Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.859.500.750.682 [Categoria DeCS]
Referências encontradas : 80 [refinar]
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[PMID]:29223569
[Au] Autor:Singh AK; Raj V; Keshari AK; Rai A; Kumar P; Rawat A; Maity B; Kumar D; Prakash A; De A; Samanta A; Bhattacharya B; Saha S
[Ad] Endereço:Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, Uttar Pradesh, India.
[Ti] Título:Isolated mangiferin and naringenin exert antidiabetic effect via PPAR /GLUT4 dual agonistic action with strong metabolic regulation.
[So] Source:Chem Biol Interact;280:33-44, 2018 Jan 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In this study, we isolated two compounds from the leaves of Salacia oblonga (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. SA1 and SA2 were orally administered to streptozotocin-induced diabetic rats at 50 and 100 mg/kg daily for 15 days. Blood glucose level, serum lipid profile, oxidative stress parameters, histopathology, docking, molecular parameters, and NMR-based metabolic perturbation studies were performed to investigate the pharmacological activities of SA1 and SA2. Results suggested that both compounds reduced blood glucose level, restored body weight, and normalized lipid concentrations in the serum and oxidative stress biomarkers in the liver and pancreas. In addition, the docking study on several diabetes-associated targets revealed that both compounds had a strong binding affinity towards peroxisome proliferator-activated receptor gamma (PPAR ) and glucose transporter type 4 (GLUT4). Further real-time reverse transcription polymerase chain reaction and western blot analyses were performed to confirm the gene and protein expression levels of PPAR and GLUT4 in the pancreatic tissues. Data obtained from the molecular studies showed that both compounds exhibited antidiabetic effects through dual activation of PPAR /GLUT4 signaling pathways. Finally, the NMR-based metabolic studies showed that both compounds normalized the diabetogenic metabolites in the serum. Altogether, we concluded that SA1 and SA2 might be potential antidiabetic lead compounds for future drug development.
[Mh] Termos MeSH primário: Flavanonas/farmacologia
Transportador de Glucose Tipo 4/metabolismo
Hipoglicemiantes/farmacologia
PPAR gama/metabolismo
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Glicemia/análise
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/tratamento farmacológico
Flavanonas/isolamento & purificação
Flavanonas/uso terapêutico
Transportador de Glucose Tipo 4/agonistas
Transportador de Glucose Tipo 4/genética
Glicogênio/metabolismo
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/uso terapêutico
Insulina/sangue
Lipídeos/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Masculino
Simulação de Acoplamento Molecular
Estresse Oxidativo/efeitos dos fármacos
PPAR gama/agonistas
PPAR gama/genética
Pâncreas/efeitos dos fármacos
Pâncreas/metabolismo
Pâncreas/patologia
Estrutura Terciária de Proteína
Ratos
Salacia/química
Salacia/metabolismo
Transdução de Sinais/efeitos dos fármacos
Estreptozocina/toxicidade
Xantonas/isolamento & purificação
Xantonas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Flavanones); 0 (Glucose Transporter Type 4); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Lipids); 0 (PPAR gamma); 0 (Xanthones); 1M84LD0UMD (mangiferin); 5W494URQ81 (Streptozocin); 9005-79-2 (Glycogen); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


