifically validated. The present study was undertaken to investigate antidiabetic effects of the hydroalcoholic leaf extract of C. abyssinica extract in rodents. MATERIALS AND METHOD: Male Animals were randomly divided into five groups for each diabetic, normoglycemic and oral glucose tolerance test (OGTT) studies. Group 1 served as controls and administered 2% Tween-80 in distilled water, (TW80); Group 2 received 5 mg/kg glibenclamide (GL5); Groups 3, 4 and 5 were given 100 (CA100), 200 (CA200) and 300 (CA300) mg/kg, respectively, of the hydroalcoholic extract of C. abyssinica. Blood samples were then collected at different time points to determine blood glucose levels (BGL). Data were analyzed using one way ANOVA followed by Dunnet's post hoc test and p < 0.05was considered as statistically significant. RESULTS: In normal mice, CA200 and GL5 induced hypoglycemia starting from the 2nd h but the hypoglycemic effect of CA300 was delayed and appeared at the 4th h (p < 0.05 in all cases). In diabetic mice, BGL was significantly reduced by CA100 (p < 0.05) and CA300 (p < 0.01) starting from the 3rd h, whereas CA200 (p < 0.001) and GL5 (p < 0.05) attained this effect as early as the 2nd h. In OGTT, TW80 (p < 0.01) and CA100 (p < 0.01) brought down BGL significantly at 120 min, while CA200 (p < 0.001) and GL5 (p < 0.001) achieved this effect at 60 min indicating the oral glucose load improving activity of the extract. By contrast, CA300 was observed to have no effect on OGTT. Acute toxicity study revealed the safety of the extract even at a dose of 2000 mg/kg. Preliminary phytochemical study demonstrated the presence of various secondary metabolites, including, among others, saponins, flavonoids and alkaloids. CONCLUSION: The results indicate that C. abyssinica is endowed with antidiabetic and oral glucose tolerance improving actions, particularly at the dose of 200 mg/kg in experimental animals. These activities of the plant extract may be related to the presence of secondary metabolites implicated in antidiabetic activities of plant extracts via different hepatic and extra-hepatic mechanisms. These results thus support the traditional use of the leaf extract for the management of diabetes mellitus.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Glucose/metabolismo
Hipoglicemiantes/administração & dosagem
Extratos Vegetais/administração & dosagem
Folhas de Planta/química
Resedaceae/química
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/metabolismo
Avaliação Pré-Clínica de Medicamentos
Teste de Tolerância a Glucose
Seres Humanos
Masculino
Camundongos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Plant Extracts); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120913
[St] Status:MEDLINE
[do] DOI:10.1186/1472-6882-12-151


  9 / 21 MEDLINE  
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[PMID]:22624993
[Au] Autor:Schempp CM; Meinke MC; Lademann J; Ferrari Y; Brecht T; Gehring W
[Ad] Endereço:Competence Centre Skintegral, Department of Dermatology, University Medical Centre Freiburg, Hauptstrasse 7, D-79104 Freiburg, Germany. christoph.schempp@uniklinik-freiburg.de
[Ti] Título:Topical antioxidants protect the skin from chemical-induced irritation in the repetitive washing test: a placebo-controlled, double-blind study.
[So] Source:Contact Dermatitis;67(4):234-7, 2012 Oct.
[Is] ISSN:1600-0536
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is increasing evidence that reactive oxygen species play an important role in the development of both irritant and allergic contact dermatitis. OBJECTIVES: To assess the potential of topical antioxidants to prevent the development of experimentally induced irritant contact dermatitis. METHODS: We evaluated the effect of a cream containing a combination of antioxidants on sodium lauryl sulfate-induced irritant contact dermatitis in the repetitive washing test. As readout parameters for skin barrier function and cutaneous inflammation stratum corneum hydration, cutaneous blood flow and transepidermal water loss were assessed in 25 volunteers with bioengineering methods. RESULTS: In comparison with the cream base and a frequently used barrier cream, the antioxidant cream had high radical scavenging activity and effectively protected the skin from chemical-induced irritation. CONCLUSIONS: The superiority of the cream with antioxidants to the cream base suggests that reactive oxygen species, at least in part, play a role in the development of irritant contact dermatitis.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Dermatite Irritante/etiologia
Dermatite Irritante/prevenção & controle
Dermatoses da Mão/etiologia
Dermatoses da Mão/prevenção & controle
Creme para a Pele/uso terapêutico
[Mh] Termos MeSH secundário: Dermatite Irritante/fisiopatologia
Método Duplo-Cego
Dermatoses da Mão/fisiopatologia
Seres Humanos
Fitoterapia
Extratos Vegetais/uso terapêutico
Espécies Reativas de Oxigênio
Resedaceae
Dodecilsulfato de Sódio/farmacologia
Tocoferóis/uso terapêutico
Ubiquinona/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 1339-63-5 (Ubiquinone); 368GB5141J (Sodium Dodecyl Sulfate); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120526
[St] Status:MEDLINE
[do] DOI:10.1111/j.1600-0536.2012.02114.x


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[PMID]:22614359
[Au] Autor:Khan S; Al-Qurainy F; Nadeem M; Tarroum M
[Ad] Endereço:Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia. salimkhan17@yahoo.co.in
[Ti] Título:Development of genetic markers for Ochradenus arabicus (Resedaceae), an endemic medicinal plant of Saudi Arabia.
[So] Source:Genet Mol Res;11(2):1300-8, 2012 May 14.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Some species of the genus Ochradenus are difficult to identify based on morphological markers. Similar limitations are found for biochemical markers. We developed genetic markers based on DNA sequences for Ochradenus arabicus, which is an endemic plant to Saudi Arabia, locally utilized as a medicinal shrub. The internal transcribed spacer sequence of nuclear ribosomal DNA and chloroplast (rpoB and rpoC1) markers were more informative than other chloroplast DNA markers. Based on these markers, we were able to discriminate this species from another species of the same genus (O. baccatus) that is widely distributed in Saudi Arabia, despite a high degree of morphological similarity. These genetic markers facilitate its identification, even when acquired in a dried state from local markets.
[Mh] Termos MeSH primário: Marcadores Genéticos
Plantas Medicinais/genética
Resedaceae/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Sequência de Bases
Primers do DNA
Dados de Sequência Molecular
Reação em Cadeia da Polimerase
Arábia Saudita
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA Primers); 0 (Genetic Markers)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:120522
[Lr] Data última revisão:
120522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120523
[St] Status:MEDLINE
[do] DOI:10.4238/2012.May.14.4



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