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[PMID]:28132032
[Au] Autor:Rajashree R; Patil R; Khlokute SD; Goudar SS
[Ti] Título:Effect of Salacia reticulata W. and Clitoria ternatea L. on the cognitive and behavioral changes in the streptozotocin-induced young diabetic rats.
[So] Source:J Basic Clin Physiol Pharmacol;28(2):107-114, 2017 Mar 01.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus (DM) of juvenile onset affects both the peripheral and central nervous systems (CNS). However, central effects are less documented and studied than peripheral deficits. Currently, the only feasible treatment available for type 1 DM (T1DM) is insulin which has its own limitations. Hence, an alternative therapy, especially a newer herbal formulation is very much the need of the time. The present study aimed to determine the effects of the alcoholic extracts of roots of the Salacia reticulata W. (SR) and Clitoria ternatea L. (CT) on cognitive and behavioral changes in juvenile diabetic rats. METHODS: Diabetes was induced in 25-day-old Wistar rats by streptozotocin (50 mg/kg bw, IP). Animals were divided into seven groups (n=6). Rats were treated with root extracts of SR and CT (100 mg/kg BW each) for 30 days, from day 1 and day 20 of diabetes confirmation. Then, rats were tested in elevated plus maze (EPM) and Morris water maze (MWM). RESULTS: A statistically significant (p<0.05) difference was observed between the SRCT group and diabetic groups of rats. Apart from decreasing FBS, the combined therapy also proved beneficial as nootropic agent in rats with early-onset diabetes. However, significant improvement is observed only in the learning and memory among preventive group, but not in the curative group. CONCLUSIONS: SRCT, a herbal formula, when used in combination, has a more potent effect in preventing the deleterious effects of juvenile diabetes on cognitive and behavioral changes.
[Mh] Termos MeSH primário: Clitoria
Transtornos Cognitivos/tratamento farmacológico
Transtornos Cognitivos/psicologia
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Experimental/psicologia
Extratos Vegetais/administração & dosagem
Salacia
[Mh] Termos MeSH secundário: Animais
Transtornos Cognitivos/etiologia
Diabetes Mellitus Experimental/complicações
Quimioterapia Combinada
Feminino
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Aprendizagem em Labirinto/fisiologia
Extratos Vegetais/isolamento & purificação
Raízes de Plantas
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


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[PMID]:27803937
[Au] Autor:Jeykodi S; Deshpande J; Juturu V
[Ad] Endereço:Research and Development, OmniActive Health Technologies Ltd., Mumbai, India.
[Ti] Título: Extract Improves Postprandial Glucose and Insulin Response: A Randomized Double-Blind, Placebo Controlled, Crossover Study in Healthy Volunteers.
[So] Source:J Diabetes Res;2016:7971831, 2016.
[Is] ISSN:2314-6753
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Thirty-five healthy subjects were randomly assigned to different doses of extract (200 mg, 300 mg, and 500 mg SCE) capsules and compared with placebo. It is a placebo controlled randomized crossover design study. Subjects were given oral sucrose solution along with capsules and plasma glucose and insulin responses were analyzed. Blood samples were collected at 0, 30, 60, 90, 120, and 180 minutes after administration. AUC insulin significantly lowered after ingestion of SCE. No significant adverse events were observed. Reducing glucose and insulin is very important in reducing postprandial hyperglycemia.
[Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos
Insulina/metabolismo
Extratos Vegetais/farmacologia
Salacia
[Mh] Termos MeSH secundário: Adulto
Glicemia/metabolismo
Estudos Cross-Over
Método Duplo-Cego
Voluntários Saudáveis
Seres Humanos
Masculino
Período Pós-Prandial/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE


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[PMID]:27015084
[Au] Autor:Tanabe G; Matsuda Y; Oka M; Kunikata Y; Tsutsui N; Xie W; Balakishan G; Amer MF; Marumoto S; Muraoka O
[Ti] Título:Highly Diastereoselective Route to α-Glucosidase Inhibitors, Neosalacinol and Neoponkoranol.
[So] Source:J Org Chem;81(8):3407-15, 2016 Apr 15.
[Is] ISSN:1520-6904
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A facile and highly diastereoselective route to potent natural α-glucosidase inhibitors, i.e., neosalacinol (4) and neoponkoranol (6), isolated from the traditional Ayurvedic medicine "Salacia" was developed by intramolecular cyclization of appropriately substituted sulfides (9 and 12).
[Mh] Termos MeSH primário: Inibidores de Glicosídeo Hidrolases/química
Inibidores de Glicosídeo Hidrolases/farmacologia
Extratos Vegetais/química
Salacia/química
Álcoois Açúcares/química
Álcoois Açúcares/farmacologia
Sulfatos/química
Sulfatos/farmacologia
Sulfetos/química
Tiofenos/química
Tiofenos/farmacologia
[Mh] Termos MeSH secundário: Ciclização
Extratos Vegetais/isolamento & purificação
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1,4-dideoxy-1,4-((2,3,4,5,6-pentahydroxyhexyl)episulfoniumylidene)arabinitol); 0 (Glycoside Hydrolase Inhibitors); 0 (Plant Extracts); 0 (Sugar Alcohols); 0 (Sulfates); 0 (Sulfides); 0 (Thiophenes); 0 (salacinol)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160415
[Lr] Data última revisão:
160415
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160326
[St] Status:MEDLINE
[do] DOI:10.1021/acs.joc.5b02894


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[PMID]:26267809
[Au] Autor:Deepak KG; Suneetha G; Surekha Ch
[Ad] Endereço:Department of Biochemistry & Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, 530 045, India.
[Ti] Título:A simple and effective method for vegetative propagation of an endangered medicinal plant Salacia oblonga Wall.
[So] Source:J Nat Med;70(1):115-9, 2016 Jan.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Salacia oblonga Wall. is an endangered medicinal plant whose conservation is urgently needed, as it is extensively used in the Indian Ayurvedic system of medicine to treat diabetes mellitus. This study shows an easy, effective and simple method of conserving genetic identity and producing elite clones of S. oblonga through vegetative propagation. Vegetative propagation was achieved using roots (R), stems with leaves (SL) and stems without leaves (S) with different concentrations (0-500 ppm) of indole butyric acid (IBA). Explants S and SL showed maximum shooting response with 300 ppm IBA and explant R showed maximum response with 200 ppm IBA.
[Mh] Termos MeSH primário: Diabetes Mellitus/terapia
Medicina Ayurvédica
Plantas Medicinais/crescimento & desenvolvimento
Salacia/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Espécies em Perigo de Extinção
Indóis/metabolismo
Reguladores de Crescimento de Planta
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Caules de Planta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Indoles); 0 (Plant Growth Regulators); 061SKE27JP (indolebutyric acid)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150813
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-015-0932-6


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[PMID]:25973644
[Au] Autor:Basu S; Pant M; Rachana R
[Ad] Endereço:a Department of Biotechnology , Jaypee Institute of Information Technology , Noida , Uttar Pradesh , India.
[Ti] Título:Protective effect of Salacia oblonga against tobacco smoke-induced DNA damage and cellular changes in pancreatic ß-cells.
[So] Source:Pharm Biol;54(3):458-64, 2016.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Tobacco smoking generates a tremendous amount of free radicals that induce oxidative stress (OS) in diabetics (pancreatic islet cells are defective). Salacia oblonga Wall. (Celastraceae) is a proven antioxidant and antidiabetic plant whose mechanism of action is yet to be explored. OBJECTIVE: The present study focuses on the protective ability of S. oblonga in tobacco smoke-induced oxidatively stressed pancreatic ß-cell line. MATERIALS AND METHODS: The RINm5f cell line was exposed to tobacco smoke concentrate (TSC) (0.5-10%, 24 h), plant extract (1-75 µg/ml, 3 h), and their combinations. Cell viability was determined through MTT assay. Microscopic analysis was carried out in unstained and nonyl acridine orange-stained cells. The effect of toxic doses of TSC on DNA integrity was analyzed through DNA fragmentation assay. The TSC-induced nitric oxide generation was determined spectrophototmetrically. The expression of anti-apoptotic protein Bcl-X under the above treatment conditions was carried out through RT-PCR. RESULTS: The LD50 dose for TSC was found to be 1% TSC. Salacia oblonga extracts (10 and 15 µg/ml) were found to be optimum safe doses that significantly increased cell viability and decreased the nitric oxide production in TSC-treated cells. Pre-treatment with plant extract suppressed apoptosis through probable increase in the expression of anti-apoptotic protein Bcl-X in TSC-treated cells. Thus, the overall efficiency of plant extract in recovering cellular damage was proven. DISCUSSION AND CONCLUSION: The results suggest that TSC-induced cellular alterations are related to rise in nitric oxide and Bcl-X mRNA expression and propose that S. oblonga may confer significant cytoprotection against OS-mediated injury in ß-cells.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Células Secretoras de Insulina/efeitos dos fármacos
Extratos Vegetais/farmacologia
Salacia
Fumaça/efeitos adversos
Tabaco/toxicidade
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Dano ao DNA/fisiologia
Relação Dose-Resposta a Droga
Células Secretoras de Insulina/patologia
Extratos Vegetais/isolamento & purificação
Substâncias Protetoras/isolamento & purificação
Substâncias Protetoras/farmacologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Protective Agents); 0 (Smoke)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150515
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1046083


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[PMID]:26630568
[Au] Autor:Oda Y; Ueda F; Utsuyama M; Kamei A; Kakinuma C; Abe K; Hirokawa K
[Ad] Endereço:Pharmaceutical and Healthcare Research Laboratories, Research and Development Management Headquarters, FUJIFILM Corporation, Kanagawa, Japan.
[Ti] Título:Improvement in Human Immune Function with Changes in Intestinal Microbiota by Salacia reticulata Extract Ingestion: A Randomized Placebo-Controlled Trial.
[So] Source:PLoS One;10(12):e0142909, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. TRIAL REGISTRATION: UMIN Clinical Trials Registry UMIN000011732.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Microbioma Gastrointestinal/efeitos dos fármacos
Perfilação da Expressão Gênica
Mucosa Intestinal/imunologia
Mucosa Intestinal/metabolismo
Extratos Vegetais/farmacologia
Salacia/química
[Mh] Termos MeSH secundário: Animais
Método Duplo-Cego
Ingestão de Alimentos
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Seres Humanos
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/microbiologia
Masculino
Meia-Idade
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Plant Extracts)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151203
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0142909


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[PMID]:26600639
[Au] Autor:Subhasree N; Kamella A; Kaliappan I; Agrawal A; Dubey GP
[Ad] Endereço:Interdisciplinary Insitute of Indian System of Medicine, SRM University, Kattankulathur, Kancheepuram, Tamil Nadu, India.
[Ti] Título:Antidiabetic and antihyperlipidemic activities of a novel polyherbal formulation in high fat diet/streptozotocin induced diabetic rat model.
[So] Source:Indian J Pharmacol;47(5):509-13, 2015 Sep-Oct.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the antidiabetic and antihyperlipidemic activities of polyherbal formulation (PHF) containing hydroalcoholic extracts of four plants namely Salacia oblonga, Salacia roxbhurgii, Garcinia indica and Lagerstroemia parviflora in streptozotocin (STZ)-induced diabetic rats by administering oral doses (200 and 400 mg/kg body weight). MATERIALS AND METHODS: Animals were divided into diabetic and nondiabetic groups. Rats were fed with a high-fat diet (HFD) and induced with a single low dose of STZ (35 mg/kg) i.p. Diabetic rats were treated with formulation (200 and 400 mg/kg) and metformin 250 mg/kg. Blood glucose levels were measured using blood glucose test strips with ACCU CHEK glucometer. Lipid profile and gluconeogenic enzymes were determined in normal and STZ-induced diabetic rats after oral administration of the PHF for 28 days. Histopathological changes in diabetic rat organs (pancreas, liver, and kidney) were also observed after PHF treatment. RESULTS: Treatment of diabetic rats with PHF and metformin decreased plasma glucose and lipid profile levels. Blood glucose level showed significant reduction after 28 days of treatment with formulation at 200 and 400 mg/kg and in metformin. Formulation treated rats showed significant (P < 0.001) decrease in the activities of gluconeogenic enzymes. Histological examination of various organ tissues of normal control, diabetic control, and drug-treated rats revealed significant results. Treatment with PHF reverses the most blood and tissue changes toward the normal level. CONCLUSION: These findings suggested the antihyperglycemic and antihyperlipidemic properties of the PHF and thus help in preventing future complications of diabetes.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/farmacologia
Hipolipemiantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Glicemia/efeitos dos fármacos
Diabetes Mellitus Experimental/fisiopatologia
Dieta Hiperlipídica
Relação Dose-Resposta a Droga
Feminino
Garcinia/química
Hipoglicemiantes/administração & dosagem
Hipoglicemiantes/isolamento & purificação
Hipolipemiantes/administração & dosagem
Hipolipemiantes/isolamento & purificação
Lagerstroemia/química
Masculino
Metformina/farmacologia
Extratos Vegetais/administração & dosagem
Ratos
Ratos Sprague-Dawley
Salacia/química
Estreptozocina
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Hypolipidemic Agents); 0 (Plant Extracts); 5W494URQ81 (Streptozocin); 9100L32L2N (Metformin)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151125
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.165200


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[PMID]:26349606
[Au] Autor:Manalil JJ; Baby M; Ramavarma SK; Suseela IM; Padikkala J; Raghavamenon A
[Ad] Endereço:Amala Cancer Research Centre (Recognized by University of Calicut, Kerala), Amala Nagar, Kerala, India.
[Ti] Título:Development of an Anti-Atherosclerotic Polyherbal Formulation: GSTC3.
[So] Source:J Environ Pathol Toxicol Oncol;34(3):237-48, 2015.
[Is] ISSN:2162-6537
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A polyherbal formulation consisting of different proportions of Commiphora mukul (Hook ex Stocks) Eng., Salacia reticulata Wight, Terminalia arjuna (Roxb.) Wight & Arn, and Curcuma longa Linn extracts was tested for free-radical scavenging and anti-lipid peroxidative effects on serum and platelets in vitro. The most active formulation (GSTC3) was evaluated for its hypolipidemic potential on a high-fat, high-cholesterol diet (HFD) fed to male Wistar rats for a period of 45 days. At a dose of 100 mg/kg body weight, GSTC3 decreased serum total cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglycerides, and phospholipids similar to standard atorvastatin while maintaining high-density lipoprotein (HDL) at normal levels. Significantly lower levels of thiobarbituric acid-reactive substances (TBARS) were observed in both the liver and sera of rats treated with GSTC3. Although the phospholipid levels in liver remained unchanged, lower values of LDL, VLDL, and atherogenic index of plasma as well as higher HMG-CoA/ mevalonate ratios suggested a significant hypolipidemic effect for GSTC3, possibly by partial inhibition of HMG-CoA reductase activity. The histopathological analysis of liver tissue did not reveal lipid accumulation or indicate tissue damage. Overall, the results of this study suggest the hypolipidemic and anti-atherogenic efficacy of a nontoxic herbal formulation.
[Mh] Termos MeSH primário: Aterosclerose/tratamento farmacológico
Depuradores de Radicais Livres/farmacologia
Hipolipemiantes/farmacologia
Peroxidação de Lipídeos/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Commiphora/química
Curcuma/química
Dieta Hiperlipídica
Relação Dose-Resposta a Droga
Masculino
Ratos
Ratos Wistar
Salacia/química
Terminalia/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0 (Hypolipidemic Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150909
[Lr] Data última revisão:
150909
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150910
[St] Status:MEDLINE


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[PMID]:26346858
[Au] Autor:Yoshino K; Kanetaka T; Koga K
[Ad] Endereço:Department of Chemistry and Biochemistry, National Institute of Technology, Numazu College.
[Ti] Título:[Antioxidant Activity of Salacia Plant (Salacia reticulata)].
[So] Source:Shokuhin Eiseigaku Zasshi;56(4):144-50, 2015.
[Is] ISSN:1882-1006
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Antioxidant activities of aqueous extracts prepared from powdered leaves and stems of Salacia reticulata, a Salacia plant that grows in Sri Lanka, were investigated. Lipid peroxide levels and some hepatic injury markers in plasma, liver and/or kidney of mice treated with ferric nitrilotriacetate (Fe-NTA) were increased as compared to those of control mice. Oral preadministration of extracts of Salacia leaves and stems at doses of 100, 200 and 400 mg/kg body weight prevented the elevations of lipid peroxides and injury markers in a dose-dependent manner. Decrease of antioxidant activity in plasma of mice treated with Fe-NTA was also prevented by administration of these extracts. In in vitro study, well-known polyphenol components exhibited antioxidant activities, but other effective components were also present in these extracts. The results of this investigation indicate that the extracts of leaves and stems of S. reticulata could be beneficial as health foods for the prevention of oxidative stress-related disorders.
[Mh] Termos MeSH primário: Antioxidantes
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
Salacia/química
[Mh] Termos MeSH secundário: Administração Oral
Animais
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Relação Dose-Resposta a Droga
Compostos Férricos
Peróxidos Lipídicos/metabolismo
Masculino
Camundongos Endogâmicos
Ácido Nitrilotriacético/análogos & derivados
Extratos Vegetais/química
Folhas de Planta/química
Caules de Planta/química
Polifenóis/administração & dosagem
Polifenóis/isolamento & purificação
Polifenóis/farmacologia
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Ferric Compounds); 0 (Lipid Peroxides); 0 (Plant Extracts); 0 (Polyphenols); 059QF0KO0R (Water); KA90006V9D (Nitrilotriacetic Acid); Z3U5ED15B9 (ferric nitrilotriacetate)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150909
[St] Status:MEDLINE
[do] DOI:10.3358/shokueishi.56.144



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